GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels ▼	GO IDs
Apelin receptor A	P79960	aplnr-a	Xenopus laevis	8355	2	angiogenesis apelin receptor activity apelin receptor signaling pathway blood vessel development branching involved in blood vessel morphogenesis cell differentiation cytoplasm gastrulation heart development negative regulation of cAMP-mediated signaling plasma membrane positive regulation of angiogenesis positive regulation of inhibitory G protein-coupled receptor phosphorylation positive regulation of release of sequestered calcium ion into cytosol	GO:0001525 GO:0001568 GO:0001569 GO:0005737 GO:0005886 GO:0007369 GO:0007507 GO:0030154 GO:0043951 GO:0045766 GO:0051281 GO:0060182 GO:0060183 GO:1904325
Ephrin-A1	Q3ZC64	EFNA1	Bos taurus	9913	1	angiogenesis aortic valve morphogenesis axon guidance cell migration endocardial cushion to mesenchymal transition involved in heart valve formation ephrin receptor binding ephrin receptor signaling pathway extracellular region mitral valve morphogenesis negative regulation of MAPK cascade negative regulation of dendritic spine morphogenesis negative regulation of epithelial to mesenchymal transition negative regulation of proteolysis involved in protein catabolic process negative regulation of thymocyte apoptotic process negative regulation of transcription by RNA polymerase II notochord formation plasma membrane positive regulation of MAPK cascade positive regulation of amyloid-beta formation positive regulation of peptidyl-tyrosine phosphorylation protein stabilization regulation of angiogenesis regulation of axonogenesis regulation of blood vessel endothelial cell migration regulation of cell adhesion mediated by integrin regulation of peptidyl-tyrosine phosphorylation side of membrane substrate adhesion-dependent cell spreading	GO:0000122 GO:0001525 GO:0003180 GO:0003183 GO:0003199 GO:0005576 GO:0005886 GO:0007411 GO:0010719 GO:0014028 GO:0016477 GO:0033628 GO:0034446 GO:0043409 GO:0043410 GO:0043535 GO:0045765 GO:0046875 GO:0048013 GO:0050730 GO:0050731 GO:0050770 GO:0050821 GO:0061002 GO:0070244 GO:0098552 GO:1902004 GO:1903051
Ephrin-A1	P97553	Efna1	Rattus norvegicus	10116	1	angiogenesis aortic valve morphogenesis axon guidance cell migration endocardial cushion to mesenchymal transition involved in heart valve formation ephrin receptor binding ephrin receptor signaling pathway extracellular region mitral valve morphogenesis negative regulation of MAPK cascade negative regulation of dendritic spine morphogenesis negative regulation of epithelial to mesenchymal transition negative regulation of proteolysis involved in protein catabolic process negative regulation of thymocyte apoptotic process negative regulation of transcription by RNA polymerase II neuron differentiation notochord formation plasma membrane positive regulation of MAPK cascade positive regulation of amyloid-beta formation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein phosphorylation protein stabilization regulation of angiogenesis regulation of axonogenesis regulation of blood vessel endothelial cell migration regulation of cell adhesion mediated by integrin regulation of peptidyl-tyrosine phosphorylation side of membrane substrate adhesion-dependent cell spreading	GO:0000122 GO:0001525 GO:0001934 GO:0003180 GO:0003183 GO:0003199 GO:0005576 GO:0005886 GO:0007411 GO:0010719 GO:0014028 GO:0016477 GO:0030182 GO:0033628 GO:0034446 GO:0043409 GO:0043410 GO:0043535 GO:0045765 GO:0046875 GO:0048013 GO:0050730 GO:0050731 GO:0050770 GO:0050821 GO:0061002 GO:0070244 GO:0098552 GO:1902004 GO:1903051
Ephrin-A1	P52793	Efna1	Mus musculus	10090	1	angiogenesis aortic valve morphogenesis axon guidance cell migration endocardial cushion to mesenchymal transition involved in heart valve formation ephrin receptor binding ephrin receptor signaling pathway extracellular region mitral valve morphogenesis negative regulation of MAPK cascade negative regulation of dendritic spine morphogenesis negative regulation of epithelial to mesenchymal transition negative regulation of proteolysis involved in protein catabolic process negative regulation of thymocyte apoptotic process negative regulation of transcription by RNA polymerase II neuron differentiation notochord formation plasma membrane positive regulation of MAPK cascade positive regulation of amyloid-beta formation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein phosphorylation protein stabilization regulation of angiogenesis regulation of axonogenesis regulation of blood vessel endothelial cell migration regulation of cell adhesion mediated by integrin regulation of peptidyl-tyrosine phosphorylation side of membrane substrate adhesion-dependent cell spreading	GO:0000122 GO:0001525 GO:0001934 GO:0003180 GO:0003183 GO:0003199 GO:0005576 GO:0005886 GO:0007411 GO:0010719 GO:0014028 GO:0016477 GO:0030182 GO:0033628 GO:0034446 GO:0043409 GO:0043410 GO:0043535 GO:0045765 GO:0046875 GO:0048013 GO:0050730 GO:0050731 GO:0050770 GO:0050821 GO:0061002 GO:0070244 GO:0098552 GO:1902004 GO:1903051
