GlyCosmos Portal

Source	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	June 4, 2024
The O-GlcNAc Database	June 3, 2024
UniProt	June 4, 2024

Displaying entries **51 - 75** of **126547** in total

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UniProt ID	Protein Name	Gene Symbol	Organism	Taxonomy ID	No. of Glycosylation Sites ▼	Gene Ontology	Gene Ontology ID
O14974	Protein phosphatase 1 regulatory subunit 12A	PPP1R12A MBS MYPT1	Homo sapiens (human)	9606	59	14-3-3 protein binding A band PTW/PP1 phosphatase complex Z disc actin cytoskeleton cellular response to xenobiotic stimulus centrosome cycle centrosome contractile fiber cytoplasm cytosol enzyme inhibitor activity focal adhesion kinetochore mitotic cell cycle negative regulation of catalytic activity nucleolus nucleoplasm phosphatase regulator activity plasma membrane positive regulation of myosin-light-chain-phosphatase activity positive regulation of transcription by RNA polymerase II protein dephosphorylation protein kinase binding regulation of cell adhesion regulation of myosin-light-chain-phosphatase activity regulation of nucleocytoplasmic transport signal transduction stress fiber	GO:0000278 GO:0000776 GO:0001725 GO:0004857 GO:0005654 GO:0005730 GO:0005737 GO:0005813 GO:0005829 GO:0005886 GO:0005925 GO:0006470 GO:0007098 GO:0007165 GO:0015629 GO:0019208 GO:0019901 GO:0030018 GO:0030155 GO:0031672 GO:0035507 GO:0035508 GO:0043086 GO:0043292 GO:0045944 GO:0046822 GO:0071466 GO:0071889 GO:0072357
Q14118	Dystroglycan 1	DAG1	Homo sapiens (human)	9606	59	GABA-ergic synapse Golgi lumen SH2 domain binding actin binding adherens junction alpha-actinin binding angiogenesis involved in wound healing axon guidance axon regeneration basement membrane organization basement membrane basolateral plasma membrane branching involved in salivary gland morphogenesis calcium ion binding calcium-dependent cell-matrix adhesion cellular response to cholesterol cellular response to mechanical stimulus collagen-containing extracellular matrix commissural neuron axon guidance contractile ring costamere cytoplasm cytoskeleton cytosol dystroglycan binding dystroglycan complex dystrophin-associated glycoprotein complex endoplasmic reticulum lumen epithelial tube branching involved in lung morphogenesis external side of plasma membrane extracellular exosome extracellular region extracellular space filopodium focal adhesion glutamatergic synapse heart morphogenesis intracellular membrane-bounded organelle lamellipodium laminin binding laminin-1 binding membrane protein ectodomain proteolysis membrane microtubule anchoring morphogenesis of an epithelial sheet morphogenesis of an epithelium muscle attachment myelination in peripheral nervous system negative regulation of MAPK cascade negative regulation of cell migration negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction nerve development nerve maturation node of Ranvier nuclear periphery nucleoplasm photoreceptor ribbon synapse plasma membrane raft plasma membrane positive regulation of basement membrane assembly involved in embryonic body morphogenesis positive regulation of cell-matrix adhesion positive regulation of myelination positive regulation of oligodendrocyte differentiation postsynaptic cytosol postsynaptic membrane protein transport protein-containing complex binding regulation of embryonic cell shape regulation of epithelial to mesenchymal transition regulation of gastrulation regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of synapse organization regulation of synaptic plasticity response to denervation involved in regulation of muscle adaptation response to muscle activity response to peptide hormone retrograde trans-synaptic signaling by trans-synaptic protein complex sarcolemma skeletal muscle tissue regeneration structural constituent of muscle tubulin binding vinculin binding virus receptor activity	GO:0001618 GO:0001954 GO:0002009 GO:0002011 GO:0002162 GO:0003007 GO:0003779 GO:0005509 GO:0005576 GO:0005604 GO:0005615 GO:0005654 GO:0005737 GO:0005788 GO:0005796 GO:0005829 GO:0005856 GO:0005886 GO:0005912 GO:0005925 GO:0006509 GO:0007411 GO:0008307 GO:0009897 GO:0010470 GO:0010717 GO:0014850 GO:0014894 GO:0015031 GO:0015631 GO:0016010 GO:0016011 GO:0016020 GO:0016203 GO:0016323 GO:0016340 GO:0016476 GO:0017166 GO:0021675 GO:0021682 GO:0022011 GO:0030027 GO:0030175 GO:0030336 GO:0031103 GO:0031643 GO:0033268 GO:0034399 GO:0034453 GO:0042169 GO:0042383 GO:0043034 GO:0043231 GO:0043236 GO:0043237 GO:0043403 GO:0043409 GO:0043434 GO:0044853 GO:0044877 GO:0045211 GO:0048167 GO:0048714 GO:0050807 GO:0051393 GO:0051898 GO:0060055 GO:0060441 GO:0060445 GO:0062023 GO:0070062 GO:0070938 GO:0071260 GO:0071397 GO:0071679 GO:0071711 GO:0098684 GO:0098696 GO:0098942 GO:0098978 GO:0098982 GO:0099524 GO:1904261
Q9BVL2	Nucleoporin p58/p45	NUP58 KIAA0410 NUPL1	Homo sapiens (human)	9606	59	identical protein binding mRNA transport nuclear envelope nuclear localization sequence binding nuclear membrane nuclear pore nucleocytoplasmic transport protein transport protein-containing complex binding regulation of protein import into nucleus structural constituent of nuclear pore	GO:0005635 GO:0005643 GO:0006913 GO:0008139 GO:0015031 GO:0017056 GO:0031965 GO:0042306 GO:0042802 GO:0044877 GO:0051028
