GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▼	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
10 kDa heat shock protein, mitochondrial	P61604	HSPE1	Homo sapiens	9606	1	ATP binding RNA binding activation of cysteine-type endopeptidase activity involved in apoptotic process chaperone cofactor-dependent protein refolding extracellular exosome membrane metal ion binding mitochondrial matrix mitochondrion osteoblast differentiation protein folding protein folding chaperone protein-folding chaperone binding response to unfolded protein unfolded protein binding	GO:0001649 GO:0003723 GO:0005524 GO:0005739 GO:0005759 GO:0006457 GO:0006919 GO:0006986 GO:0016020 GO:0044183 GO:0046872 GO:0051082 GO:0051085 GO:0051087 GO:0070062
10 kDa heat shock protein, mitochondrial	Q64433	Hspe1	Mus musculus	10090		ATP binding chaperone cofactor-dependent protein refolding metal ion binding mitochondrial matrix mitochondrion protein folding chaperone protein-folding chaperone binding unfolded protein binding	GO:0005524 GO:0005739 GO:0005759 GO:0044183 GO:0046872 GO:0051082 GO:0051085 GO:0051087
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	P16885	PLCG2	Homo sapiens	9606		B cell differentiation B cell receptor signaling pathway Fc-epsilon receptor signaling pathway T cell receptor signaling pathway Wnt signaling pathway antifungal innate immune response calcium-mediated signaling cell activation cellular response to calcium ion cellular response to lectin cellular response to lipid cytoplasm cytosol extracellular exosome follicular B cell differentiation inositol trisphosphate biosynthetic process intracellular signal transduction intracellular vesicle lipopolysaccharide-mediated signaling pathway macrophage activation involved in immune response membrane raft negative regulation of programmed cell death perinuclear region of cytoplasm phosphatidylinositol biosynthetic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipid catabolic process phosphorylation-dependent protein binding phosphotyrosine residue binding plasma membrane platelet activation positive regulation of DNA-binding transcription factor activity positive regulation of I-kappaB phosphorylation positive regulation of MAPK cascade positive regulation of NF-kappaB transcription factor activity positive regulation of NLRP3 inflammasome complex assembly positive regulation of calcium-mediated signaling positive regulation of cell cycle G1/S phase transition positive regulation of dendritic cell cytokine production positive regulation of epithelial cell migration positive regulation of gene expression positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of neuroinflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis, engulfment positive regulation of reactive oxygen species biosynthetic process positive regulation of receptor internalization positive regulation of tumor necrosis factor production positive regulation of type I interferon production programmed cell death protein kinase binding protein tyrosine kinase binding regulation of calcineurin-NFAT signaling cascade regulation of canonical NF-kappaB signal transduction regulation of lipid metabolic process release of sequestered calcium ion into cytosol response to axon injury response to yeast ruffle membrane scaffold protein binding stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway	GO:0001775 GO:0001784 GO:0001878 GO:0002092 GO:0002223 GO:0002224 GO:0002281 GO:0002316 GO:0002732 GO:0004435 GO:0004629 GO:0005737 GO:0005829 GO:0005886 GO:0006661 GO:0009395 GO:0010628 GO:0010634 GO:0012501 GO:0016055 GO:0019216 GO:0019722 GO:0019901 GO:0030168 GO:0030183 GO:0031663 GO:0032481 GO:0032587 GO:0032733 GO:0032735 GO:0032743 GO:0032747 GO:0032755 GO:0032760 GO:0032959 GO:0035556 GO:0038095 GO:0043069 GO:0043122 GO:0043410 GO:0045121 GO:0048015 GO:0048471 GO:0048678 GO:0050731 GO:0050850 GO:0050852 GO:0050853 GO:0051091 GO:0051092 GO:0051209 GO:0060100 GO:0060907 GO:0061760 GO:0070062 GO:0070884 GO:0071277 GO:0071396 GO:0097110 GO:0097708 GO:0140031 GO:0150078 GO:1900227 GO:1902808 GO:1903428 GO:1903721 GO:1990782 GO:1990858
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P19174	PLCG1	Homo sapiens	9606	1	COP9 signalosome Fc-epsilon receptor signaling pathway Schaffer collateral - CA1 synapse T cell receptor signaling pathway calcium ion binding calcium-dependent phospholipase C activity calcium-mediated signaling cell migration cell projection cell-cell junction cellular response to epidermal growth factor stimulus cytoplasm cytosol epidermal growth factor receptor signaling pathway glutamate receptor binding glutamatergic synapse in utero embryonic development lamellipodium modulation of chemical synaptic transmission negative regulation of inflammatory response to antigenic stimulus neurotrophin TRKA receptor binding phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipid catabolic process plasma membrane positive regulation of angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell apoptotic process positive regulation of epithelial cell migration positive regulation of release of sequestered calcium ion into cytosol positive regulation of vascular endothelial cell proliferation protein kinase binding receptor tyrosine kinase binding release of sequestered calcium ion into cytosol ruffle ruffle membrane	GO:0001701 GO:0001726 GO:0002862 GO:0004435 GO:0004629 GO:0005168 GO:0005509 GO:0005737 GO:0005829 GO:0005886 GO:0005911 GO:0007173 GO:0008180 GO:0009395 GO:0010634 GO:0016477 GO:0019722 GO:0019901 GO:0030027 GO:0030971 GO:0032587 GO:0035254 GO:0038095 GO:0042995 GO:0043536 GO:0045766 GO:0046488 GO:0048015 GO:0050429 GO:0050804 GO:0050852 GO:0051209 GO:0051281 GO:0071364 GO:0098685 GO:0098978 GO:1905564 GO:2000353
