GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Lipase	Q3UT41	Lipo3	Mus musculus	10090	2	intracellular membrane-bounded organelle lipid catabolic process sterol esterase activity sterol metabolic process	GO:0004771 GO:0016042 GO:0016125 GO:0043231
Contactin-6	Q9JMB8	Cntn6	Mus musculus	10090	13	Notch signaling pathway axon axon guidance cell-cell adhesion mediator activity dendrite self-avoidance homophilic cell adhesion via plasma membrane adhesion molecules parallel fiber to Purkinje cell synapse plasma membrane positive regulation of Notch signaling pathway presynapse presynaptic membrane side of membrane	GO:0005886 GO:0007156 GO:0007219 GO:0007411 GO:0030424 GO:0042734 GO:0045747 GO:0070593 GO:0098552 GO:0098632 GO:0098688 GO:0098793
Chondroadherin-like protein	E9Q7T7	Chadl	Mus musculus	10090	2	cell surface collagen binding collagen fibril binding collagen-containing extracellular matrix extracellular matrix extracellular space negative regulation of chondrocyte differentiation negative regulation of collagen fibril organization	GO:0005518 GO:0005615 GO:0009986 GO:0031012 GO:0032331 GO:0062023 GO:0098633 GO:1904027
Protocadherin 1 (Fragment)	F7BJK1	Pcdh1	Mus musculus	10090	3	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell junction cell-cell junction homophilic cell adhesion via plasma membrane adhesion molecules intracellular membrane-bounded organelle nucleolus nucleoplasm plasma membrane	GO:0005509 GO:0005654 GO:0005730 GO:0005886 GO:0005911 GO:0007155 GO:0007156 GO:0016339 GO:0030054 GO:0043231
Metal cation symporter ZIP14	Q75N73	Slc39a14	Mus musculus	10090	4	apical plasma membrane basolateral plasma membrane cadmium ion transmembrane transporter activity cellular response to glucose stimulus cellular response to insulin stimulus chondrocyte differentiation early endosome membrane ferrous iron transmembrane transporter activity gluconeogenesis import across plasma membrane inorganic cation transmembrane transport insulin receptor signaling pathway intracellular zinc ion homeostasis iron import into cell iron ion transmembrane transport iron ion transmembrane transporter activity iron ion transport late endosome membrane lysosomal membrane manganese ion homeostasis manganese ion transmembrane transport manganese ion transmembrane transporter activity membrane monoatomic anion:monoatomic cation symporter activity monoatomic cation:bicarbonate symporter activity negative regulation of cyclic-nucleotide phosphodiesterase activity plasma membrane positive regulation of G protein-coupled receptor signaling pathway regulation of hormone levels zinc ion import across plasma membrane zinc ion transmembrane transport zinc ion transmembrane transporter activity zinc ion transport	GO:0002062 GO:0005381 GO:0005384 GO:0005385 GO:0005765 GO:0005886 GO:0006094 GO:0006826 GO:0006829 GO:0006882 GO:0008286 GO:0010817 GO:0015086 GO:0015093 GO:0015296 GO:0016020 GO:0016323 GO:0016324 GO:0031901 GO:0031902 GO:0032869 GO:0033212 GO:0034755 GO:0045745 GO:0051344 GO:0055071 GO:0071333 GO:0071421 GO:0071577 GO:0071578 GO:0098662 GO:0098739 GO:0140410
DNA mismatch repair protein Mlh1	Q9JK91	Mlh1	Mus musculus	10090	1	ATP binding ATP hydrolysis activity ATP-dependent DNA damage sensor activity DNA damage response DNA repair MutLalpha complex MutSalpha complex binding chiasma chromatin binding chromosome condensed chromosome condensed nuclear chromosome double-strand break repair via nonhomologous end joining enzyme binding female meiosis chromosome segregation guanine/thymine mispair binding homologous chromosome pairing at meiosis homologous chromosome segregation intrinsic apoptotic signaling pathway in response to DNA damage isotype switching late recombination nodule male germ cell nucleus male meiosis chromosome segregation male meiotic nuclear division meiotic cell cycle meiotic chromosome segregation meiotic metaphase I homologous chromosome alignment meiotic spindle midzone assembly meiotic telomere clustering mismatch repair negative regulation of mitotic recombination nuclear-transcribed mRNA poly(A) tail shortening nucleoplasm nucleus oogenesis positive regulation of isotype switching to IgA isotypes positive regulation of isotype switching to IgG isotypes reciprocal meiotic recombination resolution of meiotic recombination intermediates response to bacterium single-stranded DNA binding somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments somatic recombination of immunoglobulin genes involved in immune response spermatogenesis synaptonemal complex	GO:0000289 GO:0000712 GO:0000793 GO:0000794 GO:0000795 GO:0001673 GO:0002204 GO:0003682 GO:0003697 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005712 GO:0005715 GO:0006281 GO:0006298 GO:0006303 GO:0006974 GO:0007060 GO:0007129 GO:0007131 GO:0007140 GO:0007283 GO:0008630 GO:0009617 GO:0016321 GO:0016446 GO:0016447 GO:0016887 GO:0019899 GO:0032137 GO:0032389 GO:0032407 GO:0043060 GO:0045132 GO:0045141 GO:0045143 GO:0045190 GO:0045950 GO:0048298 GO:0048304 GO:0048477 GO:0051257 GO:0051321 GO:0140664
