GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Basement membrane-specific heparan sulfate proteoglycan core protein	P98160	HSPG2	Homo sapiens	9606	85	Golgi lumen amyloid-beta binding angiogenesis animal organ regeneration basement membrane brain development calcium ion binding cell differentiation circulatory system development collagen V binding collagen-containing extracellular matrix embryo implantation extracellular exosome extracellular matrix structural constituent conferring compression resistance extracellular region extracellular space focal adhesion inflammatory response lipid metabolic process low-density lipoprotein particle receptor binding lysosomal lumen negative regulation of angiogenesis negative regulation of cell adhesion negative regulation of cell population proliferation plasma membrane plasma membrane protein complex positive regulation of endothelial cell proliferation receptor-mediated endocytosis response to hypoxia response to xenobiotic stimulus smoothened signaling pathway	GO:0001525 GO:0001540 GO:0001666 GO:0001938 GO:0005509 GO:0005576 GO:0005604 GO:0005615 GO:0005796 GO:0005886 GO:0005925 GO:0006629 GO:0006898 GO:0006954 GO:0007162 GO:0007224 GO:0007420 GO:0007566 GO:0008285 GO:0009410 GO:0016525 GO:0030021 GO:0030154 GO:0031100 GO:0043202 GO:0050750 GO:0062023 GO:0070052 GO:0070062 GO:0072359 GO:0098797
Foot protein 1 variant 1	A1X158	fp-1	Perna viridis	73031	80	extracellular region	GO:0005576
Protein bassoon	Q9UPA5	BSN	Homo sapiens	9606	79	GABA-ergic synapse Schaffer collateral - CA1 synapse axon cell surface chemical synaptic transmission cochlear hair cell ribbon synapse cytoskeleton of presynaptic active zone dendrite excitatory synapse glutamatergic synapse metal ion binding neuron projection terminus nucleus postsynaptic density presynapse to nucleus signaling pathway presynaptic active zone presynaptic active zone assembly protein localization to synapse regulation of synaptic vesicle cycle structural constituent of presynaptic active zone synaptic vesicle synaptic vesicle clustering synaptic vesicle membrane	GO:0005634 GO:0007268 GO:0008021 GO:0009986 GO:0014069 GO:0030424 GO:0030425 GO:0030672 GO:0035418 GO:0044306 GO:0046872 GO:0048786 GO:0048788 GO:0060076 GO:0097091 GO:0098683 GO:0098685 GO:0098693 GO:0098882 GO:0098978 GO:0098982 GO:0099526 GO:1904071
Nuclear receptor corepressor 1	O75376	NCOR1	Homo sapiens	9606	78	RNA polymerase II-specific DNA-binding transcription factor binding chromatin chromatin organization cytosol histone deacetylase binding histone deacetylase complex locomotor rhythm membrane mitotic spindle negative regulation of DNA-templated transcription negative regulation of JNK cascade negative regulation of androgen receptor signaling pathway negative regulation of fatty acid metabolic process negative regulation of glycolytic process negative regulation of miRNA transcription negative regulation of transcription by RNA polymerase II nuclear receptor binding nuclear thyroid hormone receptor binding nucleoplasm nucleus spindle assembly transcription cis-regulatory region binding transcription corepressor activity transcription repressor complex	GO:0000118 GO:0000122 GO:0000785 GO:0000976 GO:0003714 GO:0005634 GO:0005654 GO:0005829 GO:0006325 GO:0016020 GO:0016922 GO:0017053 GO:0042826 GO:0045475 GO:0045820 GO:0045892 GO:0045922 GO:0046329 GO:0046966 GO:0051225 GO:0060766 GO:0061629 GO:0072686 GO:1902894
Low-density lipoprotein receptor-related protein 2	P98164	LRP2	Homo sapiens	9606	76	Golgi apparatus SH3 domain binding amyloid-beta clearance aorta development apical plasma membrane axon brush border membrane calcium ion binding cargo receptor activity cellular response to growth factor stimulus clathrin-coated endocytic vesicle membrane clathrin-coated pit cobalamin transport coronary artery morphogenesis dendrite diol metabolic process endocytosis endoplasmic reticulum endosome lumen external side of plasma membrane extracellular exosome folate import across plasma membrane forebrain development hormone binding insulin-like growth factor I binding kidney development lipid metabolic process low-density