GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Low-density lipoprotein receptor-related protein 10	Q7Z4F1	LRP10	Homo sapiens	9606	4	clathrin-coated pit inner ear development lipid metabolic process lipid transport low-density lipoprotein particle receptor activity membrane plasma membrane	GO:0005041 GO:0005886 GO:0005905 GO:0006629 GO:0006869 GO:0016020 GO:0048839
DNA mismatch repair protein Mlh1	Q9JK91	Mlh1	Mus musculus	10090	1	ATP binding ATP hydrolysis activity ATP-dependent DNA damage sensor activity DNA damage response DNA repair MutLalpha complex MutSalpha complex binding chiasma chromatin binding chromosome condensed chromosome condensed nuclear chromosome double-strand break repair via nonhomologous end joining enzyme binding female meiosis chromosome segregation guanine/thymine mispair binding homologous chromosome pairing at meiosis homologous chromosome segregation intrinsic apoptotic signaling pathway in response to DNA damage isotype switching late recombination nodule male germ cell nucleus male meiosis chromosome segregation male meiotic nuclear division meiotic cell cycle meiotic chromosome segregation meiotic metaphase I homologous chromosome alignment meiotic spindle midzone assembly meiotic telomere clustering mismatch repair negative regulation of mitotic recombination nuclear-transcribed mRNA poly(A) tail shortening nucleoplasm nucleus oogenesis positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes reciprocal meiotic recombination resolution of meiotic recombination intermediates response to bacterium single-stranded DNA binding somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments somatic recombination of immunoglobulin genes involved in immune response spermatogenesis synaptonemal complex	GO:0000289 GO:0000712 GO:0000793 GO:0000794 GO:0000795 GO:0001673 GO:0002204 GO:0003682 GO:0003697 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005712 GO:0005715 GO:0006281 GO:0006298 GO:0006303 GO:0006974 GO:0007060 GO:0007129 GO:0007131 GO:0007140 GO:0007283 GO:0008630 GO:0009617 GO:0016321 GO:0016446 GO:0016447 GO:0016887 GO:0019899 GO:0032137 GO:0032389 GO:0032407 GO:0043060 GO:0045132 GO:0045141 GO:0045143 GO:0045190 GO:0045950 GO:0048298 GO:0048304 GO:0048477 GO:0051257 GO:0051321 GO:0140664
Ephrin-A4	O08542	Efna4	Mus musculus	10090	2	axon guidance ephrin receptor binding ephrin receptor signaling pathway plasma membrane side of membrane	GO:0005886 GO:0007411 GO:0046875 GO:0048013 GO:0098552
Metal cation symporter ZIP14	Q75N73	Slc39a14	Mus musculus	10090	4	apical plasma membrane basolateral plasma membrane cadmium ion transmembrane transporter activity cellular response to glucose stimulus cellular response to insulin stimulus chondrocyte differentiation early endosome membrane ferrous iron transmembrane transporter activity gluconeogenesis import across plasma membrane inorganic cation transmembrane transport insulin receptor signaling pathway intracellular zinc ion homeostasis iron import into cell iron ion transmembrane transport iron ion transmembrane transporter activity iron ion transport late endosome membrane lysosomal membrane manganese ion homeostasis manganese ion transmembrane transport manganese ion transmembrane transporter activity membrane monoatomic anion:monoatomic cation symporter activity monoatomic cation:bicarbonate symporter activity negative regulation of cyclic-nucleotide phosphodiesterase activity plasma membrane positive regulation of G protein-coupled receptor signaling pathway regulation of hormone levels zinc ion import across plasma membrane zinc ion transmembrane transport zinc ion transmembrane transporter activity zinc ion transport	GO:0002062 GO:0005381 GO:0005384 GO:0005385 GO:0005765 GO:0005886 GO:0006094 GO:0006826 GO:0006829 GO:0006882 GO:0008286 GO:0010817 GO:0015086 GO:0015093 GO:0015296 GO:0016020 GO:0016323 GO:0016324 GO:0031901 GO:0031902 GO:0032869 GO:0033212 GO:0034755 GO:0045745 GO:0051344 GO:0055071 GO:0071333 GO:0071421 GO:0071577 GO:0071578 GO:0098662 GO:0098739 GO:0140410
