GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Protein AF-17	P55198	MLLT6	Homo sapiens	9606	31	chromatin organization histone binding metal ion binding negative regulation of urine volume nucleosome binding nucleus positive regulation of sodium ion transport positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II renal potassium excretion renal sodium excretion renal water absorption	GO:0005634 GO:0006325 GO:0006355 GO:0006357 GO:0010765 GO:0031491 GO:0035811 GO:0035812 GO:0036359 GO:0042393 GO:0045944 GO:0046872 GO:0070295
Attractin	O75882	ATRN	Homo sapiens	9606	31	Golgi apparatus carbohydrate binding cerebellum development extracellular exosome extracellular space inflammatory response myelination pigmentation plasma membrane regulation of multicellular organism growth signaling receptor activity	GO:0005615 GO:0005794 GO:0005886 GO:0006954 GO:0021549 GO:0030246 GO:0038023 GO:0040014 GO:0042552 GO:0043473 GO:0070062
Envelope glycoprotein gp160	P04581	env	Human immunodeficiency virus type 1 (ELI ISOLATE)	11689	31	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endosome membrane host cell plasma membrane membrane positive regulation of establishment of T cell polarity positive regulation of plasma membrane raft polarization positive regulation of receptor clustering structural molecule activity viral envelope viral protein processing virion attachment to host cell virion membrane virus-mediated perturbation of host defense response	GO:0005198 GO:0016020 GO:0019031 GO:0019049 GO:0019062 GO:0019064 GO:0019082 GO:0020002 GO:0039654 GO:0044175 GO:0055036 GO:0075512 GO:1903905 GO:1903908 GO:1903911
PMA1 stabilization in the Golgi protein 1	P36081	PSG1	Saccharomyces cerevisiae S288C	559292	31	COPI-coated vesicle membrane Golgi apparatus Golgi lumen endoplasmic reticulum protein maturation protein targeting	GO:0005783 GO:0005794 GO:0005796 GO:0006605 GO:0030663 GO:0051604
Major surface glycoprotein G	P27026	G	Human respiratory syncytial virus (strain RSB6614)	11257	31	extracellular region host cell plasma membrane membrane viral entry into host cell virion attachment to host cell virion membrane virus-mediated perturbation of host defense response	GO:0005576 GO:0016020 GO:0019049 GO:0019062 GO:0020002 GO:0046718 GO:0055036
Apolipoprotein B-100	P04114	APOB	Homo sapiens	9606	31	artery morphogenesis cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol transfer activity cholesterol transport chylomicron chylomicron remnant clathrin-coated endocytic vesicle membrane cytoplasm cytosol early endosome endocytic vesicle lumen endoplasmic reticulum exit site endoplasmic reticulum lumen endoplasmic reticulum membrane endosome lumen endosome membrane establishment of localization in cell extracellular exosome extracellular region extracellular space fertilization flagellated sperm motility heparin binding in utero embryonic development intermediate-density lipoprotein particle intracellular membrane-bounded organelle lipase binding lipid droplet lipoprotein biosynthetic process lipoprotein catabolic process lipoprotein transport low-density lipoprotein particle low-density lipoprotein particle clearance low-density lipoprotein particle receptor binding low-density lipoprotein particle remodeling lysosomal lumen mature chylomicron nervous system development neuronal cell body phospholipid binding plasma membrane positive regulation of cholesterol storage positive regulation of gene expression positive regulation of lipid storage positive regulation of macrophage derived foam cell differentiation post-embryonic development regulation of cholesterol biosynthetic process response to virus smooth endoplasmic reticulum spermatogenesis triglyceride catabolic process triglyceride mobilization very-low-density lipoprotein particle very-low-density lipoprotein particle assembly	GO:0001701 GO:0005543 GO:0005576 GO:0005615 GO:0005737 GO:0005769 GO:0005788 GO:0005789 GO:0005790 GO:0005811 GO:0005829 GO:0005886 GO:0006642 GO:0007283 GO:0007399 GO:0008201 GO:0008203 GO:0009566 GO:0009615 GO:0009791 GO:0010008 GO:0010628 GO:0010744 GO:0010884 GO:0010886 GO:0019433 GO:0030301 GO:0030317 GO:0030669 GO:0031904 GO:0033344 GO:0034359 GO:0034360 GO:0034361 GO:0034362 GO:0034363 GO:0034374 GO:0034379 GO:0034383 GO:0035473 GO:0042158 GO:0042159 GO:0042627 GO:0042632 GO:0042953 GO:0043025 GO:0043202 GO:0043231 GO:0045540 GO:0048844 GO:0050750 GO:0051649 GO:0070062 GO:0070971 GO:0071682 GO:0120020
