GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Leukosialin	P16150	SPN	Homo sapiens	9606	30	Hsp70 protein binding PML body T cell costimulation T cell proliferation T-helper 1 cell lineage commitment apoptotic signaling pathway basement membrane cell surface cell surface receptor signaling pathway cellular defense response chemotaxis defense response to bacterium establishment or maintenance of cell polarity external side of plasma membrane extracellular exosome extracellular space heat shock protein binding immune response leukocyte tethering or rolling membrane microvillus negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of type IV hypersensitivity negative thymic T cell selection plasma membrane positive regulation of T cell migration positive regulation of T cell proliferation positive regulation of protein phosphorylation positive regulation of tumor necrosis factor production regulation of T cell migration regulation of defense response to virus regulation of immune response response to protozoan signal transduction transmembrane signaling receptor activity uropod	GO:0001562 GO:0001808 GO:0001931 GO:0001934 GO:0002296 GO:0004888 GO:0005604 GO:0005615 GO:0005886 GO:0005902 GO:0006935 GO:0006955 GO:0006968 GO:0007162 GO:0007163 GO:0007165 GO:0007166 GO:0009897 GO:0009986 GO:0016020 GO:0016605 GO:0030544 GO:0031072 GO:0031295 GO:0032760 GO:0042098 GO:0042102 GO:0042130 GO:0042742 GO:0045060 GO:0050688 GO:0050776 GO:0050901 GO:0070062 GO:0097190 GO:2000404 GO:2000406
Envelope glycoprotein gp160	P04577	env	Human immunodeficiency virus type 2 (ISOLATE ROD)	11720	30	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane host cell endosome membrane host cell plasma membrane membrane structural molecule activity suppression by virus of host tetherin activity suppression by virus of host type I interferon-mediated signaling pathway viral envelope virion attachment to host cell virion membrane	GO:0005198 GO:0016020 GO:0019031 GO:0019062 GO:0020002 GO:0039502 GO:0039587 GO:0039654 GO:0044175 GO:0055036 GO:0075512
Envelope glycoprotein gp160	P05882	env	Human immunodeficiency virus type 1 (Z-84 ISOLATE)	11681	30	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endosome membrane host cell plasma membrane membrane positive regulation of establishment of T cell polarity positive regulation of plasma membrane raft polarization positive regulation of receptor clustering structural molecule activity viral envelope viral protein processing virion attachment to host cell virion membrane virus-mediated perturbation of host defense response	GO:0005198 GO:0016020 GO:0019031 GO:0019049 GO:0019062 GO:0019064 GO:0019082 GO:0020002 GO:0039654 GO:0044175 GO:0055036 GO:0075512 GO:1903905 GO:1903908 GO:1903911
von Willebrand factor	P04275	VWF	Homo sapiens	9606	30	Weibel-Palade body blood coagulation cell adhesion cell-substrate adhesion collagen binding collagen-containing extracellular matrix endoplasmic reticulum extracellular exosome extracellular matrix extracellular region extracellular space hemostasis identical protein binding immunoglobulin binding integrin binding platelet activation platelet alpha granule platelet alpha granule lumen positive regulation of intracellular signal transduction protease binding protein-folding chaperone binding response to wounding	GO:0002020 GO:0005178 GO:0005518 GO:0005576 GO:0005615 GO:0005783 GO:0007155 GO:0007596 GO:0007599 GO:0009611 GO:0019865 GO:0030168 GO:0031012 GO:0031091 GO:0031093 GO:0031589 GO:0033093 GO:0042802 GO:0051087 GO:0062023 GO:0070062 GO:1902533
Zinc finger protein 281	Q9Y2X9	ZNF281	Homo sapiens	9606	30	DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding embryonic body morphogenesis metal ion binding negative regulation of DNA-templated transcription negative regulation of gene expression negative regulation of transcription by RNA polymerase II nucleoplasm nucleus positive regulation of DNA-templated transcription regulation of DNA-templated transcription sequence-specific DNA binding sequence-specific double-stranded DNA binding stem cell differentiation transcription cis-regulatory region binding	GO:0000122 GO:0000976 GO:0000978 GO:0000981 GO:0001227 GO:0003700 GO:0005634 GO:0005654 GO:0006355 GO:0010172 GO:0010629 GO:0043565 GO:0045892 GO:0045893 GO:0046872 GO:0048863 GO:1990837
Death-inducer obliterator 1	Q9BTC0	DIDO1	Homo sapiens	9606	30	DNA-templated transcription RNA binding apoptotic signaling pathway cytoplasm metal ion binding nucleus spindle	GO:0003723 GO:0005634 GO:0005737 GO:0005819 GO:0006351 GO:0046872 GO:0097190
Zinc finger CCCH domain-containing protein 14	Q6PJT7	ZC3H14	Homo sapiens	9606	30	RNA binding axon cytoplasm cytoplasm dendrite cytoplasm metal ion binding negative regulation of mRNA polyadenylation nuclear speck nucleolus nucleus poly(A) binding regulation of mRNA stability ribonucleoprotein complex	GO:0003723 GO:0005634 GO:0005730 GO:0005737 GO:0008143 GO:0016607 GO:0032839 GO:0043488 GO:0046872 GO:1900364 GO:1904115 GO:1990904
Catenin delta-2	O35927	Ctnnd2	Mus musculus	10090	30	adherens junction beta-catenin binding cadherin binding cell-cell adhesion cell-cell junction assembly cytoplasm dendrite dendritic spine morphogenesis glutamatergic synapse learning morphogenesis of a branching structure nucleus perikaryon plasma membrane postsynaptic density regulation of canonical Wnt signaling pathway regulation of postsynaptic membrane neurotransmitter receptor levels regulation of synaptic plasticity structural constituent of postsynaptic density synapse organization	GO:0001763 GO:0005634 GO:0005737 GO:0005886 GO:0005912 GO:0007043 GO:0007612 GO:0008013 GO:0014069 GO:0030425 GO:0043204 GO:0045296 GO:0048167 GO:0050808 GO:0060828 GO:0060997 GO:0098609 GO:0098919 GO:0098978 GO:0099072
Stabilin-2	Q8WWQ8	STAB2	Homo sapiens	9606	30	angiogenesis calcium ion binding cell adhesion cytosol defense response to Gram-positive bacterium defense response to bacterium endocytic vesicle membrane endocytosis external side of plasma membrane hyaluronan catabolic process hyaluronic acid binding low-density lipoprotein particle binding low-density lipoprotein particle receptor activity plasma membrane protein-disulfide reductase activity receptor-mediated endocytosis scavenger receptor activity	GO:0001525 GO:0005041 GO:0005044 GO:0005509 GO:0005540 GO:0005829 GO:0005886 GO:0006897 GO:0006898 GO:0007155 GO:0009897 GO:0015035 GO:0030169 GO:0030214 GO:0030666 GO:0042742 GO:0050830
Envelope glycoprotein gp160	Q79670	env	HIV-1 O_MVP5180	388816	30	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endosome membrane host cell plasma membrane membrane positive regulation of establishment of T cell polarity positive regulation of plasma membrane raft polarization positive regulation of receptor clustering structural molecule activity viral envelope viral protein processing virion attachment to host cell virion membrane virus-mediated perturbation of host defense response	GO:0005198 GO:0016020 GO:0019031 GO:0019049 GO:0019062 GO:0019064 GO:0019082 GO:0020002 GO:0039654 GO:0044175 GO:0055036 GO:0075512 GO:1903905 GO:1903908 GO:1903911