GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	Q9NQ66	PLCB1	Homo sapiens	9606	4	G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway G2/M transition of mitotic cell cycle GABA-ergic synapse GTPase activator activity activation of meiosis involved in egg activation calcium ion binding calmodulin binding cellular response to fluoride cellular response to glyceraldehyde cellular response to ionomycin cellular response to vasopressin cerebral cortex development chromatin cytoplasm cytosol enzyme binding extracellular exosome fat cell differentiation glutamate receptor signaling pathway glutamatergic synapse identical protein binding inositol trisphosphate metabolic process insulin-like growth factor receptor signaling pathway interleukin-1-mediated signaling pathway interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway ion channel modulating, G protein-coupled receptor signaling pathway lamin binding learning ligand-gated ion channel signaling pathway memory negative regulation of DNA-templated transcription negative regulation of monocyte extravasation nuclear membrane nuclear speck nucleus phosphatidylinositol catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipase C activity phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway positive regulation of CD24 production positive regulation of DNA-templated transcription positive regulation of G1/S transition of mitotic cell cycle positive regulation of JNK cascade positive regulation of acrosome reaction positive regulation of developmental growth positive regulation of embryonic development positive regulation of insulin secretion positive regulation of interleukin-12 production positive regulation of myoblast differentiation postsynaptic cytosol postsynaptic modulation of chemical synaptic transmission regulation of G protein-coupled receptor signaling pathway regulation of establishment of endothelial barrier regulation of fertilization regulation of retrograde trans-synaptic signaling by endocanabinoid release of sequestered calcium ion into cytosol signal transduction	GO:0000086 GO:0000785 GO:0004435 GO:0004629 GO:0005096 GO:0005509 GO:0005516 GO:0005521 GO:0005546 GO:0005634 GO:0005737 GO:0005829 GO:0007165 GO:0007186 GO:0007207 GO:0007213 GO:0007215 GO:0007612 GO:0007613 GO:0008277 GO:0016607 GO:0019899 GO:0021987 GO:0031161 GO:0031965 GO:0032024 GO:0032735 GO:0032957 GO:0035722 GO:0035723 GO:0040019 GO:0042802 GO:0045444 GO:0045663 GO:0045892 GO:0045893 GO:0046330 GO:0046488 GO:0048009 GO:0048015 GO:0048639 GO:0051209 GO:0060466 GO:0070062 GO:0070498 GO:0080154 GO:0098978 GO:0098982 GO:0099105 GO:0099170 GO:0099178 GO:0099524 GO:1900087 GO:1902618 GO:1903140 GO:1904117 GO:1904637 GO:1905631 GO:1990806 GO:2000344 GO:2000438 GO:2000560
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	P51432	Plcb3	Mus musculus	10090		G protein-coupled receptor signaling pathway calcium ion binding calmodulin binding cytosol inositol trisphosphate metabolic process molecular adaptor activity molecular function activator activity nucleus phosphatidylinositol catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling post-Golgi vesicle-mediated transport postsynaptic cytosol protein-containing complex regulation of systemic arterial blood pressure release of sequestered calcium ion into cytosol sarcolemma	GO:0003073 GO:0004435 GO:0005509 GO:0005516 GO:0005634 GO:0005829 GO:0006892 GO:0007186 GO:0031161 GO:0032957 GO:0032991 GO:0042383 GO:0046488 GO:0048015 GO:0051209 GO:0060090 GO:0099524 GO:0140677
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3	Q01970	PLCB3	Homo sapiens	9606		G protein-coupled receptor signaling pathway cadherin binding calcium ion binding calmodulin binding cytosol lipid catabolic process membrane molecular adaptor activity molecular function activator activity nucleus phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity postsynaptic cytosol protein-containing complex regulation of systemic arterial blood pressure release of sequestered calcium ion into cytosol	GO:0003073 GO:0004435 GO:0004629 GO:0005509 GO:0005516 GO:0005634 GO:0005829 GO:0007186 GO:0016020 GO:0016042 GO:0032991 GO:0045296 GO:0046488 GO:0048015 GO:0051209 GO:0060090 GO:0099524 GO:0140677
