GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID ▲	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Ion transport domain-containing protein	K7FSE3	CACNA1C	Pelodiscus sinensis	13735	1	metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
Beta-secretase 2	K7FSR1	BACE2	Pelodiscus sinensis	13735	2	Golgi apparatus aspartic-type endopeptidase activity endosome glucose homeostasis melanosome membrane melanosome organization membrane protein ectodomain proteolysis negative regulation of amyloid precursor protein biosynthetic process plasma membrane protein processing	GO:0004190 GO:0005768 GO:0005794 GO:0005886 GO:0006509 GO:0016485 GO:0032438 GO:0033162 GO:0042593 GO:0042985
Voltage-dependent T-type calcium channel subunit alpha	K7FT08	CACNA1G	Pelodiscus sinensis	13735	1	action potential calcium ion import chemical synaptic transmission cytoplasm low voltage-gated calcium channel activity metal ion binding regulation of atrial cardiac muscle cell membrane depolarization regulation of heart rate regulation of monoatomic ion transmembrane transport response to nickel cation scaffold protein binding synapse voltage-gated calcium channel complex	GO:0001508 GO:0002027 GO:0005737 GO:0005891 GO:0007268 GO:0008332 GO:0010045 GO:0034765 GO:0045202 GO:0046872 GO:0060371 GO:0070509 GO:0097110
ADAM metallopeptidase with thrombospondin type 1 motif 1	K7FTU9	ADAMTS1	Pelodiscus sinensis	13735	2	basement membrane cytoplasmic vesicle extracellular matrix organization extracellular region heart trabecula formation heparin binding kidney development metalloendopeptidase activity negative regulation of angiogenesis ovulation from ovarian follicle positive regulation of G1/S transition of mitotic cell cycle positive regulation of vascular associated smooth muscle cell migration positive regulation of vascular associated smooth muscle cell proliferation proteolysis zinc ion binding	GO:0001542 GO:0001822 GO:0004222 GO:0005576 GO:0005604 GO:0006508 GO:0008201 GO:0008270 GO:0016525 GO:0030198 GO:0031410 GO:0060347 GO:1900087 GO:1904707 GO:1904754
Voltage-dependent N-type calcium channel subunit alpha	K7FUT3	CACNA1B	Pelodiscus sinensis	13735	1	high voltage-gated calcium channel activity metal ion binding modulation of chemical synaptic transmission regulation of monoatomic ion transmembrane transport response to amyloid-beta voltage-gated calcium channel complex	GO:0005891 GO:0008331 GO:0034765 GO:0046872 GO:0050804 GO:1904645
P2X purinoceptor	K7FV31	P2RX4	Pelodiscus sinensis	13735	1	ATP binding apoptotic signaling pathway cadherin binding cellular response to ATP extracellularly ATP-gated monoatomic cation channel activity identical protein binding ligand-gated calcium channel activity lysosomal membrane membrane depolarization negative regulation of cardiac muscle hypertrophy perinuclear region of cytoplasm plasma membrane positive regulation of blood vessel endothelial cell migration positive regulation of calcium ion transport into cytosol positive regulation of calcium-mediated signaling positive regulation of endothelial cell chemotaxis postsynapse purinergic nucleotide receptor activity regulation of blood pressure regulation of cardiac muscle contraction relaxation of cardiac muscle response to fluid shear stress	GO:0001614 GO:0004931 GO:0005524 GO:0005765 GO:0005886 GO:0008217 GO:0010524 GO:0010614 GO:0034405 GO:0042802 GO:0043536 GO:0045296 GO:0048471 GO:0050850 GO:0051899 GO:0055117 GO:0055119 GO:0071318 GO:0097190 GO:0098794 GO:0099604 GO:2001028
Hyaluronidase	K7G385	SPAM1	Pelodiscus sinensis	13735	1	carbohydrate metabolic process fusion of sperm to egg plasma membrane involved in single fertilization hyalurononglucosaminidase activity plasma membrane	GO:0004415 GO:0005886 GO:0005975 GO:0007342
Hyaluronidase	K7G388	SPAM1	Pelodiscus sinensis	13735	1	carbohydrate metabolic process fusion of sperm to egg plasma membrane involved in single fertilization hyalurononglucosaminidase activity plasma membrane	GO:0004415 GO:0005886 GO:0005975 GO:0007342
P2X purinoceptor	K7G3A2	P2RX3	Pelodiscus sinensis	13735	1	ATP binding Schaffer collateral - CA1 synapse axon behavioral response to pain cellular response to ATP establishment of localization in cell extracellularly ATP-gated monoatomic cation channel activity hippocampal mossy fiber to CA3 synapse inorganic cation transmembrane transport neuromuscular synaptic transmission peristalsis plasma membrane postsynapse protein homotrimerization purinergic nucleotide receptor activity receptor complex regulation of synaptic plasticity response to carbohydrate response to cold response to heat response to hypoxia response to mechanical stimulus sensory perception of taste urinary bladder smooth muscle contraction	GO:0001614 GO:0001666 GO:0004931 GO:0005524 GO:0005886 GO:0007274 GO:0009408 GO:0009409 GO:0009612 GO:0009743 GO:0014832 GO:0030424 GO:0030432 GO:0043235 GO:0048167 GO:0048266 GO:0050909 GO:0051649 GO:0070207 GO:0071318 GO:0098662 GO:0098685 GO:0098686 GO:0098794
Cathepsin D	K7G789	CTSD	Pelodiscus sinensis	13735	2	aspartic-type endopeptidase activity autophagosome assembly endosome lumen endosome membrane extracellular space insulin catabolic process insulin receptor recycling lipoprotein catabolic process lysosomal membrane membrane raft positive regulation of apoptotic process proteolysis regulation of establishment of protein localization	GO:0000045 GO:0004190 GO:0005615 GO:0005765 GO:0006508 GO:0010008 GO:0031904 GO:0038020 GO:0042159 GO:0043065 GO:0045121 GO:0070201 GO:1901143