GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels ▼	GO IDs
Prefoldin subunit 4	Q9NQP4	PFDN4	Homo sapiens	9606		amyloid-beta binding chaperone-mediated protein folding cytoplasm cytosol mitochondrion negative regulation of amyloid fibril formation nucleus prefoldin complex protein folding protein-folding chaperone binding unfolded protein binding	GO:0001540 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006457 GO:0016272 GO:0051082 GO:0051087 GO:0061077 GO:1905907
Prefoldin subunit 3	P61758	VBP1	Homo sapiens	9606		amyloid-beta binding chaperone-mediated protein folding cytoplasm cytosol intracellular membrane-bounded organelle microtubule-based process negative regulation of amyloid fibril formation nucleus polysome prefoldin complex protein folding tubulin binding tubulin complex assembly unfolded protein binding	GO:0001540 GO:0005634 GO:0005737 GO:0005829 GO:0005844 GO:0006457 GO:0007017 GO:0007021 GO:0015631 GO:0016272 GO:0043231 GO:0051082 GO:0061077 GO:1905907
Membrane-associated progesterone receptor component 1	O00264	PGRMC1	Homo sapiens	9606		amyloid-beta binding cell body endomembrane system endoplasmic reticulum extracellular region heme binding heme biosynthetic process membrane metal ion binding mitochondrial outer membrane neuron projection neuronal cell body plasma membrane positive regulation of protein localization to plasma membrane protein homodimerization activity smooth endoplasmic reticulum membrane specific granule membrane steroid binding synapse	GO:0001540 GO:0005496 GO:0005576 GO:0005741 GO:0005783 GO:0005886 GO:0006783 GO:0012505 GO:0016020 GO:0020037 GO:0030868 GO:0035579 GO:0042803 GO:0043005 GO:0043025 GO:0044297 GO:0045202 GO:0046872 GO:1903078
Integrin beta-2	P32592	ITGB2	Bos taurus	9913	5	amyloid-beta binding cell adhesion cell surface cellular response to low-density lipoprotein particle stimulus focal adhesion integrin binding integrin complex integrin-mediated signaling pathway membrane membrane raft metal ion binding phagocytosis positive regulation of leukocyte adhesion to vascular endothelial cell receptor internalization	GO:0001540 GO:0005178 GO:0005925 GO:0006909 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0016020 GO:0031623 GO:0045121 GO:0046872 GO:0071404 GO:1904996
Integrin beta-2	P53714	ITGB2	Sus scrofa	9823	5	amyloid-beta binding cell adhesion cell surface cellular response to low-density lipoprotein particle stimulus focal adhesion integrin binding integrin complex integrin-mediated signaling pathway membrane membrane raft metal ion binding phagocytosis positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of phagocytosis receptor internalization	GO:0001540 GO:0005178 GO:0005925 GO:0006909 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0016020 GO:0031623 GO:0045121 GO:0046872 GO:0050766 GO:0071404 GO:1904996
Hemoglobin subunit alpha-1/2	P01946	Hba1	Rattus norvegicus	10116		amyloid-beta binding carbon dioxide transport cellular oxidant detoxification erythrocyte development haptoglobin-hemoglobin complex heme binding hemoglobin complex hydrogen peroxide catabolic process in utero embryonic development iron ion binding negative regulation of blood pressure nitric oxide transport organic acid binding oxygen binding oxygen carrier activity oxygen transport response to bacterium response to stilbenoid	GO:0001540 GO:0001701 GO:0005344 GO:0005506 GO:0005833 GO:0009617 GO:0015670 GO:0015671 GO:0019825 GO:0020037 GO:0030185 GO:0031838 GO:0035634 GO:0042744 GO:0043177 GO:0045776 GO:0048821 GO:0098869
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	O00555	CACNA1A	Homo sapiens	9606	1	amyloid-beta binding calcium ion import across plasma membrane calcium ion transmembrane transport cell projection cellular response to amyloid-beta chemical synaptic transmission cytoplasm high voltage-gated calcium channel activity membrane metal ion binding modulation of chemical synaptic transmission neuronal cell body nucleus plasma membrane positive regulation of cytosolic calcium ion concentration regulation of monoatomic ion transmembrane transport response to amyloid-beta synapse syntaxin binding voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0001540 GO:0005245 GO:0005634 GO:0005737 GO:0005886 GO:0005891 GO:0007204 GO:0007268 GO:0008331 GO:0016020 GO:0019905 GO:0034765 GO:0042995 GO:0043025 GO:0045202 GO:0046872 GO:0050804 GO:0070588 GO:0098703 GO:1904645 GO:1904646