lipoprotein particle receptor activity lysosomal membrane lysosome male gonad development metal ion transport negative regulation of BMP signaling pathway negative regulation of apoptotic process neural tube closure neuron projection arborization outflow tract septum morphogenesis plasma membrane positive regulation of lysosomal protein catabolic process positive regulation of neurogenesis positive regulation of oligodendrocyte progenitor proliferation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction protein transport protein transporter activity protein-folding chaperone binding pulmonary artery morphogenesis receptor complex receptor-mediated endocytosis response to leptin retinoid metabolic process secondary heart field specification sensory perception of sound transcytosis transport across blood-brain barrier vagina development ventricular compact myocardium morphogenesis ventricular septum development vitamin D metabolic process	GO:0001523 GO:0001822 GO:0001843 GO:0003139 GO:0003148 GO:0003223 GO:0003281 GO:0005041 GO:0005509 GO:0005764 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0005905 GO:0006629 GO:0006897 GO:0006898 GO:0007605 GO:0008584 GO:0009897 GO:0015031 GO:0015889 GO:0016324 GO:0017124 GO:0030001 GO:0030424 GO:0030425 GO:0030514 GO:0030669 GO:0030900 GO:0031526 GO:0031904 GO:0031994 GO:0034311 GO:0035904 GO:0038024 GO:0042359 GO:0042562 GO:0043066 GO:0043235 GO:0044321 GO:0045056 GO:0050769 GO:0051087 GO:0051897 GO:0060068 GO:0060982 GO:0061156 GO:0070062 GO:0070447 GO:0071363 GO:0097242 GO:0140058 GO:0140318 GO:0150104 GO:1904447 GO:1905167
Nuclear pore complex protein Nup214	Q80U93	Nup214	Mus musculus	10090	74	RNA export from nucleus cytoplasmic side of nuclear pore mRNA export from nucleus nuclear envelope nuclear export signal receptor activity nuclear localization sequence binding nuclear pore nucleocytoplasmic transport protein export from nucleus protein import into nucleus regulation of cell cycle regulation of nucleocytoplasmic transport structural constituent of nuclear pore	GO:0005049 GO:0005635 GO:0005643 GO:0006405 GO:0006406 GO:0006606 GO:0006611 GO:0006913 GO:0008139 GO:0017056 GO:0046822 GO:0051726 GO:1990876
Podocalyxin	O00592	PODXL	Homo sapiens	9606	72	apical plasma membrane cell adhesion cell migration centriolar satellite cytoplasm epithelial tube formation extracellular exosome extracellular space filopodium intracellular membrane-bounded organelle lamellipodium membrane raft microvillus membrane negative regulation of cell adhesion negative regulation of cell-cell adhesion nucleolus plasma membrane podocyte development positive regulation of cell migration positive regulation of cell-cell adhesion mediated by integrin regulation of microvillus assembly ruffle slit diaphragm	GO:0001726 GO:0005615 GO:0005730 GO:0005737 GO:0005886 GO:0007155 GO:0007162 GO:0016324 GO:0016477 GO:0022408 GO:0030027 GO:0030175 GO:0030335 GO:0031528 GO:0032534 GO:0033634 GO:0034451 GO:0036057 GO:0043231 GO:0045121 GO:0070062 GO:0072015 GO:0072175
Msx2-interacting protein	Q96T58	SPEN	Homo sapiens	9606	71	DNA binding Notch signaling pathway RNA binding RNA polymerase II-specific DNA-binding transcription factor binding extracellular exosome mRNA binding negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nucleoplasm nucleus positive regulation of neurogenesis regulation of transcription by RNA polymerase II transcription corepressor activity transcription repressor complex	GO:0000122 GO:0003677 GO:0003714 GO:0003723 GO:0003729 GO:0005634 GO:0005654 GO:0006357 GO:0007219 GO:0017053 GO:0045892 GO:0050769 GO:0061629 GO:0070062
Zinc finger RNA-binding protein	Q96KR1	ZFR	Homo sapiens	9606	70	DNA binding RNA binding chromosome cytoplasm double-stranded RNA binding nucleus single-stranded RNA binding zinc ion binding	GO:0003677 GO:0003723 GO:0003725 GO:0003727 GO:0005634 GO:0005694 GO:0005737 GO:0008270
BRCA2-interacting transcriptional repressor EMSY	Q7Z589	EMSY	Homo sapiens	9606	70	DNA repair chromatin organization identical protein binding nucleoplasm regulation of DNA-templated transcription	GO:0005654 GO:0006281 GO:0006325 GO:0006355 GO:0042802