GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Receptor-type tyrosine-protein phosphatase C	P08575	PTPRC	Homo sapiens	9606	39	B cell differentiation B cell proliferation B cell receptor signaling pathway DN2 thymocyte differentiation MAPK cascade T cell activation T cell differentiation T cell receptor signaling pathway alpha-beta T cell proliferation ankyrin binding bleb bone marrow development calcium-mediated signaling using intracellular calcium source cell cycle phase transition cell surface cell surface receptor signaling pathway cellular response to extracellular stimulus cytoplasmic side of plasma membrane defense response to virus dephosphorylation external side of plasma membrane extracellular exosome extrinsic apoptotic signaling pathway focal adhesion gamma-delta T cell differentiation hematopoietic progenitor cell differentiation heparan sulfate proteoglycan binding heparin binding heterotypic cell-cell adhesion leukocyte cell-cell adhesion membrane membrane microdomain membrane raft natural killer cell differentiation negative regulation of ERK1 and ERK2 cascade negative regulation of T cell mediated cytotoxicity negative regulation of cell adhesion involved in substrate-bound cell migration negative regulation of cytokine-mediated signaling pathway negative regulation of interleukin-2 production negative regulation of microglial cell activation negative regulation of protein autophosphorylation negative regulation of protein kinase activity negative regulation of protein tyrosine kinase activity negative thymic T cell selection plasma membrane plasma membrane raft distribution positive regulation of B cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of MAPK cascade positive regulation of T cell mediated cytotoxicity positive regulation of T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of antigen receptor-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of gamma-delta T cell differentiation positive regulation of hematopoietic stem cell migration positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of immunoglobulin production positive regulation of interleukin-2 production positive regulation of isotype switching to IgG isotypes positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase activity positive regulation of protein tyrosine phosphatase activity positive regulation of stem cell proliferation positive regulation of tumor necrosis factor production positive thymic T cell selection protein dephosphorylation protein kinase binding protein tyrosine phosphatase activity regulation of cell cycle regulation of gene expression regulation of interleukin-8 production regulation of phagocytosis regulation of protein tyrosine kinase activity regulation of receptor signaling pathway via JAK-STAT release of sequestered calcium ion into cytosol response to aldosterone response to gamma radiation secretory granule membrane signaling receptor binding spectrin binding stem cell development transmembrane receptor protein tyrosine phosphatase activity	GO:0000165 GO:0001779 GO:0001915 GO:0001916 GO:0001960 GO:0002244 GO:0002639 GO:0002925 GO:0004725 GO:0005001 GO:0005102 GO:0005886 GO:0005925 GO:0006469 GO:0006470 GO:0006933 GO:0007159 GO:0007166 GO:0008201 GO:0009897 GO:0009898 GO:0009986 GO:0010332 GO:0010468 GO:0016020 GO:0016311 GO:0019901 GO:0030183 GO:0030217 GO:0030506 GO:0030507 GO:0030667 GO:0030890 GO:0031668 GO:0031953 GO:0032059 GO:0032677 GO:0032703 GO:0032743 GO:0032760 GO:0034113 GO:0035584 GO:0042100 GO:0042102 GO:0042110 GO:0042492 GO:0043395 GO:0043410 GO:0044770 GO:0044855 GO:0045059 GO:0045060 GO:0045121 GO:0045588 GO:0045860 GO:0046425 GO:0046633 GO:0046641 GO:0048304 GO:0048539 GO:0048864 GO:0050731 GO:0050764 GO:0050852 GO:0050853 GO:0050857 GO:0051209 GO:0051607 GO:0051726 GO:0061097 GO:0061099 GO:0070062 GO:0070373 GO:0070374 GO:0097191 GO:0098857 GO:1903615 GO:1903979 GO:1904044 GO:1904155 GO:1905451 GO:2000473 GO:2000648 GO:2001238
Microtubule-associated protein 4	P27816	MAP4	Homo sapiens	9606	39	RNA binding axon axoneme cell division cilium disassembly cytosol establishment of spindle orientation microtubule microtubule associated complex microtubule binding microtubule cytoskeleton microtubule cytoskeleton organization microtubule organizing center microtubule polymerization microtubule sliding microtubule stabilizing activity mitotic spindle mitotic spindle organization negative regulation of non-motile cilium assembly neuron projection neuron projection development plasma membrane structural molecule activity	GO:0000226 GO:0003723 GO:0005198 GO:0005815 GO:0005829 GO:0005874 GO:0005875 GO:0005886 GO:0005930 GO:0007052 GO:0008017 GO:0015630 GO:0030424 GO:0031175 GO:0043005 GO:0046785 GO:0051012 GO:0051294 GO:0051301 GO:0061523 GO:0072686 GO:0140778 GO:1902856
