GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
17-beta-hydroxysteroid dehydrogenase type 6	Q3T001	HSD17B6	Bos taurus	9913	2	5alpha-androstane-3beta,17beta-diol dehydrogenase activity NAD-retinol dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity brexanolone catabolic process endoplasmic reticulum membrane estradiol 17-beta-dehydrogenase [NAD(P)] activity intracellular membrane-bounded organelle retinol metabolic process steroid metabolic process testosterone 17-beta-dehydrogenase (NADP+) activity testosterone dehydrogenase (NAD+) activity	GO:0004303 GO:0004745 GO:0005789 GO:0008202 GO:0042572 GO:0043231 GO:0047023 GO:0047024 GO:0047035 GO:0047044 GO:0047045 GO:0062175
17-beta-hydroxysteroid dehydrogenase type 6	O14756	HSD17B6	Homo sapiens	9606	3	5alpha-androstane-3beta,17beta-diol dehydrogenase activity NAD-retinol dehydrogenase activity androgen biosynthetic process androgen catabolic process androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity brexanolone catabolic process catalytic activity early endosome membrane electron transfer activity endoplasmic reticulum estradiol 17-beta-dehydrogenase [NAD(P)] activity intracellular membrane-bounded organelle oxidoreductase activity retinol metabolic process steroid metabolic process testosterone 17-beta-dehydrogenase (NADP+) activity testosterone dehydrogenase (NAD+) activity	GO:0003824 GO:0004303 GO:0004745 GO:0005783 GO:0006702 GO:0006710 GO:0008202 GO:0009055 GO:0016491 GO:0031901 GO:0042572 GO:0043231 GO:0047023 GO:0047024 GO:0047035 GO:0047044 GO:0047045 GO:0062175
1700074P13Rik protein	Q9D9G7	Prss59	Mus musculus	10090	1	Golgi apparatus proteolysis secretory granule serine-type endopeptidase activity	GO:0004252 GO:0005794 GO:0006508 GO:0030141
182 kDa tankyrase-1-binding protein	P58871	Tnks1bp1	Mus musculus	10090	5	CCR4-NOT complex adherens junction ankyrin repeat binding cellular response to ionizing radiation cytoplasm cytoskeleton double-strand break repair enzyme binding heterochromatin nucleus plasma membrane positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation positive regulation of protein autophosphorylation protein-containing complex binding	GO:0000792 GO:0005634 GO:0005737 GO:0005856 GO:0005886 GO:0005912 GO:0006302 GO:0010800 GO:0019899 GO:0030014 GO:0031954 GO:0033138 GO:0044877 GO:0071479 GO:0071532
182 kDa tankyrase-1-binding protein	Q9C0C2	TNKS1BP1	Homo sapiens	9606	4	CCR4-NOT complex adherens junction ankyrin repeat binding cadherin binding cellular response to ionizing radiation cytoplasm cytoskeleton cytosol double-strand break repair enzyme binding heterochromatin nuclear-transcribed mRNA poly(A) tail shortening nucleus plasma membrane positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation positive regulation of protein autophosphorylation protein-containing complex binding telomere maintenance via telomerase	GO:0000289 GO:0000792 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005912 GO:0006302 GO:0007004 GO:0010800 GO:0019899 GO:0030014 GO:0031954 GO:0033138 GO:0044877 GO:0045296 GO:0071479 GO:0071532
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P09543	CNP	Homo sapiens	9606		2',3'-cyclic-nucleotide 3'-phosphodiesterase activity RNA binding adult locomotory behavior axonogenesis chemical synaptic transmission cyclic nucleotide binding cyclic nucleotide catabolic process cytoplasm extracellular exosome extracellular space forebrain development melanosome membrane microtubule microvillus mitochondrial inner membrane mitochondrial outer membrane myelin sheath abaxonal region myelin sheath adaxonal region oligodendrocyte differentiation perinuclear region of cytoplasm pseudopodium regulation of mitochondrial membrane permeability response to lipopolysaccharide response to toxic substance substantia nigra development synapse	GO:0003723 GO:0004113 GO:0005615 GO:0005737 GO:0005741 GO:0005743 GO:0005874 GO:0005902 GO:0007268 GO:0007409 GO:0008344 GO:0009214 GO:0009636 GO:0016020 GO:0021762 GO:0030551 GO:0030900 GO:0031143 GO:0032496 GO:0035748 GO:0035749 GO:0042470 GO:0045202 GO:0046902 GO:0048471 GO:0048709 GO:0070062