Ephrin-A1	P20827	EFNA1	Homo sapiens	9606	4	angiogenesis aortic valve morphogenesis axon guidance cell migration cell-cell signaling endocardial cushion to mesenchymal transition involved in heart valve formation ephrin receptor binding ephrin receptor signaling pathway extracellular region mitral valve morphogenesis negative regulation of MAPK cascade negative regulation of dendritic spine morphogenesis negative regulation of epithelial to mesenchymal transition negative regulation of proteolysis involved in protein catabolic process negative regulation of thymocyte apoptotic process negative regulation of transcription by RNA polymerase II notochord formation plasma membrane positive regulation of MAPK cascade positive regulation of amyloid-beta formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein phosphorylation positive regulation of protein tyrosine kinase activity protein stabilization regulation of angiogenesis regulation of axonogenesis regulation of blood vessel endothelial cell migration regulation of cell adhesion mediated by integrin regulation of peptidyl-tyrosine phosphorylation side of membrane signaling receptor binding substrate adhesion-dependent cell spreading	GO:0000122 GO:0001525 GO:0001934 GO:0003180 GO:0003183 GO:0003199 GO:0005102 GO:0005576 GO:0005886 GO:0007267 GO:0007411 GO:0010719 GO:0014028 GO:0016477 GO:0033628 GO:0034446 GO:0043409 GO:0043410 GO:0043535 GO:0045765 GO:0046875 GO:0048013 GO:0050730 GO:0050731 GO:0050770 GO:0050821 GO:0061002 GO:0061098 GO:0070244 GO:0098552 GO:1902004 GO:1902961 GO:1903051
Plexin-D1	Q3UH93	Plxnd1	Mus musculus	10090	11	angiogenesis aorta development axon branching involved in blood vessel morphogenesis cardiac septum development cell body coronary vasculature development dichotomous subdivision of terminal units involved in salivary gland branching endothelial cell migration glutamatergic synapse kidney development lamellipodium lamellipodium membrane negative regulation of cell adhesion negative regulation of neuron apoptotic process outflow tract morphogenesis plasma membrane positive regulation of axonogenesis protein domain specific binding regulation of angiogenesis regulation of cell migration regulation of cell shape semaphorin receptor activity semaphorin receptor complex semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance synapse assembly synaptic target recognition	GO:0001525 GO:0001569 GO:0001822 GO:0002116 GO:0003151 GO:0003279 GO:0005886 GO:0007162 GO:0007416 GO:0008039 GO:0008360 GO:0017154 GO:0019904 GO:0030027 GO:0030334 GO:0030424 GO:0031258 GO:0035904 GO:0043524 GO:0043542 GO:0044297 GO:0045765 GO:0050772 GO:0060666 GO:0060976 GO:0071526 GO:0098978 GO:1902287
Plexin-D1	Q9Y4D7	PLXND1	Homo sapiens	9606	19	angiogenesis aorta development axon branching involved in blood vessel morphogenesis cardiac septum development cell body coronary vasculature development dichotomous subdivision of terminal units involved in salivary gland branching endothelial cell migration glutamatergic synapse kidney development lamellipodium lamellipodium membrane negative regulation of cell adhesion negative regulation of neuron apoptotic process outflow tract morphogenesis plasma membrane positive regulation of axonogenesis protein domain specific binding regulation of angiogenesis regulation of cell migration regulation of cell shape semaphorin receptor activity semaphorin receptor complex semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in axon guidance synapse assembly synaptic target recognition	GO:0001525 GO:0001569 GO:0001822 GO:0002116 GO:0003151 GO:0003279 GO:0005886 GO:0007162 GO:0007416 GO:0008039 GO:0008360 GO:0017154 GO:0019904 GO:0030027 GO:0030334 GO:0030424 GO:0031258 GO:0035904 GO:0043524 GO:0043542 GO:0044297 GO:0045765 GO:0050772 GO:0060666 GO:0060976 GO:0071526 GO:0098978 GO:1902287