O00468	Agrin	AGRN AGRIN	Homo sapiens (human)	9606	58	G protein-coupled acetylcholine receptor signaling pathway Golgi lumen basement membrane calcium ion binding chondroitin sulfate binding clustering of voltage-gated sodium channels collagen-containing extracellular matrix dystroglycan binding extracellular exosome extracellular region heparan sulfate proteoglycan binding laminin binding lysosomal lumen neuromuscular junction development plasma membrane positive regulation of GTPase activity positive regulation of filopodium assembly positive regulation of synaptic assembly at neuromuscular junction positive regulation of transcription by RNA polymerase II receptor clustering sialic acid binding signal transduction structural constituent of cytoskeleton synapse organization synapse	GO:0002162 GO:0005200 GO:0005509 GO:0005576 GO:0005604 GO:0005796 GO:0005886 GO:0007165 GO:0007213 GO:0007528 GO:0033691 GO:0035374 GO:0043113 GO:0043202 GO:0043236 GO:0043395 GO:0043547 GO:0045162 GO:0045202 GO:0045887 GO:0045944 GO:0050808 GO:0051491 GO:0062023 GO:0070062
Q99NH0	Ankyrin repeat domain-containing protein 17	Ankrd17 Foe Gtar Kiaa0697	Mus musculus (house mouse)	10090	58	RNA binding blood vessel maturation chromatin binding chromatin cytoplasm defense response to bacterium endoderm development innate immune response male germ cell nucleus negative regulation of smooth muscle cell differentiation nuclear membrane nucleoplasm nucleus positive regulation of G1/S transition of mitotic cell cycle positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway positive regulation of canonical NF-kappaB signal transduction positive regulation of cell cycle regulation of DNA replication	GO:0000785 GO:0001673 GO:0001955 GO:0003682 GO:0003723 GO:0005634 GO:0005654 GO:0005737 GO:0006275 GO:0007492 GO:0031965 GO:0042742 GO:0043123 GO:0045087 GO:0045787 GO:0051151 GO:1900087 GO:1900245 GO:1900246
P46531	Neurogenic locus notch homolog protein 1	NOTCH1 TAN1	Homo sapiens (human)	9606	57	DNA-binding transcription activator activity, RNA polymerase II-specific Golgi membrane MAML1-RBP-Jkappa- ICN1 complex Notch binding Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Notch signaling pathway T-helper 17 type immune response acrosomal vesicle adherens junction animal organ regeneration aortic valve morphogenesis apical plasma membrane apoptotic process involved in embryonic digit morphogenesis arterial endothelial cell differentiation astrocyte differentiation atrioventricular node development atrioventricular valve morphogenesis auditory receptor cell fate commitment axon guidance branching morphogenesis of an epithelial tube calcium ion binding calcium-ion regulated exocytosis cardiac atrium morphogenesis cardiac chamber formation cardiac epithelial to mesenchymal transition cardiac left ventricle morphogenesis cardiac muscle cell myoblast differentiation cardiac muscle cell proliferation cardiac muscle tissue morphogenesis cardiac right atrium morphogenesis cardiac right ventricle formation cardiac septum morphogenesis cardiac vascular smooth muscle cell development cardiac ventricle morphogenesis cell differentiation in spinal cord cell migration involved in endocardial cushion formation cell surface cellular response to follicle-stimulating hormone stimulus cellular response to hypoxia cellular response to tumor cell cellular response to vascular endothelial growth factor stimulus chromatin DNA binding cilium assembly cis-regulatory region sequence-specific DNA binding collecting duct development compartment pattern specification coronary artery morphogenesis coronary sinus valve morphogenesis coronary vein morphogenesis cytosol determination of left/right symmetry distal tubule development embryonic hindlimb morphogenesis endocardial cell differentiation endocardial cushion morphogenesis endocardium development endocardium morphogenesis endoderm development endoplasmic reticulum membrane endosome membrane enzyme binding enzyme inhibitor activity epidermal cell fate specification epithelial cell fate commitment epithelial cell proliferation epithelial to mesenchymal transition involved in endocardial cushion formation epithelial to mesenchymal transition extracellular region forebrain development foregut morphogenesis glomerular mesangial cell development growth involved in heart morphogenesis hair follicle morphogenesis heart development heart looping heart trabecula morphogenesis homeostasis of number of cells within a tissue humoral immune response identical protein binding immune response in utero embryonic development inflammatory response to antigenic stimulus inhibition of neuroepithelial cell differentiation interleukin-17-mediated signaling pathway keratinocyte differentiation left/right axis specification liver development lung development luteolysis mesenchymal cell development mitral valve formation negative regulation of BMP signaling pathway negative regulation of DNA-templated transcription negative regulation of anoikis negative regulation of biomineral tissue development negative regulation of calcium ion-dependent exocytosis negative