GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Hemagglutinin-neuraminidase	E3UM81	HN	Avian metaavulavirus 2	2560313	1	exo-alpha-(2->3)-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity host cell plasma membrane host cell surface receptor binding plasma membrane viral entry into host cell viral envelope virion attachment to host cell virion membrane	GO:0005886 GO:0019031 GO:0019062 GO:0020002 GO:0046718 GO:0046789 GO:0052794 GO:0052795 GO:0052796 GO:0055036
Interleukin-10	Q2PE73	IL10	Bubalus carabanensis	346063	1	cytokine activity extracellular space immune response negative regulation of B cell proliferation negative regulation of cytokine production involved in immune response negative regulation of inflammatory response negative regulation of interleukin-6 production negative regulation of membrane protein ectodomain proteolysis positive regulation of B cell apoptotic process positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription positive regulation of cytokine production response to glucocorticoid response to molecule of bacterial origin	GO:0001819 GO:0002237 GO:0002719 GO:0002904 GO:0005125 GO:0005615 GO:0006955 GO:0030889 GO:0032715 GO:0045893 GO:0050728 GO:0051045 GO:0051091 GO:0051384
Fibroblast growth factor receptor	A0A8C3F684	FGFR2	Chrysemys picta bellii	8478	8	ATP binding fibroblast growth factor receptor activity phosphorylation plasma membrane positive regulation of cell population proliferation	GO:0005007 GO:0005524 GO:0005886 GO:0008284 GO:0016310
Serpin family A member 3 (Fragment)	G3V595	SERPINA3	Homo sapiens	9606	5	extracellular space serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005615
Xyloglucan endotransglucosylase/hydrolase	A0A6J5TJD3	CURHAP_LOCUS5204	Prunus armeniaca	36596	1	apoplast cell wall biogenesis cell wall organization hydrolase activity, hydrolyzing O-glycosyl compounds xyloglucan metabolic process xyloglucan:xyloglucosyl transferase activity	GO:0004553 GO:0010411 GO:0016762 GO:0042546 GO:0048046 GO:0071555
Biglycan	O46390	BGN	Ovis aries	9940	4	extracellular region	GO:0005576
Protein Wnt-5a	Q9QXQ7	Wnt5a	Rattus norvegicus	10116	4	BMP signaling pathway JNK cascade Schaffer collateral - CA1 synapse Wnt signaling pathway Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway anterior/posterior axis specification, embryo anterior/posterior pattern specification atrial septum development axis elongation axon extension involved in axon guidance axon guidance axonogenesis canonical Wnt signaling pathway cartilage development cell differentiation cell fate commitment cell migration cell population proliferation cell surface cellular response to calcium ion cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to transforming growth factor beta stimulus cellular response to type II interferon cervix development chemoattractant activity involved in axon guidance chemoattraction of serotonergic neuron axon chemorepulsion of dopaminergic neuron axon cochlea morphogenesis convergent extension convergent extension involved in axis elongation convergent extension involved in organogenesis cytokine activity determination of left/right symmetry development of primary male sexual characteristics digestive tract morphogenesis dopaminergic neuron differentiation embryonic digit morphogenesis embryonic limb morphogenesis embryonic skeletal system development epithelial cell migration epithelial cell proliferation epithelial cell proliferation involved in mammary gland duct elongation epithelial to mesenchymal transition establishment of epithelial cell apical/basal polarity establishment of planar polarity estrous cycle extracellular matrix extracellular space face development fibroblast growth factor receptor signaling pathway frizzled binding genitalia development glutamatergic synapse heart looping hematopoietic stem cell proliferation hindgut morphogenesis hypophysis morphogenesis inflammatory response inner ear morphogenesis keratinocyte differentiation kidney development lateral sprouting involved in mammary gland duct morphogenesis limb morphogenesis lung alveolus development lung development macrophage derived foam