Ephrin-A4	O08542	Efna4	Mus musculus	10090	2	axon guidance ephrin receptor binding ephrin receptor signaling pathway plasma membrane side of membrane	GO:0005886 GO:0007411 GO:0046875 GO:0048013 GO:0098552
Low-density lipoprotein receptor-related protein 10	Q7Z4F1	LRP10	Homo sapiens	9606	4	clathrin-coated pit inner ear development lipid metabolic process lipid transport low-density lipoprotein particle receptor activity membrane plasma membrane	GO:0005041 GO:0005886 GO:0005905 GO:0006629 GO:0006869 GO:0016020 GO:0048839
Cytochrome b558/566 subunit A	O54088	cbsA	Sulfolobus acidocaldarius DSM 639	330779	16	electron transport chain heme binding metal ion binding plasma membrane	GO:0005886 GO:0020037 GO:0022900 GO:0046872
Interleukin-12 subunit beta	P29460	IL12B	Homo sapiens	9606	3	T cell proliferation T-helper 1 type immune response T-helper cell differentiation cell migration cellular response to lipopolysaccharide cellular response to type II interferon cytokine activity cytokine binding cytokine receptor activity cytokine-mediated signaling pathway cytosol defense response to Gram-negative bacterium defense response to protozoan defense response to virus endoplasmic reticulum lumen external side of plasma membrane extracellular region extracellular space identical protein binding interleukin-12 alpha subunit binding interleukin-12 complex interleukin-12 receptor binding interleukin-12-mediated signaling pathway interleukin-23 complex late endosome lumen natural killer cell activation natural killer cell activation involved in immune response negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of inflammatory response to antigenic stimulus negative regulation of interleukin-10 production negative regulation of interleukin-17 production negative regulation of protein secretion negative regulation of smooth muscle cell proliferation negative regulation of vascular endothelial growth factor signaling pathway positive regulation of NK T cell activation positive regulation of NK T cell proliferation positive regulation of T cell mediated cytotoxicity positive regulation of T cell proliferation positive regulation of T-helper 1 type immune response positive regulation of T-helper 17 cell lineage commitment positive regulation of T-helper 17 type immune response positive regulation of activated T cell proliferation positive regulation of activation of Janus kinase activity positive regulation of cell adhesion positive regulation of defense response to virus by host positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of inflammatory response positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of lymphocyte proliferation positive regulation of memory T cell differentiation positive regulation of mononuclear cell proliferation positive regulation of natural killer cell activation positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of natural killer cell proliferation positive regulation of non-canonical NF-kappaB signal transduction positive regulation of osteoclast differentiation positive regulation of smooth muscle cell apoptotic process positive regulation of tissue remodeling positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein heterodimerization activity protein-containing complex binding receptor complex regulation of cytokine production regulation of tyrosine phosphorylation of STAT protein response to UV-B sexual reproduction	GO:0001817 GO:0001916 GO:0002230 GO:0002323 GO:0002827 GO:0002860 GO:0002862 GO:0004896 GO:0005125 GO:0005143 GO:0005576 GO:0005615 GO:0005788 GO:0005829 GO:0009897 GO:0010224 GO:0010536 GO:0016477 GO:0019221 GO:0019953 GO:0019955 GO:0030101 GO:0031906 GO:0032693 GO:0032700 GO:0032725 GO:0032729 GO:0032733 GO:0032735 GO:0032740 GO:0032760 GO:0032816 GO:0032819 GO:0032946 GO:0034105 GO:0034393 GO:0035722 GO:0042088 GO:0042093 GO:0042098 GO:0042102 GO:0042104 GO:0042164 GO:0042509 GO:0042531 GO:0042802 GO:0042832 GO:0043235 GO:0043382 GO:0043514 GO:0044877 GO:0045672 GO:0045785 GO:0046982 GO:0048662 GO:0050671 GO:0050709 GO:0050729 GO:0050829 GO:0051135 GO:0051142 GO:0051607 GO:0070743 GO:0071222 GO:0071346 GO:1900747 GO:1901224 GO:1903588 GO:2000318 GO:2000330