GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
P2X purinoceptor 7	Q99572	P2RX7	Homo sapiens	9606	5	ATP binding MAPK cascade NAD transport T cell apoptotic process T cell homeostasis T cell mediated cytotoxicity T cell proliferation apoptotic signaling pathway bleb bleb assembly calcium ion transmembrane transport calcium-mediated signaling using extracellular calcium source cell morphogenesis cell surface receptor signaling pathway cell-cell junction cellular response to ATP cellular response to dsRNA cellular response to extracellular stimulus ceramide biosynthetic process collagen metabolic process cytoplasm defense response to Gram-positive bacterium external side of plasma membrane extracellularly ATP-gated monoatomic cation channel activity extrinsic apoptotic signaling pathway gamma-aminobutyric acid secretion glutamate secretion homeostasis of number of cells within a tissue identical protein binding inflammatory response lipopolysaccharide binding membrane membrane depolarization membrane protein ectodomain proteolysis mitochondrial depolarization mitochondrion mitochondrion organization negative regulation of MAPK cascade negative regulation of bone resorption negative regulation of cell volume neuromuscular junction neuronal cell body obsolete cell surface receptor signaling pathway involved in cell-cell signaling phagolysosome assembly phospholipid transfer to membrane plasma membrane plasma membrane phospholipid scrambling pore complex assembly positive regulation of MAPK cascade positive regulation of T cell apoptotic process positive regulation of T cell mediated cytotoxicity positive regulation of bleb assembly positive regulation of bone mineralization positive regulation of calcium ion transport into cytosol positive regulation of cytoskeleton organization positive regulation of gamma-aminobutyric acid secretion positive regulation of gene expression positive regulation of glutamate secretion positive regulation of glycolytic process positive regulation of interleukin-1 alpha production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of macrophage cytokine production positive regulation of mitochondrial depolarization positive regulation of monoatomic ion transmembrane transport positive regulation of prostaglandin secretion positive regulation of protein phosphorylation positive regulation of protein secretion postsynapse presynapse prostaglandin secretion protein catabolic process protein processing protein secretion purinergic nucleotide receptor activity purinergic nucleotide receptor signaling pathway reactive oxygen species metabolic process regulation of killing of cells of another organism regulation of sodium ion transport release of sequestered calcium ion into cytosol response to ATP response to calcium ion response to electrical stimulus response to fluid shear stress response to ischemia response to lipopolysaccharide response to mechanical stimulus response to xenobiotic stimulus response to zinc ion sensory perception of pain signaling receptor binding skeletal system morphogenesis synaptic vesicle exocytosis vesicle budding from membrane	GO:0000165 GO:0000902 GO:0001530 GO:0001614 GO:0001845 GO:0001913 GO:0001916 GO:0001934 GO:0002028 GO:0002931 GO:0004931 GO:0005102 GO:0005524 GO:0005737 GO:0005739 GO:0005886 GO:0005911 GO:0006509 GO:0006649 GO:0006900 GO:0006954 GO:0007005 GO:0007166 GO:0009306 GO:0009410 GO:0009612 GO:0009897 GO:0010043 GO:0010524 GO:0010628 GO:0014047 GO:0014049 GO:0014051 GO:0014054 GO:0016020 GO:0016079 GO:0016485 GO:0017121 GO:0019233 GO:0030163 GO:0030501 GO:0031594 GO:0031668 GO:0032059 GO:0032060 GO:0032308 GO:0032310 GO:0032496 GO:0032730 GO:0032731 GO:0032755 GO:0032963 GO:0033198 GO:0034405 GO:0034767 GO:0035585 GO:0035590 GO:0042098 GO:0042802 GO:0043025 GO:0043029 GO:0043132 GO:0043409 GO:0043410 GO:0045779 GO:0045794 GO:0045821 GO:0046513 GO:0046931 GO:0048705 GO:0048873 GO:0050714 GO:0050830 GO:0051209 GO:0051495 GO:0051592 GO:0051602 GO:0051709 GO:0051882 GO:0051899 GO:0051901 GO:0060907 GO:0070231 GO:0070234 GO:0070588 GO:0071318 GO:0071359 GO:0072593 GO:0097190 GO:0097191 GO:0098793 GO:0098794 GO:1904172 GO:1905114
Carbohydrate sulfotransferase 8	Q8BQ86	Chst8	Mus musculus	10090	5	Golgi membrane N-acetylgalactosamine 4-O-sulfotransferase activity carbohydrate biosynthetic process hormone biosynthetic process peptide hormone processing proteoglycan biosynthetic process sulfotransferase activity sulfur compound metabolic process	GO:0000139 GO:0001537 GO:0006790 GO:0008146 GO:0016051 GO:0016486 GO:0030166 GO:0042446
