GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
14-3-3 protein eta	P68510	Ywhah	Mus musculus	10090	1	actin binding cerebellar granule cell to Purkinje cell synapse cytoplasm cytoskeleton organization cytosol enzyme binding glucocorticoid catabolic process glucocorticoid receptor signaling pathway glutamatergic synapse identical protein binding intercalated disc intracellular protein transport membrane depolarization during action potential negative regulation of apoptotic process negative regulation of dendrite morphogenesis nuclear glucocorticoid receptor binding plasma membrane positive regulation of DNA-templated transcription presynapse presynaptic modulation of chemical synaptic transmission protein domain specific binding protein heterodimerization activity regulation of mitotic nuclear division regulation of sodium ion transmembrane transporter activity regulation of sodium ion transport signal transduction sodium channel regulator activity synapse transmembrane transporter binding	GO:0002028 GO:0003779 GO:0005737 GO:0005829 GO:0005886 GO:0006713 GO:0006886 GO:0007010 GO:0007088 GO:0007165 GO:0014704 GO:0017080 GO:0019899 GO:0019904 GO:0035259 GO:0042802 GO:0042921 GO:0043066 GO:0044325 GO:0045202 GO:0045893 GO:0046982 GO:0050774 GO:0086010 GO:0098793 GO:0098978 GO:0099171 GO:0150048 GO:2000649
14-3-3 protein eta	Q04917	YWHAH	Homo sapiens	9606		actin binding cerebellar granule cell to Purkinje cell synapse cytoplasm cytosol enzyme binding extracellular exosome glucocorticoid catabolic process glucocorticoid receptor signaling pathway identical protein binding insulin-like growth factor receptor binding intercalated disc intracellular protein transport membrane depolarization during action potential negative regulation of dendrite morphogenesis nuclear glucocorticoid receptor binding plasma membrane positive regulation of DNA-templated transcription presynapse presynaptic modulation of chemical synaptic transmission protein domain specific binding protein heterodimerization activity regulation of neuron differentiation regulation of sodium ion transmembrane transporter activity regulation of sodium ion transport regulation of synaptic plasticity signal transduction sodium channel regulator activity substantia nigra development transmembrane transporter binding	GO:0002028 GO:0003779 GO:0005159 GO:0005737 GO:0005829 GO:0005886 GO:0006713 GO:0006886 GO:0007165 GO:0014704 GO:0017080 GO:0019899 GO:0019904 GO:0021762 GO:0035259 GO:0042802 GO:0042921 GO:0044325 GO:0045664 GO:0045893 GO:0046982 GO:0048167 GO:0050774 GO:0070062 GO:0086010 GO:0098793 GO:0099171 GO:0150048 GO:2000649
14-3-3 protein eta	P68511	Ywhah	Rattus norvegicus	10116		actin binding cerebellar granule cell to Purkinje cell synapse cytoplasm enzyme binding glucocorticoid catabolic process glucocorticoid receptor signaling pathway glutamatergic synapse identical protein binding intracellular protein transport membrane depolarization during action potential negative regulation of dendrite morphogenesis nuclear glucocorticoid receptor binding plasma membrane positive regulation of DNA-templated transcription presynapse presynaptic modulation of chemical synaptic transmission protein domain specific binding protein heterodimerization activity regulation of sodium ion transmembrane transporter activity regulation of sodium ion transport signal transduction sodium channel regulator activity synapse transmembrane transporter binding	GO:0002028 GO:0003779 GO:0005737 GO:0005886 GO:0006713 GO:0006886 GO:0007165 GO:0017080 GO:0019899 GO:0019904 GO:0035259 GO:0042802 GO:0042921 GO:0044325 GO:0045202 GO:0045893 GO:0046982 GO:0050774 GO:0086010 GO:0098793 GO:0098978 GO:0099171 GO:0150048 GO:2000649
14-3-3 protein gamma	P61983	Ywhag	Rattus norvegicus	10116		actin binding cellular response to glucose starvation cellular response to insulin stimulus cytoplasm enzyme regulator activity identical protein binding insulin-like growth factor receptor binding negative regulation of TORC1 signaling phosphoserine residue binding presynapse protein domain specific binding protein kinase C binding protein sequestering activity protein targeting receptor tyrosine kinase binding regulation of neuron differentiation regulation of synaptic plasticity signal transduction synapse vesicle	GO:0003779 GO:0005080 GO:0005159 GO:0005737 GO:0006605 GO:0007165 GO:0019904 GO:0030234 GO:0030971 GO:0031982 GO:0032869 GO:0042149 GO:0042802 GO:0045202 GO:0045664 GO:0048167 GO:0050815 GO:0098793 GO:0140311 GO:1904262
