GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Lysyl oxidase homolog 2	Q9Y4K0	LOXL2	Homo sapiens	9606	3	basement membrane calcium ion binding chromatin collagen fibril organization collagen-containing extracellular matrix copper ion binding endoplasmic reticulum endothelial cell migration endothelial cell proliferation epithelial to mesenchymal transition extracellular space heterochromatin organization membrane negative regulation of DNA-templated transcription negative regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II nucleoplasm nucleus oligosaccharide binding peptidyl-lysine oxidation positive regulation of chondrocyte differentiation positive regulation of epithelial to mesenchymal transition protein modification process protein-lysine 6-oxidase activity response to copper ion response to hypoxia sprouting angiogenesis	GO:0000122 GO:0000785 GO:0001666 GO:0001837 GO:0001935 GO:0002040 GO:0004720 GO:0005507 GO:0005509 GO:0005604 GO:0005615 GO:0005634 GO:0005654 GO:0005783 GO:0010718 GO:0016020 GO:0018057 GO:0030199 GO:0032332 GO:0036211 GO:0043542 GO:0045892 GO:0046688 GO:0062023 GO:0070492 GO:0070828 GO:1902455
Glucose-6-phosphatase catalytic subunit 1	P35575	G6PC1	Homo sapiens	9606	1	cholesterol homeostasis endoplasmic reticulum membrane gluconeogenesis glucose 6-phosphate metabolic process glucose homeostasis glucose-6-phosphatase activity glucose-6-phosphate transport glycogen catabolic process glycogen metabolic process membrane multicellular organism growth phosphate ion binding phosphotransferase activity, alcohol group as acceptor regulation of gene expression steroid metabolic process triglyceride metabolic process urate metabolic process	GO:0004346 GO:0005789 GO:0005977 GO:0005980 GO:0006094 GO:0006641 GO:0008202 GO:0010468 GO:0015760 GO:0016020 GO:0016773 GO:0035264 GO:0042301 GO:0042593 GO:0042632 GO:0046415 GO:0051156
Semaphorin-3G	Q9NS98	SEMA3G	Homo sapiens	9606	2	axon guidance chemorepellent activity extracellular exosome negative chemotaxis negative regulation of axon extension negative regulation of axon extension involved in axon guidance neural crest cell migration positive regulation of cell migration semaphorin receptor binding semaphorin-plexin signaling pathway signaling receptor binding	GO:0001755 GO:0005102 GO:0007411 GO:0030215 GO:0030335 GO:0030517 GO:0045499 GO:0048843 GO:0050919 GO:0070062 GO:0071526
HLA class II histocompatibility antigen, DR beta 3 chain	P79483	HLA-DRB3	Homo sapiens	9606	1	ER to Golgi transport vesicle membrane Golgi membrane MHC class II protein complex MHC class II protein complex binding MHC class II receptor activity T cell receptor signaling pathway adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II clathrin-coated endocytic vesicle membrane endocytic vesicle membrane late endosome membrane lumenal side of endoplasmic reticulum membrane lysosomal membrane membrane myeloid dendritic cell antigen processing and presentation peptide antigen assembly with MHC class II protein complex peptide antigen binding plasma membrane positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of T cell activation positive regulation of T cell mediated immune response to tumor cell positive regulation of immune response signal transduction trans-Golgi network membrane transport vesicle membrane	GO:0000139 GO:0002250 GO:0002469 GO:0002503 GO:0002842 GO:0005765 GO:0005886 GO:0007165 GO:0012507 GO:0016020 GO:0019886 GO:0023026 GO:0030658 GO:0030666 GO:0030669 GO:0031902 GO:0032395 GO:0032588 GO:0042605 GO:0042613 GO:0050778 GO:0050852 GO:0050870 GO:0098553 GO:2000516
Hyaluronan and proteoglycan link protein 1	P10915	HAPLN1	Homo sapiens	9606	2	cell adhesion central nervous system development collagen-containing extracellular matrix extracellular matrix extracellular region extracellular space glial cell differentiation hyaluronic acid binding perineuronal net positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0002052 GO:0005540 GO:0005576 GO:0005615 GO:0007155 GO:0007417 GO:0010001 GO:0031012 GO:0045202 GO:0062023 GO:0072534
BPI fold-containing family B member 1	Q8TDL5	BPIFB1	Homo sapiens	9606	3	extracellular exosome extracellular region innate immune response in mucosa lipid binding negative regulation of toll-like receptor 4 signaling pathway	GO:0002227 GO:0005576 GO:0008289 GO:0034144 GO:0070062
CXADR-like membrane protein	Q9H6B4	CLMP	Homo sapiens	9606	2	bicellular tight junction cell surface cytoplasmic microtubule digestive tract development plasma membrane	GO:0005881 GO:0005886 GO:0005923 GO:0009986 GO:0048565
Beta-1,4-glucuronyltransferase 1	O43505	B4GAT1	Homo sapiens	9606	2	Golgi apparatus Golgi membrane N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity axon guidance extracellular exosome glucuronosyltransferase activity keratan sulfate biosynthetic process metal ion binding protein O-linked mannosylation	GO:0000139 GO:0005794 GO:0007411 GO:0008532 GO:0015020 GO:0018146 GO:0035269 GO:0046872 GO:0070062
Carboxypeptidase A4	Q9UI42	CPA4	Homo sapiens	9606	1	extracellular space histone acetylation metallocarboxypeptidase activity proteolysis zinc ion binding	GO:0004181 GO:0005615 GO:0006508 GO:0008270 GO:0016573
Plexin-B3	Q9ULL4	PLXNB3	Homo sapiens	9606	8	Rho GDP-dissociation inhibitor binding cell chemotaxis cell surface cell-cell adhesion mediator activity homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of GTPase activity negative regulation of cell adhesion negative regulation of cell migration negative regulation of lamellipodium assembly plasma membrane positive chemotaxis positive regulation of axonogenesis positive regulation of endothelial cell proliferation positive regulation of neuron projection development protein domain specific binding regulation of cell shape semaphorin receptor activity semaphorin receptor complex semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance	GO:0001938 GO:0002116 GO:0005886 GO:0007156 GO:0007162 GO:0008360 GO:0009986 GO:0010593 GO:0010976 GO:0017154 GO:0019904 GO:0030336 GO:0034260 GO:0050772 GO:0050918 GO:0051022 GO:0060326 GO:0071526 GO:0098632 GO:1902287