GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Guanylate-binding protein 5	Q96PP8	GBP5	Homo sapiens	9606		GTP binding GTPase activity Golgi apparatus Golgi membrane activation of innate immune response cellular response to lipopolysaccharide cellular response to type II interferon cytolysis in another organism cytoplasm cytoplasmic vesicle cytoplasmic vesicle membrane defense response to bacterium defense response to virus endopeptidase inhibitor activity identical protein binding inflammatory response membrane molecular function inhibitor activity perinuclear region of cytoplasm positive regulation of AIM2 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly positive regulation of cytokine production involved in inflammatory response positive regulation of innate immune response positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production positive regulation of pyroptosis protein homodimerization activity protein homotetramerization protein localization to Golgi apparatus protein targeting side of membrane symbiont cell surface	GO:0000139 GO:0002218 GO:0003924 GO:0004866 GO:0005525 GO:0005737 GO:0005794 GO:0006605 GO:0006954 GO:0016020 GO:0030659 GO:0031410 GO:0032731 GO:0032741 GO:0034067 GO:0042742 GO:0042802 GO:0042803 GO:0045089 GO:0048471 GO:0051289 GO:0051607 GO:0051715 GO:0071222 GO:0071346 GO:0098552 GO:0106139 GO:0140639 GO:0140678 GO:0140973 GO:1900017 GO:1900227
Eosinophil cationic protein	P47779	RNASE3	Macaca fascicularis	9541	2	endonuclease activity extracellular region nucleic acid binding	GO:0003676 GO:0004519 GO:0005576
Opsin, blue-sensitive	P90680	BLOP	Apis mellifera	7460	1	G protein-coupled receptor activity detection of light stimulus involved in visual perception membrane photoreceptor activity phototransduction	GO:0004930 GO:0007602 GO:0009881 GO:0016020 GO:0050908
Beta-secretase 2	A0A7J8A437	mPipKuh1_001328	Pipistrellus kuhlii	59472	2	aspartic-type endopeptidase activity endosome membrane proteolysis	GO:0004190 GO:0005768 GO:0006508 GO:0016020
G-protein coupled receptor 39	Q5U431	Gpr39	Mus musculus	10090	2	G protein-coupled receptor activity G protein-coupled receptor signaling pathway adult feeding behavior cellular response to zinc ion cholesterol homeostasis diet induced thermogenesis establishment of localization in cell gastric acid secretion gastric emptying glucose homeostasis insulin secretion insulin secretion involved in cellular response to glucose stimulus metal ion binding negative regulation of gastric acid secretion neuron cellular homeostasis plasma membrane positive regulation of insulin secretion positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of release of sequestered calcium ion into cytosol regulation of cellular pH regulation of lipid metabolic process regulation of membrane potential release of sequestered calcium ion into cytosol	GO:0001696 GO:0002024 GO:0004930 GO:0005886 GO:0007186 GO:0008343 GO:0019216 GO:0030073 GO:0030641 GO:0032024 GO:0035483 GO:0035773 GO:0035774 GO:0042391 GO:0042593 GO:0042632 GO:0046872 GO:0051209 GO:0051281 GO:0051649 GO:0060455 GO:0070050 GO:0071294
Non-structural glycoprotein 4	D1GG63	NSP4	Rotavirus A human/Bethesda/DC139/1976/G3P[8]	641329	2	extracellular region host caveola host cell rough endoplasmic reticulum membrane induction by virus of host autophagy membrane metal ion binding monoatomic ion channel activity protein complex oligomerization toxin activity virus-mediated pore formation in host cell membrane	GO:0005216 GO:0005576 GO:0016020 GO:0039520 GO:0039707 GO:0044155 GO:0044169 GO:0046872 GO:0051259 GO:0090729
Voltage-dependent L-type calcium channel subunit alpha	A0A2U3WEB7	CACNA1C	Odobenus rosmarus divergens	9708	1	T-tubule calmodulin binding dendrite metal ion binding perikaryon postsynaptic density membrane regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005516 GO:0005891 GO:0030315 GO:0030425 GO:0034765 GO:0043204 GO:0046872 GO:0098839
Subtilisin-like protease 2	Q64K35	SUB2	Trichophyton benhamiae	63400	4	extracellular region proteolysis serine-type endopeptidase activity	GO:0004252 GO:0005576 GO:0006508
Phosphoinositide phospholipase C	A0A6J0U1D8	PLCD3	Pogona vitticeps	103695	1	calcium ion binding intracellular signal transduction lipid catabolic process phosphatidylinositol phospholipase C activity	GO:0004435 GO:0005509 GO:0016042 GO:0035556
Matrix protein 2	A0A0X8EH57	M2	Influenza A virus (A/Alaska/246/2015(H3N2))	1788579	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036