cell differentiation male gonad development mammary gland branching involved in thelarche meiotic nuclear division melanocyte proliferation mesenchymal cell proliferation mesenchymal-epithelial cell signaling mesodermal to mesenchymal transition involved in gastrulation midbrain development midbrain dopaminergic neuron differentiation midgut development modulation of chemical synaptic transmission morphogenesis of an epithelium negative chemotaxis negative regulation of BMP signaling pathway negative regulation of DNA-templated transcription negative regulation of apoptotic process negative regulation of axon extension involved in axon guidance negative regulation of canonical Wnt signaling pathway negative regulation of cell proliferation in midbrain negative regulation of epithelial cell proliferation negative regulation of fat cell differentiation negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of melanin biosynthetic process negative regulation of mesenchymal cell proliferation negative regulation of prostatic bud formation negative regulation of synapse assembly neural tube closure neural tube development neurogenesis neuron differentiation neuron projection morphogenesis non-canonical Wnt signaling pathway notochord morphogenesis obsolete Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation obsolete non-canonical Wnt signaling pathway via JNK cascade obsolete positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway olfactory bulb interneuron development paraxial mesoderm formation pericardium morphogenesis planar cell polarity pathway involved in axis elongation planar cell polarity pathway involved in axon guidance planar cell polarity pathway involved in cardiac muscle tissue morphogenesis planar cell polarity pathway involved in cardiac right atrium morphogenesis planar cell polarity pathway involved in gastrula mediolateral intercalation planar cell polarity pathway involved in neural tube closure planar cell polarity pathway involved in outflow tract morphogenesis planar cell polarity pathway involved in pericardium morphogenesis planar cell polarity pathway involved in ventricular septum morphogenesis positive regulation of DNA-templated transcription positive regulation of JNK cascade positive regulation of T cell chemotaxis positive regulation of angiogenesis positive regulation of apoptotic signaling pathway positive regulation of cartilage development positive regulation of cell-cell adhesion positive regulation of cell-cell adhesion mediated by cadherin positive regulation of chemokine production positive regulation of cytokine production positive regulation of cytokine production involved in immune response positive regulation of dendrite extension positive regulation of dendrite morphogenesis positive regulation of endocytosis positive regulation of endothelial cell migration positive regulation of endothelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of fibroblast proliferation positive regulation of gene expression positive regulation of hematopoietic stem cell proliferation positive regulation of inflammatory response positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of macrophage activation positive regulation of macrophage cytokine production positive regulation of meiotic nuclear division positive regulation of mesenchymal cell proliferation positive regulation of neuron projection arborization positive regulation of neuron projection development positive regulation of non-canonical Wnt signaling pathway positive regulation of ossification positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation positive regulation of protein catabolic process positive regulation of protein kinase C signaling positive regulation of protein phosphorylation positive regulation of response to cytokine stimulus positive regulation of stem cell proliferation positive regulation of thymocyte apoptotic process positive regulation of timing of anagen positive regulation of transcription by RNA polymerase II positive regulation of tumor necrosis factor production positive regulation of type I interferon-mediated signaling pathway