Integrin alpha-2	Q62469	Itga2	Mus musculus	10090	9	amyloid-beta binding axon axon terminus basal part of cell cell adhesion mediated by integrin cell projection cell surface cell-cell adhesion cell-matrix adhesion cell-substrate adhesion cellular response to estradiol stimulus cellular response to mechanical stimulus collagen binding collagen binding involved in cell-matrix adhesion collagen receptor activity collagen-activated signaling pathway detection of mechanical stimulus involved in sensory perception of pain external side of plasma membrane female pregnancy focal adhesion focal adhesion assembly hepatocyte differentiation hypotonic response integrin alpha2-beta1 complex integrin binding integrin complex integrin-mediated signaling pathway laminin binding mammary gland development mesodermal cell differentiation metal ion binding perinuclear region of cytoplasm plasma membrane positive regulation of cell adhesion positive regulation of cell projection organization positive regulation of collagen biosynthetic process positive regulation of epithelial cell migration positive regulation of leukocyte migration positive regulation of phagocytosis, engulfment positive regulation of positive chemotaxis positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of translation positive regulation of transmission of nerve impulse presynapse protein-containing complex binding response to L-ascorbic acid response to amine response to hypoxia response to muscle activity response to parathyroid hormone response to xenobiotic stimulus skin morphogenesis substrate-dependent cell migration	GO:0001540 GO:0001666 GO:0002687 GO:0005178 GO:0005518 GO:0005886 GO:0005925 GO:0006929 GO:0006971 GO:0007160 GO:0007229 GO:0007565 GO:0008305 GO:0009410 GO:0009897 GO:0009986 GO:0010634 GO:0014075 GO:0014850 GO:0014911 GO:0030424 GO:0030879 GO:0031346 GO:0031589 GO:0032967 GO:0033591 GO:0033627 GO:0034666 GO:0038064 GO:0038065 GO:0042995 GO:0043236 GO:0043589 GO:0043679 GO:0044877 GO:0045178 GO:0045727 GO:0045785 GO:0045987 GO:0046872 GO:0048041 GO:0048333 GO:0048471 GO:0048661 GO:0050927 GO:0050966 GO:0051971 GO:0060100 GO:0070365 GO:0071107 GO:0071260 GO:0071392 GO:0098609 GO:0098639 GO:0098793
Complement C1q subcomponent subunit A	P02745	C1QA	Homo sapiens	9606	5	amyloid-beta binding astrocyte activation cell-cell signaling collagen trimer collagen-containing extracellular matrix complement activation complement activation, classical pathway complement component C1 complex complement component C1q complex complement-mediated synapse pruning extracellular region innate immune response microglial cell activation neuron remodeling postsynapse synapse synapse organization synapse pruning vertebrate eye-specific patterning	GO:0001540 GO:0001774 GO:0005576 GO:0005581 GO:0005602 GO:0006956 GO:0006958 GO:0007267 GO:0016322 GO:0045087 GO:0045202 GO:0048143 GO:0050808 GO:0062023 GO:0062167 GO:0098794 GO:0098883 GO:0150062 GO:0150064
Clusterin	Q549A5	Clu	Mus musculus	10090	4	amyloid-beta binding apical dendrite cell morphogenesis cell periphery cell surface central nervous system myelin maintenance chaperone-mediated protein complex assembly chaperone-mediated protein folding chromaffin granule cytoskeleton cytosol low-density lipoprotein particle receptor binding microglial cell activation microglial cell proliferation misfolded protein binding mitochondrial inner membrane negative regulation of amyloid fibril formation negative regulation of amyloid-beta formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of protein-containing complex assembly negative regulation of response to endoplasmic reticulum stress neurofibrillary tangle nucleus perinuclear endoplasmic reticulum lumen positive regulation of neurofibrillary tangle assembly positive regulation of nitric oxide biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein-containing complex assembly positive regulation of receptor-mediated endocytosis positive regulation of tumor necrosis factor production protein carrier chaperone protein import protein stabilization protein targeting to lysosome involved in chaperone-mediated autophagy protein-containing complex binding regulation of amyloid-beta clearance regulation of cell population proliferation regulation of neuronal signal transduction response to misfolded protein response to virus spherical high-density lipoprotein particle tau protein binding ubiquitin protein ligase binding unfolded protein binding	GO:0000902 GO:0001540 GO:0001774 GO:0005634 GO:0005743 GO:0005829 GO:0005856 GO:0009615 GO:0009986 GO:0017038 GO:0031333 GO:0031334 GO:0031625 GO:0032286 GO:0032436 GO:0032760 GO:0034366 GO:0042127 GO:0042583 GO:0044877 GO:0045429 GO:0048156 GO:0048260 GO:0050750 GO:0050821 GO:0051082 GO:0051131 GO:0051787 GO:0051788 GO:0061077 GO:0061518 GO:0061740 GO:0071944 GO:0097418 GO:0097440 GO:0099020 GO:0140597 GO:1900221 GO:1902230 GO:1902430 GO:1902847 GO:1902998 GO:1903573 GO:1905907