GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Toll-like receptor 4	Q8SPE9	TLR4	Pongo pygmaeus	9600	10	NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating detection of lipopolysaccharide early endosome inflammatory response innate immune response lipopolysaccharide immune receptor activity lipopolysaccharide receptor complex macrophage activation plasma membrane positive regulation of NLRP3 inflammasome complex assembly positive regulation of interleukin-1 beta production ruffle toll-like receptor signaling pathway transmembrane signaling receptor activity	GO:0001726 GO:0001875 GO:0002224 GO:0004888 GO:0005769 GO:0005886 GO:0006954 GO:0032497 GO:0032731 GO:0042116 GO:0045087 GO:0046696 GO:0050135 GO:0061809 GO:1900227
Matrix protein 2	A0A0N9RGZ5	M2	Influenza A virus (A/Delaware/31/2014(H3N2))	1731079	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Interleukin-18 receptor 1	Q61098	Il18r1	Mus musculus	10090	10	NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating T-helper 1 cell differentiation inflammatory response interleukin-18 binding interleukin-18 receptor activity interleukin-18 receptor complex interleukin-18-mediated signaling pathway natural killer cell activation negative regulation of cold-induced thermogenesis non-canonical NF-kappaB signal transduction positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 1 cell cytokine production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of type II interferon production	GO:0006954 GO:0030101 GO:0032729 GO:0035655 GO:0038061 GO:0042007 GO:0042008 GO:0045063 GO:0045092 GO:0050135 GO:0051092 GO:0061809 GO:0120163 GO:1901224 GO:2000556
WD repeat-containing protein 46	Q9Z0H1	Wdr46	Mus musculus	10090		maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleolus ribosomal small subunit biogenesis small-subunit processome	GO:0000462 GO:0005730 GO:0032040 GO:0042274
Voltage-dependent L-type calcium channel subunit alpha	A0A3P9D1D2	CACNA1D	Maylandia zebra	106582	1	metal ion binding regulation of monoatomic ion transmembrane transport voltage-gated calcium channel activity voltage-gated calcium channel complex	GO:0005245 GO:0005891 GO:0034765 GO:0046872
Prosaposin	Q3U897	Psap	Mus musculus	10090	4	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway extracellular region lysosome regulation of lipid metabolic process sphingolipid metabolic process	GO:0005576 GO:0005764 GO:0006665 GO:0007193 GO:0019216
ERO1-like protein alpha	Q96HE7	ERO1A	Homo sapiens	9606	3	FAD binding Golgi lumen brown fat cell differentiation cell redox homeostasis cellular response to hypoxia chaperone cofactor-dependent protein refolding dendrite endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response extracellular matrix organization extracellular space intracellular membrane-bounded organelle intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress membrane oxidoreductase activity protein folding protein folding in endoplasmic reticulum protein maturation by protein folding protein modification process protein-disulfide reductase activity release of sequestered calcium ion into cytosol response to endoplasmic reticulum stress response to oxidative stress response to temperature stimulus thiol oxidase activity	GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005796 GO:0006457 GO:0006979 GO:0009266 GO:0015035 GO:0016020 GO:0016491 GO:0016972 GO:0022417 GO:0030198 GO:0030425 GO:0030968 GO:0034975 GO:0034976 GO:0036211 GO:0043231 GO:0045454 GO:0050873 GO:0051085 GO:0051209 GO:0070059 GO:0071456 GO:0071949
Zinc finger protein 518A	Q6AHZ1	ZNF518A	Homo sapiens	9606		DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin organization metal ion binding nucleus regulation of transcription by RNA polymerase II	GO:0000977 GO:0000981 GO:0005634 GO:0006325 GO:0006357 GO:0046872
Matrix protein 2	A0A193AS80	M2	Influenza A virus (A/Colorado/27/2016(H3N2))	1865785	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Basic leucine zipper transcription factor	Q9FNB9	bzip13	Arabidopsis thaliana	3702		DNA-binding transcription factor activity nucleus positive regulation of DNA-templated transcription transcription cis-regulatory region binding	GO:0000976 GO:0003700 GO:0005634 GO:0045893