GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels ▼	GO IDs
Integrin alpha-2	P17301	ITGA2	Homo sapiens	9606	10	amyloid-beta binding animal organ morphogenesis axon terminus basal part of cell blood coagulation cell adhesion cell adhesion mediated by integrin cell surface cell-cell adhesion cell-matrix adhesion cell-substrate adhesion cellular response to estradiol stimulus cellular response to mechanical stimulus collagen binding collagen binding involved in cell-matrix adhesion collagen receptor activity collagen-activated signaling pathway detection of mechanical stimulus involved in sensory perception of pain external side of plasma membrane female pregnancy focal adhesion focal adhesion assembly heparan sulfate proteoglycan binding hepatocyte differentiation hypotonic response integrin alpha2-beta1 complex integrin binding integrin complex integrin-mediated signaling pathway laminin binding mammary gland development mesodermal cell differentiation metal ion binding perinuclear region of cytoplasm plasma membrane positive regulation of cell adhesion positive regulation of cell projection organization positive regulation of collagen biosynthetic process positive regulation of epithelial cell migration positive regulation of leukocyte migration positive regulation of phagocytosis, engulfment positive regulation of positive chemotaxis positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of smooth muscle contraction positive regulation of translation positive regulation of transmission of nerve impulse protein-containing complex binding response to L-ascorbic acid response to amine response to hypoxia response to muscle activity response to parathyroid hormone response to xenobiotic stimulus skin morphogenesis substrate-dependent cell migration virus receptor activity	GO:0001540 GO:0001618 GO:0001666 GO:0002687 GO:0005178 GO:0005518 GO:0005886 GO:0005925 GO:0006929 GO:0006971 GO:0007155 GO:0007160 GO:0007229 GO:0007565 GO:0007596 GO:0008305 GO:0009410 GO:0009887 GO:0009897 GO:0009986 GO:0010634 GO:0014075 GO:0014850 GO:0014911 GO:0030879 GO:0031346 GO:0031589 GO:0032967 GO:0033591 GO:0033627 GO:0034666 GO:0038064 GO:0038065 GO:0043236 GO:0043395 GO:0043589 GO:0043679 GO:0044877 GO:0045178 GO:0045727 GO:0045785 GO:0045987 GO:0046872 GO:0048041 GO:0048333 GO:0048471 GO:0048661 GO:0050927 GO:0050966 GO:0051971 GO:0060100 GO:0070365 GO:0071107 GO:0071260 GO:0071392 GO:0098609 GO:0098639
Scavenger receptor class B member 1	P97943	Scarb1	Rattus norvegicus	10116	10	amyloid-beta binding androgen biosynthetic process apolipoprotein A-I binding apolipoprotein binding blood vessel endothelial cell migration carotenoid transport caveola cell surface cholesterol catabolic process cholesterol efflux cholesterol homeostasis cholesterol import cholesterol transport cytoplasm detection of lipopolysaccharide endothelial cell proliferation high-density lipoprotein particle binding high-density lipoprotein particle clearance high-density lipoprotein particle receptor activity high-density lipoprotein particle remodeling identical protein binding intestinal lipid absorption lipid binding lipid transport lipid transporter activity lipopolysaccharide binding lipopolysaccharide immune receptor activity lipopolysaccharide transport low-density lipoprotein particle binding low-density lipoprotein particle clearance membrane microvillus membrane phagocytosis, recognition phosphatidylserine binding phospholipid transport plasma lipoprotein particle clearance plasma membrane positive regulation of cholesterol storage positive regulation of triglyceride biosynthetic process recognition of apoptotic cell regulation of phagocytosis regulation of phosphatidylcholine catabolic process reverse cholesterol transport scavenger receptor activity steroid biosynthetic process triglyceride homeostasis vitamin transmembrane transport	GO:0001530 GO:0001540 GO:0001786 GO:0001875 GO:0001935 GO:0005044 GO:0005319 GO:0005737 GO:0005886 GO:0005901 GO:0006694 GO:0006702 GO:0006707 GO:0006869 GO:0006910 GO:0008035 GO:0008289 GO:0009986 GO:0010867 GO:0010886 GO:0010899 GO:0015914 GO:0015920 GO:0016020 GO:0030169 GO:0030301 GO:0031528 GO:0032497 GO:0033344 GO:0034185 GO:0034186 GO:0034375 GO:0034381 GO:0034383 GO:0034384 GO:0035461 GO:0042632 GO:0042802 GO:0043534 GO:0043654 GO:0043691 GO:0046867 GO:0050764 GO:0070328 GO:0070506 GO:0070508 GO:0098856
Macrophage scavenger receptor types I and II	P30204	Msr1	Mus musculus	10090	7	amyloid-beta binding amyloid-beta clearance cargo receptor activity cholesterol transport collagen trimer establishment of localization in cell lipoprotein transport low-density lipoprotein particle low-density lipoprotein particle binding negative regulation of gene expression phagocytosis, engulfment plasma lipoprotein particle clearance plasma membrane positive regulation of cholesterol storage positive regulation of macrophage derived foam cell differentiation receptor-mediated endocytosis scavenger receptor activity	GO:0001540 GO:0005044 GO:0005581 GO:0005886 GO:0006898 GO:0006911 GO:0010629 GO:0010744 GO:0010886 GO:0030169 GO:0030301 GO:0034362 GO:0034381 GO:0038024 GO:0042953 GO:0051649 GO:0097242