regulation of canonical Wnt signaling pathway negative regulation of cardiac muscle hypertrophy negative regulation of catalytic activity negative regulation of cell adhesion molecule production negative regulation of cell migration involved in sprouting angiogenesis negative regulation of cell population proliferation negative regulation of cell proliferation involved in heart valve morphogenesis negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell-substrate adhesion negative regulation of cold-induced thermogenesis negative regulation of collagen biosynthetic process negative regulation of endothelial cell chemotaxis negative regulation of epithelial cell proliferation negative regulation of extracellular matrix constituent secretion negative regulation of gene expression negative regulation of glial cell proliferation negative regulation of inner ear auditory receptor cell differentiation negative regulation of myoblast differentiation negative regulation of myotube differentiation negative regulation of neurogenesis negative regulation of oligodendrocyte differentiation negative regulation of ossification negative regulation of osteoblast differentiation negative regulation of photoreceptor cell differentiation negative regulation of pro-B cell differentiation negative regulation of stem cell differentiation negative regulation of transcription by RNA polymerase II neural tube development neuroendocrine cell differentiation neuronal stem cell population maintenance nucleoplasm nucleus oligodendrocyte differentiation outflow tract morphogenesis pericardium morphogenesis plasma membrane positive regulation of BMP signaling pathway positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of Notch signaling pathway positive regulation of Ras protein signal transduction positive regulation of aorta morphogenesis positive regulation of apoptotic process involved in morphogenesis positive regulation of astrocyte differentiation positive regulation of cardiac epithelial to mesenchymal transition positive regulation of cardiac muscle cell proliferation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of endothelial cell differentiation positive regulation of epithelial cell proliferation positive regulation of gene expression positive regulation of keratinocyte differentiation positive regulation of neuroblast proliferation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of smooth muscle cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of viral genome replication prostate gland epithelium morphogenesis protein catabolic process protein import into nucleus pulmonary valve morphogenesis receptor complex regulation of DNA-templated transcription regulation of cell adhesion involved in heart morphogenesis regulation of epithelial cell proliferation involved in prostate gland development regulation of extracellular matrix assembly regulation of somitogenesis regulation of stem cell proliferation regulation of transcription by RNA polymerase II response to lipopolysaccharide response to muramyl dipeptide retinal cone cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development skeletal muscle cell differentiation somatic stem cell division spermatogenesis sprouting angiogenesis tissue regeneration transcription by RNA polymerase II transcription coactivator activity transcription regulator activator activity transmembrane signaling receptor activity tube formation vasculogenesis involved in coronary vascular morphogenesis venous endothelial cell differentiation ventricular septum morphogenesis ventricular trabecula myocardium morphogenesis	GO:0000122 GO:0000139 GO:0000987 GO:0001228 GO:0001554 GO:0001669 GO:0001701 GO:0001837 GO:0001889 GO:0001947 GO:0002040 GO:0002052 GO:0002085 GO:0002193 GO:0002437 GO:0003151 GO:0003157 GO:0003160 GO:0003162 GO:0003169 GO:0003180 GO:0003181 GO:0003182 GO:0003184 GO:0003192 GO:0003198 GO:0003203 GO:0003207 GO:0003208 GO:0003209 GO:0003213 GO:0003214 GO:0003219 GO:0003222 GO:0003241 GO:0003252 GO:0003270 GO:0003273 GO:0003332 GO:0003344 GO:0003713 GO:0004857 GO:0004888 GO:0005112 GO:0005509 GO:0005576 GO:0005634 GO:0005654 GO:0005789 GO:0005829 GO:0005886 GO:0005912 GO:0006355 GO:0006357 GO:0006366 GO:0006606 GO:0006955 GO:0006959 GO:0007219 GO:0007221 GO:0007283 GO:0007368 GO:0007386 GO:0007411 GO:0007440 GO:0007492 GO:0007507 GO:0008284 GO:0008285 GO:0009912 GO:0009957 GO:0009986 GO:0010008 GO:0010614 GO:0010628 GO:0010629 GO:0010812 GO:0010832 GO:0014031 GO:0014807 GO:0016324 GO:0017156 GO:0019899 GO:0021515 GO:0021915 GO:0030163 GO:0030216 GO:0030279 GO:0030324 GO:0030335 GO:0030513 GO:0030514 GO:0030900 GO:0031069 GO:0031100 GO:0031490 GO:0032495 GO:0032496 GO:0032966 GO:0035116 GO:0035148 GO:0035914 GO:0035924 GO:0042246 GO:0042670 GO:0042802 GO:0043086 GO:0043235 GO:0045070 GO:0045603 GO:0045608 GO:0045618 GO:0045662 GO:0045668 GO:0045747 GO:0045892 GO:0045893 GO:0045944 GO:0045955 GO:0046427 GO:0046533 GO:0046579 GO:0048103 GO:0048708 GO:0048709 GO:0048711 GO:0048715 GO:0048754 GO:0048873 GO:0050673 GO:0050679 GO:0050680 GO:0050768 GO:0051152 GO:0055008 GO:0060038 GO:0060045 GO:0060253 GO:0060271 GO:0060317 GO:0060354 GO:0060379 GO:0060411 GO:0060412 GO:0060528 GO:0060740 GO:0060768 GO:0060842 GO:0060843 GO:0060948 GO:0060956 GO:0060979 GO:0060982 GO:0061101 GO:0061344 GO:0061384 GO:0062043 GO:0070168 GO:0070374 GO:0070986 GO:0071228 GO:0071372 GO:0071456 GO:0072017 GO:0072044 GO:0072091 GO:0072144 GO:0072148 GO:0072538 GO:0090051 GO:0090090 GO:0097150 GO:0097400 GO:0120163 GO:0140537 GO:1901201 GO:1902263 GO:1902339 GO:1903849 GO:2000048 GO:2000737 GO:2000811 GO:2000974 GO:2001027
