GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	GO Labels	GO IDs
Keratin, type II cytoskeletal 3	P12035	KRT3	Homo sapiens	9606	cytosol epithelial cell differentiation extracellular exosome intermediate filament intermediate filament cytoskeleton organization intermediate filament organization keratin filament keratinization structural constituent of skin epidermis	GO:0005829 GO:0005882 GO:0030280 GO:0030855 GO:0031424 GO:0045095 GO:0045104 GO:0045109 GO:0070062
Lon protease homolog, mitochondrial	P36776	LONP1	Homo sapiens	9606	ADP binding ATP binding ATP hydrolysis activity ATP-dependent peptidase activity DNA polymerase binding G-quadruplex DNA binding PH domain binding cellular response to oxidative stress chaperone-mediated protein complex assembly cytosol identical protein binding insulin receptor substrate binding membrane mitochondrial DNA metabolic process mitochondrial genome maintenance mitochondrial matrix mitochondrial nucleoid mitochondrion mitochondrion organization negative regulation of insulin receptor signaling pathway nucleoplasm oxidation-dependent protein catabolic process protein quality control for misfolded or incompletely synthesized proteins proteolysis involved in protein catabolic process regulation of peptidyl-tyrosine phosphorylation response to aluminum ion response to hormone response to hypoxia sequence-specific DNA binding serine-type endopeptidase activity single-stranded DNA binding single-stranded RNA binding	GO:0000002 GO:0001666 GO:0003697 GO:0003727 GO:0004176 GO:0004252 GO:0005524 GO:0005654 GO:0005739 GO:0005759 GO:0005829 GO:0006515 GO:0007005 GO:0009725 GO:0010044 GO:0016020 GO:0016887 GO:0032042 GO:0034599 GO:0042645 GO:0042731 GO:0042802 GO:0043531 GO:0043560 GO:0043565 GO:0046627 GO:0050730 GO:0051131 GO:0051603 GO:0051880 GO:0070182 GO:0070407
Adenylate kinase	V5BMU5	TCDM_13973	Trypanosoma cruzi Dm28c	1416333	ATP binding nucleobase-containing compound kinase activity nucleobase-containing compound metabolic process phosphorylation	GO:0005524 GO:0006139 GO:0016310 GO:0019205
Ribosomal protein S19	V5DM12	TCDM_13966	Trypanosoma cruzi Dm28c	1416333	ribonucleoprotein complex ribosome structural constituent of ribosome translation	GO:0003735 GO:0005840 GO:0006412 GO:1990904
Zinc finger protein RFP	P14373	TRIM27	Homo sapiens	9606	Arp2/3 complex-mediated actin nucleation DNA binding PML body SUMO transferase activity cytoplasm cytosol early endosome endosome fibrillar center identical protein binding innate immune response metal ion binding mitochondrion negative regulation of adaptive immune response negative regulation of autophagy negative regulation of calcium ion import negative regulation of gene expression, epigenetic negative regulation of interleukin-2 production negative regulation of protein kinase activity negative regulation of transcription by RNA polymerase II negative regulation of tumor necrosis factor production negative regulation of type I interferon production negative regulation of viral transcription nuclear membrane nucleic acid binding nucleolus nucleoplasm nucleus positive regulation of DNA-binding transcription factor activity positive regulation of actin nucleation positive regulation of type II interferon production protein K63-linked ubiquitination protein sumoylation retrograde transport, endosome to Golgi spermatogenesis suppression of viral release by host transcription coactivator activity ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding	GO:0000122 GO:0001650 GO:0002820 GO:0003676 GO:0003677 GO:0003713 GO:0004842 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005768 GO:0005769 GO:0005829 GO:0006469 GO:0007283 GO:0008270 GO:0010507 GO:0016605 GO:0016925 GO:0019789 GO:0031965 GO:0032480 GO:0032703 GO:0032720 GO:0032729 GO:0032897 GO:0034314 GO:0042147 GO:0042802 GO:0044790 GO:0045087 GO:0045814 GO:0046872 GO:0051091 GO:0051127 GO:0061630 GO:0070534 GO:0090281
