GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Gene Symbol Aliases	Gene Symbol All	Species	Taxonomy ID	No. of Glycosylation Sites	No. of GlyTouCan IDs	Disease Name	Aliases Disease Name ▼	GO Labels	GO IDs
Lysosomal acid glucosylceramidase	P04062	GBA1	GBA GC GLUC	GBA1 GBA GC GLUC	Homo sapiens	9606	8	29	Gaucher disease, type I Gaucher disease, type II Gaucher disease, type II, neuronopathic form, classic type Gaucher disease, type II, perinatal lethal form Gaucher disease, type III Gaucher disease, type IIIC	neuronopathic form neuronopathic form, cardiovascular form non-neuronopathic form	Golgi apparatus T cell differentiation in thymus antigen processing and presentation autophagosome organization autophagy beta-glucoside catabolic process brain morphogenesis cell maturation cellular response to starvation cellular response to tumor necrosis factor ceramide biosynthetic process cerebellar Purkinje cell layer formation cholesterol metabolic process determination of adult lifespan endoplasmic reticulum establishment of skin barrier extracellular exosome galactosylceramidase activity glucosylceramidase activity glucosylceramide catabolic process glucosyltransferase activity hematopoietic stem cell proliferation homeostasis of number of cells lipid glycosylation lipid storage lymphocyte migration lysosomal lumen lysosomal membrane lysosome lysosome organization microglia differentiation microglial cell proliferation motor behavior negative regulation of MAP kinase activity negative regulation of inflammatory response negative regulation of interleukin-6 production negative regulation of neuron apoptotic process negative regulation of protein-containing complex assembly neuromuscular process neuron apoptotic process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization positive regulation of neuronal action potential positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein dephosphorylation positive regulation of protein lipidation positive regulation of protein-containing complex disassembly proteasome-mediated ubiquitin-dependent protein catabolic process pyramidal neuron differentiation regulation of TOR signaling regulation of lysosomal protein catabolic process regulation of macroautophagy respiratory electron transport chain response to dexamethasone response to estrogen response to pH response to testosterone response to thyroid hormone scavenger receptor binding signaling receptor binding sphingosine biosynthetic process steryl-beta-glucosidase activity termination of signal transduction trans-Golgi network	GO:0004336 GO:0004348 GO:0005102 GO:0005124 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005802 GO:0006680 GO:0006914 GO:0007040 GO:0008203 GO:0008340 GO:0009267 GO:0009268 GO:0014004 GO:0016241 GO:0019882 GO:0019915 GO:0021694 GO:0021859 GO:0022904 GO:0023021 GO:0030259 GO:0031333 GO:0032006 GO:0032436 GO:0032715 GO:0033077 GO:0033574 GO:0035307 GO:0043161 GO:0043202 GO:0043243 GO:0043407 GO:0043524 GO:0043627 GO:0046512 GO:0046513 GO:0046527 GO:0048469 GO:0048854 GO:0048872 GO:0050295 GO:0050728 GO:0050905 GO:0051402 GO:0061436 GO:0061518 GO:0061744 GO:0070062 GO:0071356 GO:0071425 GO:0071548 GO:0072676 GO:0097066 GO:1901805 GO:1903061 GO:1904457 GO:1904925 GO:1905037 GO:1905165
Sphingomyelin phosphodiesterase	P17405	SMPD1	ASM	SMPD1 ASM	Homo sapiens	9606	6	1	Niemann-Pick disease, type A Niemann-Pick disease, type B	neurological type non-neurological type	acid sphingomyelin phosphodiesterase activity cellular response to UV cellular response to calcium ion ceramide biosynthetic process cholesterol metabolic process endolysosome endosome extracellular exosome extracellular space glycosphingolipid metabolic process hydrolase activity, acting on glycosyl bonds lamellar body lipid droplet lysosomal lumen lysosome negative regulation of MAP kinase activity nervous system development phosphatidylcholine phospholipase C activity plasma membrane plasma membrane repair positive regulation of apoptotic process positive regulation of endocytosis positive regulation of protein dephosphorylation positive regulation