Q96L91	E1A-binding protein p400	EP400 CAGH32 KIAA1498 KIAA1818 TNRC12	Homo sapiens (human)	9606	57	ATP binding ATP-dependent chromatin remodeler activity DNA binding DNA repair NuA4 histone acetyltransferase complex Swr1 complex chromatin binding helicase activity hydrolase activity nuclear speck nucleoplasm nucleosome positive regulation of DNA-templated transcription positive regulation of double-strand break repair via homologous recombination protein antigen binding regulation of apoptotic process regulation of cell cycle regulation of double-strand break repair	GO:0000786 GO:0000812 GO:0003677 GO:0003682 GO:0004386 GO:0005524 GO:0005654 GO:0006281 GO:0016607 GO:0016787 GO:0035267 GO:0042981 GO:0045893 GO:0051726 GO:0140658 GO:1905168 GO:1990405 GO:2000779
Q01705	Neurogenic locus notch homolog protein 1	Notch1 Motch	Mus musculus (house mouse)	10090	57	DNA-binding transcription activator activity, RNA polymerase II-specific Golgi membrane MAML1-RBP-Jkappa- ICN1 complex Notch binding Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Notch signaling pathway T-helper 17 type immune response acrosomal vesicle adherens junction animal organ regeneration aortic valve morphogenesis apical plasma membrane apoptotic process involved in embryonic digit morphogenesis apoptotic process arterial endothelial cell differentiation astrocyte differentiation atrioventricular node development atrioventricular valve morphogenesis auditory receptor cell fate commitment axon guidance axonogenesis branching morphogenesis of an epithelial tube calcium ion binding calcium-ion regulated exocytosis cardiac atrium morphogenesis cardiac chamber formation cardiac epithelial to mesenchymal transition cardiac left ventricle morphogenesis cardiac muscle cell myoblast differentiation cardiac muscle cell proliferation cardiac muscle tissue morphogenesis cardiac right atrium morphogenesis cardiac right ventricle formation cardiac septum morphogenesis cardiac vascular smooth muscle cell development cardiac ventricle morphogenesis cell differentiation in spinal cord cell differentiation cell migration involved in endocardial cushion formation cell periphery cell population proliferation cell surface cellular response to follicle-stimulating hormone stimulus cellular response to hypoxia cellular response to tumor cell cellular response to vascular endothelial growth factor stimulus chromatin DNA binding chromatin binding cilium assembly cis-regulatory region sequence-specific DNA binding collecting duct development compartment pattern specification coronary artery morphogenesis coronary sinus valve morphogenesis coronary vein morphogenesis cytoplasm cytoplasmic vesicle cytoskeleton cytosol determination of left/right symmetry distal tubule development embryonic hindlimb morphogenesis embryonic limb morphogenesis endocardial cell differentiation endocardial cushion development endocardial cushion morphogenesis endocardium development endocardium morphogenesis endoderm development endoplasmic reticulum membrane endoplasmic reticulum endosome membrane enzyme binding enzyme inhibitor activity epidermal cell fate specification epidermis development epithelial cell fate commitment epithelial cell proliferation epithelial to mesenchymal transition involved in endocardial cushion formation epithelial to mesenchymal transition establishment or maintenance of epithelial cell apical/basal polarity extracellular region forebrain development foregut morphogenesis gene expression glial cell differentiation glomerular mesangial cell development growth involved in heart morphogenesis hair follicle morphogenesis heart looping heart trabecula morphogenesis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homeostasis of number of cells within a tissue humoral immune response identical protein binding in utero embryonic development inflammatory response to antigenic stimulus inhibition of neuroepithelial cell differentiation interleukin-17-mediated signaling pathway keratinocyte differentiation lamellipodium left/right axis specification liver development lung development luteolysis mesenchymal cell development mitral valve formation negative regulation of BMP signaling pathway negative regulation of DNA-templated transcription negative regulation of anoikis negative regulation of biomineral tissue development negative regulation of calcium ion-dependent exocytosis negative regulation of canonical Wnt signaling pathway negative regulation of cardiac muscle hypertrophy negative regulation of catalytic activity negative regulation of cell adhesion molecule production negative regulation of cell migration involved in sprouting angiogenesis negative regulation of cell population proliferation negative regulation of cell proliferation involved