GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Latent-transforming growth factor beta-binding protein 1	Q14766	LTBP1	Homo sapiens	9606	65	calcium ion binding collagen-containing extracellular matrix endoplasmic reticulum lumen extracellular matrix extracellular region microfibril microfibril binding molecular adaptor activity protein-containing complex regulation of transforming growth factor beta activation sequestering of TGFbeta in extracellular matrix transforming growth factor beta binding transforming growth factor beta receptor activity	GO:0001527 GO:0005024 GO:0005509 GO:0005576 GO:0005788 GO:0031012 GO:0032991 GO:0035583 GO:0050431 GO:0050436 GO:0060090 GO:0062023 GO:1901388
Fibrocystin	P08F94	PKHD1	Homo sapiens	9606	64	9+0 non-motile cilium Golgi apparatus apical plasma membrane branching morphogenesis of an epithelial tube cell-cell adhesion cell-cell junction organization centrosome chromosome, centromeric region ciliary basal body cilium cilium assembly cytoplasm endoplasmic reticulum epithelial cell morphogenesis establishment of centrosome localization establishment of mitotic spindle orientation external side of plasma membrane extracellular exosome homeostatic process intracellular calcium ion homeostasis kidney development mitotic spindle negative regulation of NF-kappaB transcription factor activity negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction nucleus perinuclear region of cytoplasm positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade regulation of TOR signaling regulation of cell adhesion regulation of cell-cell adhesion regulation of cell-matrix adhesion regulation of centrosome duplication regulation of cholangiocyte proliferation regulation of establishment of planar polarity signaling receptor activity	GO:0000132 GO:0000775 GO:0001822 GO:0001952 GO:0003382 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005813 GO:0005929 GO:0006874 GO:0008284 GO:0009897 GO:0010824 GO:0016324 GO:0022407 GO:0030155 GO:0032006 GO:0032088 GO:0036064 GO:0038023 GO:0042592 GO:0043066 GO:0045216 GO:0048471 GO:0048754 GO:0050679 GO:0051660 GO:0051898 GO:0060271 GO:0070062 GO:0070372 GO:0072686 GO:0090175 GO:0097731 GO:0098609 GO:1904036 GO:1904054
Prolow-density lipoprotein receptor-related protein 1	Q07954	LRP1	Homo sapiens	9606	63	Golgi apparatus RNA binding alpha-2 macroglobulin receptor activity amyloid-beta binding amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis aorta morphogenesis apolipoprotein binding apolipoprotein receptor activity apoptotic cell clearance astrocyte activation involved in immune response basolateral plasma membrane calcium ion binding cargo receptor activity cellular response to amyloid-beta clathrin heavy chain binding clathrin-coated pit cytoskeleton early endosome endocytic vesicle membrane enzyme-linked receptor protein signaling pathway focal adhesion heparan sulfate proteoglycan binding lipid metabolic process lipoprotein particle receptor binding lipoprotein transport low-density lipoprotein particle receptor activity lysosomal membrane lysosomal transport membrane negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of gene expression negative regulation of metallopeptidase activity negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration nucleus phagocytosis plasma membrane plasma membrane protein complex positive regulation of amyloid-beta clearance positive regulation of cholesterol efflux positive regulation of endocytosis positive regulation of lipid transport positive regulation of lysosomal protein catabolic process positive regulation of protein binding positive regulation of protein localization to plasma membrane positive regulation of transcytosis protein-containing complex binding receptor complex receptor internalization receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of extracellular matrix disassembly regulation of phospholipase A2 activity retinoid metabolic process scavenger receptor activity signaling receptor activity transcytosis transport across blood-brain barrier	GO:0001523 GO:0001540 GO:0002265 GO:0003723 GO:0005041 GO:0005044 GO:0005509 GO:0005634 GO:0005765 GO:0005769 GO:0005794 GO:0005856 GO:0005886 GO:0005905 GO:0005925 GO:0006629 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0010629 GO:0010715 GO:0010875 GO:0014912 GO:0016020 GO:0016323 GO:0016964 GO:0030178 GO:0030226 GO:0030666 GO:0031623 GO:0032050 GO:0032092 GO:0032370 GO:0032374 GO:0032429 GO:0032956 GO:0034185 GO:0035909 GO:0038023 GO:0038024 GO:0042953 GO:0043235 GO:0043277 GO:0043395 GO:0044877 GO:0045056 GO:0045807 GO:0060392 GO:0070325 GO:0097242 GO:0098797 GO:0150093 GO:0150094 GO:0150104 GO:1900223 GO:1903078 GO:1904300 GO:1904646 GO:1905049 GO:1905167 GO:2000587