of viral entry into host cell response to cocaine response to interleukin-1 response to ionizing radiation response to tumor necrosis factor response to type I interferon response to virus response to xenobiotic stimulus signal transduction sphingomyelin catabolic process sphingomyelin metabolic process sphingomyelin phosphodiesterase activity termination of signal transduction viral entry into host cell wound healing zinc ion binding	GO:0001778 GO:0004767 GO:0005615 GO:0005764 GO:0005768 GO:0005811 GO:0005886 GO:0006684 GO:0006685 GO:0006687 GO:0007165 GO:0007399 GO:0008203 GO:0008270 GO:0009410 GO:0009615 GO:0010212 GO:0016798 GO:0023021 GO:0034340 GO:0034480 GO:0034612 GO:0034644 GO:0035307 GO:0036019 GO:0042060 GO:0042220 GO:0042599 GO:0043065 GO:0043202 GO:0043407 GO:0045807 GO:0046513 GO:0046598 GO:0046718 GO:0061750 GO:0070062 GO:0070555 GO:0071277
Polypeptide N-acetylgalactosaminyltransferase 3	Q14435	GALNT3		GALNT3	Homo sapiens	9606	6	4	GALNT3-CDG	Tumoral calcinosis, hyperphosphatemic, familial	Golgi apparatus Golgi cisterna membrane Golgi membrane O-glycan processing calcium ion binding carbohydrate binding carbohydrate metabolic process extracellular exosome fibroblast growth factor receptor signaling pathway manganese ion binding membrane perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine spermatogenesis	GO:0000139 GO:0004653 GO:0005509 GO:0005794 GO:0005975 GO:0006493 GO:0007283 GO:0008543 GO:0016020 GO:0016266 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471 GO:0070062
Chondroitin sulfate synthase 1	Q86X52	CHSY1	CHSY CSS1 KIAA0990	CHSY1 CHSY CSS1 KIAA0990	Homo sapiens	9606	6	2	Temtamy preaxial brachydactyly syndrome	TPBS	Golgi cisterna membrane Golgi membrane N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity bone morphogenesis chondrocyte development chondroitin sulfate biosynthetic process extracellular region glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity membrane metal ion binding negative regulation of ossification positive regulation of smoothened signaling pathway proximal/distal pattern formation response to nutrient levels sulfation	GO:0000139 GO:0002063 GO:0005576 GO:0009954 GO:0016020 GO:0030206 GO:0030279 GO:0031667 GO:0032580 GO:0045880 GO:0046872 GO:0047238 GO:0050510 GO:0051923 GO:0060349
Carbohydrate sulfotransferase 3	Q7LGC8	CHST3		CHST3	Homo sapiens	9606	6		Spondyloepiphyseal dysplasia with congenital joint dislocations	Spondyloepiphyseal dysplasia, Omani type	Golgi membrane N-acetylglucosamine 6-O-sulfotransferase activity N-acetylglucosamine metabolic process T cell homeostasis carbohydrate metabolic process chondroitin 6-sulfotransferase activity chondroitin sulfate biosynthetic process proteoglycan sulfotransferase activity sulfur compound metabolic process trans-Golgi network	GO:0000139 GO:0001517 GO:0005802 GO:0005975 GO:0006044 GO:0006790 GO:0008459 GO:0030206 GO:0043029 GO:0050698
Prosaposin	P07602	PSAP	GLBA SAP1	PSAP GLBA SAP1	Homo sapiens	9606	15	159	Combined saposin deficiency Gaucher disease, atypical, due to saposin C deficiency Metachromatic leukodystrophy, due to saposin B deficiency	Sphingolipid activator protein 1 deficiency prosaposin deficiency saposin deficiency	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway azurophil granule membrane collagen-containing extracellular matrix enzyme activator activity epithelial cell differentiation involved in prostate gland development extracellular exosome extracellular region extracellular space ganglioside GM1 binding ganglioside GM1 transport to membrane ganglioside GM2 binding ganglioside GM3 binding ganglioside GP1c binding ganglioside GT1b binding identical protein binding intracellular membrane-bounded organelle late endosome lysosomal lumen lysosomal membrane lysosomal transport lysosome phospholipid binding plasma membrane positive regulation of beta-galactosidase activity prostate gland growth protease binding protein homodimerization activity regulation of autophagy regulation of lipid metabolic process scaffold protein binding sphingolipid metabolic process	GO:0002020 GO:0005543 GO:0005576 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005886 GO:0006665 GO:0007041 GO:0007193 GO:0008047 GO:0010506 GO:0019216 GO:0035577 GO:0042802 GO:0042803 GO:0043202 GO:0043231 GO:0060736 GO:0060742 GO:0062023 GO:0070062 GO:0097110 GO:1903771 GO:1905572 GO:1905573 GO:1905574 GO:1905575 GO:1905576 GO:1905577
