GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▼	UniProt ID	Gene Symbol	Species	Taxonomy ID	GO Labels	GO IDs
14-3-3 protein epsilon	P62258	YWHAE	Homo sapiens	9606	MAPK cascade MHC class II protein complex binding RNA binding cadherin binding calcium channel regulator activity cellular response to heat cerebral cortex development cytoplasm cytosol enzyme binding extracellular exosome focal adhesion hippocampus development histone deacetylase binding identical protein binding intracellular signal transduction melanosome membrane membrane repolarization during cardiac muscle cell action potential negative regulation of calcium ion export across plasma membrane negative regulation of calcium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation neuron migration nucleus phosphoprotein binding phosphoserine residue binding positive regulation of protein export from nucleus potassium channel regulator activity protein domain specific binding protein heterodimerization activity protein localization to nucleus protein phosphatase binding protein sequestering activity protein targeting regulation of cytosolic calcium ion concentration regulation of heart rate by cardiac conduction regulation of heart rate by hormone regulation of membrane repolarization regulation of mitotic cell cycle regulation of potassium ion transmembrane transporter activity scaffold protein binding signal transduction substantia nigra development transmembrane transporter binding ubiquitin protein ligase binding	GO:0000165 GO:0001764 GO:0003064 GO:0003723 GO:0005246 GO:0005634 GO:0005737 GO:0005829 GO:0005925 GO:0006605 GO:0007165 GO:0007346 GO:0015459 GO:0016020 GO:0019899 GO:0019903 GO:0019904 GO:0021762 GO:0021766 GO:0021987 GO:0023026 GO:0031625 GO:0034504 GO:0034605 GO:0035556 GO:0042470 GO:0042802 GO:0042826 GO:0044325 GO:0045296 GO:0046827 GO:0046982 GO:0050815 GO:0051219 GO:0051480 GO:0060306 GO:0070062 GO:0086013 GO:0086091 GO:0097110 GO:0140311 GO:1901016 GO:1901020 GO:1902309 GO:1905913
14-3-3 protein epsilon	P62260	Ywhae	Rattus norvegicus	10116	MAPK cascade axon calcium channel regulator activity cellular response to heat central region of growth cone cerebral cortex development cytoplasm enzyme binding glutamatergic synapse hippocampus development histone deacetylase binding identical protein binding kinesin complex melanosome negative regulation of calcium ion export across plasma membrane negative regulation of peptidyl-serine dephosphorylation negative regulation of protein dephosphorylation neuron migration nucleus phosphoprotein binding phosphoserine residue binding positive regulation of protein export from nucleus potassium channel regulator activity protein domain specific binding protein heterodimerization activity protein kinase C inhibitor activity protein localization to nucleus protein phosphatase binding protein targeting protein-containing complex binding regulation of cytosolic calcium ion concentration regulation of membrane repolarization regulation of mitotic cell cycle regulation of postsynaptic membrane neurotransmitter receptor levels scaffold protein binding signal transduction synapse transmembrane transporter binding ubiquitin protein ligase binding	GO:0000165 GO:0001764 GO:0005246 GO:0005634 GO:0005737 GO:0005871 GO:0006605 GO:0007165 GO:0007346 GO:0008426 GO:0015459 GO:0019899 GO:0019903 GO:0019904 GO:0021766 GO:0021987 GO:0030424 GO:0031625 GO:0034504 GO:0034605 GO:0035308 GO:0042470 GO:0042802 GO:0042826 GO:0044325 GO:0044877 GO:0045202 GO:0046827 GO:0046982 GO:0050815 GO:0051219 GO:0051480 GO:0060306 GO:0090724 GO:0097110 GO:0098978 GO:0099072 GO:1902309 GO:1905913
