GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
14-3-3 protein theta	P68254	Ywhaq	Mus musculus	10090		14-3-3 protein binding cytoplasm cytosol identical protein binding negative regulation of DNA-templated transcription negative regulation of monoatomic ion transmembrane transport protein domain specific binding protein targeting protein-containing complex signal transduction small GTPase mediated signal transduction synapse transmembrane transporter binding	GO:0005737 GO:0005829 GO:0006605 GO:0007165 GO:0007264 GO:0019904 GO:0032991 GO:0034766 GO:0042802 GO:0044325 GO:0045202 GO:0045892 GO:0071889
14-3-3 protein zeta/delta	P63104	YWHAZ	Homo sapiens	9606	1	DNA-binding transcription factor binding Golgi reassembly RNA binding blood microparticle cadherin binding cellular response to glucose starvation cytoplasm cytosol establishment of Golgi localization extracellular exosome extracellular space focal adhesion glutamatergic synapse identical protein binding melanosome negative regulation of TORC1 signaling negative regulation of apoptotic process negative regulation of innate immune response negative regulation of protein localization to nucleus negative regulation of transcription by RNA polymerase II nucleoplasm nucleus phosphoserine residue binding protein kinase binding protein phosphorylation protein sequestering activity regulation of ERK1 and ERK2 cascade regulation of synapse maturation signal transduction transmembrane transporter binding ubiquitin protein ligase binding vesicle	GO:0000122 GO:0003723 GO:0005615 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005925 GO:0006468 GO:0007165 GO:0019901 GO:0031625 GO:0031982 GO:0042149 GO:0042470 GO:0042802 GO:0043066 GO:0044325 GO:0045296 GO:0045824 GO:0050815 GO:0051683 GO:0070062 GO:0070372 GO:0072562 GO:0090128 GO:0090168 GO:0098978 GO:0140297 GO:0140311 GO:1900181 GO:1904262
14-3-3 protein zeta/delta	P63102	Ywhaz	Rattus norvegicus	10116		DNA-binding transcription factor binding ERK1 and ERK2 cascade Golgi reassembly angiogenesis cell leading edge cytoplasm cytosol establishment of Golgi localization glutamatergic synapse hippocampal mossy fiber to CA3 synapse histamine secretion by mast cell identical protein binding lung development melanosome negative regulation of innate immune response negative regulation of protein localization to nucleus negative regulation of transcription by RNA polymerase II nucleus perinuclear region of cytoplasm phosphoserine residue binding postsynaptic specialization protein domain specific binding protein kinase binding protein phosphorylation protein sequestering activity protein targeting protein targeting to mitochondrion protein-containing complex protein-containing complex binding regulation of ERK1 and ERK2 cascade regulation of programmed cell death regulation of synapse maturation respiratory system process response to xenobiotic stimulus signal transduction synaptic target recognition transmembrane transporter binding tube formation ubiquitin protein ligase binding	GO:0000122 GO:0001525 GO:0002553 GO:0003016 GO:0005634 GO:0005737 GO:0005829 GO:0006468 GO:0006605 GO:0006626 GO:0007165 GO:0008039 GO:0009410 GO:0019901 GO:0019904 GO:0030324 GO:0031252 GO:0031625 GO:0032991 GO:0035148 GO:0042470 GO:0042802 GO:0043067 GO:0044325 GO:0044877 GO:0045824 GO:0048471 GO:0050815 GO:0051683 GO:0070371 GO:0070372 GO:0090128 GO:0090168 GO:0098686 GO:0098978 GO:0099572 GO:0140297 GO:0140311 GO:1900181