CD180 antigen	Q62192	Cd180	Mus musculus	10090	10	B cell proliferation involved in immune response cellular response to lipopolysaccharide extracellular matrix extracellular space inflammatory response innate immune response lipopolysaccharide-mediated signaling pathway mitotic spindle nucleolus nucleoplasm plasma membrane positive regulation of lipopolysaccharide-mediated signaling pathway	GO:0002322 GO:0005615 GO:0005654 GO:0005730 GO:0005886 GO:0006954 GO:0031012 GO:0031663 GO:0031666 GO:0045087 GO:0071222 GO:0072686
Protocadherin beta-3	Q9Y5E6	PCDHB3	Homo sapiens	9606	4	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules membrane nervous system development plasma membrane synapse synapse assembly	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0007268 GO:0007399 GO:0007416 GO:0016020 GO:0016339 GO:0045202
Protocadherin beta-14	Q9Y5E9	PCDHB14	Homo sapiens	9606	6	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules membrane plasma membrane synapse synapse assembly	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0007268 GO:0007416 GO:0016020 GO:0016339 GO:0045202
Low-density lipoprotein receptor-related protein 5	O75197	LRP5	Homo sapiens	9606	6	Norrin signaling pathway Wnt receptor activity Wnt signalosome Wnt-Frizzled-LRP5/6 complex Wnt-protein binding adipose tissue development amino acid transport anatomical structure regression anterior/posterior pattern specification apoptotic process involved in blood vessel morphogenesis bone marrow development bone morphogenesis bone remodeling branching involved in mammary gland duct morphogenesis canonical Wnt signaling pathway cell migration involved in gastrulation cell-cell adhesion cell-cell signaling involved in mammary gland development cholesterol homeostasis cholesterol metabolic process coreceptor activity embryonic digit morphogenesis endocytosis endoplasmic reticulum establishment of blood-brain barrier establishment of blood-retinal barrier extracellular matrix-cell signaling gastrulation with mouth forming second gene expression glucose catabolic process mesodermal cell migration negative regulation of osteoblast differentiation negative regulation of protein serine/threonine kinase activity obsolete coreceptor activity involved in canonical Wnt signaling pathway osteoblast development osteoblast proliferation plasma membrane positive regulation of DNA-templated transcription positive regulation of cell population proliferation positive regulation of fat cell differentiation positive regulation of mesenchymal cell proliferation positive regulation of mitotic nuclear division positive regulation of osteoblast differentiation positive regulation of osteoblast proliferation positive regulation of transcription by RNA polymerase II receptor complex regulation of apoptotic process regulation of blood pressure regulation of insulin secretion involved in cellular response to glucose stimulus response to peptide hormone retina morphogenesis in camera-type eye retinal blood vessel morphogenesis somatic stem cell population maintenance	GO:0001702 GO:0002053 GO:0002076 GO:0005783 GO:0005886 GO:0006007 GO:0006865 GO:0006897 GO:0008078 GO:0008203 GO:0008217 GO:0008284 GO:0009952 GO:0010467 GO:0015026 GO:0017147 GO:0033687 GO:0033690 GO:0035019 GO:0035426 GO:0042074 GO:0042632 GO:0042733 GO:0042813 GO:0042981 GO:0043235 GO:0043434 GO:0045600 GO:0045668 GO:0045669 GO:0045840 GO:0045893 GO:0045944 GO:0046849 GO:0048539 GO:0060033 GO:0060042 GO:0060070 GO:0060349 GO:0060444 GO:0060612 GO:0060764 GO:0060856 GO:0061178 GO:0061304 GO:0071901 GO:0098609 GO:0110135 GO:1902262 GO:1904928 GO:1990851 GO:1990909 GO:1990963
Protocadherin beta-2	Q9Y5E7	PCDHB2	Homo sapiens	9606	4	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules membrane nervous system development plasma membrane synapse synapse assembly	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0007268 GO:0007399 GO:0007416 GO:0016020 GO:0016339 GO:0045202
Protocadherin beta-15	Q9Y5E8	PCDHB15	Homo sapiens	9606	2	calcium ion binding cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules nervous system development photoreceptor connecting cilium plasma membrane	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0007399 GO:0032391
Transmembrane protein 158	Q6F5E0	Tmem158	Mus musculus	10090	1	membrane peptide binding	GO:0016020 GO:0042277
Protocadherin alpha-12	Q9UN75	PCDHA12	Homo sapiens	9606	3	calcium ion binding cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules plasma membrane	GO:0005509 GO:0005886 GO:0007155 GO:0007156