GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Leucine-rich repeat-containing protein 4	Q9HBW1	LRRC4	Homo sapiens	9606	9	Schaffer collateral - CA1 synapse dendritic spine excitatory synapse excitatory synapse assembly glutamatergic synapse modulation of chemical synaptic transmission plasma membrane postsynaptic density membrane postsynaptic density protein 95 clustering synaptic membrane adhesion	GO:0005886 GO:0043197 GO:0050804 GO:0060076 GO:0097119 GO:0098685 GO:0098839 GO:0098978 GO:0099560 GO:1904861
Calcium-activated potassium channel subunit alpha-1	Q12791	KCNMA1	Homo sapiens	9606	1	actin binding apical plasma membrane calcium-activated potassium channel activity caveola identical protein binding intracellular potassium ion homeostasis large conductance calcium-activated potassium channel activity membrane metal ion binding micturition negative regulation of cell volume plasma membrane positive regulation of apoptotic process postsynaptic membrane potassium ion transmembrane transport potassium ion transport regulation of membrane potential regulation of monoatomic ion transmembrane transport response to calcium ion response to carbon monoxide response to hypoxia response to osmotic stress smooth muscle contraction involved in micturition vasodilation voltage-gated potassium channel activity voltage-gated potassium channel complex	GO:0001666 GO:0003779 GO:0005249 GO:0005886 GO:0005901 GO:0006813 GO:0006970 GO:0008076 GO:0015269 GO:0016020 GO:0016324 GO:0030007 GO:0034465 GO:0034765 GO:0042311 GO:0042391 GO:0042802 GO:0043065 GO:0045211 GO:0045794 GO:0046872 GO:0051592 GO:0060072 GO:0060073 GO:0060083 GO:0071805
Major facilitator superfamily domain-containing protein 6	Q6ZSS7	MFSD6	Homo sapiens	9606	1	antigen processing and presentation of exogenous peptide antigen via MHC class I membrane plasma membrane	GO:0005886 GO:0016020 GO:0042590
VWFA and cache domain-containing protein 1	Q5VU97	CACHD1	Homo sapiens	9606	3	voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891
Thrombomodulin	P07204	THBD	Homo sapiens	9606	8	apicolateral plasma membrane blood coagulation blood coagulation, common pathway calcium ion binding cell surface external side of plasma membrane extracellular space female pregnancy negative regulation of blood coagulation negative regulation of fibrinolysis negative regulation of platelet activation plasma membrane proteolysis response to X-ray response to cAMP response to lipopolysaccharide serine-type endopeptidase complex signaling receptor activity transmembrane signaling receptor activity vacuolar membrane zymogen activation	GO:0004888 GO:0005509 GO:0005615 GO:0005774 GO:0005886 GO:0006508 GO:0007565 GO:0007596 GO:0009897 GO:0009986 GO:0010165 GO:0010544 GO:0016327 GO:0030195 GO:0031638 GO:0032496 GO:0038023 GO:0051591 GO:0051918 GO:0072377 GO:1905370
Prominin-2	Q8N271	PROM2	Homo sapiens	9606	4	apical plasma membrane basolateral plasma membrane cell projection cell surface cholesterol binding ciliary membrane cilium cytoplasmic vesicle extracellular exosome microspike microvillus microvillus membrane negative regulation of caveolin-mediated endocytosis negative regulation of pinocytosis plasma membrane positive regulation of cell projection organization positive regulation of protein phosphorylation prominosome regulation of GTPase activity	GO:0001934 GO:0005886 GO:0005902 GO:0005929 GO:0009986 GO:0015485 GO:0016323 GO:0016324 GO:0031346 GO:0031410 GO:0031528 GO:0042995 GO:0043087 GO:0044393 GO:0048550 GO:0060170 GO:0070062 GO:0071914 GO:2001287
Heparan N-sulfatase	Q9EQ08	Sgsh	Mus musculus	10090	1	N-sulfoglucosamine sulfohydrolase activity determination of adult lifespan glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process heparan sulfate proteoglycan metabolic process lysosomal lumen lysosome motor behavior sulfuric ester hydrolase activity	GO:0005764 GO:0006027 GO:0008340 GO:0008484 GO:0016250 GO:0030200 GO:0030201 GO:0043202 GO:0061744
Inactive phospholipase C-like protein 2	Q8K394	Plcl2	Mus musculus	10090	1	B cell proliferation involved in immune response B-1a B cell differentiation GABA receptor binding cytoplasm gamma-aminobutyric acid signaling pathway inositol 1,4,5 trisphosphate binding intracellular signal transduction lipid metabolic process negative regulation of B cell receptor signaling pathway negative regulation of cold-induced thermogenesis phosphatidylinositol phospholipase C activity regulation of synaptic transmission, GABAergic	GO:0002322 GO:0002337 GO:0004435 GO:0005737 GO:0006629 GO:0007214 GO:0032228 GO:0035556 GO:0050811 GO:0050859 GO:0070679 GO:0120163
Phospholipid-transporting ATPase ABCA3	Q8R420	Abca3	Mus musculus	10090	7	ABC-type xenobiotic transporter activity ATP binding ATP hydrolysis activity ATPase-coupled transmembrane transporter activity alveolar lamellar body alveolar lamellar body membrane cytoplasmic vesicle membrane intracellular membrane-bounded organelle lamellar body lamellar body membrane late endosome lipid transport lipid transporter activity lung development lysosomal membrane multivesicular body membrane organelle assembly phosphatidylcholine flippase activity phosphatidylcholine metabolic process phosphatidylcholine transfer activity phosphatidylglycerol metabolic process phospholipid homeostasis phospholipid transport plasma membrane positive regulation of cholesterol efflux positive regulation of phospholipid efflux positive regulation of phospholipid transport positive regulation of protein homooligomerization regulation of lipid biosynthetic process regulation of lipid transport regulation of phosphatidylcholine metabolic process response to glucocorticoid surfactant homeostasis xenobiotic export from cell xenobiotic transmembrane transport xenobiotic transport	GO:0005319 GO:0005524 GO:0005765 GO:0005770 GO:0005886 GO:0006855 GO:0006869 GO:0008559 GO:0010875 GO:0015914 GO:0016887 GO:0030324 GO:0030659 GO:0032368 GO:0032464 GO:0032585 GO:0042599 GO:0042626 GO:0042908 GO:0043129 GO:0043231 GO:0046470 GO:0046471 GO:0046618 GO:0046890 GO:0051384 GO:0055091 GO:0070925 GO:0097208 GO:0097232 GO:0097233 GO:0120019 GO:0140345 GO:0150172 GO:1902995 GO:2001140
Semaphorin-4G	Q9WUH7	Sema4g	Mus musculus	10090	6	axon guidance chemorepellent activity negative chemotaxis negative regulation of axon extension involved in axon guidance neural crest cell migration plasma membrane positive regulation of cell migration semaphorin receptor binding semaphorin-plexin signaling pathway	GO:0001755 GO:0005886 GO:0007411 GO:0030215 GO:0030335 GO:0045499 GO:0048843 GO:0050919 GO:0071526