GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
3-hydroxy-3-methylglutaryl coenzyme A reductase AN1593	C8VN86	AN1593	Aspergillus nidulans FGSC A4	227321	2	coenzyme A metabolic process endoplasmic reticulum membrane ergosterol biosynthetic process hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane secondary metabolic process	GO:0004420 GO:0005778 GO:0005789 GO:0006696 GO:0008299 GO:0015936 GO:0019748
3-hydroxy-3-methylglutaryl coenzyme A reductase mlcD	Q8J0F4	mlcD	Penicillium citrinum	5077	5	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936
3-hydroxy-3-methylglutaryl coenzyme A reductase mokG	Q3S2U3	mokG	Monascus pilosus	89488	2	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P51639	Hmgcr	Rattus norvegicus	10116	1	GTPase regulator activity NADPH binding bile acid signaling pathway cholesterol biosynthetic process cholesterol homeostasis coenzyme A binding coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity identical protein binding isoprenoid biosynthetic process long-term synaptic potentiation myoblast differentiation negative regulation of amyloid-beta clearance negative regulation of apoptotic process negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of protein catabolic process negative regulation of protein secretion negative regulation of striated muscle cell apoptotic process peroxisomal membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cardiac muscle cell apoptotic process positive regulation of cell population proliferation positive regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation positive regulation of stress-activated MAPK cascade positive regulation of vasoconstriction protein phosphatase 2A binding regulation of ERK1 and ERK2 cascade response to cholesterol response to ethanol response to nutrient response to nutrient levels sterol biosynthetic process triglyceride homeostasis ubiquinone metabolic process visual learning	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0006743 GO:0007584 GO:0008284 GO:0008299 GO:0008542 GO:0010664 GO:0010666 GO:0015936 GO:0016126 GO:0030695 GO:0031667 GO:0032874 GO:0038183 GO:0042177 GO:0042632 GO:0042802 GO:0043066 GO:0045445 GO:0045471 GO:0045907 GO:0048643 GO:0048661 GO:0050709 GO:0051721 GO:0060291 GO:0061179 GO:0070328 GO:0070372 GO:0070374 GO:0070402 GO:0070723 GO:0120225 GO:1900222
3-hydroxy-3-methylglutaryl-coenzyme A reductase	O74164	HMG	Cyberlindnera jadinii	4903	3	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process sterol biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936 GO:0016126
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q01237	Hmgcr	Mus musculus	10090	1	GTPase regulator activity NADPH binding cholesterol biosynthetic process coenzyme A binding coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity identical protein binding isoprenoid biosynthetic process long-term synaptic potentiation negative regulation of amyloid-beta clearance negative regulation of apoptotic process negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of protein catabolic process negative regulation of protein secretion negative regulation of striated muscle cell apoptotic process peroxisomal membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cardiac muscle cell apoptotic process positive regulation of cell population proliferation positive regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation positive regulation of stress-activated MAPK cascade positive regulation of vasoconstriction protein phosphatase 2A binding regulation of ERK1 and ERK2 cascade sterol biosynthetic process ubiquinone metabolic process visual learning	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0006743 GO:0008284 GO:0008299 GO:0008542 GO:0010664 GO:0010666 GO:0015936 GO:0016126 GO:0030695 GO:0032874 GO:0042177 GO:0042802 GO:0043066 GO:0045907 GO:0048643 GO:0048661 GO:0050709 GO:0051721 GO:0060291 GO:0061179 GO:0070372 GO:0070374 GO:0070402 GO:0120225 GO:1900222
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q1W675	HMGCR	Sus scrofa	9823	2	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane sterol biosynthetic process	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0016126 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P04035	HMGCR	Homo sapiens	9606	3	GTPase regulator activity NADPH binding cholesterol biosynthetic process coenzyme A binding coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process long-term synaptic potentiation negative regulation of amyloid-beta clearance negative regulation of protein catabolic process negative regulation of protein secretion peroxisomal membrane regulation of ERK1 and ERK2 cascade sterol biosynthetic process visual learning	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0008542 GO:0015936 GO:0016126 GO:0030695 GO:0042177 GO:0050709 GO:0060291 GO:0070372 GO:0070402 GO:0120225 GO:1900222
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q12649	hmgA	Phycomyces blakesleeanus NRRL 1555(-)	763407	4	NADP binding coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process sterol biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936 GO:0016126 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P09610	HMGCR	Mesocricetus auratus	10036	1	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0050661