GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
ubiquitinyl hydrolase 1	Q4DPS6	Tc00.1047053507047.110	Trypanosoma cruzi strain CL Brener	353153		cysteine-type deubiquitinase activity proteolysis	GO:0004843 GO:0006508
ubiquitinyl hydrolase 1	D6RHQ6	Usp16	Mus musculus	10090	2	cysteine-type deubiquitinase activity proteolysis zinc ion binding	GO:0004843 GO:0006508 GO:0008270
ubiquitinyl hydrolase 1	M0R7V5	Tnfaip3	Rattus norvegicus	10116		B-1 B cell homeostasis DNA binding K63-linked deubiquitinase activity K63-linked polyubiquitin modification-dependent protein binding cell migration cellular response to hydrogen peroxide cellular response to lipopolysaccharide cysteine-type deubiquitinase activity cytoplasm cytoskeleton organization establishment of protein localization to vacuole identical protein binding kinase binding negative regulation of B cell activation negative regulation of CD40 signaling pathway negative regulation of canonical NF-kappaB signal transduction negative regulation of chronic inflammatory response negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of inflammatory response negative regulation of innate immune response negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of protein ubiquitination negative regulation of smooth muscle cell proliferation negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway negative regulation of tumor necrosis factor production nucleus positive regulation of Wnt signaling pathway positive regulation of hepatocyte proliferation positive regulation of protein catabolic process protease binding protein self-association proteolysis regulation of germinal center formation response to molecule of bacterial origin response to muramyl dipeptide tolerance induction to lipopolysaccharide ubiquitin binding ubiquitin-protein transferase activity zinc ion binding	GO:0001922 GO:0002020 GO:0002237 GO:0002634 GO:0002677 GO:0003677 GO:0004842 GO:0004843 GO:0005634 GO:0005737 GO:0006508 GO:0007010 GO:0008270 GO:0016477 GO:0019900 GO:0030177 GO:0031397 GO:0032495 GO:0032691 GO:0032703 GO:0032715 GO:0032720 GO:0034140 GO:0034148 GO:0042802 GO:0043124 GO:0043130 GO:0043621 GO:0045732 GO:0045824 GO:0048662 GO:0050728 GO:0050869 GO:0061578 GO:0070301 GO:0070429 GO:0070433 GO:0070530 GO:0071222 GO:0072573 GO:0072666 GO:1902042 GO:2000347 GO:2000349 GO:2000352 GO:2001237
ubiquitinyl hydrolase 1	A0A0R4J260	Otud4	Mus musculus	10090		cysteine-type deubiquitinase activity proteolysis	GO:0004843 GO:0006508
ubiquitinyl hydrolase 1	E9Q6Y8	Usp31	Mus musculus	10090		cysteine-type deubiquitinase activity nucleus proteolysis	GO:0004843 GO:0005634 GO:0006508
ubiquitinyl hydrolase 1	A0A8I6AL23	Tnfaip3	Rattus norvegicus	10116		B-1 B cell homeostasis DNA binding K63-linked deubiquitinase activity K63-linked polyubiquitin modification-dependent protein binding cell migration cellular response to hydrogen peroxide cellular response to lipopolysaccharide cysteine-type deubiquitinase activity cytoplasm cytoskeleton organization establishment of protein localization to vacuole identical protein binding kinase binding negative regulation of B cell activation negative regulation of CD40 signaling pathway negative regulation of canonical NF-kappaB signal transduction negative regulation of chronic inflammatory response negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of inflammatory response negative regulation of innate immune response negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of protein ubiquitination negative regulation of smooth muscle cell proliferation negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 5 signaling pathway negative regulation of tumor necrosis factor production nucleus positive regulation of Wnt signaling pathway positive regulation of hepatocyte proliferation positive regulation of protein catabolic process protease binding protein self-association proteolysis regulation of germinal center formation response to molecule of bacterial origin response to muramyl dipeptide tolerance induction to lipopolysaccharide ubiquitin binding ubiquitin-protein transferase activity zinc ion binding	GO:0001922 GO:0002020 GO:0002237 GO:0002634 GO:0002677 GO:0003677 GO:0004842 GO:0004843 GO:0005634 GO:0005737 GO:0006508 GO:0007010 GO:0008270 GO:0016477 GO:0019900 GO:0030177 GO:0031397 GO:0032495 GO:0032691 GO:0032703 GO:0032715 GO:0032720 GO:0034140 GO:0034148 GO:0042802 GO:0043124 GO:0043130 GO:0043621 GO:0045732 GO:0045824 GO:0048662 GO:0050728 GO:0050869 GO:0061578 GO:0070301 GO:0070429 GO:0070433 GO:0070530 GO:0071222 GO:0072573 GO:0072666 GO:1902042 GO:2000347 GO:2000349 GO:2000352 GO:2001237
ubiquitinyl hydrolase 1 (Fragment)	B0QZF8	Usp36	Mus musculus	10090		cysteine-type deubiquitinase activity proteolysis	GO:0004843 GO:0006508
ubiquitinyl hydrolase 1 (Fragment)	A0A087WP81	Uchl5	Mus musculus	10090		Ino80 complex cysteine-type deubiquitinase activity proteasome binding ubiquitin-dependent protein catabolic process	GO:0004843 GO:0006511 GO:0031011 GO:0070628
urocanate hydratase	Q4D9S6	Tc00.1047053504045.110	Trypanosoma cruzi strain CL Brener	353153		histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate urocanate hydratase activity	GO:0016153 GO:0019556 GO:0019557
urocanate hydratase	V5BMH1	TCDM_03985	Trypanosoma cruzi Dm28c	1416333		histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate transaminase activity urocanate hydratase activity	GO:0008483 GO:0016153 GO:0019556 GO:0019557