GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	GO Labels	GO IDs
Toll/interleukin-1 receptor domain-containing adapter protein	P58753	TIRAP	Homo sapiens	9606	3'-UTR-mediated mRNA stabilization MyD88-dependent toll-like receptor signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway Toll-like receptor 2 binding Toll-like receptor 4 binding activation of NF-kappaB-inducing kinase activity canonical NF-kappaB signal transduction cell surface cell surface receptor signaling pathway cellular response to bacterial lipopeptide cellular response to lipoteichoic acid cytoplasm cytosol defense response to Gram-positive bacterium endocytic vesicle extrinsic component of cytoplasmic side of plasma membrane identical protein binding inflammatory response innate immune response molecular adaptor activity myeloid cell differentiation phosphatidylinositol-4,5-bisphosphate binding plasma membrane positive regulation of B cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive regulation of NF-kappaB transcription factor activity positive regulation of canonical NF-kappaB signal transduction positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of neutrophil chemotaxis positive regulation of protein-containing complex assembly positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of tumor necrosis factor production protein kinase C binding protein-macromolecule adaptor activity regulation of innate immune response regulation of interferon-beta production regulation of stress-activated MAPK cascade response to lipopolysaccharide ruffle membrane toll-like receptor 4 signaling pathway	GO:0002755 GO:0005080 GO:0005546 GO:0005737 GO:0005829 GO:0005886 GO:0006954 GO:0007166 GO:0007249 GO:0007250 GO:0009986 GO:0030099 GO:0030139 GO:0030674 GO:0030890 GO:0031234 GO:0031334 GO:0032496 GO:0032587 GO:0032648 GO:0032735 GO:0032738 GO:0032755 GO:0032757 GO:0032760 GO:0032872 GO:0034137 GO:0034141 GO:0034142 GO:0034145 GO:0035662 GO:0035663 GO:0035665 GO:0042802 GO:0043123 GO:0045087 GO:0045088 GO:0046330 GO:0050830 GO:0051092 GO:0060090 GO:0070374 GO:0070935 GO:0071221 GO:0071223 GO:0090023 GO:2000340 GO:2000343
UTP--glucose-1-phosphate uridylyltransferase	Q91ZJ5	Ugp2	Mus musculus	10090	UDP-glucose metabolic process UTP-monosaccharide-1-phosphate uridylyltransferase activity UTP:glucose-1-phosphate uridylyltransferase activity brain development cytoplasm glucose 1-phosphate metabolic process glucose binding glycogen biosynthetic process glycogen metabolic process identical protein binding metal ion binding pyrimidine ribonucleotide binding	GO:0003983 GO:0005536 GO:0005737 GO:0005977 GO:0005978 GO:0006011 GO:0007420 GO:0019255 GO:0032557 GO:0042802 GO:0046872 GO:0051748
Histone deacetylase 4	Q6NZM9	Hdac4	Mus musculus	10090	A band DNA binding DNA-binding transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding SUMO transferase activity Z disc actomyosin cell population proliferation chromatin chromatin binding chromatin remodeling cytoplasm cytosol epigenetic regulation of gene expression histone deacetylase activity histone deacetylase binding histone deacetylase complex identical protein binding molecular adaptor activity negative regulation of DNA-templated transcription negative regulation of cell population proliferation negative regulation of glycolytic process negative regulation of miRNA transcription negative regulation of myotube differentiation negative regulation of osteoblast differentiation negative regulation of transcription by RNA polymerase II neuromuscular junction nuclear speck nucleoplasm nucleus osteoblast development osteoblast differentiation positive regulation of DNA-templated transcription positive regulation of cell population proliferation positive regulation of lamellipodium assembly positive regulation of male mating behavior positive regulation of