GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID ▼	No. of Glycosylation Sites	GO Labels	GO IDs
Ammonium transporter Rh type B	Q95JD4	RHBG	Oryctolagus cuniculus	9986	1	ammonium transmembrane transport ammonium transmembrane transporter activity ankyrin binding basolateral plasma membrane carbon dioxide transmembrane transporter activity spectrin-associated cytoskeleton transepithelial ammonium transport	GO:0008519 GO:0014731 GO:0016323 GO:0030506 GO:0035379 GO:0070634 GO:0072488
Interleukin-6	Q9MZR1	IL6	Oryctolagus cuniculus	9986	1	T-helper 17 cell lineage commitment acute-phase response cytokine activity extracellular space glucose homeostasis growth factor activity hepatocyte proliferation interleukin-6 receptor binding interleukin-6-mediated signaling pathway liver regeneration positive regulation of multicellular organismal process positive regulation of receptor signaling pathway via STAT regulation of glucagon secretion regulation of insulin secretion response to activity vascular endothelial growth factor production	GO:0005125 GO:0005138 GO:0005615 GO:0006953 GO:0008083 GO:0010573 GO:0014823 GO:0042593 GO:0050796 GO:0051240 GO:0070092 GO:0070102 GO:0072540 GO:0072574 GO:0097421 GO:1904894
Complement component C8 gamma chain	Q28679	C8G	Oryctolagus cuniculus	9986	1	complement activation, alternative pathway complement activation, classical pathway extracellular region killing of cells of another organism membrane attack complex retinol binding	GO:0005576 GO:0005579 GO:0006957 GO:0006958 GO:0019841 GO:0031640
B2 bradykinin receptor	Q28642	BDKRB2	Oryctolagus cuniculus	9986	3	bradykinin receptor activity plasma membrane smooth muscle contraction vasoconstriction	GO:0004947 GO:0005886 GO:0006939 GO:0042310
Prostaglandin G/H synthase 2	O02768	PTGS2	Oryctolagus cuniculus	9986	4	brown fat cell differentiation cellular response to fluid shear stress cellular response to hypoxia cellular response to non-ionic osmotic stress cyclooxygenase pathway cytoplasm decidualization dioxygenase activity embryo implantation endoplasmic reticulum membrane enzyme binding heme binding metal ion binding negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress neuron projection nuclear inner membrane nuclear outer membrane peroxidase activity positive regulation of brown fat cell differentiation positive regulation of fever generation positive regulation of peptidyl-serine phosphorylation positive regulation of prostaglandin biosynthetic process prostaglandin biosynthetic process prostaglandin secretion prostaglandin-endoperoxide synthase activity protein homodimerization activity regulation of blood pressure regulation of cell population proliferation regulation of neuroinflammatory response response to nematode response to oxidative stress	GO:0001516 GO:0004601 GO:0004666 GO:0005637 GO:0005640 GO:0005737 GO:0005789 GO:0006979 GO:0007566 GO:0008217 GO:0009624 GO:0019371 GO:0019899 GO:0020037 GO:0031394 GO:0031622 GO:0032310 GO:0033138 GO:0042127 GO:0042803 GO:0043005 GO:0046697 GO:0046872 GO:0050873 GO:0051213 GO:0071456 GO:0071471 GO:0071498 GO:0090336 GO:0150077 GO:1902219
Prostaglandin E2 receptor EP3 subtype	P46069	PTGER3	Oryctolagus cuniculus	9986	3	plasma membrane prostaglandin E receptor activity	GO:0004957 GO:0005886
Bone morphogenetic protein 2	O46564	BMP2	Oryctolagus cuniculus	9986	3	BMP receptor binding BMP signaling pathway SMAD binding cardiac epithelial to mesenchymal transition cardiocyte differentiation cartilage development cell surface cytokine activity epithelial to mesenchymal transition extracellular space growth factor activity heart induction lung vasculature development mesenchymal cell differentiation negative regulation of DNA-templated transcription negative regulation of Wnt signaling pathway involved in heart development negative regulation of cardiac muscle cell differentiation negative regulation of cell cycle negative regulation of cell population proliferation negative regulation of transcription by RNA polymerase II osteoblast differentiation phosphatase activator activity positive regulation of SMAD protein signal transduction positive regulation of apoptotic process positive regulation of bone mineralization positive regulation of bone mineralization involved in bone maturation positive regulation of cartilage development positive regulation of ossification positive regulation of phosphatase activity positive regulation of protein phosphorylation positive regulation of transcription by RNA polymerase II telencephalon development	GO:0000122 GO:0001649 GO:0001837 GO:0001934 GO:0003129 GO:0003308 GO:0005125 GO:0005615 GO:0008083 GO:0008285 GO:0009986 GO:0010922 GO:0019211 GO:0021537 GO:0030501 GO:0030509 GO:0035051 GO:0043065 GO:0045778 GO:0045786 GO:0045892 GO:0045944 GO:0046332 GO:0048762 GO:0051216 GO:0060317 GO:0060391 GO:0060426 GO:0061036 GO:0070700 GO:1900159 GO:2000726
Trehalase	P19813	TREH	Oryctolagus cuniculus	9986	3	alpha,alpha-trehalase activity membrane plasma membrane side of membrane trehalose catabolic process	GO:0004555 GO:0005886 GO:0005993 GO:0016020 GO:0098552
Adenosine receptor A2b	Q32ZE2	ADORA2B	Oryctolagus cuniculus	9986	2	G protein-coupled adenosine receptor activity Schaffer collateral - CA1 synapse adenylate cyclase-activating G protein-coupled receptor signaling pathway cGMP-mediated signaling cellular response to extracellular stimulus glutamatergic synapse mast cell degranulation plasma membrane positive regulation of cGMP-mediated signaling positive regulation of chemokine production positive regulation of chronic inflammatory response to non-antigenic stimulus positive regulation of interleukin-6 production positive regulation of mast cell degranulation positive regulation of vascular endothelial growth factor production presynapse presynaptic modulation of chemical synaptic transmission relaxation of vascular associated smooth muscle	GO:0001609 GO:0002882 GO:0005886 GO:0007189 GO:0010575 GO:0010753 GO:0019934 GO:0031668 GO:0032722 GO:0032755 GO:0043303 GO:0043306 GO:0060087 GO:0098685 GO:0098793 GO:0098978 GO:0099171
ADAM metallopeptidase with thrombospondin type 1 motif 5	G1SIH2	ADAMTS5	Oryctolagus cuniculus	9986	2	aortic valve morphogenesis collagen-containing extracellular matrix defense response to bacterium endocardial cushion morphogenesis extracellular matrix binding extracellular matrix disassembly extracellular space heparin binding identical protein binding metalloendopeptidase activity myoblast fusion negative regulation of cold-induced thermogenesis proteolysis pulmonary valve morphogenesis zinc ion binding	GO:0003180 GO:0003184 GO:0003203 GO:0004222 GO:0005615 GO:0006508 GO:0007520 GO:0008201 GO:0008270 GO:0022617 GO:0042742 GO:0042802 GO:0050840 GO:0062023 GO:0120163