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	Cnp	Mus musculus	10090		2',3'-cyclic-nucleotide 3'-phosphodiesterase activity RNA binding adult locomotory behavior axonogenesis cell projection cyclic nucleotide binding cyclic nucleotide catabolic process cytoplasm extracellular space forebrain development melanosome membrane microtubule microvillus mitochondrial inner membrane mitochondrial outer membrane myelin sheath myelin sheath abaxonal region myelin sheath adaxonal region oligodendrocyte differentiation perinuclear region of cytoplasm plasma membrane pseudopodium regulation of mitochondrial membrane permeability response to lipopolysaccharide response to toxic substance	GO:0003723 GO:0004113 GO:0005615 GO:0005737 GO:0005741 GO:0005743 GO:0005874 GO:0005886 GO:0005902 GO:0007409 GO:0008344 GO:0009214 GO:0009636 GO:0016020 GO:0030551 GO:0030900 GO:0031143 GO:0032496 GO:0035748 GO:0035749 GO:0042470 GO:0042995 GO:0043209 GO:0046902 GO:0048471 GO:0048709
2',5'-phosphodiesterase 12	Q6L8Q7	PDE12	Homo sapiens	9606		3'-5'-RNA exonuclease activity antiviral innate immune response cellular response to dsRNA cellular response to interferon-alpha cellular response to type II interferon cytosol defense response to virus exonuclease activity mRNA processing metal ion binding mitochondrial mRNA catabolic process mitochondrial matrix mitochondrion nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay obsolete nucleic acid phosphodiester bond hydrolysis oligoribonucleotidase activity poly(A)-specific ribonuclease activity positive regulation of viral genome replication regulation of mitochondrial mRNA stability	GO:0000175 GO:0000288 GO:0000958 GO:0004527 GO:0004535 GO:0005739 GO:0005759 GO:0005829 GO:0006397 GO:0034611 GO:0035457 GO:0044528 GO:0045070 GO:0046872 GO:0051607 GO:0071346 GO:0071359 GO:0090305 GO:0140374
2',5'-phosphodiesterase 12	Q3TIU4	Pde12	Mus musculus	10090		3'-5'-RNA exonuclease activity antiviral innate immune response cellular response to dsRNA cellular response to interferon-alpha cellular response to type II interferon exonuclease activity mRNA processing metal ion binding mitochondrial mRNA catabolic process mitochondrial matrix mitochondrion nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay obsolete nucleic acid phosphodiester bond hydrolysis poly(A)-specific ribonuclease activity positive regulation of viral genome replication regulation of mitochondrial mRNA stability	GO:0000175 GO:0000288 GO:0000958 GO:0004527 GO:0004535 GO:0005739 GO:0005759 GO:0006397 GO:0035457 GO:0044528 GO:0045070 GO:0046872 GO:0071346 GO:0071359 GO:0090305 GO:0140374
2'-5'-oligoadenylate synthase 3	Q9Y6K5	OAS3	Homo sapiens	9606	1	2'-5'-oligoadenylate synthetase activity ATP binding MDA-5 signaling pathway RIG-I signaling pathway cytoplasm cytosol defense response to bacterium defense response to virus double-stranded RNA binding extracellular space innate immune response intracellular membrane-bounded organelle membrane metal ion binding negative regulation of IP-10 production negative regulation of chemokine (C-C motif) ligand 5 production negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of chemokine (C-X-C motif) ligand 9 production negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication nucleobase-containing compound metabolic process nucleoplasm plasma membrane positive regulation of interferon-beta production positive regulation of monocyte chemotactic protein-1 production positive regulation of tumor necrosis factor production regulation of ribonuclease activity response to virus	GO:0001730 GO:0003725 GO:0005524 GO:0005615 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006139 GO:0009615 GO:0016020 GO:0032728 GO:0032760 GO:0035395 GO:0039529 GO:0039530 GO:0042742 GO:0043231 GO:0045071 GO:0045087 GO:0046872 GO:0051607 GO:0060339 GO:0060700 GO:0071639 GO:0071650 GO:0071659 GO:2000342