Polycystin-1	O08852	Pkd1	Mus musculus	10090	63	Golgi apparatus Wnt receptor activity basolateral plasma membrane blood vessel development branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport carbohydrate binding cartilage condensation cation channel complex cell surface cell-cell adhesion cell-cell signaling by wnt cilium cytoplasm cytoplasmic sequestering of transcription factor detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development monoatomic cation channel activity motile cilium neural tube development nitrogen compound metabolic process nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cytosolic calcium ion concentration positive regulation of protein binding positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transmembrane transporter binding	GO:0001502 GO:0001568 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005261 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006807 GO:0006816 GO:0007204 GO:0007259 GO:0007507 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0031514 GO:0032092 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0042994 GO:0043588 GO:0044325 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051290 GO:0051726 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0098609 GO:0198738 GO:2000045
Mucin-5AC	P98088	MUC5AC	Homo sapiens	9606	62	Golgi lumen extracellular exosome extracellular matrix extracellular matrix structural constituent extracellular space metal ion binding mucus layer plasma membrane	GO:0005201 GO:0005615 GO:0005796 GO:0005886 GO:0031012 GO:0046872 GO:0070062 GO:0070701
Nuclear factor related to kappa-B-binding protein	Q6P4R8	NFRKB	Homo sapiens	9606	61	DNA binding DNA recombination DNA repair Ino80 complex chromatin remodeling nucleoplasm nucleus positive regulation of DNA repair positive regulation of DNA-templated transcription positive regulation of telomere maintenance in response to DNA damage protease binding regulation of DNA repair regulation of DNA replication regulation of DNA strand elongation regulation of cell cycle regulation of chromosome organization regulation of embryonic development telomere maintenance	GO:0000723 GO:0002020 GO:0003677 GO:0005634 GO:0005654 GO:0006275 GO:0006281 GO:0006282 GO:0006310 GO:0006338 GO:0031011 GO:0033044 GO:0045739 GO:0045893 GO:0045995 GO:0051726 GO:0060382 GO:1904507
Proteoglycan 4	Q9JM99	Prg4	Mus musculus	10090	61	collagen-containing extracellular matrix extracellular space hematopoietic stem cell proliferation immune response negative regulation of interleukin-6 production polysaccharide binding regulation of cell population proliferation scavenger receptor activity	GO:0005044 GO:0005615 GO:0006955 GO:0030247 GO:0032715 GO:0042127 GO:0062023 GO:0071425
Polycystin-1	P98161	PKD1	Homo sapiens	9606	60	Golgi apparatus Golgi membrane Golgi-associated vesicle membrane Wnt receptor activity anatomical structure morphogenesis basolateral plasma membrane branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport calcium-independent cell-matrix adhesion carbohydrate binding cartilage condensation cartilage development cation channel complex cell surface cell-cell signaling by wnt cell-matrix adhesion ciliary membrane cilium cytoplasm cytoplasmic sequestering of transcription factor detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development homophilic cell adhesion via plasma membrane adhesion molecules in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development mesonephric tubule development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development motile cilium neural tube development nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cytosolic calcium ion concentration positive