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	Q6NYC1	JMJD6	Homo sapiens	9606	P-TEFb complex binding RNA binding RNA splicing T cell differentiation in thymus cell surface receptor signaling pathway chromatin remodeling cytoplasm cytosol erythrocyte development heart development histone H3R2 demethylase activity histone H4R3 demethylase activity histone demethylase activity identical protein binding iron ion binding kidney development lung development mRNA processing macrophage activation negative regulation of protein homooligomerization non-membrane-bounded organelle assembly nucleolus nucleoplasm nucleus oxidative RNA demethylase activity oxidative RNA demethylation peptidyl-lysine 5-dioxygenase activity peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine phagocytosis plasma membrane positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II protein demethylase activity protein homooligomerization recognition of apoptotic cell regulation of mRNA splicing, via spliceosome retina development in camera-type eye ribonucleoprotein complex signaling receptor activity single-stranded RNA binding sprouting angiogenesis transcription regulator activator activity	GO:0001822 GO:0002040 GO:0003723 GO:0003727 GO:0005506 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0005886 GO:0006338 GO:0006397 GO:0006909 GO:0007166 GO:0007507 GO:0008380 GO:0018395 GO:0030324 GO:0032452 GO:0032463 GO:0033077 GO:0033746 GO:0033749 GO:0035513 GO:0035515 GO:0038023 GO:0042116 GO:0042802 GO:0043654 GO:0045893 GO:0045944 GO:0048024 GO:0048821 GO:0051260 GO:0060041 GO:0070815 GO:0106140 GO:0140457 GO:0140537 GO:0140694 GO:1990904
Palmitoyltransferase ZDHHC15	Q96MV8	ZDHHC15	Homo sapiens	9606	Golgi apparatus Golgi membrane endoplasmic reticulum palmitoyltransferase activity peptidyl-L-cysteine S-palmitoylation positive regulation of dendrite development postsynapse postsynaptic density protein localization to membrane protein localization to postsynapse protein palmitoylation protein targeting to Golgi apparatus protein targeting to membrane protein-cysteine S-myristoyltransferase activity protein-cysteine S-palmitoyltransferase activity protein-cysteine S-stearoyltransferase activity regulation of dendritic spine morphogenesis synaptic vesicle maturation zinc ion binding	GO:0000139 GO:0005783 GO:0005794 GO:0006612 GO:0008270 GO:0014069 GO:0016188 GO:0016409 GO:0018230 GO:0018345 GO:0019705 GO:0019706 GO:0061001 GO:0062237 GO:0072657 GO:0098794 GO:0140439 GO:0140450 GO:1900006
Exosome complex component RRP42	Q15024	EXOSC7	Homo sapiens	9606	3'-5'-RNA exonuclease activity RNA binding RNA catabolic process RNA processing U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing cytoplasmic exosome (RNase complex) cytosol exonucleolytic catabolism of deadenylated mRNA exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) exosome (RNase complex) nuclear exosome (RNase complex) nuclear mRNA surveillance nuclear polyadenylation-dependent mRNA catabolic process nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' nucleolar exosome (RNase complex) nucleolus nucleoplasm nucleus rRNA processing	GO:0000175 GO:0000176 GO:0000177 GO:0000178 GO:0000467 GO:0003723 GO:0005634 GO:0005654 GO:0005730 GO:0005829 GO:0006364 GO:0006396 GO:0006401 GO:0034427 GO:0034473 GO:0034475 GO:0034476 GO:0043928 GO:0071028 GO:0071035 GO:0071038 GO:0071042 GO:0101019
Cohesin subunit SA-3	Q9UJ98	STAG3	Homo sapiens	9606	chromatin chromatin binding chromosome, centromeric region cohesin complex establishment of meiotic sister chromatid cohesion extracellular space meiotic cohesin complex nucleolus nucleoplasm nucleus sister chromatid cohesion synaptonemal complex synaptonemal complex assembly	GO:0000775 GO:0000785 GO:0000795 GO:0003682 GO:0005615 GO:0005634 GO:0005654 GO:0005730 GO:0007062 GO:0007130 GO:0008278 GO:0030893 GO:0034089
Uncharacterized protein	Q4DY53	Tc00.1047053511727.50	Trypanosoma cruzi strain CL Brener	353153	RISC complex cytoplasm nuclease activity regulatory ncRNA-mediated gene silencing	GO:0004518 GO:0005737 GO:0016442 GO:0031047