GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Xylosyl- and glucuronyltransferase LARGE2	Q8N3Y3	LARGE2	Homo sapiens	9606	3	Golgi apparatus Golgi membrane UDP-xylosyltransferase activity glucuronosyltransferase activity manganese ion binding muscle cell cellular homeostasis protein O-linked glycosylation protein O-linked mannosylation xylosyltransferase activity	GO:0000139 GO:0005794 GO:0006493 GO:0015020 GO:0030145 GO:0035252 GO:0035269 GO:0042285 GO:0046716
Tolloid-like protein 1	O43897	TLL1	Homo sapiens	9606	5	calcium ion binding cell differentiation collagen fibril organization dorsal/ventral pattern formation extracellular region extracellular space metalloendopeptidase activity protein processing serine-type endopeptidase activity skeletal system development zinc ion binding	GO:0001501 GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005615 GO:0008270 GO:0009953 GO:0016485 GO:0030154 GO:0030199
Fibroblast growth factor receptor-like 1	Q8N441	FGFRL1	Homo sapiens	9606	4	Golgi apparatus cell-cell adhesion via plasma-membrane adhesion molecules cell-cell contact zone diaphragm development fibroblast growth factor binding fibroblast growth factor receptor activity heart valve morphogenesis heparin binding identical protein binding negative regulation of cell population proliferation plasma membrane skeletal system development transport vesicle ventricular septum morphogenesis	GO:0001501 GO:0003179 GO:0005007 GO:0005794 GO:0005886 GO:0008201 GO:0008285 GO:0017134 GO:0030133 GO:0042802 GO:0044291 GO:0060412 GO:0060539 GO:0098742
Cell cycle exit and neuronal differentiation protein 1	Q5FVI4	Cend1	Rattus norvegicus	10116	1	adult walking behavior cerebellar Purkinje cell differentiation cerebellar granular layer maturation membrane mitochondrion negative regulation of cerebellar granule cell precursor proliferation neuron differentiation radial glia guided migration of cerebellar granule cell vesicle	GO:0005739 GO:0007628 GO:0016020 GO:0021686 GO:0021702 GO:0021933 GO:0021941 GO:0030182 GO:0031982
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	Q8NES3	LFNG	Homo sapiens	9606	1	Golgi membrane O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity T cell differentiation animal organ morphogenesis compartment pattern specification extracellular region extracellular vesicle marginal zone B cell differentiation metal ion binding negative regulation of Notch signaling pathway involved in somitogenesis ovarian follicle development positive regulation of Notch signaling pathway positive regulation of meiotic cell cycle regulation of Notch signaling pathway regulation of somitogenesis somitogenesis	GO:0000139 GO:0001541 GO:0001756 GO:0002315 GO:0005576 GO:0007386 GO:0008593 GO:0009887 GO:0014807 GO:0030217 GO:0033829 GO:0045747 GO:0046872 GO:0051446 GO:1902367 GO:1903561
Amphoterin-induced protein 1	Q80ZD8	Amigo1	Mus musculus	10090	5	axonal fasciculation axonogenesis brain development cell adhesion cellular response to L-glutamate dendrite heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules membrane myelination neuron projection fasciculation neuronal cell body neuronal cell body membrane pericellular basket perikaryon positive regulation of axonogenesis positive regulation of neuron projection development positive regulation of potassium ion transmembrane transport positive regulation of synapse assembly potassium channel regulator activity	GO:0007155 GO:0007156 GO:0007157 GO:0007409 GO:0007413 GO:0007420 GO:0010976 GO:0015459 GO:0016020 GO:0030425 GO:0032809 GO:0042552 GO:0043025 GO:0043204 GO:0050772 GO:0051965 GO:0106030 GO:1901381 GO:1905232 GO:1990030
Disintegrin and metalloproteinase domain-containing protein 8	P78325	ADAM8	Homo sapiens	9606	4	alpha9-beta1 integrin-ADAM8 complex angiogenesis calcium ion binding cell adhesion molecule binding cell morphogenesis cell surface cell-cell adhesion cellular response to hypoxia cytoplasm dense core granule membrane extracellular matrix disassembly ficolin-1-rich granule membrane inflammatory response leukocyte migration involved in inflammatory response lymphocyte chemotaxis metalloendopeptidase activity metallopeptidase activity negative regulation of neuron apoptotic process phagolysosome plasma membrane podosome positive regulation of MAP kinase activity positive regulation of NF-kappaB transcription factor activity positive regulation of T cell differentiation in thymus positive regulation of acute inflammatory response positive regulation of bone resorption positive regulation of cell adhesion positive regulation of cellular extravasation positive regulation of eosinophil migration positive regulation of epithelial to mesenchymal transition positive regulation of fibronectin-dependent thymocyte migration positive regulation of innate immune response positive regulation of membrane protein ectodomain proteolysis positive regulation of neutrophil extravasation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein processing positive regulation of protein secretion positive regulation of thymocyte apoptotic process positive regulation of transforming growth factor beta1 activation positive regulation of tumor necrosis factor (ligand) superfamily member 11 production protein self-association proteolysis regulation of cell-cell adhesion serine-type endopeptidase activity specific granule specific granule membrane tertiary granule tertiary granule membrane zinc ion binding	GO:0000902 GO:0001525 GO:0002102 GO:0002523 GO:0002675 GO:0002693 GO:0004222 GO:0004252 GO:0005509 GO:0005737 GO:0005886 GO:0006508 GO:0006954 GO:0008237 GO:0008270 GO:0009986 GO:0010718 GO:0010954 GO:0022407 GO:0022617 GO:0032010 GO:0032127 GO:0033089 GO:0035579 GO:0042581 GO:0043406 GO:0043524 GO:0043621 GO:0045089 GO:0045780 GO:0045785 GO:0048247 GO:0050714 GO:0050839 GO:0051044 GO:0051092 GO:0051897 GO:0070245 GO:0070820 GO:0070821 GO:0071133 GO:0071456 GO:0098609 GO:0101003 GO:1901394 GO:2000309 GO:2000391 GO:2000415 GO:2000418
Avidin	P02701	AVD	Gallus gallus	9031	1	antibacterial humoral response biotin binding extracellular region	GO:0005576 GO:0009374 GO:0019731
Putative stereocilin-like protein	A6NGW2	STRCP1	Homo sapiens	9606	5	cell surface cell-matrix adhesion extracellular region kinocilium stereocilium tip	GO:0005576 GO:0007160 GO:0009986 GO:0032426 GO:0060091
Immunoglobulin superfamily member 5	Q9NSI5	IGSF5	Homo sapiens	9606	4	apical plasma membrane bicellular tight junction cell surface cell-cell adhesion	GO:0005923 GO:0009986 GO:0016324 GO:0098609