neuron apoptotic process positive regulation of protein sumoylation positive regulation of reactive oxygen species biosynthetic process positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of transcription by RNA polymerase II potassium ion binding promoter-specific chromatin binding protein kinase binding protein lysine deacetylase activity protein-containing complex regulation of cardiac muscle contraction by calcium ion signaling regulation of skeletal muscle fiber development regulation of skeletal muscle fiber differentiation response to denervation involved in regulation of muscle adaptation response to interleukin-1 response to xenobiotic stimulus sarcomere skeletal system development transcription corepressor activity transcription repressor complex type I interferon-mediated signaling pathway zinc ion binding	GO:0000118 GO:0000122 GO:0000785 GO:0000978 GO:0001501 GO:0001649 GO:0002076 GO:0003677 GO:0003682 GO:0003714 GO:0004407 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006338 GO:0008270 GO:0008283 GO:0008284 GO:0008285 GO:0009410 GO:0010592 GO:0010832 GO:0010882 GO:0014894 GO:0014911 GO:0016607 GO:0017053 GO:0019789 GO:0019901 GO:0030017 GO:0030018 GO:0030955 GO:0031594 GO:0031672 GO:0032991 GO:0033235 GO:0033558 GO:0040029 GO:0042641 GO:0042802 GO:0042826 GO:0043525 GO:0045668 GO:0045820 GO:0045892 GO:0045893 GO:0045944 GO:0048661 GO:0048742 GO:0060090 GO:0060337 GO:0061629 GO:0070555 GO:0140297 GO:1902437 GO:1902809 GO:1902894 GO:1903428 GO:1990841
Zinc finger protein 583	Q96ND8	ZNF583	Homo sapiens	9606	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding metal ion binding nucleus regulation of transcription by RNA polymerase II	GO:0000978 GO:0000981 GO:0005634 GO:0006357 GO:0046872
Zinc finger protein 706	Q9Y5V0	ZNF706	Homo sapiens	9606	cytoplasm metal ion binding negative regulation of DNA-templated transcription negative regulation of stem cell population maintenance nucleus regulation of translation	GO:0005634 GO:0005737 GO:0006417 GO:0045892 GO:0046872 GO:1902455
Glucosamine 6-phosphate N-acetyltransferase	Q4DGL9	Tc00.1047053511671.70	Trypanosoma cruzi strain CL Brener	353153	UDP-N-acetylglucosamine biosynthetic process glucosamine 6-phosphate N-acetyltransferase activity	GO:0004343 GO:0006048
Ubiquitin-like protein 5	Q9BZL1	UBL5	Homo sapiens	9606	cytoplasm mRNA splicing, via spliceosome nucleoplasm nucleus positive regulation of protein targeting to mitochondrion protein modification process protein tag activity	GO:0000398 GO:0005634 GO:0005654 GO:0005737 GO:0031386 GO:0036211 GO:1903955
NHL repeat-containing protein 2	Q8BZW8	Nhlrc2	Mus musculus	10090	cytosol	GO:0005829
U6 snRNA-associated Sm-like protein LSm4	Q9Y4Z0	LSM4	Homo sapiens	9606	Lsm2-8 complex P-body P-body assembly PH domain binding RNA binding RNA splicing U2-type precatalytic spliceosome U4/U6 x U5 tri-snRNP complex U6 snRNA binding U6 snRNP cytosol mRNA splicing, via spliceosome membrane nuclear-transcribed mRNA catabolic process nucleoplasm nucleus protein-containing complex spliceosomal snRNP assembly spliceosomal tri-snRNP complex	GO:0000387 GO:0000398 GO:0000932 GO:0000956 GO:0003723 GO:0005634 GO:0005654 GO:0005688 GO:0005829 GO:0008380 GO:0016020 GO:0017070 GO:0032991 GO:0033962 GO:0042731 GO:0046540 GO:0071005 GO:0097526 GO:0120115
Period circadian protein homolog 3	P56645	PER3	Homo sapiens	9606	circadian regulation of gene expression cytoplasm entrainment of circadian clock by photoperiod kinase binding negative regulation of transcription by RNA polymerase II nucleus protein stabilization regulation of circadian sleep/wake cycle, sleep transcription cis-regulatory region binding transcription corepressor binding ubiquitin protein ligase binding	GO:0000122 GO:0000976 GO:0001222 GO:0005634 GO:0005737 GO:0019900 GO:0031625 GO:0032922 GO:0043153 GO:0045187 GO:0050821