GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
2-aminoethanethiol dioxygenase	Q6PDY2	Ado	Mus musculus	10090	1	cellular response to hypoxia cysteamine dioxygenase activity iron ion binding mitochondrion	GO:0005506 GO:0005739 GO:0047800 GO:0071456
2-aminoethanethiol dioxygenase	Q96SZ5	ADO	Homo sapiens	9606		cellular response to hypoxia cysteamine dioxygenase activity cytosol iron ion binding	GO:0005506 GO:0005829 GO:0047800 GO:0071456
2-aminomuconic semialdehyde dehydrogenase	Q8BH00	Aldh8a1	Mus musculus	10090		9-cis-retinoic acid biosynthetic process L-kynurenine catabolic process aminomuconate-semialdehyde dehydrogenase activity cytoplasm retinal dehydrogenase activity retinal metabolic process retinoic acid metabolic process	GO:0001758 GO:0005737 GO:0042573 GO:0042574 GO:0042904 GO:0047102 GO:0097053
2-aminomuconic semialdehyde dehydrogenase	Q9H2A2	ALDH8A1	Homo sapiens	9606		9-cis-retinoic acid biosynthetic process L-kynurenine catabolic process aminomuconate-semialdehyde dehydrogenase activity cytosol extracellular exosome retinal dehydrogenase activity retinal metabolic process retinoic acid metabolic process	GO:0001758 GO:0005829 GO:0042573 GO:0042574 GO:0042904 GO:0047102 GO:0070062 GO:0097053
2-hydroxy-3-oxopropionate reductase, putative	Q4DFE2	Tc00.1047053507017.40	Trypanosoma cruzi strain CL Brener	353153		2-hydroxy-3-oxopropionate reductase activity 3-hydroxyisobutyrate dehydrogenase activity NAD binding NADP binding	GO:0008442 GO:0008679 GO:0050661 GO:0051287
2-hydroxyacyl-CoA lyase 1	Q9QXE0	Hacl1	Mus musculus	10090		2-hydroxyacyl-CoA lyase activity 2-hydroxyphytanoyl-CoA lyase activity ATP binding carbon-carbon lyase activity fatty acid alpha-oxidation fatty acid metabolic process identical protein binding intracellular membrane-bounded organelle lipid metabolic process lyase activity magnesium ion binding methyl-branched fatty acid metabolic process nucleoplasm peroxisome phytanic acid metabolic process protein targeting to peroxisome thiamine pyrophosphate binding	GO:0000287 GO:0001561 GO:0005524 GO:0005654 GO:0005777 GO:0006625 GO:0006629 GO:0006631 GO:0016829 GO:0016830 GO:0030976 GO:0042802 GO:0043231 GO:0097089 GO:0106359 GO:0106376 GO:1903512
2-hydroxyacyl-CoA lyase 1	Q9UJ83	HACL1	Homo sapiens	9606	1	2-hydroxyacyl-CoA lyase activity 2-hydroxyphytanoyl-CoA lyase activity ATP binding carbon-carbon lyase activity cytosol fatty acid alpha-oxidation fatty acid metabolic process identical protein binding intracellular membrane-bounded organelle magnesium ion binding methyl-branched fatty acid metabolic process nucleoplasm peroxisomal matrix peroxisome phytanic acid metabolic process protein targeting to peroxisome thiamine pyrophosphate binding	GO:0000287 GO:0001561 GO:0005524 GO:0005654 GO:0005777 GO:0005782 GO:0005829 GO:0006625 GO:0006631 GO:0016830 GO:0030976 GO:0042802 GO:0043231 GO:0097089 GO:0106359 GO:0106376 GO:1903512
2-hydroxyacyl-CoA lyase 2	A1L0T0	ILVBL	Homo sapiens	9606	1	acetolactate synthase activity acetolactate synthase complex endoplasmic reticulum membrane fatty acid alpha-oxidation flavin adenine dinucleotide binding isoleucine biosynthetic process lyase activity magnesium ion binding membrane thiamine pyrophosphate binding valine biosynthetic process	GO:0000287 GO:0001561 GO:0003984 GO:0005789 GO:0005948 GO:0009097 GO:0009099 GO:0016020 GO:0016829 GO:0030976 GO:0050660
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	Q09426	Ugt8	Rattus norvegicus	10116	3	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity N-acylsphingosine galactosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity cytoskeleton organization endoplasmic reticulum galactosylceramide biosynthetic process glycosphingolipid biosynthetic process membrane myelination neuron projection morphogenesis paranodal junction assembly protein localization to paranode region of axon response to immobilization stress	GO:0002175 GO:0003851 GO:0005783 GO:0006682 GO:0006688 GO:0007010 GO:0008489 GO:0016020 GO:0030913 GO:0035902 GO:0042552 GO:0047263 GO:0048812
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	Q64676	Ugt8	Mus musculus	10090	3	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity N-acylsphingosine galactosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity ceramide glucosyltransferase activity cytoskeleton organization endoplasmic reticulum galactosylceramide biosynthetic process glycolipid biosynthetic process membrane myelination neuron projection morphogenesis paranodal junction assembly protein localization to paranode region of axon response to immobilization stress	GO:0002175 GO:0003851 GO:0005783 GO:0006682 GO:0007010 GO:0008120 GO:0008489 GO:0009247 GO:0016020 GO:0030913 GO:0035902 GO:0042552 GO:0047263 GO:0048812