GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID ▼	No. of Glycosylation Sites	GO Labels	GO IDs
Voltage-dependent L-type calcium channel subunit alpha	A0A1S3GBI4	Cacna1d	Dipodomys ordii	10020	1	metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
P2X purinoceptor	A0A1S3FPU5	P2rx4	Dipodomys ordii	10020	1	ATP binding extracellularly ATP-gated monoatomic cation channel activity plasma membrane postsynapse purinergic nucleotide receptor activity response to ATP	GO:0001614 GO:0004931 GO:0005524 GO:0005886 GO:0033198 GO:0098794
Hyaluronidase	A0A1S3G4D2	Hyal2	Dipodomys ordii	10020	1	RNA polymerase II transcription regulator complex apical plasma membrane carbohydrate metabolic process cartilage development cellular response to UV-B cellular response to fibroblast growth factor stimulus cellular response to interleukin-1 cellular response to transforming growth factor beta stimulus cellular response to tumor necrosis factor cytosol defense response to virus endocytic vesicle external side of plasma membrane fusion of virus membrane with host plasma membrane hematopoietic progenitor cell differentiation hyaluronan catabolic process hyaluronic acid binding hyaluronoglucuronidase activity hyalurononglucosaminidase activity lysosome membrane raft microvillus monocyte activation multicellular organismal-level iron ion homeostasis negative regulation of cell growth negative regulation of fibroblast migration negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction perinuclear region of cytoplasm positive regulation of extrinsic apoptotic signaling pathway positive regulation of inflammatory response positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of protein import into nucleus positive regulation of transcription by RNA polymerase II receptor signaling protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding response to antibiotic response to reactive oxygen species skeletal system morphogenesis transcription coactivator activity transforming growth factor beta binding virus receptor activity	GO:0000302 GO:0001618 GO:0002244 GO:0003713 GO:0004415 GO:0005540 GO:0005764 GO:0005829 GO:0005902 GO:0005975 GO:0009897 GO:0010764 GO:0016324 GO:0019064 GO:0030139 GO:0030214 GO:0030294 GO:0030308 GO:0030971 GO:0032755 GO:0032757 GO:0033906 GO:0042117 GO:0042307 GO:0044344 GO:0045121 GO:0045944 GO:0046677 GO:0048471 GO:0048705 GO:0050431 GO:0050729 GO:0051216 GO:0051607 GO:0051898 GO:0060586 GO:0071347 GO:0071356 GO:0071493 GO:0071560 GO:0090575 GO:2001238
Voltage-dependent L-type calcium channel subunit alpha	A0A1S3GDX8	Cacna1d	Dipodomys ordii	10020	1	metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
Hyaluronidase	A0A1S3G413	Hyal1	Dipodomys ordii	10020	1	carbohydrate metabolic process hyalurononglucosaminidase activity	GO:0004415 GO:0005975
P2X purinoceptor	A0A1S3G6Y0	P2rx3	Dipodomys ordii	10020	1	ATP binding Schaffer collateral - CA1 synapse axon behavioral response to pain cellular response to ATP establishment of localization in cell extracellularly ATP-gated monoatomic cation channel activity hippocampal mossy fiber to CA3 synapse inorganic cation transmembrane transport neuromuscular synaptic transmission peristalsis plasma membrane postsynapse protein homotrimerization purinergic nucleotide receptor activity receptor complex regulation of synaptic plasticity response to carbohydrate response to cold response to heat response to hypoxia response to mechanical stimulus sensory perception of taste urinary bladder smooth muscle contraction	GO:0001614 GO:0001666 GO:0004931 GO:0005524 GO:0005886 GO:0007274 GO:0009408 GO:0009409 GO:0009612 GO:0009743 GO:0014832 GO:0030424 GO:0030432 GO:0043235 GO:0048167 GO:0048266 GO:0050909 GO:0051649 GO:0070207 GO:0071318 GO:0098662 GO:0098685 GO:0098686 GO:0098794
Hyaluronidase	A0A1S3FH40	LOC105988321	Dipodomys ordii	10020	1	carbohydrate metabolic process hyalurononglucosaminidase activity membrane	GO:0004415 GO:0005975 GO:0016020
Cathepsin D	A0A1S3FJV1	Ctsd	Dipodomys ordii	10020	2	aspartic-type endopeptidase activity extracellular space lysosome proteolysis	GO:0004190 GO:0005615 GO:0005764 GO:0006508
Prothrombin	A0A1S3G9C4	F2	Dipodomys ordii	10020	3	G protein-coupled receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide calcium ion binding cell surface receptor signaling pathway cytolysis by host of symbiont cells external side of plasma membrane extracellular space fibrinolysis heparin binding ligand-gated ion channel signaling pathway lipopolysaccharide binding negative regulation of astrocyte differentiation negative regulation of cytokine production involved in inflammatory response negative regulation of proteolysis neutrophil-mediated killing of gram-negative bacterium platelet activation positive regulation of blood coagulation positive regulation of cell growth positive regulation of cell population proliferation positive regulation of collagen biosynthetic process positive regulation of insulin secretion positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of protein localization to nucleus positive regulation of protein phosphorylation positive regulation of reactive oxygen species metabolic process positive regulation of release of sequestered calcium ion into cytosol proteolysis regulation of cell shape regulation of cytosolic calcium ion concentration serine-type endopeptidase activity signaling receptor binding thrombospondin receptor activity	GO:0001530 GO:0001934 GO:0004252 GO:0005102 GO:0005509 GO:0005615 GO:0006508 GO:0006953 GO:0007166 GO:0007186 GO:0008201 GO:0008284 GO:0008360 GO:0009897 GO:0030168 GO:0030194 GO:0030307 GO:0032024 GO:0032967 GO:0042730 GO:0045861 GO:0048712 GO:0051281 GO:0051480 GO:0051838 GO:0061844 GO:0070053 GO:0070945 GO:1900016 GO:1900182 GO:1900738 GO:1990806 GO:2000379
Hemopexin	A0A1S3GT02	Hpx	Dipodomys ordii	10020	1	extracellular region heme transmembrane transporter activity intracellular iron ion homeostasis metal ion binding	GO:0005576 GO:0006879 GO:0015232 GO:0046872