Macrophage scavenger receptor types I and II	P21757	MSR1	Homo sapiens	9606	7	amyloid-beta binding amyloid-beta clearance cargo receptor activity cellular response to organic cyclic compound cholesterol transport collagen trimer endocytic vesicle membrane establishment of localization in cell lipoprotein transport low-density lipoprotein particle low-density lipoprotein particle binding membrane negative regulation of gene expression phagocytosis, engulfment plasma lipoprotein particle clearance plasma membrane positive regulation of cholesterol storage positive regulation of macrophage derived foam cell differentiation receptor-mediated endocytosis scavenger receptor activity	GO:0001540 GO:0005044 GO:0005581 GO:0005886 GO:0006898 GO:0006911 GO:0010629 GO:0010744 GO:0010886 GO:0016020 GO:0030169 GO:0030301 GO:0030666 GO:0034362 GO:0034381 GO:0038024 GO:0042953 GO:0051649 GO:0071407 GO:0097242
Integrin alpha-M	P11215	ITGAM	Homo sapiens	9606	19	amyloid-beta binding amyloid-beta clearance cargo receptor activity cell adhesion cell adhesion mediated by integrin cell surface cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cell-matrix adhesion complement component C3b binding complement-mediated synapse pruning ectodermal cell differentiation external side of plasma membrane extracellular exosome extracellular space forebrain development heat shock protein binding innate immune response integrin alphaM-beta2 complex integrin binding integrin complex integrin-mediated signaling pathway metal ion binding microglial cell activation negative regulation of dopamine metabolic process obsolete cell surface receptor signaling pathway involved in cell-cell signaling phagocytosis, engulfment plasma membrane plasma membrane raft positive regulation of microglial cell mediated cytotoxicity positive regulation of neutrophil degranulation positive regulation of prostaglandin-E synthase activity positive regulation of protein targeting to membrane positive regulation of superoxide anion generation receptor-mediated endocytosis specific granule membrane tertiary granule membrane vertebrate eye-specific patterning	GO:0001540 GO:0001774 GO:0001851 GO:0005178 GO:0005615 GO:0005886 GO:0006898 GO:0006911 GO:0007155 GO:0007160 GO:0007229 GO:0008305 GO:0009897 GO:0009986 GO:0010668 GO:0030900 GO:0031072 GO:0032930 GO:0033627 GO:0034688 GO:0035579 GO:0038024 GO:0043315 GO:0044853 GO:0045087 GO:0045963 GO:0046872 GO:0070062 GO:0070821 GO:0090314 GO:0097242 GO:0098609 GO:0098742 GO:0150062 GO:0150064 GO:1904151 GO:1905114 GO:2000363
Transmembrane and coiled-coil domains protein 2	Q80W04	Tmcc2	Mus musculus	10090		amyloid precursor protein metabolic process endomembrane system endoplasmic reticulum endoplasmic reticulum membrane	GO:0005783 GO:0005789 GO:0012505 GO:0042982
Kallikrein-6	Q92876	KLK6	Homo sapiens	9606	1	amyloid precursor protein metabolic process central nervous system development collagen catabolic process cornified envelope cytoplasm endoplasmic reticulum extracellular region extracellular space hormone metabolic process intercellular bridge mitochondrion myelination nuclear membrane nucleolus nucleoplasm positive regulation of G protein-coupled receptor signaling pathway protein autoprocessing regulation of cell differentiation regulation of neuron projection development response to wounding secretory granule serine-type endopeptidase activity tissue regeneration	GO:0001533 GO:0004252 GO:0005576 GO:0005615 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005783 GO:0007417 GO:0009611 GO:0010975 GO:0016540 GO:0030141 GO:0030574 GO:0031965 GO:0042246 GO:0042445 GO:0042552 GO:0042982 GO:0045171 GO:0045595 GO:0045745
Small EDRK-rich factor 1	O75920	SERF1A SERF1B	Homo sapiens	9606	3	amyloid fibril formation cytosol nervous system development nucleus protein destabilization protein-containing complex	GO:0005634 GO:0005829 GO:0007399 GO:0031648 GO:0032991 GO:1990000
Cell wall protein PGA59	Q5AF39	PGA59	Candida albicans SC5314	237561	2	amyloid fibril formation cellular response to neutral pH extracellular region filamentous growth filamentous growth of a population of unicellular organisms in response to neutral pH fungal-type cell wall fungal-type cell wall biogenesis fungal-type cell wall organization side of membrane	GO:0005576 GO:0009272 GO:0009277 GO:0030447 GO:0031505 GO:0036178 GO:0036244 GO:0098552 GO:1990000
Corneodesmosin	Q15517	CDSN	Homo sapiens	9606	5	amyloid fibril formation cell adhesion cell-cell adhesion cell-cell junction corneocyte desquamation cornified envelope desmosome epidermis development extracellular region keratinocyte differentiation negative regulation of cornification plasma membrane protein homodimerization activity skin morphogenesis	GO:0001533 GO:0003336 GO:0005576 GO:0005886 GO:0005911 GO:0007155 GO:0008544 GO:0030057 GO:0030216 GO:0042803 GO:0043589 GO:0098609 GO:1905716 GO:1990000