regulation of protein binding positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transmembrane transporter binding	GO:0000139 GO:0001502 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006816 GO:0007156 GO:0007160 GO:0007161 GO:0007204 GO:0007259 GO:0007507 GO:0009653 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0030660 GO:0031514 GO:0032092 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0042994 GO:0043588 GO:0044325 GO:0045737 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051216 GO:0051290 GO:0051726 GO:0060170 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072164 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0198738 GO:2000045
Dystroglycan 1	Q14118	DAG1	Homo sapiens	9606	59	GABA-ergic synapse Golgi lumen SH2 domain binding actin binding adherens junction alpha-actinin binding angiogenesis involved in wound healing axon guidance axon regeneration basement membrane basement membrane organization basolateral plasma membrane branching involved in salivary gland morphogenesis calcium ion binding calcium-dependent cell-matrix adhesion cellular response to cholesterol cellular response to mechanical stimulus collagen-containing extracellular matrix commissural neuron axon guidance contractile ring costamere cytoplasm cytoskeleton cytosol dystroglycan binding dystroglycan complex dystrophin-associated glycoprotein complex endoplasmic reticulum lumen epithelial tube branching involved in lung morphogenesis external side of plasma membrane extracellular exosome extracellular region extracellular space filopodium focal adhesion glutamatergic synapse heart morphogenesis intracellular membrane-bounded organelle lamellipodium laminin binding laminin-1 binding membrane membrane protein ectodomain proteolysis microtubule anchoring morphogenesis of an epithelial sheet morphogenesis of an epithelium muscle attachment myelination in peripheral nervous system negative regulation of MAPK cascade negative regulation of cell migration negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction nerve development nerve maturation node of Ranvier nuclear periphery nucleoplasm photoreceptor ribbon synapse plasma membrane plasma membrane raft positive regulation of basement membrane assembly involved in embryonic body morphogenesis positive regulation of cell-matrix adhesion positive regulation of myelination positive regulation of oligodendrocyte differentiation postsynaptic cytosol postsynaptic membrane protein transport protein-containing complex binding regulation of embryonic cell shape regulation of epithelial to mesenchymal transition regulation of gastrulation regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of synapse organization regulation of synaptic plasticity response to denervation involved in regulation of muscle adaptation response to muscle activity response to peptide hormone retrograde trans-synaptic signaling by trans-synaptic protein complex sarcolemma skeletal muscle tissue regeneration structural constituent of muscle tubulin binding vinculin binding virus receptor activity	GO:0001618 GO:0001954 GO:0002009 GO:0002011 GO:0002162 GO:0003007 GO:0003779 GO:0005509 GO:0005576 GO:0005604 GO:0005615 GO:0005654 GO:0005737 GO:0005788 GO:0005796 GO:0005829 GO:0005856 GO:0005886 GO:0005912 GO:0005925 GO:0006509 GO:0007411 GO:0008307 GO:0009897 GO:0010470 GO:0010717 GO:0014850 GO:0014894 GO:0015031 GO:0015631 GO:0016010 GO:0016011 GO:0016020 GO:0016203 GO:0016323 GO:0016340 GO:0016476 GO:0017166 GO:0021675 GO:0021682 GO:0022011 GO:0030027 GO:0030175 GO:0030336 GO:0031103 GO:0031643 GO:0033268 GO:0034399 GO:0034453 GO:0042169 GO:0042383 GO:0043034 GO:0043231 GO:0043236 GO:0043237 GO:0043403 GO:0043409 GO:0043434 GO:0044853 GO:0044877 GO:0045211 GO:0048167 GO:0048714 GO:0050807 GO:0051393 GO:0051898 GO:0060055 GO:0060441 GO:0060445 GO:0062023 GO:0070062 GO:0070938 GO:0071260 GO:0071397 GO:0071679 GO:0071711 GO:0098684 GO:0098696 GO:0098942 GO:0098978 GO:0098982 GO:0099524 GO:1904261
Ubiquitin-associated protein 2	Q5T6F2	UBAP2	Homo sapiens	9606	58	P-body RNA binding cadherin binding chromosome cytoplasm nucleus regulation of gene expression	GO:0000932 GO:0003723 GO:0005634 GO:0005694 GO:0005737 GO:0010468 GO:0045296