Ubiquitin-associated protein 2	Q91VX2	Ubap2	Mus musculus	10090	30	chromosome cytoplasm nucleus	GO:0005634 GO:0005694 GO:0005737
Endosialin	Q91V98	Cd248	Mus musculus	10090	30	anatomical structure regression calcium ion binding carbohydrate binding cell migration cytoplasm endothelial cell apoptotic process external side of plasma membrane extracellular matrix binding extracellular matrix protein binding fibroblast migration fibroblast proliferation lymph node development plasma membrane positive regulation of endothelial cell apoptotic process positive regulation of fibroblast proliferation	GO:0005509 GO:0005737 GO:0005886 GO:0009897 GO:0010761 GO:0016477 GO:0030246 GO:0048144 GO:0048146 GO:0048535 GO:0050840 GO:0060033 GO:0072577 GO:1990430 GO:2000353
Sortilin-related receptor	O88307	Sorl1	Mus musculus	10090	30	Golgi apparatus Golgi cisterna Golgi membrane adaptive thermogenesis amyloid-beta binding cell migration cell surface diet induced thermogenesis early endosome early endosome membrane endoplasmic reticulum endoplasmic reticulum membrane endosome endosome to plasma membrane protein transport extracellular space insulin receptor recycling low-density lipoprotein particle binding membrane multivesicular body multivesicular body membrane negative regulation of BMP signaling pathway negative regulation of MAP kinase activity negative regulation of amyloid-beta formation negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of neurofibrillary tangle assembly negative regulation of neurogenesis negative regulation of protein binding negative regulation of protein-containing complex assembly negative regulation of tau-protein kinase activity negative regulation of triglyceride catabolic process neuronal cell body neuropeptide binding neuropeptide signaling pathway nuclear envelope lumen perinuclear region of cytoplasm perinucleolar compartment plasma membrane positive regulation of ER to Golgi vesicle-mediated transport positive regulation of adipose tissue development positive regulation of choline O-acetyltransferase activity positive regulation of early endosome to recycling endosome transport positive regulation of endocytic recycling positive regulation of glial cell-derived neurotrophic factor production positive regulation of insulin receptor signaling pathway positive regulation of protein catabolic process positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization to early endosome post-Golgi vesicle-mediated transport protein localization to Golgi apparatus protein maturation protein retention in Golgi apparatus protein targeting protein targeting to lysosome receptor-mediated endocytosis recycling endosome recycling endosome membrane regulation of smooth muscle cell migration small GTPase binding trans-Golgi network transmembrane signaling receptor activity transport vesicle membrane	GO:0000139 GO:0001540 GO:0002024 GO:0004888 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005771 GO:0005783 GO:0005789 GO:0005794 GO:0005802 GO:0005886 GO:0006605 GO:0006622 GO:0006892 GO:0006898 GO:0007218 GO:0009986 GO:0010897 GO:0014910 GO:0016020 GO:0016477 GO:0030169 GO:0030514 GO:0030658 GO:0031267 GO:0031333 GO:0031901 GO:0031985 GO:0032091 GO:0032585 GO:0034067 GO:0038020 GO:0042923 GO:0043025 GO:0043407 GO:0045053 GO:0045732 GO:0046628 GO:0048471 GO:0050768 GO:0051604 GO:0055037 GO:0055038 GO:0070863 GO:0097356 GO:0099638 GO:1900168 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:1904179 GO:1990845 GO:2001137
Mucin-1	P15941	MUC1	Homo sapiens	9606	30	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Golgi lumen RNA polymerase II cis-regulatory region sequence-specific DNA binding apical plasma membrane chromatin extracellular exosome extracellular space localization negative regulation of cell adhesion mediated by integrin negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of transcription by competitive promoter binding nucleus obsolete positive regulation of transcription from RNA polymerase II promoter in response to stress obsolete regulation of transcription from RNA polymerase II promoter in response to stress p53 binding plasma membrane transcription coregulator activity vesicle	GO:0000785 GO:0000978 GO:0002039 GO:0003712 GO:0005615 GO:0005634 GO:0005796 GO:0005886 GO:0006977 GO:0006978 GO:0010944 GO:0016324 GO:0031982 GO:0033629 GO:0036003 GO:0043618 GO:0051179 GO:0070062 GO:1902166