in heart valve morphogenesis negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell-substrate adhesion negative regulation of cold-induced thermogenesis negative regulation of collagen biosynthetic process negative regulation of endothelial cell chemotaxis negative regulation of epithelial cell proliferation negative regulation of extracellular matrix constituent secretion negative regulation of gene expression negative regulation of glial cell proliferation negative regulation of inner ear auditory receptor cell differentiation negative regulation of myoblast differentiation negative regulation of myotube differentiation negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of ossification negative regulation of osteoblast differentiation negative regulation of photoreceptor cell differentiation negative regulation of pro-B cell differentiation negative regulation of programmed cell death negative regulation of stem cell differentiation negative regulation of transcription by RNA polymerase II neural tube development neuroendocrine cell differentiation neuron differentiation neuron fate commitment neuronal stem cell population maintenance nucleoplasm nucleus oligodendrocyte differentiation osteoblast fate commitment outflow tract morphogenesis pericardium morphogenesis plasma membrane positive regulation of BMP signaling pathway positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of Notch signaling pathway positive regulation of Ras protein signal transduction positive regulation of aorta morphogenesis positive regulation of apoptotic process involved in morphogenesis positive regulation of apoptotic process positive regulation of astrocyte differentiation positive regulation of cardiac epithelial to mesenchymal transition positive regulation of cardiac muscle cell proliferation positive regulation of cell migration positive regulation of endothelial cell differentiation positive regulation of ephrin receptor signaling pathway positive regulation of epithelial cell proliferation positive regulation of epithelial to mesenchymal transition positive regulation of gene expression positive regulation of glial cell differentiation positive regulation of keratinocyte differentiation positive regulation of neuroblast proliferation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of smooth muscle cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of viral genome replication prostate gland epithelium morphogenesis protein catabolic process protein import into nucleus pulmonary valve morphogenesis receptor complex regulation of Notch signaling pathway regulation of cardioblast proliferation regulation of cell adhesion involved in heart morphogenesis regulation of cell migration regulation of cell population proliferation regulation of epithelial cell proliferation involved in prostate gland development regulation of epithelial cell proliferation regulation of extracellular matrix assembly regulation of gene expression regulation of inner ear auditory receptor cell differentiation regulation of neurogenesis regulation of somitogenesis regulation of stem cell proliferation regulation of transcription by RNA polymerase II response to lipopolysaccharide response to muramyl dipeptide retinal cone cell differentiation ruffle secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development skeletal muscle cell differentiation somatic stem cell division spermatogenesis sprouting angiogenesis tissue regeneration transcription by RNA polymerase II transcription coactivator activity transcription regulator activator activity transmembrane signaling receptor activity tube formation vasculogenesis involved in coronary vascular morphogenesis venous blood vessel morphogenesis venous endothelial cell differentiation ventricular septum morphogenesis ventricular trabecula myocardium morphogenesis	GO:0000122 GO:0000139 GO:0000987 GO:0001228 GO:0001554 GO:0001669 GO:0001701 GO:0001726 GO:0001837 GO:0001889 GO:0001947 GO:0002040 GO:0002051 GO:0002052 GO:0002085 GO:0002193 GO:0002437 GO:0003151 GO:0003157 GO:0003160 GO:0003162 GO:0003169 GO:0003180 GO:0003181 GO:0003182 GO:0003184 GO:0003192 GO:0003197 GO:0003198 GO:0003203 GO:0003207 GO:0003208 GO:0003209 GO:0003213 GO:0003214 GO:0003219 GO:0003222 GO:0003241 GO:0003252 GO:0003264 GO:0003270 GO:0003273 GO:0003332 GO:0003344 GO:0003682 GO:0003713 GO:0004857 GO:0004888 GO:0005112 GO:0005509 GO:0005576 GO:0005634 GO:0005654 GO:0005737 GO:0005783 GO:0005789 GO:0005829 GO:0005856 GO:0005886 GO:0005912 GO:0006357 GO:0006366 GO:0006606 GO:0006915 GO:0006959 GO:0007157 GO:0007219 GO:0007221 GO:0007283 GO:0007368 GO:0007386 GO:0007409 GO:0007411 GO:0007440 GO:0007492 GO:0008283 GO:0008285 GO:0008544 GO:0008593 GO:0009912 GO:0009957 GO:0009986 GO:0010001 GO:0010008 GO:0010467 GO:0010468 GO:0010614 GO:0010628 GO:0010629 GO:0010718 GO:0010812 GO:0010832 GO:0014031 GO:0014807 GO:0016324 GO:0017156 GO:0019899 GO:0021515 GO:0021915 GO:0030027 GO:0030154 GO:0030163 GO:0030182 GO:0030216 GO:0030279 GO:0030324 GO:0030326 GO:0030334 GO:0030335 GO:0030513 GO:0030514 GO:0030900 GO:0031069 GO:0031100 GO:0031410 GO:0031490 GO:0032495 GO:0032496 GO:0032966 GO:0035116 GO:0035148 GO:0035914 GO:0035924 