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4	Q15147	PLCB4	Homo sapiens	9606		G protein-coupled receptor signaling pathway calcium ion binding cytosol lipid catabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity release of sequestered calcium ion into cytosol	GO:0004435 GO:0004629 GO:0005509 GO:0005829 GO:0007186 GO:0016042 GO:0048015 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	Q8R3B1	Plcd1	Mus musculus	10090	2	G protein-coupled receptor signaling pathway GTPase activating protein binding angiogenesis calcium ion binding calcium-dependent phospholipid binding cytoplasm cytosol inositol 1,4,5 trisphosphate binding labyrinthine layer blood vessel development lipid catabolic process mitochondrial membrane phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipid binding positive regulation of inositol trisphosphate biosynthetic process positive regulation of norepinephrine secretion regulation of cell population proliferation regulation of cytosolic calcium ion concentration release of sequestered calcium ion into cytosol response to calcium ion response to peptide hormone	GO:0001525 GO:0004435 GO:0005509 GO:0005543 GO:0005544 GO:0005546 GO:0005737 GO:0005829 GO:0007186 GO:0010701 GO:0016042 GO:0031966 GO:0032794 GO:0032962 GO:0042127 GO:0043434 GO:0046488 GO:0048015 GO:0051209 GO:0051480 GO:0051592 GO:0060716 GO:0070679
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	P10895	PLCD1	Bos taurus	9913	2	calcium ion binding lipid catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol	GO:0004435 GO:0005509 GO:0005546 GO:0016042 GO:0046488 GO:0048015 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	P51178	PLCD1	Homo sapiens	9606	4	GTPase activating protein binding calcium ion binding cytoplasm extracellular exosome lipid catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipid metabolic process plasma membrane release of sequestered calcium ion into cytosol	GO:0004435 GO:0005509 GO:0005546 GO:0005737 GO:0005886 GO:0006644 GO:0016042 GO:0032794 GO:0046488 GO:0048015 GO:0051209 GO:0070062
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	P10688	Plcd1	Rattus norvegicus	10116	2	G protein-coupled receptor signaling pathway GTPase activating protein binding angiogenesis calcium ion binding calcium-dependent phospholipid binding cytoplasm cytosol inositol 1,4,5 trisphosphate binding labyrinthine layer blood vessel development lipid catabolic process mitochondrial membrane phosphatidic acid binding phosphatidylinositol metabolic process phosphatidylinositol phosphate binding phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipase C activity phospholipid binding positive regulation of inositol trisphosphate biosynthetic process positive regulation of norepinephrine secretion regulation of cell population proliferation regulation of cytosolic calcium ion concentration release of sequestered calcium ion into cytosol response to aluminum ion response to calcium ion response to hyperoxia response to organonitrogen compound response to peptide hormone response to prostaglandin F	GO:0001525 GO:0004435 GO:0004629 GO:0005509 GO:0005543 GO:0005544 GO:0005546 GO:0005737 GO:0005829 GO:0007186 GO:0010044 GO:0010243 GO:0010701 GO:0016042 GO:0031966 GO:0032794 GO:0032962 GO:0034696 GO:0042127 GO:0043434 GO:0046488 GO:0048015 GO:0051209 GO:0051480 GO:0051592 GO:0055093 GO:0060716 GO:0070300 GO:0070679 GO:1901981
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Q8K4S1	Plce1	Mus musculus	10090	1	G protein-coupled receptor signaling pathway Golgi membrane Ras protein signal transduction cytosol diacylglycerol biosynthetic process enzyme binding epidermal growth factor receptor signaling pathway glomerulus development guanyl-nucleotide exchange factor activity lamellipodium lipid catabolic process metal ion binding phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of lamellipodium assembly regulation of G protein-coupled receptor signaling pathway regulation of Ras protein signal transduction regulation of protein kinase activity release of sequestered calcium ion into cytosol small GTPase binding	GO:0000139 GO:0004435 GO:0004629 GO:0005085 GO:0005829 GO:0005886 GO:0006651 GO:0007173 GO:0007186 GO:0007200 GO:0007265 GO:0008277 GO:0010592 GO:0016042 GO:0019899 GO:0030027 GO:0031267 GO:0032835 GO:0043410 GO:0045859 GO:0046578 GO:0046872 GO:0048015 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Q9P212	PLCE1	Homo sapiens	9606	1	Golgi membrane Ras protein signal transduction calcium-mediated signaling cytoskeleton organization cytosol diacylglycerol biosynthetic process enzyme binding epidermal growth factor receptor signaling pathway glomerulus development guanyl-nucleotide exchange factor activity heart development lamellipodium lipid catabolic process metal ion binding obsolete inositol phosphate-mediated signaling phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration positive regulation of lamellipodium assembly regulation of G protein-coupled receptor signaling pathway regulation of Ras protein signal transduction regulation of cell growth regulation of protein kinase activity regulation of smooth muscle contraction release of sequestered calcium ion into cytosol small GTPase binding	GO:0000139 GO:0001558 GO:0004435 GO:0004629 GO:0005085 GO:0005829 GO:0005886 GO:0006651 GO:0006940 GO:0007010 GO:0007173 GO:0007200 GO:0007204 GO:0007265 GO:0007507 GO:0008277 GO:0010592 GO:0016042 GO:0019722 GO:0019899 GO:0030027 GO:0031267 GO:0032835 GO:0043410 GO:0045859 GO:0046578 GO:0046872 GO:0048015 GO:0048016 GO:0051209