14-3-3 protein gamma	P61981	YWHAG	Homo sapiens	9606		RNA binding cellular response to glucose starvation cellular response to insulin stimulus cytoplasm cytosol extracellular exosome focal adhesion identical protein binding insulin-like growth factor receptor binding membrane negative regulation of TORC1 signaling negative regulation of protein kinase activity phosphoserine residue binding presynapse protein domain specific binding protein kinase C binding protein kinase C inhibitor activity protein sequestering activity protein targeting receptor tyrosine kinase binding regulation of neuron differentiation regulation of signal transduction regulation of synaptic plasticity signal transduction	GO:0003723 GO:0005080 GO:0005159 GO:0005737 GO:0005829 GO:0005925 GO:0006469 GO:0006605 GO:0007165 GO:0008426 GO:0009966 GO:0016020 GO:0019904 GO:0030971 GO:0032869 GO:0042149 GO:0042802 GO:0045664 GO:0048167 GO:0050815 GO:0070062 GO:0098793 GO:0140311 GO:1904262
14-3-3 protein gamma	P61982	Ywhag	Mus musculus	10090		actin binding cellular response to glucose starvation cellular response to insulin stimulus cytoplasm cytosol identical protein binding insulin-like growth factor receptor binding myelin sheath negative regulation of TORC1 signaling phosphoserine residue binding presynapse protein domain specific binding protein kinase C binding protein sequestering activity protein targeting receptor tyrosine kinase binding regulation of neuron differentiation regulation of synaptic plasticity signal transduction synapse vesicle	GO:0003779 GO:0005080 GO:0005159 GO:0005737 GO:0005829 GO:0006605 GO:0007165 GO:0019904 GO:0030971 GO:0031982 GO:0032869 GO:0042149 GO:0042802 GO:0043209 GO:0045202 GO:0045664 GO:0048167 GO:0050815 GO:0098793 GO:0140311 GO:1904262
14-3-3 protein sigma	Q9JJ20	Sfn	Mus musculus	10090		cytoplasm intracellular protein transport	GO:0005737 GO:0006886
14-3-3 protein sigma	P31947	SFN	Homo sapiens	9606	2	cadherin binding cytoplasm cytosol establishment of skin barrier extracellular exosome extracellular space identical protein binding intrinsic apoptotic signaling pathway in response to DNA damage keratinization keratinocyte development keratinocyte proliferation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of keratinocyte proliferation negative regulation of protein kinase activity negative regulation of stem cell proliferation negative regulation of transcription by RNA polymerase II nucleus phosphoprotein binding positive regulation of cell growth positive regulation of epidermal cell differentiation positive regulation of protein export from nucleus protein export from nucleus protein kinase A signaling protein kinase C inhibitor activity protein kinase binding regulation of cell cycle regulation of epidermal cell division release of cytochrome c from mitochondria signal transduction stem cell proliferation	GO:0000122 GO:0001836 GO:0003334 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006469 GO:0006611 GO:0007165 GO:0008426 GO:0008630 GO:0010482 GO:0010737 GO:0010839 GO:0019901 GO:0030307 GO:0031424 GO:0042802 GO:0043154 GO:0043616 GO:0045296 GO:0045606 GO:0046827 GO:0051219 GO:0051726 GO:0061436 GO:0070062 GO:0072089 GO:2000647
14-3-3 protein theta	P27348	YWHAQ	Homo sapiens	9606	6	14-3-3 protein binding cytoplasm cytosol extracellular exosome focal adhesion identical protein binding membrane negative regulation of DNA-templated transcription negative regulation of monoatomic ion transmembrane transport protein domain specific binding protein targeting protein-containing complex signal transduction small GTPase mediated signal transduction substantia nigra development synapse transmembrane transporter binding	GO:0005737 GO:0005829 GO:0005925 GO:0006605 GO:0007165 GO:0007264 GO:0016020 GO:0019904 GO:0021762 GO:0032991 GO:0034766 GO:0042802 GO:0044325 GO:0045202 GO:0045892 GO:0070062 GO:0071889
14-3-3 protein theta	P68255	Ywhaq	Rattus norvegicus	10116		14-3-3 protein binding cytoplasm identical protein binding negative regulation of DNA-templated transcription negative regulation of monoatomic ion transmembrane transport protein domain specific binding protein targeting protein-containing complex signal transduction small GTPase mediated signal transduction synapse transmembrane transporter binding	GO:0005737 GO:0006605 GO:0007165 GO:0007264 GO:0019904 GO:0032991 GO:0034766 GO:0042802 GO:0044325 GO:0045202 GO:0045892 GO:0071889