14-3-3 protein beta/alpha	Q9CQV8	Ywhab	Mus musculus	10090	cytoplasm cytoplasmic sequestering of protein cytosol enzyme binding histone deacetylase binding identical protein binding melanosome negative regulation of DNA-templated transcription negative regulation of G protein-coupled receptor signaling pathway negative regulation of protein dephosphorylation perinuclear region of cytoplasm phosphoprotein binding phosphoserine residue binding protein domain specific binding protein kinase inhibitor activity protein targeting protein-containing complex protein-containing complex binding signal transduction transcription repressor complex	GO:0004860 GO:0005737 GO:0005829 GO:0006605 GO:0007165 GO:0017053 GO:0019899 GO:0019904 GO:0032991 GO:0035308 GO:0042470 GO:0042802 GO:0042826 GO:0044877 GO:0045744 GO:0045892 GO:0048471 GO:0050815 GO:0051219 GO:0051220
14-3-3 protein beta/alpha	P31946	YWHAB	Homo sapiens	9606	cadherin binding cytoplasm cytoplasmic sequestering of protein cytosol enzyme binding extracellular exosome focal adhesion histone deacetylase binding identical protein binding melanosome membrane negative regulation of G protein-coupled receptor signaling pathway negative regulation of protein dephosphorylation perinuclear region of cytoplasm phosphoprotein binding phosphoserine residue binding positive regulation of catalytic activity protein domain specific binding protein kinase inhibitor activity protein targeting signal transduction vacuolar membrane	GO:0004860 GO:0005737 GO:0005774 GO:0005829 GO:0005925 GO:0006605 GO:0007165 GO:0016020 GO:0019899 GO:0019904 GO:0035308 GO:0042470 GO:0042802 GO:0042826 GO:0043085 GO:0045296 GO:0045744 GO:0048471 GO:0050815 GO:0051219 GO:0051220 GO:0070062
14-3-3 protein beta/alpha	P35213	Ywhab	Rattus norvegicus	10116	cytoplasm cytoplasmic sequestering of protein cytosol enzyme binding histone deacetylase binding identical protein binding melanosome negative regulation of DNA-templated transcription negative regulation of G protein-coupled receptor signaling pathway negative regulation of protein dephosphorylation perinuclear region of cytoplasm phosphoprotein binding phosphoserine residue binding protein domain specific binding protein kinase inhibitor activity protein targeting protein-containing complex protein-containing complex binding signal transduction transcription repressor complex	GO:0004860 GO:0005737 GO:0005829 GO:0006605 GO:0007165 GO:0017053 GO:0019899 GO:0019904 GO:0032991 GO:0035308 GO:0042470 GO:0042802 GO:0042826 GO:0044877 GO:0045744 GO:0045892 GO:0048471 GO:0050815 GO:0051219 GO:0051220
14-3-3 protein	Q6B9P3	TCF2	Trypanosoma cruzi	5693
14-3-3 protein	L0GED8	14R2	Triticum aestivum	4565	cytoplasm signal transduction	GO:0005737 GO:0007165
14-3-3 protein	B9Q0N7	BN1205_049880	Toxoplasma gondii VEG	432359
14 kDa phosphohistidine phosphatase	Q9DAK9	Phpt1	Mus musculus	10090	actin cytoskeleton organization actin filament binding calcium channel inhibitor activity cytosol lamellipodium organization leading edge of lamellipodium negative regulation of T cell receptor signaling pathway nuclear body nucleoplasm plasma membrane positive regulation of cell motility protein histidine phosphatase activity transmembrane transporter binding	GO:0005654 GO:0005829 GO:0005886 GO:0016604 GO:0019855 GO:0030036 GO:0044325 GO:0050860 GO:0051015 GO:0061851 GO:0097581 GO:0101006 GO:2000147
14 kDa phosphohistidine phosphatase	Q9NRX4	PHPT1	Homo sapiens	9606	actin cytoskeleton organization actin filament binding calcium channel inhibitor activity cytosol extracellular exosome lamellipodium organization leading edge of lamellipodium negative regulation of ATP citrate synthase activity negative regulation of T cell receptor signaling pathway negative regulation of lyase activity nuclear body nucleoplasm peptidyl-histidine dephosphorylation plasma membrane positive regulation of cell motility protein dephosphorylation protein histidine phosphatase activity transmembrane transporter binding	GO:0005654 GO:0005829 GO:0005886 GO:0006470 GO:0016604 GO:0019855 GO:0030036 GO:0035971 GO:0044325 GO:0050860 GO:0051015 GO:0051350 GO:0061851 GO:0070062 GO:0097581 GO:0101006 GO:2000147 GO:2000984