Protocadherin 1 (Fragment)	F7BJK1	Pcdh1	Mus musculus	10090	3	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell junction cell-cell junction homophilic cell adhesion via plasma membrane adhesion molecules intracellular membrane-bounded organelle nucleolus nucleoplasm plasma membrane	GO:0005509 GO:0005654 GO:0005730 GO:0005886 GO:0005911 GO:0007155 GO:0007156 GO:0016339 GO:0030054 GO:0043231
Heparan N-sulfatase	Q9EQ08	Sgsh	Mus musculus	10090	1	N-sulfoglucosamine sulfohydrolase activity determination of adult lifespan glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process heparan sulfate proteoglycan metabolic process lysosomal lumen lysosome motor behavior sulfuric ester hydrolase activity	GO:0005764 GO:0006027 GO:0008340 GO:0008484 GO:0016250 GO:0030200 GO:0030201 GO:0043202 GO:0061744
Inactive phospholipase C-like protein 2	Q8K394	Plcl2	Mus musculus	10090	1	B cell proliferation involved in immune response B-1a B cell differentiation GABA receptor binding cytoplasm gamma-aminobutyric acid signaling pathway inositol 1,4,5 trisphosphate binding intracellular signal transduction lipid metabolic process negative regulation of B cell receptor signaling pathway negative regulation of cold-induced thermogenesis phosphatidylinositol phospholipase C activity regulation of synaptic transmission, GABAergic	GO:0002322 GO:0002337 GO:0004435 GO:0005737 GO:0006629 GO:0007214 GO:0032228 GO:0035556 GO:0050811 GO:0050859 GO:0070679 GO:0120163
Phospholipid-transporting ATPase ABCA3	Q8R420	Abca3	Mus musculus	10090	7	ABC-type xenobiotic transporter activity ATP binding ATP hydrolysis activity ATPase-coupled transmembrane transporter activity alveolar lamellar body alveolar lamellar body membrane cytoplasmic vesicle membrane intracellular membrane-bounded organelle lamellar body lamellar body membrane late endosome lipid transport lipid transporter activity lung development lysosomal membrane multivesicular body membrane organelle assembly phosphatidylcholine flippase activity phosphatidylcholine metabolic process phosphatidylcholine transfer activity phosphatidylglycerol metabolic process phospholipid homeostasis phospholipid transport plasma membrane positive regulation of cholesterol efflux positive regulation of phospholipid efflux positive regulation of phospholipid transport positive regulation of protein homooligomerization regulation of lipid biosynthetic process regulation of lipid transport regulation of phosphatidylcholine metabolic process response to glucocorticoid surfactant homeostasis xenobiotic export from cell xenobiotic transmembrane transport xenobiotic transport	GO:0005319 GO:0005524 GO:0005765 GO:0005770 GO:0005886 GO:0006855 GO:0006869 GO:0008559 GO:0010875 GO:0015914 GO:0016887 GO:0030324 GO:0030659 GO:0032368 GO:0032464 GO:0032585 GO:0042599 GO:0042626 GO:0042908 GO:0043129 GO:0043231 GO:0046470 GO:0046471 GO:0046618 GO:0046890 GO:0051384 GO:0055091 GO:0070925 GO:0097208 GO:0097232 GO:0097233 GO:0120019 GO:0140345 GO:0150172 GO:1902995 GO:2001140
Semaphorin-4G	Q9WUH7	Sema4g	Mus musculus	10090	6	axon guidance chemorepellent activity negative chemotaxis negative regulation of axon extension involved in axon guidance neural crest cell migration plasma membrane positive regulation of cell migration semaphorin receptor binding semaphorin-plexin signaling pathway	GO:0001755 GO:0005886 GO:0007411 GO:0030215 GO:0030335 GO:0045499 GO:0048843 GO:0050919 GO:0071526
Lipase	Q3UT41	Lipo3	Mus musculus	10090	2	intracellular membrane-bounded organelle lipid catabolic process sterol esterase activity sterol metabolic process	GO:0004771 GO:0016042 GO:0016125 GO:0043231