positive regulation of type II interferon production post-anal tail morphogenesis postsynapse postsynaptic modulation of chemical synaptic transmission primary heart field specification primitive streak formation prostate gland development protein domain specific binding protein localization receptor tyrosine kinase-like orphan receptor binding regulation of branching involved in mammary gland duct morphogenesis regulation of canonical NF-kappaB signal transduction regulation of postsynapse organization regulation of postsynaptic cytosolic calcium ion concentration regulation of postsynaptic specialization assembly regulation of protein localization regulation of synapse organization regulation of synaptic signaling by nitric oxide response to estradiol response to glucocorticoid response to hyperoxia response to organic cyclic compound response to organic substance response to quercetin response to testosterone secondary heart field specification secondary palate development signaling receptor binding somite development somitogenesis stem cell proliferation thymocyte apoptotic process tube closure type B pancreatic cell development urinary bladder development uterus development vagina development ventricular septum development wound healing	GO:0001736 GO:0001756 GO:0001819 GO:0001822 GO:0001837 GO:0001843 GO:0001934 GO:0001938 GO:0001947 GO:0002009 GO:0002053 GO:0002720 GO:0003138 GO:0003139 GO:0003281 GO:0003283 GO:0003323 GO:0003344 GO:0003401 GO:0003402 GO:0005102 GO:0005109 GO:0005115 GO:0005125 GO:0005615 GO:0006954 GO:0007223 GO:0007254 GO:0007368 GO:0007409 GO:0007411 GO:0007442 GO:0007494 GO:0008104 GO:0008283 GO:0008543 GO:0008584 GO:0008595 GO:0009952 GO:0009986 GO:0010033 GO:0010463 GO:0010595 GO:0010628 GO:0010631 GO:0010742 GO:0010800 GO:0010820 GO:0010976 GO:0014070 GO:0016055 GO:0016477 GO:0019904 GO:0021891 GO:0021915 GO:0022008 GO:0022409 GO:0030154 GO:0030182 GO:0030216 GO:0030324 GO:0030326 GO:0030509 GO:0030514 GO:0030850 GO:0030901 GO:0031012 GO:0032355 GO:0032722 GO:0032729 GO:0032731 GO:0032755 GO:0032757 GO:0032760 GO:0032880 GO:0033138 GO:0033574 GO:0035108 GO:0035567 GO:0036342 GO:0036517 GO:0036518 GO:0038031 GO:0040037 GO:0042060 GO:0042472 GO:0042733 GO:0043032 GO:0043066 GO:0043122 GO:0044849 GO:0045165 GO:0045198 GO:0045599 GO:0045732 GO:0045766 GO:0045778 GO:0045807 GO:0045836 GO:0045892 GO:0045893 GO:0045944 GO:0046330 GO:0046546 GO:0048022 GO:0048146 GO:0048286 GO:0048341 GO:0048546 GO:0048570 GO:0048706 GO:0048806 GO:0048812 GO:0048843 GO:0048846 GO:0048850 GO:0050673 GO:0050679 GO:0050680 GO:0050729 GO:0050775 GO:0050804 GO:0050807 GO:0050919 GO:0051216 GO:0051384 GO:0051885 GO:0051964 GO:0055093 GO:0060026 GO:0060028 GO:0060029 GO:0060065 GO:0060067 GO:0060068 GO:0060070 GO:0060071 GO:0060157 GO:0060324 GO:0060340 GO:0060599 GO:0060606 GO:0060638 GO:0060686 GO:0060744 GO:0060750 GO:0060760 GO:0060762 GO:0060775 GO:0060809 GO:0060907 GO:0061036 GO:0061053 GO:0061347 GO:0061348 GO:0061349 GO:0061350 GO:0061354 GO:0062009 GO:0070242 GO:0070245 GO:0071219 GO:0071222 GO:0071277 GO:0071346 GO:0071425 GO:0071542 GO:0071560 GO:0072089 GO:0072201 GO:0090009 GO:0090037 GO:0090082 GO:0090090 GO:0090103 GO:0090179 GO:0097325 GO:0098685 GO:0098794 GO:0098978 GO:0099150 GO:0099170 GO:0099175 GO:0099566 GO:0140013 GO:0150012 GO:0150045 GO:1902035 GO:1902379 GO:1903861 GO:1904934 GO:1904938 GO:1904948 GO:1904953 GO:1905235 GO:2000049 GO:2000052 GO:2000648 GO:2001235
Phosphoinositide phospholipase C	A0A8C4FJK9	plcd1	Denticeps clupeoides	299321	1	calcium ion binding intracellular signal transduction lipid catabolic process phosphatidylinositol phospholipase C activity	GO:0004435 GO:0005509 GO:0016042 GO:0035556
Spike glycoprotein	Q3I5J5	S	Bat SARS CoV Rp3/2004	349344	23	endocytosis involved in viral entry into host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell plasma membrane membrane receptor-mediated virion attachment to host cell viral envelope virion membrane	GO:0016020 GO:0019031 GO:0019064 GO:0020002 GO:0039654 GO:0044173 GO:0046813 GO:0055036 GO:0075509
Transmembrane protein 26	Q6ZUK4	TMEM26	Homo sapiens	9606	1	membrane	GO:0016020