GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs ▼
alpha-1,2-Mannosidase (Fragment)	Q8BYV2	Edem1	Mus musculus	10090	1	calcium ion binding carbohydrate metabolic process endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane response to unfolded protein	GO:0004571 GO:0005509 GO:0005783 GO:0005975 GO:0006986 GO:0016020
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	P32906	MNS1	Saccharomyces cerevisiae S288C	559292	3	calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum membrane mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane protein deglycosylation involved in glycoprotein catabolic process ubiquitin-dependent ERAD pathway	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005975 GO:0016020 GO:0030433 GO:0035977
ER degradation-enhancing alpha-mannosidase-like protein 1	Q92611	EDEM1	Homo sapiens	9606	7	aggresome calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity misfolded protein binding positive regulation of retrograde protein transport, ER to cytosol protein targeting to ER response to unfolded protein ubiquitin-dependent ERAD pathway ubiquitin-dependent glycoprotein ERAD pathway	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005975 GO:0006986 GO:0016235 GO:0030433 GO:0044322 GO:0045047 GO:0051787 GO:0097466 GO:1904154 GO:1904382
ER degradation-enhancing alpha-mannosidase-like protein 1	Q925U4	Edem1	Mus musculus	10090	5	aggresome calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum quality control compartment mannosyl-oligosaccharide 1,2-alpha-mannosidase activity misfolded protein binding positive regulation of retrograde protein transport, ER to cytosol protein targeting to ER response to unfolded protein trimming of terminal mannose on C branch ubiquitin-dependent ERAD pathway ubiquitin-dependent glycoprotein ERAD pathway	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005975 GO:0006986 GO:0016235 GO:0030433 GO:0036510 GO:0044322 GO:0045047 GO:0051787 GO:0097466 GO:1904154
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Q9UKM7	MAN1B1	Homo sapiens	9606	17	Golgi apparatus calcium ion binding cytoplasmic vesicle endoplasmic reticulum endoplasmic reticulum mannose trimming endoplasmic reticulum membrane endoplasmic reticulum quality control compartment extracellular vesicle mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane oligosaccharide metabolic process protein alpha-1,2-demannosylation trimming of terminal mannose on B branch ubiquitin-dependent ERAD pathway viral protein processing	GO:0004571 GO:0005509 GO:0005783 GO:0005789 GO:0005794 GO:0009311 GO:0016020 GO:0019082 GO:0030433 GO:0031410 GO:0036508 GO:0036509 GO:0044322 GO:1903561 GO:1904380 GO:1904382
ER degradation-enhancing alpha-mannosidase-like protein 2	Q8BJT9	Edem2	Mus musculus	10090	4	calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum lumen mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane positive regulation of retrograde protein transport, ER to cytosol response to unfolded protein ubiquitin-dependent glycoprotein ERAD pathway	GO:0004571 GO:0005509 GO:0005783 GO:0005788 GO:0005975 GO:0006986 GO:0016020 GO:0097466 GO:1904154
ER degradation-enhancing alpha-mannosidase-like protein 3	Q9BZQ6	EDEM3	Homo sapiens	9606	8	calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum quality control compartment mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane response to unfolded protein	GO:0004571 GO:0005509 GO:0005783 GO:0005788 GO:0005975 GO:0006986 GO:0016020 GO:0044322 GO:1904382
ER degradation-enhancing alpha-mannosidase-like protein 1	P38888	MNL1	Saccharomyces cerevisiae S288C	559292	4	calcium ion binding carbohydrate binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum mannose trimming endoplasmic reticulum quality control compartment mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase complex membrane positive regulation of endoplasmic reticulum unfolded protein response protein alpha-1,2-demannosylation response to unfolded protein ubiquitin-dependent glycoprotein ERAD pathway	GO:0004571 GO:0005509 GO:0005783 GO:0005788 GO:0005975 GO:0006986 GO:0016020 GO:0030246 GO:0036508 GO:0044322 GO:0097466 GO:0106055 GO:1900103 GO:1904380 GO:1904382
ER degradation-enhancing alpha-mannosidase-like protein 2	Q9BV94	EDEM2	Homo sapiens	9606	4	calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum quality control compartment mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane positive regulation of retrograde protein transport, ER to cytosol response to unfolded protein trimming of terminal mannose on B branch ubiquitin-dependent glycoprotein ERAD pathway viral protein processing	GO:0004571 GO:0005509 GO:0005783 GO:0005788 GO:0005975 GO:0006986 GO:0016020 GO:0019082 GO:0036509 GO:0044322 GO:0097466 GO:1904154 GO:1904382
ER degradation-enhancing alpha-mannosidase-like protein 3	Q2HXL6	Edem3	Mus musculus	10090	7	calcium ion binding carbohydrate metabolic process endoplasmic reticulum endoplasmic reticulum lumen glycoprotein catabolic process mannose trimming involved in glycoprotein ERAD pathway mannosyl-oligosaccharide 1,2-alpha-mannosidase activity membrane proteasome-mediated ubiquitin-dependent protein catabolic process response to unfolded protein	GO:0004571 GO:0005509 GO:0005783 GO:0005788 GO:0005975 GO:0006516 GO:0006986 GO:0016020 GO:0043161 GO:1904382