GO:0042127 GO:0042246 GO:0042670 GO:0042802 GO:0043065 GO:0043069 GO:0043086 GO:0043235 GO:0045070 GO:0045197 GO:0045603 GO:0045607 GO:0045608 GO:0045618 GO:0045662 GO:0045665 GO:0045668 GO:0045687 GO:0045747 GO:0045892 GO:0045893 GO:0045944 GO:0045955 GO:0046427 GO:0046533 GO:0046579 GO:0048103 GO:0048663 GO:0048708 GO:0048709 GO:0048711 GO:0048715 GO:0048754 GO:0048845 GO:0048873 GO:0050673 GO:0050678 GO:0050679 GO:0050680 GO:0050767 GO:0050768 GO:0051152 GO:0055008 GO:0060038 GO:0060045 GO:0060253 GO:0060271 GO:0060317 GO:0060354 GO:0060379 GO:0060411 GO:0060412 GO:0060528 GO:0060740 GO:0060768 GO:0060842 GO:0060843 GO:0060948 GO:0060956 GO:0060979 GO:0060982 GO:0061101 GO:0061344 GO:0061384 GO:0062043 GO:0070168 GO:0070374 GO:0070986 GO:0071228 GO:0071372 GO:0071456 GO:0071944 GO:0072017 GO:0072044 GO:0072091 GO:0072144 GO:0072148 GO:0072538 GO:0090051 GO:0090090 GO:0097150 GO:0097400 GO:0120163 GO:0140537 GO:1901189 GO:1901201 GO:1902263 GO:1902339 GO:1903849 GO:2000048 GO:2000737 GO:2000811 GO:2000974 GO:2001027
O60494	Cubilin	CUBN IFCR	Homo sapiens (human)	9606	54	Golgi apparatus apical plasma membrane brush border membrane calcium ion binding cargo receptor activity cholesterol metabolic process clathrin-coated pit cobalamin binding cobalamin metabolic process cobalamin transport cytosol endocytic vesicle endoplasmic reticulum endosome establishment of localization in cell extracellular exosome extrinsic component of external side of plasma membrane lipoprotein transport lysosomal lumen lysosomal membrane membrane microvillus membrane plasma membrane protein homodimerization activity receptor complex receptor-mediated endocytosis response to bacterium signaling receptor activity tissue homeostasis	GO:0001894 GO:0005509 GO:0005765 GO:0005768 GO:0005783 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006898 GO:0008203 GO:0009235 GO:0009617 GO:0015889 GO:0016020 GO:0016324 GO:0030139 GO:0031232 GO:0031419 GO:0031526 GO:0031528 GO:0038023 GO:0038024 GO:0042803 GO:0042953 GO:0043202 GO:0043235 GO:0051649 GO:0070062
Q9HC84	Mucin-5B	MUC5B MUC5	Homo sapiens (human)	9606	54	Golgi lumen extracellular exosome extracellular matrix extracellular space intracellular membrane-bounded organelle metal ion binding plasma membrane	GO:0005615 GO:0005796 GO:0005886 GO:0031012 GO:0043231 GO:0046872 GO:0070062
P0DTC2	Spike glycoprotein	S	Severe acute respiratory syndrome coronavirus 2	2697049	54	entry receptor-mediated virion attachment to host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell plasma membrane host cell surface receptor binding host cell surface host extracellular space identical protein binding membrane fusion membrane plasma membrane positive regulation of viral entry into host cell receptor ligand activity receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell structural constituent of virion suppression by virus of host tetherin activity viral envelope viral translation virion attachment to host cell virion membrane	GO:0005886 GO:0016020 GO:0019031 GO:0019062 GO:0019064 GO:0019065 GO:0019081 GO:0020002 GO:0039587 GO:0039654 GO:0039660 GO:0042802 GO:0043655 GO:0044173 GO:0044228 GO:0046598 GO:0046789 GO:0046813 GO:0048018 GO:0055036 GO:0061025 GO:0098670
Q9H4A3	Serine/threonine-protein kinase WNK1	WNK1 HSN2 KDP KIAA0344 PRKWNK1	Homo sapiens (human)	9606	53	ATP binding T cell receptor signaling pathway cell volume homeostasis cellular hyperosmotic response cellular response to chemokine chemokine (C-C motif) ligand 21 signaling pathway cytoplasm cytosol heart development intracellular chloride ion homeostasis intracellular non-membrane-bounded organelle intracellular signal transduction lymphocyte migration into lymph node membrane mitotic spindle molecular condensate scaffold activity monoatomic cation homeostasis monoatomic ion transport negative regulation of GTPase activity negative regulation of autophagy negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion negative regulation of leukocyte cell-cell adhesion negative regulation of pancreatic juice secretion negative regulation of protein localization to plasma membrane negative regulation of protein ubiquitination negative regulation of sodium ion transport neuron development non-membrane-bounded organelle assembly nucleus peptidyl-serine phosphorylation peptidyl-threonine phosphorylation phosphatase binding positive regulation of T cell chemotaxis positive regulation of angiogenesis positive regulation of canonical Wnt signaling pathway positive regulation of mitotic cytokinesis positive regulation of potassium ion import across plasma membrane positive regulation of systemic arterial blood pressure positive regulation of termination of RNA polymerase II transcription potassium channel inhibitor activity potassium ion homeostasis protein insertion into ER membrane by stop-transfer membrane-anchor sequence protein kinase activator activity protein kinase activity protein kinase binding protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity protein-containing complex regulation of mRNA export from nucleus regulation of monoatomic cation transmembrane transport regulation of sodium ion transmembrane transport regulation of sodium ion transport signal transduction sodium ion transmembrane transport	GO:0002028 GO:0003084 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006468 GO:0006811 GO:0006884 GO:0007165 GO:0007507 GO:0010507 GO:0010766 GO:0010793 GO:0010820 GO:0016020 GO:0018105 GO:0018107 GO:0019870 GO:0019901 GO:0019902 GO:0030295 GO:0030644 GO:0031397 GO:0032991 GO:0033633 GO:0034115 GO:0034260 GO:0035556 GO:0035725 GO:0038116 GO:0043232 GO:0045050 GO:0045766 GO:0048666 GO:0050852 GO:0055075 GO:0055080 GO:0071474 GO:0072686 GO:0090188 GO:0090263 GO:0097022 GO:0106310 GO:0140693 GO:0140694 GO:1902305 GO:1903038 GO:1903077 GO:1903288 GO:1903490 GO:1904062 GO:1904595 GO:1990869
