GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Proteoglycan 4	Q92954	PRG4	Homo sapiens	9606	119	collagen-containing extracellular matrix extracellular space immune response polysaccharide binding scavenger receptor activity	GO:0005044 GO:0005615 GO:0006955 GO:0030247 GO:0062023
Host cell factor 1	Q61191	Hcfc1	Mus musculus	10090	113	DNA-binding transcription factor binding MLL1 complex MLL1/2 complex NSL complex RNA polymerase II cis-regulatory region sequence-specific DNA binding Set1C/COMPASS complex axon blastocyst hatching cell cycle chromatin DNA binding chromatin binding chromatin remodeling collagen-containing extracellular matrix cytoplasm dendrite histone acetyltransferase complex histone methyltransferase complex identical protein binding negative regulation of transcription by RNA polymerase II neuronal cell body nuclear chromosome nucleoplasm nucleus obsolete regulation of dosage compensation by inactivation of X chromosome positive regulation of DNA-templated transcription positive regulation of gene expression positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of transcription by RNA polymerase II protein stabilization protein-containing complex protein-macromolecule adaptor activity regulation of DNA-templated transcription regulation of protein-containing complex assembly release from viral latency transcription coactivator activity	GO:0000122 GO:0000123 GO:0000228 GO:0000978 GO:0001835 GO:0003682 GO:0003713 GO:0005634 GO:0005654 GO:0005737 GO:0006338 GO:0006355 GO:0007049 GO:0010628 GO:0019046 GO:0030424 GO:0030425 GO:0030674 GO:0031490 GO:0032991 GO:0035097 GO:0035774 GO:0042802 GO:0043025 GO:0043254 GO:0044545 GO:0044665 GO:0045893 GO:0045944 GO:0048188 GO:0050821 GO:0051571 GO:0062023 GO:0071339 GO:0140297 GO:1900095
Vitelline envelope sperm lysin receptor	Q8WR62	VERL	Haliotis rufescens	6454	109	extracellular region plasma membrane sperm-egg recognition vitelline envelope	GO:0005576 GO:0005886 GO:0035036 GO:0060388
Neuroblast differentiation-associated protein AHNAK	Q09666	AHNAK	Homo sapiens	9606	109	RNA binding S100 protein binding T-tubule actin cytoskeleton cadherin binding cell-cell contact zone costamere cytoplasm cytosol extracellular exosome focal adhesion identical protein binding lysosomal membrane membrane nucleus plasma membrane plasma membrane protein complex positive regulation of plasma membrane repair regulation of RNA splicing regulation of voltage-gated calcium channel activity sarcolemma structural molecule activity conferring elasticity vesicle	GO:0003723 GO:0005634 GO:0005737 GO:0005765 GO:0005829 GO:0005886 GO:0005925 GO:0015629 GO:0016020 GO:0030315 GO:0031982 GO:0042383 GO:0042802 GO:0043034 GO:0043484 GO:0044291 GO:0044548 GO:0045296 GO:0070062 GO:0097493 GO:0098797 GO:1901385 GO:1905686
Nuclear pore complex protein Nup98-Nup96	P52948	NUP98	Homo sapiens	9606	108	RNA binding RNA export from nucleus cytosol mRNA binding mRNA transport nuclear body nuclear envelope nuclear inclusion body nuclear localization sequence binding nuclear membrane nuclear periphery nuclear pore nuclear pore complex assembly nuclear pore cytoplasmic filaments nuclear pore nuclear basket nuclear pore organization nuclear pore outer ring nucleocytoplasmic transport nucleoplasm positive regulation of mRNA splicing, via spliceosome post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery promoter-specific chromatin binding protein import into nucleus proteolysis ribonucleoprotein complex serine-type peptidase activity structural constituent of nuclear pore telomere tethering at nuclear periphery transcription coactivator activity	GO:0000973 GO:0003713 GO:0003723 GO:0003729 GO:0005635 GO:0005643 GO:0005654 GO:0005829 GO:0006405 GO:0006508 GO:0006606 GO:0006913 GO:0006999 GO:0008139 GO:0008236 GO:0016604 GO:0017056 GO:0031080 GO:0031965 GO:0034398 GO:0034399 GO:0042405 GO:0044614 GO:0044615 GO:0048026 GO:0051028 GO:0051292 GO:1990841 GO:1990904
