GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▲	GO Labels	GO IDs
Ig-like domain-containing protein	Q3UWA5	H2-Q4	Mus musculus	10090	1	CD8 receptor binding CD8-positive, alpha-beta T cell activation Golgi apparatus Golgi medial cisterna MHC class I peptide loading complex MHC class I protein binding MHC class I protein complex MHC class Ib protein complex T cell receptor binding TAP binding TAP complex binding adaptive immune response antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib beta-2-microglobulin binding cell surface defense response to Gram-positive bacterium endoplasmic reticulum endoplasmic reticulum exit site external side of plasma membrane extracellular space immune response natural killer cell lectin-like receptor binding natural killer cell tolerance induction negative regulation of natural killer cell mediated cytotoxicity peptide antigen binding peptide binding plasma membrane positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of T cell mediated cytotoxicity positive regulation of TRAIL production positive regulation of antibody-dependent cellular cytotoxicity positive regulation of immunoglobulin production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell proliferation positive regulation of tumor necrosis factor production protection from natural killer cell mediated cytotoxicity protein-containing complex binding protein-folding chaperone binding regulation of natural killer cell mediated immunity signaling receptor binding	GO:0001815 GO:0001916 GO:0002250 GO:0002476 GO:0002477 GO:0002486 GO:0002519 GO:0002639 GO:0002715 GO:0002717 GO:0002729 GO:0005102 GO:0005615 GO:0005783 GO:0005794 GO:0005797 GO:0005886 GO:0006955 GO:0009897 GO:0009986 GO:0019731 GO:0030881 GO:0032398 GO:0032736 GO:0032753 GO:0032759 GO:0032760 GO:0032819 GO:0036037 GO:0042270 GO:0042277 GO:0042288 GO:0042605 GO:0042608 GO:0042610 GO:0042612 GO:0042824 GO:0044877 GO:0045953 GO:0045954 GO:0046703 GO:0046977 GO:0050830 GO:0051087 GO:0062061 GO:0070971 GO:2000566 GO:2001187
Glutathione peroxidase 1	P00435	GPX1	Bos taurus	9913	1	Lewy body SH3 domain binding UV protection angiogenesis involved in wound healing arachidonic acid metabolic process biological process involved in interaction with symbiont blood vessel endothelial cell migration cell redox homeostasis cytosol endothelial cell development epigenetic regulation of gene expression fat cell differentiation fibroblast proliferation glutathione metabolic process glutathione peroxidase activity heart contraction hydrogen peroxide catabolic process intrinsic apoptotic signaling pathway in response to oxidative stress lipoxygenase pathway mitochondrion myoblast differentiation myoblast proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of inflammatory response to antigenic stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of release of cytochrome c from mitochondria neuron apoptotic process phospholipid-hydroperoxide glutathione peroxidase activity positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of supramolecular fiber organization regulation of mammary gland epithelial cell proliferation regulation of proteasomal protein catabolic process response to gamma radiation response to hydrogen peroxide response to hydroperoxide response to selenium ion response to symbiotic bacterium response to xenobiotic stimulus sensory perception of sound skeletal muscle fiber development skeletal muscle tissue regeneration temperature homeostasis triglyceride metabolic process vasodilation	GO:0001659 GO:0001885 GO:0002862 GO:0004602 GO:0005739 GO:0005829 GO:0006641 GO:0006749 GO:0007605 GO:0008631 GO:0009410 GO:0009609 GO:0009650 GO:0010269 GO:0010332 GO:0017124 GO:0019369 GO:0019372 GO:0033194 GO:0033599 GO:0040029 GO:0042311 GO:0042542 GO:0042744 GO:0043403 GO:0043534 GO:0045444 GO:0045445 GO:0045454 GO:0047066 GO:0048144 GO:0048741 GO:0051402 GO:0051450 GO:0051702 GO:0051897 GO:0060047 GO:0060055 GO:0061136 GO:0090201 GO:0097413 GO:1902042 GO:1902176 GO:1902905
Beta-secretase 2 (Fragment)	A0A093ET83	N341_11597	Tyto alba	56313	1	aspartic-type endopeptidase activity endosome membrane proteolysis	GO:0004190 GO:0005768 GO:0006508 GO:0016020
Matrix protein 2	A0A1U9Y965	M2	Influenza A virus (A/Washington/20/2017(H3N2))	1969871	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Matrix protein 2	A0A0C5AHZ2	M2	Influenza A virus (A/duck/Jiangxi/34858/2013(H7N3))	1594128	1	host cell plasma membrane membrane monoatomic ion channel activity protein complex oligomerization proton transmembrane transporter activity suppression by virus of host autophagy virion membrane virus-mediated pore formation in host cell membrane	GO:0005216 GO:0015078 GO:0016020 GO:0020002 GO:0039521 GO:0039707 GO:0051259 GO:0055036
Inactive rhomboid protein 1	Q6GMF8	rhbdf1	Danio rerio	7955	1	Golgi membrane cell migration cell population proliferation endoplasmic reticulum membrane growth factor binding negative regulation of protein secretion protein transport regulation of epidermal growth factor receptor signaling pathway regulation of proteasomal protein catabolic process regulation of protein secretion	GO:0000139 GO:0005789 GO:0008283 GO:0015031 GO:0016477 GO:0019838 GO:0042058 GO:0050708 GO:0050709 GO:0061136
Sprouty-related, EVH1 domain-containing protein 1	Q7Z699	SPRED1	Homo sapiens	9606	1	caveola cytosol negative regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade negative regulation of angiogenesis negative regulation of cell migration involved in sprouting angiogenesis negative regulation of epithelial to mesenchymal transition negative regulation of lens fiber cell differentiation negative regulation of peptidyl-threonine phosphorylation negative regulation of protein kinase activity negative regulation of transforming growth factor beta receptor signaling pathway nucleoplasm phosphatase binding plasma membrane positive regulation of DNA damage response, signal transduction by p53 class mediator protein kinase binding protein serine/threonine kinase inhibitor activity regulation of MAPK cascade regulation of protein deacetylation stem cell factor receptor binding vasculogenesis involved in coronary vascular morphogenesis	GO:0005173 GO:0005654 GO:0005829 GO:0005886 GO:0005901 GO:0006469 GO:0010719 GO:0010801 GO:0016525 GO:0019901 GO:0019902 GO:0030291 GO:0030512 GO:0043408 GO:0043409 GO:0043517 GO:0060979 GO:0070373 GO:0090051 GO:0090311 GO:1902747
Hyaluronidase	A0A8U1BTU8	si:dkey-72l14.3	Salvelinus namaycush	8040	1	carbohydrate metabolic process hyalurononglucosaminidase activity	GO:0004415 GO:0005975
FIC domain-containing protein (Fragment)	A0A0F6QKQ7	Ficd	Melanotaenia affinis	120850	1	ATP binding	GO:0005524
GON-4-like protein	Q3T8J9	GON4L	Homo sapiens	9606	1	nuclear body nucleoplasm nucleus regulation of DNA-templated transcription transcription coregulator activity	GO:0003712 GO:0005634 GO:0005654 GO:0006355 GO:0016604