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	Q8NES3	LFNG		LFNG	Homo sapiens	9606	1	1	LFNG-CDG	SCDO3 Spondylocostal dysostosis 3, autosomal recessive	Golgi membrane O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity T cell differentiation animal organ morphogenesis compartment pattern specification extracellular region extracellular vesicle marginal zone B cell differentiation metal ion binding negative regulation of Notch signaling pathway involved in somitogenesis ovarian follicle development positive regulation of Notch signaling pathway positive regulation of meiotic cell cycle regulation of Notch signaling pathway regulation of somitogenesis somitogenesis	GO:0000139 GO:0001541 GO:0001756 GO:0002315 GO:0005576 GO:0007386 GO:0008593 GO:0009887 GO:0014807 GO:0030217 GO:0033829 GO:0045747 GO:0046872 GO:0051446 GO:1902367 GO:1903561
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	P37287	PIGA		PIGA	Homo sapiens	9606	1		Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION)	PNH1 Paroxysmal nocturnal hemoglobinuria 1	UDP-glycosyltransferase activity cellular response to leukemia inhibitory factor endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane phosphatidylinositol N-acetylglucosaminyltransferase activity preassembly of GPI anchor in ER membrane	GO:0000506 GO:0005789 GO:0008194 GO:0016020 GO:0016254 GO:0017176 GO:1990830
NPC intracellular cholesterol transporter 1	O15118	NPC1		NPC1	Homo sapiens	9606	26	4	Niemann-Pick disease, type C1	Niemann-Pick disease, type D, included	Golgi apparatus adult walking behavior autophagy bile acid metabolic process cellular response to low-density lipoprotein particle stimulus cellular response to steroid hormone stimulus cholesterol binding cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage cholesterol transport cyclodextrin metabolic process endocytosis endoplasmic reticulum establishment of protein localization to membrane extracellular exosome extracellular region gene expression intestinal cholesterol absorption intracellular cholesterol transport late endosome membrane liver development lysosomal membrane lysosomal transport lysosome macroautophagy membrane membrane raft membrane raft organization negative regulation of TORC1 signaling negative regulation of epithelial cell apoptotic process negative regulation of macroautophagy neurogenesis nuclear envelope perinuclear region of cytoplasm plasma membrane programmed cell death protein glycosylation response to cadmium ion response to xenobiotic stimulus signaling receptor activity sterol transporter activity transmembrane signaling receptor activity viral entry into host cell virus receptor activity	GO:0001618 GO:0001889 GO:0004888 GO:0005576 GO:0005635 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0006486 GO:0006897 GO:0006914 GO:0007041 GO:0007628 GO:0008203 GO:0008206 GO:0009410 GO:0010467 GO:0010878 GO:0012501 GO:0015248 GO:0015485 GO:0016020 GO:0016236 GO:0016242 GO:0022008 GO:0030299 GO:0030301 GO:0031579 GO:0031902 GO:0032367 GO:0033344 GO:0038023 GO:0042632 GO:0045121 GO:0046686 GO:0046718 GO:0048471 GO:0070062 GO:0071383 GO:0071404 GO:0090150 GO:1904036 GO:1904262 GO:2000900
Tumor suppressor candidate 3	Q13454	TUSC3	N33	TUSC3 N33	Homo sapiens	9606	1	1	TUSC3-CDG	Mental retardation, autosomal recessive 22 Mental retardation, autosomal recessive 7 (MRT7) Oligosaccharyltransferase TUSC3 subunit defect	cognition endoplasmic reticulum membrane magnesium ion transmembrane transporter activity magnesium ion transport mitochondrion oligosaccharyltransferase complex plasma membrane protein N-linked glycosylation protein N-linked glycosylation via asparagine transmembrane transport	GO:0005739 GO:0005789 GO:0005886 GO:0006487 GO:0008250 GO:0015095 GO:0015693 GO:0018279 GO:0050890 GO:0055085