Ubiquitin-associated protein 2-like	Q14157	UBAP2L	Homo sapiens	9606	104	PcG protein complex RNA binding binding of sperm to zona pellucida chromosome cytoplasm cytoplasmic stress granule hematopoietic stem cell homeostasis nucleus positive regulation of stress granule assembly stress granule assembly	GO:0003723 GO:0005634 GO:0005694 GO:0005737 GO:0007339 GO:0010494 GO:0031519 GO:0034063 GO:0061484 GO:0062029
Nuclear pore glycoprotein p62	P37198	NUP62	Homo sapiens	9606	101	Flemming body Hsp70 protein binding Hsp90 protein binding PTB domain binding RNA export from nucleus SH2 domain binding cell surface receptor signaling pathway cellular senescence centriole assembly centrosome centrosome cycle chromatin binding cytoplasm mRNA transport mitotic centrosome separation mitotic metaphase chromosome alignment mitotic spindle negative regulation of Ras protein signal transduction negative regulation of apoptotic process negative regulation of cell population proliferation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of programmed cell death nuclear envelope nuclear membrane nuclear pore nuclear pore central transport channel nucleocytoplasmic transport nucleoplasm phospholipid binding positive regulation of DNA-templated transcription positive regulation of canonical NF-kappaB signal transduction positive regulation of centriole replication positive regulation of epidermal growth factor receptor signaling pathway positive regulation of mitotic cytokinetic process positive regulation of mitotic nuclear division positive regulation of protein localization to centrosome protein import into nucleus regulation of Ras protein signal transduction regulation of mitotic spindle organization regulation of signal transduction ribonucleoprotein complex signaling receptor complex adaptor activity spindle pole structural constituent of nuclear pore ubiquitin binding	GO:0000922 GO:0003682 GO:0005543 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005813 GO:0006405 GO:0006606 GO:0006913 GO:0007080 GO:0007098 GO:0007100 GO:0007166 GO:0008285 GO:0009966 GO:0017056 GO:0030159 GO:0030544 GO:0031965 GO:0042059 GO:0042169 GO:0043066 GO:0043069 GO:0043123 GO:0043130 GO:0044613 GO:0045742 GO:0045840 GO:0045893 GO:0046578 GO:0046580 GO:0046601 GO:0051028 GO:0051425 GO:0051879 GO:0060236 GO:0072686 GO:0090398 GO:0090543 GO:0098534 GO:1903438 GO:1904781 GO:1990904
Coagulation factor V	P12259	F5	Homo sapiens	9606	93	COPII-coated ER to Golgi transport vesicle blood circulation blood coagulation copper ion binding endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment membrane extracellular region extracellular space extracellular vesicle membrane plasma membrane platelet alpha granule platelet alpha granule lumen response to vitamin K	GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0007596 GO:0008015 GO:0016020 GO:0030134 GO:0031091 GO:0031093 GO:0032571 GO:0033116 GO:1903561
Aggrecan core protein	P16112	ACAN	Homo sapiens	9606	88	Golgi lumen carbohydrate binding cell adhesion central nervous system development collagen-containing extracellular matrix extracellular matrix structural constituent extracellular region extracellular space glial cell differentiation hyaluronic acid binding lysosomal lumen metal ion binding perineuronal net positive regulation of neuroblast proliferation proteolysis skeletal system development synapse	GO:0001501 GO:0002052 GO:0005201 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0006508 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0043202 GO:0045202 GO:0046872 GO:0062023 GO:0072534
Protein PRRC2C	Q9Y520	PRRC2C	Homo sapiens	9606	87	RNA binding cytoplasmic stress granule cytosol hematopoietic progenitor cell differentiation membrane stress granule assembly	GO:0002244 GO:0003723 GO:0005829 GO:0010494 GO:0016020 GO:0034063