14-3-3 protein zeta/delta	P63101	Ywhaz	Mus musculus	10090		DNA-binding transcription factor binding ERK1 and ERK2 cascade Golgi reassembly angiogenesis cell leading edge cytoplasm cytosol establishment of Golgi localization glutamatergic synapse hippocampal mossy fiber to CA3 synapse histamine secretion by mast cell identical protein binding lung development melanosome mitochondrion negative regulation of innate immune response negative regulation of protein localization to nucleus negative regulation of transcription by RNA polymerase II nucleus perinuclear region of cytoplasm phosphoserine residue binding postsynaptic specialization protein domain specific binding protein kinase binding protein phosphorylation protein sequestering activity protein targeting protein targeting to mitochondrion protein-containing complex protein-containing complex binding regulation of ERK1 and ERK2 cascade regulation of programmed cell death regulation of synapse maturation respiratory system process response to xenobiotic stimulus signal transduction synaptic target recognition transmembrane transporter binding tube formation ubiquitin protein ligase binding	GO:0000122 GO:0001525 GO:0002553 GO:0003016 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006468 GO:0006605 GO:0006626 GO:0007165 GO:0008039 GO:0009410 GO:0019901 GO:0019904 GO:0030324 GO:0031252 GO:0031625 GO:0032991 GO:0035148 GO:0042470 GO:0042802 GO:0043067 GO:0044325 GO:0044877 GO:0045824 GO:0048471 GO:0050815 GO:0051683 GO:0070371 GO:0070372 GO:0090128 GO:0090168 GO:0098686 GO:0098978 GO:0099572 GO:0140297 GO:0140311 GO:1900181
14-3-3 protein, putative	K2NW21	MOQ_000542	Trypanosoma cruzi marinkellei	85056
14-3-3-like protein 2	Q20655	ftt-2	Caenorhabditis elegans	6239		DNA-binding transcription factor binding cytoplasm cytoplasmic sequestering of protein dauer larval development maintenance of protein location in nucleus negative regulation of gene expression negative regulation of protein import into nucleus nucleus regulation of gene expression signal transduction	GO:0005634 GO:0005737 GO:0007165 GO:0010468 GO:0010629 GO:0040024 GO:0042308 GO:0051220 GO:0051457 GO:0140297
17-beta-hydroxysteroid dehydrogenase 13	Q7Z5P4	HSD17B13	Homo sapiens	9606	1	NAD-retinol dehydrogenase activity cytosol endoplasmic reticulum estradiol 17-beta-dehydrogenase [NAD(P)] activity lipid droplet lipid metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor positive regulation of lipid biosynthetic process steroid dehydrogenase activity	GO:0004303 GO:0004745 GO:0005783 GO:0005811 GO:0005829 GO:0006629 GO:0016229 GO:0016616 GO:0046889
17-beta-hydroxysteroid dehydrogenase 13	Q8VCR2	Hsd17b13	Mus musculus	10090		NAD-retinol dehydrogenase activity endoplasmic reticulum estradiol 17-beta-dehydrogenase [NAD(P)] activity lipid droplet lipid metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor positive regulation of lipid biosynthetic process steroid dehydrogenase activity	GO:0004303 GO:0004745 GO:0005783 GO:0005811 GO:0006629 GO:0016229 GO:0016616 GO:0046889
17-beta-hydroxysteroid dehydrogenase type 6	Q9R092	Hsd17b6	Mus musculus	10090	3	5alpha-androstane-3beta,17beta-diol dehydrogenase activity NAD-retinol dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity brexanolone catabolic process early endosome membrane endoplasmic reticulum estradiol 17-beta-dehydrogenase [NAD(P)] activity intracellular membrane-bounded organelle retinol metabolic process steroid metabolic process testosterone 17-beta-dehydrogenase (NADP+) activity testosterone dehydrogenase (NAD+) activity	GO:0004303 GO:0004745 GO:0005783 GO:0008202 GO:0031901 GO:0042572 GO:0043231 GO:0047023 GO:0047024 GO:0047035 GO:0047044 GO:0047045 GO:0062175
17-beta-hydroxysteroid dehydrogenase type 6	O54753	Hsd17b6	Rattus norvegicus	10116	1	5alpha-androstane-3beta,17beta-diol dehydrogenase activity NAD-retinol dehydrogenase activity androgen metabolic process androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity brexanolone catabolic process endoplasmic reticulum membrane estradiol 17-beta-dehydrogenase [NAD(P)] activity intracellular membrane-bounded organelle retinol metabolic process steroid metabolic process testosterone 17-beta-dehydrogenase (NADP+) activity testosterone dehydrogenase (NAD+) activity	GO:0004303 GO:0004745 GO:0005789 GO:0008202 GO:0008209 GO:0042572 GO:0043231 GO:0047023 GO:0047024 GO:0047035 GO:0047044 GO:0047045 GO:0062175