Histidine-rich glycoprotein	Q9ESB3	Hrg	Mus musculus	10090	6	angiogenesis antimicrobial humoral immune response mediated by antimicrobial peptide cell surface chemotaxis collagen-containing extracellular matrix cysteine-type endopeptidase inhibitor activity cytolysis by host of symbiont cells defense response to fungus endolysosome extracellular region fibrinolysis heme binding heme export heme transport heparan sulfate proteoglycan binding heparin binding immunoglobulin binding metal ion binding negative regulation of angiogenesis negative regulation of blood vessel endothelial cell migration negative regulation of cell adhesion negative regulation of cell adhesion mediated by integrin negative regulation of cell growth negative regulation of cell population proliferation negative regulation of endothelial cell chemotaxis negative regulation of fibrinolysis negative regulation of lamellipodium assembly negative regulation of vascular endothelial growth factor signaling pathway obsolete regulation of transcription from RNA polymerase II promoter in response to iron phagolysosome membrane platelet activation positive regulation of apoptotic process positive regulation of blood vessel remodeling positive regulation of focal adhesion assembly positive regulation of immune response to tumor cell regulation of actin cytoskeleton organization regulation of blood coagulation regulation of gene expression regulation of peptidyl-tyrosine phosphorylation regulation of platelet activation regulation of protein-containing complex assembly response to organic cyclic compound serine-type endopeptidase inhibitor activity signaling receptor binding vesicle zinc ion binding	GO:0001525 GO:0002839 GO:0004867 GO:0004869 GO:0005102 GO:0005576 GO:0006935 GO:0007162 GO:0008201 GO:0008270 GO:0008285 GO:0009986 GO:0010468 GO:0010543 GO:0010593 GO:0014070 GO:0015886 GO:0016525 GO:0019865 GO:0020037 GO:0030168 GO:0030193 GO:0030308 GO:0031982 GO:0032956 GO:0033629 GO:0034395 GO:0036019 GO:0042730 GO:0043065 GO:0043254 GO:0043395 GO:0043537 GO:0046872 GO:0050730 GO:0050832 GO:0051838 GO:0051894 GO:0051918 GO:0061474 GO:0061844 GO:0062023 GO:0097037 GO:1900747 GO:2000504 GO:2001027
Histidine-rich glycoprotein	P04196	HRG	Homo sapiens	9606	7	angiogenesis antimicrobial humoral immune response mediated by antimicrobial peptide blood microparticle cell surface chemotaxis collagen-containing extracellular matrix cysteine-type endopeptidase inhibitor activity cytolysis by host of symbiont cells defense response to fungus endolysosome extracellular exosome extracellular region fibrinolysis heme binding heme transport heparan sulfate proteoglycan binding heparin binding immunoglobulin binding metal ion binding negative regulation of angiogenesis negative regulation of blood vessel endothelial cell migration negative regulation of cell adhesion negative regulation of cell adhesion mediated by integrin negative regulation of cell growth negative regulation of cell population proliferation negative regulation of endothelial cell chemotaxis negative regulation of fibrinolysis negative regulation of lamellipodium assembly negative regulation of vascular endothelial growth factor signaling pathway plasma membrane platelet activation platelet alpha granule lumen positive regulation of apoptotic process positive regulation of blood vessel remodeling positive regulation of focal adhesion assembly positive regulation of immune response to tumor cell regulation of actin cytoskeleton organization regulation of blood coagulation regulation of gene expression regulation of peptidyl-tyrosine phosphorylation regulation of platelet activation regulation of protein-containing complex assembly serine-type endopeptidase inhibitor activity signaling receptor binding zinc ion binding	GO:0001525 GO:0002839 GO:0004867 GO:0004869 GO:0005102 GO:0005576 GO:0005886 GO:0006935 GO:0007162 GO:0008201 GO:0008270 GO:0008285 GO:0009986 GO:0010468 GO:0010543 GO:0010593 GO:0015886 GO:0016525 GO:0019865 GO:0020037 GO:0030168 GO:0030193 GO:0030308 GO:0031093 GO:0032956 GO:0033629 GO:0036019 GO:0042730 GO:0043065 GO:0043254 GO:0043395 GO:0043537 GO:0046872 GO:0050730 GO:0050832 GO:0051838 GO:0051894 GO:0051918 GO:0061844 GO:0062023 GO:0070062 GO:0072562 GO:1900747 GO:2000504 GO:2001027
Netrin receptor UNC5B	Q8IZJ1	UNC5B	Homo sapiens	9606	3	angiogenesis anterior/posterior axon guidance apoptotic process membrane raft negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of neuron apoptotic process netrin receptor activity plasma membrane positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO:0001525 GO:0005042 GO:0005886 GO:0006915 GO:0033564 GO:0043524 GO:0045121 GO:0051897 GO:2001240