GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID ▲	No. of Glycosylation Sites	GO Labels	GO IDs
Potassium channel subfamily K member	A0A8C2LP72	Kcnk1	Cricetulus griseus	10029	1	dendrite perikaryon potassium channel activity recycling endosome synaptic membrane	GO:0005267 GO:0030425 GO:0043204 GO:0055037 GO:0097060
Toll-like receptor 4	Q9WV82	TLR4	Cricetulus griseus	10029	11	B cell proliferation involved in immune response ERK1 and ERK2 cascade JNK cascade MHC class II biosynthetic process MyD88-dependent toll-like receptor signaling pathway NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating TRIF-dependent toll-like receptor signaling pathway astrocyte development canonical NF-kappaB signal transduction cellular response to amyloid-beta cellular response to lipoteichoic acid cellular response to mechanical stimulus cellular response to oxidised low-density lipoprotein particle stimulus cellular response to platelet-derived growth factor stimulus cellular response to type II interferon defense response to Gram-negative bacterium detection of lipopolysaccharide early endosome external side of plasma membrane gene expression identical protein binding intestinal epithelial structure maintenance lipopolysaccharide binding lipopolysaccharide immune receptor activity lipopolysaccharide receptor complex macrophage activation microglia differentiation negative regulation of ERK1 and ERK2 cascade negative regulation of cold-induced thermogenesis negative regulation of interleukin-17 production negative regulation of interleukin-23 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of type II interferon production nitric oxide biosynthetic process nitric oxide production involved in inflammatory response nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway perinuclear region of cytoplasm phagocytic cup phagocytosis positive regulation of B cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of JNK cascade positive regulation of MHC class II biosynthetic process positive regulation of NLRP3 inflammasome complex assembly positive regulation of canonical NF-kappaB signal transduction positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cytokine production involved in inflammatory response positive regulation of extrinsic apoptotic signaling pathway positive regulation of inflammatory response positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of macrophage activation positive regulation of macrophage cytokine production positive regulation of matrix metallopeptidase secretion positive regulation of nitric oxide biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of non-canonical NF-kappaB signal transduction positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of platelet activation positive regulation of reactive oxygen species biosynthetic process positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of transcription by RNA polymerase II positive regulation of tumor necrosis factor production positive regulation of type II interferon production protein heterodimerization activity regulation of dendritic cell cytokine production ruffle signaling receptor binding toll-like receptor 4 signaling pathway transmembrane signaling receptor activity wound healing involved in inflammatory response	GO:0001530 GO:0001726 GO:0001875 GO:0001891 GO:0002246 GO:0002322 GO:0002537 GO:0002730 GO:0002755 GO:0004888 GO:0005102 GO:0005769 GO:0006809 GO:0006909 GO:0007249 GO:0007254 GO:0009897 GO:0010467 GO:0010572 GO:0014002 GO:0014004 GO:0014911 GO:0030890 GO:0032497 GO:0032689 GO:0032700 GO:0032707 GO:0032715 GO:0032720 GO:0032727 GO:0032728 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032755 GO:0032757 GO:0032760 GO:0034142 GO:0035666 GO:0036120 GO:0042116 GO:0042802 GO:0043032 GO:0043123 GO:0045342 GO:0045348 GO:0045429 GO:0045944 GO:0046330 GO:0046696 GO:0046982 GO:0048471 GO:0048661 GO:0050135 GO:0050729 GO:0050829 GO:0051770 GO:0060729 GO:0060907 GO:0061809 GO:0070371 GO:0070373 GO:0070374 GO:0070427 GO:0070430 GO:0070431 GO:0070434 GO:0071223 GO:0071260 GO:0071346 GO:0120163 GO:0140052 GO:1900017 GO:1900227 GO:1901224 GO:1903428 GO:1903974 GO:1904466 GO:1904646 GO:2000343 GO:2001238
P2X purinoceptor	A0A8C2MXT6	P2rx4	Cricetulus griseus	10029	1	ATP binding extracellularly ATP-gated monoatomic cation channel activity plasma membrane postsynapse purinergic nucleotide receptor activity response to ATP	GO:0001614 GO:0004931 GO:0005524 GO:0005886 GO:0033198 GO:0098794
ceramidase	A0A3L7INC1	Naaa	Cricetulus griseus	10029	4	DNA-binding transcription factor binding N-(long-chain-acyl)ethanolamine deacylase activity N-acylethanolamine metabolic process N-acylphosphatidylethanolamine metabolic process N-acylsphingosine amidohydrolase activity ceramidase activity fatty acid amide hydrolase activity fatty acid metabolic process lysosome membrane sphingosine metabolic process	GO:0005764 GO:0006631 GO:0006670 GO:0016020 GO:0017040 GO:0017064 GO:0047412 GO:0070291 GO:0070292 GO:0102121 GO:0140297
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase	A0A8C2QM57	B3gat2	Cricetulus griseus	10029	1	Golgi membrane galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity metal ion binding	GO:0000139 GO:0015018 GO:0046872
Paraoxonase	A0A8C2ME55	Pon3	Cricetulus griseus	10029	2	arylesterase activity metal ion binding	GO:0004064 GO:0046872
Neurogenic locus notch homolog protein 1	G3I6Z6	NOTCH1	Cricetulus griseus	10029	47	Golgi lumen Golgi membrane Notch signaling involved in heart development adherens junction angiogenesis apical plasma membrane calcium ion binding cell differentiation cilium assembly nucleus regulation of DNA-templated transcription regulation of developmental process signaling receptor activity	GO:0000139 GO:0001525 GO:0005509 GO:0005634 GO:0005796 GO:0005912 GO:0006355 GO:0016324 GO:0030154 GO:0038023 GO:0050793 GO:0060271 GO:0061314
Tartrate-resistant acid phosphatase type 5 (Fragment)	A0A061I831	H671_4g12128	Cricetulus griseus	10029	1	acid phosphatase activity metal ion binding	GO:0003993 GO:0046872
Membrane-bound transcription factor site-1 protease	Q9Z2A8	MBTPS1	Cricetulus griseus	10029	6	Golgi membrane Golgi stack cholesterol metabolic process endoplasmic reticulum membrane lysosome organization membrane protein intracellular domain proteolysis mitotic G2 DNA damage checkpoint signaling protein processing proteolysis regulation of vesicle-mediated transport response to endoplasmic reticulum stress serine-type endopeptidase activity	GO:0000139 GO:0004252 GO:0005789 GO:0005795 GO:0006508 GO:0007040 GO:0007095 GO:0008203 GO:0016485 GO:0031293 GO:0034976 GO:0060627
Integrin alpha-3	P17852	ITGA3	Cricetulus griseus	10029	12	anchoring junction cell adhesion filopodium membrane integrin complex integrin-mediated signaling pathway metal ion binding positive regulation of protein localization to plasma membrane protein heterodimerization activity	GO:0007155 GO:0007229 GO:0008305 GO:0031527 GO:0046872 GO:0046982 GO:0070161 GO:1903078