A1X159	Foot protein 1 variant 2	fp-1	Perna viridis (Asian green mussel)	73031	53	extracellular region	GO:0005576
Q03650	Cysteine-rich, acidic integral membrane protein	CRAM	Trypanosoma brucei brucei	5702	53	ciliary pocket endocytosis plasma membrane	GO:0005886 GO:0006897 GO:0020016
Q5R6R1	Protein eyes shut homolog	EYS EGFL10 EGFL11 SPAM	Pongo abelii (Sumatran orangutan)	9601	52	Notch binding Notch signaling pathway calcium ion binding centrosome cytoplasm detection of light stimulus involved in visual perception extracellular region interphotoreceptor matrix photoreceptor outer segment skeletal muscle tissue regeneration	GO:0001750 GO:0005112 GO:0005509 GO:0005576 GO:0005737 GO:0005813 GO:0007219 GO:0033165 GO:0043403 GO:0050908
O43493	Trans-Golgi network integral membrane protein 2	TGOLN2 TGN46 TGN51	Homo sapiens (human)	9606	52	Golgi apparatus clathrin-coated endocytic vesicle membrane endoplasmic reticulum lumen endosome nucleoplasm plasma membrane trans-Golgi network transport vesicle trans-Golgi network transport vesicle	GO:0005654 GO:0005768 GO:0005788 GO:0005794 GO:0005802 GO:0005886 GO:0030133 GO:0030140 GO:0030669
Q12465	Bud site selection protein RAX2	RAX2	Saccharomyces cerevisiae S288C	559292	52	axial cellular bud site selection bipolar cellular bud site selection cellular bud neck cellular bud scar cellular bud site selection cellular bud tip endoplasmic reticulum mitochondrion plasma membrane of growing cell tip protein localization	GO:0000282 GO:0005621 GO:0005739 GO:0005783 GO:0005934 GO:0005935 GO:0007120 GO:0007121 GO:0008104 GO:1902929
O75179	Ankyrin repeat domain-containing protein 17	ANKRD17 GTAR KIAA0697	Homo sapiens (human)	9606	51	RNA binding blood vessel maturation chromatin binding chromatin cytoplasm defense response to bacterium innate immune response male germ cell nucleus membrane negative regulation of smooth muscle cell differentiation nuclear membrane nucleoplasm nucleus positive regulation of G1/S transition of mitotic cell cycle positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway positive regulation of canonical NF-kappaB signal transduction positive regulation of cell cycle regulation of DNA replication	GO:0000785 GO:0001673 GO:0001955 GO:0003682 GO:0003723 GO:0005634 GO:0005654 GO:0005737 GO:0006275 GO:0016020 GO:0031965 GO:0042742 GO:0043123 GO:0045087 GO:0045787 GO:0051151 GO:1900087 GO:1900245 GO:1900246
Q01844	RNA-binding protein EWS	EWSR1 EWS	Homo sapiens (human)	9606	51	Cajal body RNA binding calmodulin binding cytoplasm identical protein binding metal ion binding nucleolus nucleoplasm nucleus plasma membrane regulation of DNA-templated transcription transcription coregulator activity	GO:0003712 GO:0003723 GO:0005516 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005886 GO:0006355 GO:0015030 GO:0042802 GO:0046872
Q91ZX7	Prolow-density lipoprotein receptor-related protein 1	Lrp1 A2mr	Mus musculus (house mouse)	10090	51	Golgi apparatus alpha-2 macroglobulin receptor activity amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis amyloid-beta clearance aorta morphogenesis apical part of cell apolipoprotein binding apoptotic cell clearance astrocyte activation involved in immune response axonal growth cone calcium ion binding cardiac septum development cargo receptor activity cellular lipid catabolic process cellular response to amyloid-beta chemoattraction of axon cholesterol metabolic process clathrin-coated pit clathrin-coated vesicle coreceptor activity coronary vasculature development dendrite endosome enzyme-linked receptor protein signaling pathway external side of plasma membrane insulin-responsive compartment low-density lipoprotein particle receptor activity lysosomal transport membrane microtubule organizing center negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of apoptotic process negative regulation of cell-substrate adhesion negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of gene expression negative regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration negative regulation of transforming growth factor beta receptor signaling pathway neuronal cell body nucleus phagocytosis plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of Schwann cell migration positive regulation of amyloid-beta clearance positive regulation of axon extension involved in regeneration positive regulation of axon extension positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cholesterol efflux positive regulation of cholesterol import positive regulation of collateral sprouting of