GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
3-hydroxy-3-methylglutaryl-coenzyme A reductase	O76819	HMGR	Agrotis ipsilon	56364	5	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q10283	hmg1	Schizosaccharomyces pombe 972h-	284812	2	coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane ergosterol biosynthetic process farnesyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity isopentenyl diphosphate biosynthetic process, mevalonate pathway isoprenoid biosynthetic process nuclear envelope nuclear membrane nuclear outer membrane-endoplasmic reticulum membrane network peroxisomal membrane sterol sensor activity	GO:0004420 GO:0005635 GO:0005778 GO:0005783 GO:0005789 GO:0006696 GO:0008299 GO:0010142 GO:0015936 GO:0019287 GO:0031965 GO:0032935 GO:0042175
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P20715	hmgcr	Xenopus laevis	8355	1	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	A7Z064	HMGCR	Bos taurus	9913	2	GTPase regulator activity NADPH binding cholesterol biosynthetic process coenzyme A binding coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process long-term synaptic potentiation negative regulation of amyloid-beta clearance negative regulation of protein catabolic process negative regulation of protein secretion peroxisomal membrane regulation of ERK1 and ERK2 cascade sterol biosynthetic process visual learning	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0008542 GO:0015936 GO:0016126 GO:0030695 GO:0042177 GO:0050709 GO:0060291 GO:0070372 GO:0070402 GO:0120225 GO:1900222
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q29512	HMGCR	Oryctolagus cuniculus	9986	2	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q5R6N3	HMGCR	Pongo abelii	9601	2	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane	GO:0004420 GO:0005778 GO:0005783 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q01559	HMGR	Nicotiana sylvestris	4096	3	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P14773	Hmgcr	Drosophila melanogaster	7227	9	NADP binding coenzyme A metabolic process ecdysis, chitin-based cuticle embryonic heart tube development endoplasmic reticulum membrane germ cell attraction germ cell migration gonad development hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process locomotory behavior peroxisomal membrane pole cell migration positive regulation of Ras protein signal transduction sterol biosynthetic process	GO:0004420 GO:0005778 GO:0005789 GO:0007280 GO:0007626 GO:0008299 GO:0008354 GO:0008406 GO:0015936 GO:0016126 GO:0018990 GO:0035050 GO:0035232 GO:0046579 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P16393	HMGCR	Strongylocentrotus purpuratus	7668	3	NADP binding cholesterol biosynthetic process coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process peroxisomal membrane sterol biosynthetic process	GO:0004420 GO:0005778 GO:0005789 GO:0006695 GO:0008299 GO:0015936 GO:0016126 GO:0050661
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Q0C8L9	ATEG_09965	Aspergillus terreus NIH2624	341663	3	coenzyme A metabolic process endoplasmic reticulum membrane hydroxymethylglutaryl-CoA reductase (NADPH) activity isoprenoid biosynthetic process sterol biosynthetic process	GO:0004420 GO:0005789 GO:0008299 GO:0015936 GO:0016126