GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Alpha-agglutinin	P20840	SAG1	Saccharomyces cerevisiae S288C	559292	33	agglutination involved in conjugation with cellular fusion cell adhesion molecule binding cell periphery extracellular region fungal-type cell wall fungal-type vacuole side of membrane	GO:0000324 GO:0000752 GO:0005576 GO:0009277 GO:0050839 GO:0071944 GO:0098552
Protein capicua homolog	Q96RK0	CIC	Homo sapiens	9606	33	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding brain development chromatin intracellular membrane-bounded organelle learning memory negative regulation of DNA-templated transcription nucleoplasm nucleus regulation of transcription by RNA polymerase II social behavior	GO:0000785 GO:0000977 GO:0000981 GO:0005634 GO:0005654 GO:0006357 GO:0007420 GO:0007612 GO:0007613 GO:0035176 GO:0043231 GO:0045892
Protein phosphatase 1 regulatory subunit 12A	Q9DBR7	Ppp1r12a	Mus musculus	10090	33	14-3-3 protein binding A band PTW/PP1 phosphatase complex Z disc actin cytoskeleton cellular response to xenobiotic stimulus centrosome centrosome cycle contractile fiber cytoplasm cytosol enzyme inhibitor activity kinetochore mitotic cell cycle negative regulation of catalytic activity nucleolus phosphatase regulator activity phosphoprotein phosphatase activity plasma membrane positive regulation of transcription by RNA polymerase II protein kinase binding regulation of cell adhesion regulation of myosin-light-chain-phosphatase activity regulation of nucleocytoplasmic transport signal transduction	GO:0000278 GO:0000776 GO:0004721 GO:0004857 GO:0005730 GO:0005737 GO:0005813 GO:0005829 GO:0005886 GO:0007098 GO:0007165 GO:0015629 GO:0019208 GO:0019901 GO:0030018 GO:0030155 GO:0031672 GO:0035507 GO:0043086 GO:0043292 GO:0045944 GO:0046822 GO:0071466 GO:0071889 GO:0072357
Cation-independent mannose-6-phosphate receptor	P11717	IGF2R	Homo sapiens	9606	33	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
BRCA2-interacting transcriptional repressor EMSY	Q8BMB0	Emsy	Mus musculus	10090	33	DNA repair chromatin organization identical protein binding nucleoplasm regulation of DNA-templated transcription	GO:0005654 GO:0006281 GO:0006325 GO:0006355 GO:0042802
mRNA-binding protein PUF3	Q07807	PUF3	Saccharomyces cerevisiae S288C	559292	33	aerobic respiration cytoplasm cytoplasmic side of mitochondrial outer membrane intracellular mRNA localization mRNA 3'-UTR binding mRNA binding mitochondrion localization mitochondrion organization nuclear-transcribed mRNA catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of translation regulation of ubiquinone biosynthetic process	GO:0000288 GO:0000956 GO:0003729 GO:0003730 GO:0005737 GO:0007005 GO:0008298 GO:0009060 GO:0010795 GO:0032473 GO:0045727 GO:0051646
Nidogen-2	Q14112	NID2	Homo sapiens	9606	33	basement membrane basement membrane organization calcium ion binding cell adhesion cell-matrix adhesion collagen binding collagen-containing extracellular matrix extracellular exosome extracellular matrix structural constituent extracellular region extracellular space plasma membrane	GO:0005201 GO:0005509 GO:0005518 GO:0005576 GO:0005604 GO:0005615 GO:0005886 GO:0007155 GO:0007160 GO:0062023 GO:0070062 GO:0071711
Proto-oncogene tyrosine-protein kinase ROS	P08922	ROS1	Homo sapiens	9606	33	ATP binding cell differentiation columnar/cuboidal epithelial cell development membrane plasma membrane protein phosphatase binding protein phosphorylation protein tyrosine kinase activity receptor complex regulation of ERK1 and ERK2 cascade regulation of TOR signaling regulation of cell growth spermatogenesis transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase signaling pathway	GO:0001558 GO:0002066 GO:0004713 GO:0004714 GO:0005524 GO:0005886 GO:0006468 GO:0007169 GO:0007283 GO:0016020 GO:0019903 GO:0030154 GO:0032006 GO:0043235 GO:0070372
Major surface glycoprotein G	P03423	G	Human respiratory syncytial virus A2	11259	33	adhesion receptor-mediated virion attachment to host cell extracellular region host cell plasma membrane membrane viral entry into host cell virion membrane virus-mediated perturbation of host defense response	GO:0005576 GO:0016020 GO:0019049 GO:0020002 GO:0046718 GO:0055036 GO:0098671
Lysosome-associated membrane glycoprotein 2	P13473	LAMP2	Homo sapiens	9606	33	autolysosome autophagosome maturation autophagosome membrane azurophil granule membrane cellular response to starvation chaperone-mediated autophagy chaperone-mediated autophagy translocation complex enzyme binding extracellular exosome extracellular space ficolin-1-rich granule membrane intracellular membrane-bounded organelle late endosome late endosome membrane lysosomal lumen lysosomal membrane lysosomal protein catabolic process lysosome membrane muscle cell cellular homeostasis negative regulation of NLRP3 inflammasome complex assembly negative regulation of protein-containing complex assembly perinuclear region of cytoplasm phagocytic vesicle membrane plasma membrane platelet dense granule membrane protein catabolic process protein domain specific binding protein import protein stabilization protein targeting protein targeting to lysosome involved in chaperone-mediated autophagy regulation of protein stability signaling adaptor activity trans-Golgi network	GO:0000421 GO:0005615 GO:0005764 GO:0005765 GO:0005770 GO:0005802 GO:0005886 GO:0006605 GO:0009267 GO:0016020 GO:0017038 GO:0019899 GO:0019904 GO:0030163 GO:0030670 GO:0031088 GO:0031333 GO:0031647 GO:0031902 GO:0035577 GO:0035591 GO:0043202 GO:0043231 GO:0044754 GO:0046716 GO:0048471 GO:0050821 GO:0061684 GO:0061740 GO:0061742 GO:0070062 GO:0097352 GO:0101003 GO:1900226 GO:1905146