Cubilin	Q9JLB4	Cubn	Mus musculus	10090	39	Golgi apparatus Golgi-associated vesicle apical part of cell apical plasma membrane brush border brush border membrane calcium ion binding cargo receptor activity cholesterol metabolic process clathrin-coated pit coated vesicle cobalamin binding cobalamin catabolic process cobalamin transport cytoplasm endocytic hemoglobin import into cell endocytic vesicle endocytic vesicle membrane endoplasmic reticulum endosome establishment of localization in cell extracellular exosome hemoglobin binding identical protein binding in utero embryonic development lipoprotein transport lysosomal lumen lysosomal membrane membrane microvillus membrane protein homodimerization activity protein-containing complex receptor complex receptor-mediated endocytosis response to bacterium response to nutrient signaling receptor activity	GO:0001701 GO:0005509 GO:0005737 GO:0005765 GO:0005768 GO:0005783 GO:0005794 GO:0005798 GO:0005903 GO:0005905 GO:0006898 GO:0007584 GO:0008203 GO:0009617 GO:0015889 GO:0016020 GO:0016324 GO:0020028 GO:0030135 GO:0030139 GO:0030492 GO:0030666 GO:0031419 GO:0031526 GO:0031528 GO:0032991 GO:0038023 GO:0038024 GO:0042366 GO:0042802 GO:0042803 GO:0042953 GO:0043202 GO:0043235 GO:0045177 GO:0051649 GO:0070062
Collagen-like protein 7	Q5UNS9	MIMI_L669	Acanthamoeba polyphaga mimivirus	212035	39	virion component	GO:0044423
Glucosylceramide transporter ABCA12	E9Q876	Abca12	Mus musculus	10090	39	ABC-type transporter activity ATP binding ATP hydrolysis activity ATPase-coupled intramembrane lipid transporter activity ATPase-coupled transmembrane transporter activity Golgi membrane apolipoprotein A-I receptor binding ceramide metabolic process ceramide transport cholesterol efflux corneocyte desquamation cytoplasm cytosol epidermal lamellar body epidermal lamellar body membrane establishment of localization in cell establishment of skin barrier intracellular membrane-bounded organelle intracellular protein transport keratinization keratinocyte differentiation lipid homeostasis lipid transport lipid transporter activity lung alveolus development mitochondrial inner membrane phospholipid efflux plasma membrane positive regulation of cholesterol efflux positive regulation of intracellular lipid transport positive regulation of protein localization to cell surface protein localization to plasma membrane regulated exocytosis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of keratinocyte differentiation secretion by cell signaling receptor binding surfactant homeostasis transport vesicle membrane	GO:0000139 GO:0003336 GO:0005102 GO:0005319 GO:0005524 GO:0005737 GO:0005743 GO:0005829 GO:0005886 GO:0006672 GO:0006869 GO:0006886 GO:0010875 GO:0016887 GO:0030216 GO:0030658 GO:0031424 GO:0032379 GO:0032940 GO:0033344 GO:0033700 GO:0034191 GO:0035627 GO:0042626 GO:0043129 GO:0043231 GO:0045055 GO:0045616 GO:0048286 GO:0051649 GO:0055088 GO:0061178 GO:0061436 GO:0072659 GO:0097209 GO:0097234 GO:0140326 GO:0140359 GO:2000010
Arf-GAP domain and FG repeat-containing protein 1	P52594	AGFG1	Homo sapiens	9606	39	DNA binding GTPase activator activity RNA binding acrosome assembly cytoplasm cytoplasmic vesicle cytosol intermediate filament organization intracellular membrane-bounded organelle mRNA export from nucleus metal ion binding nuclear pore spermatid nucleus differentiation	GO:0001675 GO:0003677 GO:0003723 GO:0005096 GO:0005643 GO:0005737 GO:0005829 GO:0006406 GO:0007289 GO:0031410 GO:0043231 GO:0045109 GO:0046872
Carboxypeptidase D	O75976	CPD	Homo sapiens	9606	39	extracellular exosome extracellular space membrane metallocarboxypeptidase activity peptide metabolic process plasma membrane protein processing serine-type carboxypeptidase activity zinc ion binding	GO:0004181 GO:0004185 GO:0005615 GO:0005886 GO:0006518 GO:0008270 GO:0016020 GO:0016485 GO:0070062
E1A-binding protein p400	Q8CHI8	Ep400	Mus musculus	10090	39	ATP binding ATP-dependent chromatin remodeler activity DNA binding DNA repair NuA4 histone acetyltransferase complex Swr1 complex chromatin binding helicase activity hydrolase activity nuclear speck nucleosome positive regulation of DNA-templated transcription positive regulation of double-strand break repair via homologous recombination protein antigen binding regulation of apoptotic process regulation of cell cycle regulation of double-strand break repair	GO:0000786 GO:0000812 GO:0003677 GO:0003682 GO:0004386 GO:0005524 GO:0006281 GO:0016607 GO:0016787 GO:0035267 GO:0042981 GO:0045893 GO:0051726 GO:0140658 GO:1905168 GO:1990405 GO:2000779
Glucoamylase I	P23176	gaI	Aspergillus luchuensis	1069201	39	glucan 1,4-alpha-glucosidase activity polysaccharide catabolic process starch binding	GO:0000272 GO:0004339 GO:2001070
Protein piccolo	Q9Y6V0	PCLO	Homo sapiens	9606	39	GABA-ergic synapse axon calcium ion binding calcium-dependent phospholipid binding cytoskeleton cytoskeleton of presynaptic active zone cytoskeleton organization extracellular exosome glutamatergic synapse insulin secretion postsynaptic density presynapse to nucleus signaling pathway presynaptic active zone assembly profilin binding protein localization to synapse regulation of exocytosis structural constituent of presynaptic active zone synapse synaptic vesicle clustering synaptic vesicle exocytosis	GO:0005509 GO:0005522 GO:0005544 GO:0005856 GO:0007010 GO:0014069 GO:0016079 GO:0017157 GO:0030073 GO:0030424 GO:0035418 GO:0045202 GO:0048788 GO:0070062 GO:0097091 GO:0098882 GO:0098978 GO:0098982 GO:0099526 GO:1904071