GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase	A0A2K5U5C7	B3GAT3	Macaca fascicularis	9541	1	Golgi membrane chondroitin sulfate proteoglycan biosynthetic process cis-Golgi network dermatan sulfate proteoglycan biosynthetic process galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process metal ion binding positive regulation of intracellular protein transport protein phosphatase activator activity	GO:0000139 GO:0005801 GO:0006024 GO:0015012 GO:0015018 GO:0046872 GO:0050650 GO:0050651 GO:0072542 GO:0090316
Apelin receptor early endogenous ligand	P0DMC3	APELA	Homo sapiens	9606	1	adult heart development angiogenesis apelin receptor binding apelin receptor signaling pathway cell migration involved in mesendoderm migration coronary vasculature development embryonic heart tube development endoderm development extracellular region extracellular space heart development hormone activity mesendoderm migration mesoderm migration involved in gastrulation placenta blood vessel development positive regulation of ERK1 and ERK2 cascade positive regulation of G protein-coupled receptor internalization positive regulation of angiogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of heart contraction positive regulation of trophoblast cell migration vasculogenesis	GO:0001525 GO:0001570 GO:0005179 GO:0005576 GO:0005615 GO:0007492 GO:0007507 GO:0007509 GO:0007512 GO:0031704 GO:0035050 GO:0045766 GO:0045823 GO:0060183 GO:0060674 GO:0060976 GO:0070374 GO:0090133 GO:0090134 GO:1901165 GO:1903589 GO:1904022
Prothrombin	A0A8C9M9Z1	F2	Panthera tigris altaica	74533	3	G protein-coupled receptor signaling pathway acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide calcium ion binding cell surface receptor signaling pathway cytolysis by host of symbiont cells external side of plasma membrane extracellular space fibrinolysis heparin binding ligand-gated ion channel signaling pathway lipopolysaccharide binding negative regulation of astrocyte differentiation negative regulation of cytokine production involved in inflammatory response negative regulation of proteolysis neutrophil-mediated killing of gram-negative bacterium platelet activation positive regulation of blood coagulation positive regulation of cell growth positive regulation of cell population proliferation positive regulation of collagen biosynthetic process positive regulation of insulin secretion positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of protein localization to nucleus positive regulation of protein phosphorylation positive regulation of reactive oxygen species metabolic process positive regulation of release of sequestered calcium ion into cytosol proteolysis regulation of cell shape regulation of cytosolic calcium ion concentration serine-type endopeptidase activity signaling receptor binding thrombospondin receptor activity	GO:0001530 GO:0001934 GO:0004252 GO:0005102 GO:0005509 GO:0005615 GO:0006508 GO:0006953 GO:0007166 GO:0007186 GO:0008201 GO:0008284 GO:0008360 GO:0009897 GO:0030168 GO:0030194 GO:0030307 GO:0032024 GO:0032967 GO:0042730 GO:0045861 GO:0048712 GO:0051281 GO:0051480 GO:0051838 GO:0061844 GO:0070053 GO:0070945 GO:1900016 GO:1900182 GO:1900738 GO:1990806 GO:2000379
Voltage-dependent L-type calcium channel subunit alpha	A0A8C5ZDQ2	CACNA1F	Marmota marmota marmota	9994	1	metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
T cell receptor alpha variable 8-1	A0A0A6YYK1	TRAV8-1	Homo sapiens	9606	1	T cell receptor complex adaptive immune response	GO:0002250 GO:0042101
Matrix protein 2	A0A2H4R9A9	M2	Influenza A virus (A/California/NHRC_CG5905/2017(H3N2))	2027141	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Dyslexia-associated protein KIAA0319	Q5VV43	KIAA0319	Homo sapiens	9606	10	clathrin-coated endocytic vesicle membrane cytoplasmic vesicle early endosome early endosome membrane intracellular membrane-bounded organelle multicellular organismal response to stress negative regulation of axon extension negative regulation of axon extension involved in regeneration negative regulation of dendrite development neuron migration plasma membrane positive regulation of SMAD protein signal transduction response to auditory stimulus	GO:0001764 GO:0005769 GO:0005886 GO:0010996 GO:0030517 GO:0030669 GO:0031410 GO:0031901 GO:0033555 GO:0043231 GO:0048692 GO:0060391 GO:2000171
Cytochrome P450 monooxygenase lcsK	A0A179HJU2	lcsK	Purpureocillium lilacinum	33203	4	heme binding iron ion binding membrane monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0004497 GO:0005506 GO:0016020 GO:0016705 GO:0020037
Fic domain protein (Fragment)	M9Z875	FICD	Apolemichthys trimaculatus	109717	1	ATP binding	GO:0005524
PR5-like receptor kinase	Q9FF29	PR5K	Arabidopsis thaliana	3702	4	ATP binding membrane phosphorylation plasmodesma protein kinase activity protein serine kinase activity response to fungus transmembrane receptor protein serine/threonine kinase activity	GO:0004672 GO:0004675 GO:0005524 GO:0009506 GO:0009620 GO:0016020 GO:0016310 GO:0106310