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Q62077	Plcg1	Mus musculus	10090		COP9 signalosome Schaffer collateral - CA1 synapse T cell receptor signaling pathway calcium ion binding calcium ion transport calcium-dependent phospholipase C activity calcium-mediated signaling cell migration cell projection cell-cell junction cellular response to epidermal growth factor stimulus clathrin-coated vesicle cytoplasm cytosol epidermal growth factor receptor signaling pathway glutamate receptor binding glutamatergic synapse in utero embryonic development inositol trisphosphate biosynthetic process inositol trisphosphate metabolic process insulin receptor binding lamellipodium modulation of chemical synaptic transmission neurotrophin TRKA receptor binding phosphatidylinositol catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phosphoprotein binding plasma membrane positive regulation of angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of endothelial cell apoptotic process positive regulation of epithelial cell migration positive regulation of release of sequestered calcium ion into cytosol positive regulation of vascular endothelial cell proliferation protein kinase binding receptor tyrosine kinase binding release of sequestered calcium ion into cytosol response to curcumin response to organonitrogen compound ruffle ruffle membrane	GO:0001701 GO:0001726 GO:0004435 GO:0004629 GO:0005158 GO:0005168 GO:0005509 GO:0005737 GO:0005829 GO:0005886 GO:0005911 GO:0006816 GO:0007173 GO:0008180 GO:0010243 GO:0010634 GO:0016477 GO:0019722 GO:0019901 GO:0030027 GO:0030136 GO:0030971 GO:0031161 GO:0032587 GO:0032957 GO:0032959 GO:0035254 GO:0042995 GO:0043536 GO:0045766 GO:0046488 GO:0048015 GO:0050429 GO:0050804 GO:0050852 GO:0051209 GO:0051219 GO:0051281 GO:0071364 GO:0098685 GO:0098978 GO:1904643 GO:1905564 GO:2000353
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma	A2A4A6	Plcg1	Mus musculus	10090		calcium ion binding cellular anatomical entity intracellular signal transduction phosphatidylinositol phospholipase C activity phospholipid catabolic process	GO:0004435 GO:0005509 GO:0009395 GO:0035556 GO:0110165
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	O75038	PLCH2	Homo sapiens	9606	1	calcium ion binding cytoplasm lipid catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane release of sequestered calcium ion into cytosol	GO:0004435 GO:0005509 GO:0005737 GO:0005886 GO:0007200 GO:0016042 GO:0046488 GO:0048015 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	Q4KWH8	PLCH1	Homo sapiens	9606	3	calcium ion binding calcium-dependent phospholipase C activity cytoplasm intracellular membrane-bounded organelle lipid catabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling plasma membrane release of sequestered calcium ion into cytosol	GO:0004435 GO:0005509 GO:0005737 GO:0005886 GO:0016042 GO:0043231 GO:0048015 GO:0050429 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Q8K4S1	Plce1	Mus musculus	10090	1	G protein-coupled receptor signaling pathway Golgi membrane Ras protein signal transduction cytosol diacylglycerol biosynthetic process enzyme binding epidermal growth factor receptor signaling pathway glomerulus development guanyl-nucleotide exchange factor activity lamellipodium lipid catabolic process metal ion binding phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of lamellipodium assembly regulation of G protein-coupled receptor signaling pathway regulation of Ras protein signal transduction regulation of protein kinase activity release of sequestered calcium ion into cytosol small GTPase binding	GO:0000139 GO:0004435 GO:0004629 GO:0005085 GO:0005829 GO:0005886 GO:0006651 GO:0007173 GO:0007186 GO:0007200 GO:0007265 GO:0008277 GO:0010592 GO:0016042 GO:0019899 GO:0030027 GO:0031267 GO:0032835 GO:0043410 GO:0045859 GO:0046578 GO:0046872 GO:0048015 GO:0051209
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	Q9P212	PLCE1	Homo sapiens	9606	1	Golgi membrane Ras protein signal transduction calcium-mediated signaling cytoskeleton organization cytosol diacylglycerol biosynthetic process enzyme binding epidermal growth factor receptor signaling pathway glomerulus development guanyl-nucleotide exchange factor activity heart development lamellipodium lipid catabolic process metal ion binding obsolete inositol phosphate-mediated signaling phosphatidylinositol phospholipase C activity phosphatidylinositol-mediated signaling phospholipase C activity phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of MAPK cascade positive regulation of cytosolic calcium ion concentration positive regulation of lamellipodium assembly regulation of G protein-coupled receptor signaling pathway regulation of Ras protein signal transduction regulation of cell growth regulation of protein kinase activity regulation of smooth muscle contraction release of sequestered calcium ion into cytosol small GTPase binding	GO:0000139 GO:0001558 GO:0004435 GO:0004629 GO:0005085 GO:0005829 GO:0005886 GO:0006651 GO:0006940 GO:0007010 GO:0007173 GO:0007200 GO:0007204 GO:0007265 GO:0007507 GO:0008277 GO:0010592 GO:0016042 GO:0019722 GO:0019899 GO:0030027 GO:0031267 GO:0032835 GO:0043410 GO:0045859 GO:0046578 GO:0046872 GO:0048015 GO:0048016 GO:0051209