injured axon positive regulation of cytosolic calcium ion concentration positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of lipid transport positive regulation of neuron projection development positive regulation of phagocytosis positive regulation of protein transport positive regulation of transcytosis positive regulation of vascular associated smooth muscle cell migration protease binding protein kinase C-activating G protein-coupled receptor signaling pathway receptor complex receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of phospholipase A2 activity regulation of pulmonary blood vessel remodeling signaling receptor binding transport across blood-brain barrier	GO:0002020 GO:0002265 GO:0003279 GO:0005041 GO:0005102 GO:0005509 GO:0005634 GO:0005768 GO:0005794 GO:0005815 GO:0005886 GO:0005905 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0007204 GO:0007205 GO:0008203 GO:0009897 GO:0010629 GO:0010812 GO:0010875 GO:0010976 GO:0010977 GO:0014912 GO:0015026 GO:0016020 GO:0016964 GO:0030136 GO:0030178 GO:0030425 GO:0030512 GO:0032370 GO:0032374 GO:0032429 GO:0032593 GO:0032956 GO:0034185 GO:0035774 GO:0035909 GO:0038024 GO:0043025 GO:0043066 GO:0043235 GO:0043277 GO:0043524 GO:0044242 GO:0044295 GO:0045177 GO:0045773 GO:0048691 GO:0048694 GO:0050766 GO:0051222 GO:0051481 GO:0051895 GO:0060392 GO:0060976 GO:0061642 GO:0070374 GO:0097242 GO:0150093 GO:0150094 GO:0150104 GO:1900149 GO:1900223 GO:1904109 GO:1904300 GO:1904646 GO:1904754 GO:1905109 GO:2000343 GO:2000587
E9PZ36	Fibrocystin	Pkhd1	Mus musculus (house mouse)	10090	51	9+0 non-motile cilium Golgi apparatus apical plasma membrane branching morphogenesis of an epithelial tube cell-cell junction organization centrosome chromosome, centromeric region ciliary basal body cilium assembly cilium endoplasmic reticulum epithelial cell morphogenesis establishment of centrosome localization establishment of mitotic spindle orientation extracellular exosome intracellular calcium ion homeostasis kidney development mitotic spindle negative regulation of epithelial cell apoptotic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction nucleus perinuclear region of cytoplasm positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade regulation of TOR signaling regulation of cell adhesion regulation of cell-cell adhesion regulation of cell-matrix adhesion regulation of centrosome duplication regulation of cholangiocyte proliferation regulation of establishment of planar polarity	GO:0000132 GO:0000775 GO:0001822 GO:0001952 GO:0003382 GO:0005634 GO:0005783 GO:0005794 GO:0005813 GO:0005929 GO:0006874 GO:0010824 GO:0016324 GO:0022407 GO:0030155 GO:0032006 GO:0036064 GO:0045216 GO:0048471 GO:0048754 GO:0050679 GO:0051660 GO:0051898 GO:0060271 GO:0070062 GO:0070372 GO:0072686 GO:0090175 GO:0097731 GO:1904036 GO:1904054
P15822	Zinc finger protein 40	HIVEP1 ZNF40	Homo sapiens (human)	9606	51	BMP signaling pathway DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding cytosol metal ion binding mitochondrion negative regulation of transcription by RNA polymerase II nuclear body nucleoplasm nucleus positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding	GO:0000122 GO:0000978 GO:0000981 GO:0001227 GO:0005634 GO:0005654 GO:0005739 GO:0005829 GO:0006357 GO:0016604 GO:0030509 GO:0045944 GO:0046872 GO:1990837
P35556	Fibrillin-2	FBN2	Homo sapiens (human)	9606	50	anatomical structure morphogenesis bone trabecula formation calcium ion binding camera-type eye development collagen-containing extracellular matrix embryonic eye morphogenesis embryonic limb morphogenesis extracellular matrix constituent conferring elasticity extracellular matrix structural constituent extracellular matrix extracellular region hormone activity microfibril positive regulation of bone mineralization positive regulation of osteoblast differentiation sequestering of TGFbeta in extracellular matrix	GO:0001527 GO:0005179 GO:0005201 GO:0005509 GO:0005576 GO:0009653 GO:0030023 GO:0030326 GO:0030501 GO:0031012 GO:0035583 GO:0043010 GO:0045669 GO:0048048 GO:0060346 GO:0062023
A0A2K5V015	Protein eyes shut homolog	EYS	Macaca fascicularis (crab-eating macaque)	9541	50	Notch binding Notch signaling pathway calcium ion binding centrosome cytoplasm extracellular region interphotoreceptor matrix photoreceptor outer segment visual perception	GO:0001750 GO:0005112 GO:0005509 GO:0005576 GO:0005737 GO:0005813 GO:0007219 GO:0007601 GO:0033165
Q2N0S6	Envelope glycoprotein gp160	env	Human immunodeficiency virus 1	11676	50	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endosome membrane host cell plasma membrane identical protein binding plasma membrane positive regulation of establishment of T cell polarity positive regulation of plasma membrane raft polarization positive regulation of receptor clustering structural molecule activity viral envelope viral protein processing virion attachment to host cell virion membrane virus-mediated perturbation of host defense response	GO:0005198 GO:0005886 GO:0019031 GO:0019049 GO:0019062 GO:0019064 GO:0019082 GO:0020002 GO:0039654 GO:0042802 GO:0044175 GO:0055036 GO:0075512 GO:1903905 GO:1903908 GO:1903911

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