GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Protein eyes shut homolog	Q5R6R1	EYS	Pongo abelii	9601	52	calcium ion binding cytoplasm detection of light stimulus involved in visual perception extracellular region interphotoreceptor matrix microtubule organizing center photoreceptor outer segment skeletal muscle tissue regeneration	GO:0001750 GO:0005509 GO:0005576 GO:0005737 GO:0005815 GO:0033165 GO:0043403 GO:0050908
Serine/threonine-protein kinase WNK1	Q9H4A3	WNK1	Homo sapiens	9606	52	ATP binding T cell receptor signaling pathway cell volume homeostasis cellular hyperosmotic response cellular response to chemokine chemokine (C-C motif) ligand 21 signaling pathway cytoplasm cytosol heart development intracellular chloride ion homeostasis intracellular non-membrane-bounded organelle intracellular signal transduction lymphocyte migration into lymph node membrane mitotic spindle molecular condensate scaffold activity monoatomic cation homeostasis monoatomic ion transport negative regulation of GTPase activity negative regulation of autophagy negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion negative regulation of leukocyte cell-cell adhesion negative regulation of pancreatic juice secretion negative regulation of protein localization to plasma membrane negative regulation of protein ubiquitination negative regulation of sodium ion transport neuron development non-membrane-bounded organelle assembly nucleus peptidyl-serine phosphorylation peptidyl-threonine phosphorylation phosphatase binding positive regulation of T cell chemotaxis positive regulation of angiogenesis positive regulation of canonical Wnt signaling pathway positive regulation of mitotic cytokinesis positive regulation of systemic arterial blood pressure positive regulation of termination of RNA polymerase II transcription potassium ion homeostasis protein insertion into ER membrane by stop-transfer membrane-anchor sequence protein kinase activator activity protein kinase activity protein kinase binding protein phosphorylation protein serine kinase activity protein serine/threonine kinase activity protein-containing complex regulation of mRNA export from nucleus regulation of monoatomic cation transmembrane transport regulation of sodium ion transmembrane transport regulation of sodium ion transport signal transduction sodium ion transmembrane transport	GO:0002028 GO:0003084 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006468 GO:0006811 GO:0006884 GO:0007165 GO:0007507 GO:0010507 GO:0010766 GO:0010793 GO:0010820 GO:0016020 GO:0018105 GO:0018107 GO:0019901 GO:0019902 GO:0030295 GO:0030644 GO:0031397 GO:0032991 GO:0033633 GO:0034115 GO:0034260 GO:0035556 GO:0035725 GO:0038116 GO:0043232 GO:0045050 GO:0045766 GO:0048666 GO:0050852 GO:0055075 GO:0055080 GO:0071474 GO:0072686 GO:0090188 GO:0090263 GO:0097022 GO:0106310 GO:0140693 GO:0140694 GO:1902305 GO:1903038 GO:1903077 GO:1903490 GO:1904062 GO:1904595 GO:1990869
Fibrocystin	E9PZ36	Pkhd1	Mus musculus	10090	51	9+0 non-motile cilium Golgi apparatus apical plasma membrane branching morphogenesis of an epithelial tube cell-cell junction organization centrosome chromosome, centromeric region ciliary basal body cilium cilium assembly cytoplasm endoplasmic reticulum epithelial cell morphogenesis establishment of centrosome localization establishment of mitotic spindle orientation extracellular exosome intracellular calcium ion homeostasis kidney development mitotic spindle negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction nucleus perinuclear region of cytoplasm positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade regulation of TOR signaling regulation of cell adhesion regulation of cell-cell adhesion regulation of cell-matrix adhesion regulation of centrosome duplication regulation of cholangiocyte proliferation regulation of establishment of planar polarity	GO:0000132 GO:0000775 GO:0001822 GO:0001952 GO:0003382 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005813 GO:0005929 GO:0006874 GO:0008284 GO:0010824 GO:0016324 GO:0022407 GO:0030155 GO:0032006 GO:0036064 GO:0043066 GO:0045216 GO:0048471 GO:0048754 GO:0050679 GO:0051660 GO:0051898 GO:0060271 GO:0070062 GO:0070372 GO:0072686 GO:0090175 GO:0097731 GO:1904036 GO:1904054
Prolow-density lipoprotein receptor-related protein 1	Q91ZX7	Lrp1	Mus musculus	10090	51	Golgi apparatus alpha-2 macroglobulin receptor activity amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis aorta morphogenesis apical part of cell apolipoprotein binding apoptotic cell clearance astrocyte activation involved in immune response axonal growth cone basolateral plasma membrane calcium ion binding cardiac septum development cargo receptor activity cellular lipid catabolic process cellular response to amyloid-beta chemoattraction of axon cholesterol metabolic process clathrin heavy chain binding clathrin-coated pit clathrin-coated vesicle coreceptor activity coronary vasculature development cytoskeleton dendrite early endosome endosome enzyme-linked receptor protein signaling pathway external side of plasma membrane insulin-responsive compartment lysosomal transport membrane negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of apoptotic process negative regulation of cell-substrate adhesion negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of gene expression negative regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration negative regulation of transforming growth factor beta receptor signaling pathway neuronal cell body nucleus phagocytosis plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of Schwann cell migration positive regulation of amyloid-beta clearance positive regulation of axon extension positive regulation of axon extension involved in regeneration positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cholesterol efflux positive regulation of cholesterol import positive regulation of collateral sprouting of injured axon positive regulation of cytosolic calcium ion concentration positive regulation of endocytosis positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of lipid transport positive regulation of lysosomal protein catabolic process positive regulation of neuron projection development positive regulation of phagocytosis positive regulation of protein localization to plasma membrane positive regulation of protein transport positive regulation of transcytosis positive regulation of vascular associated smooth muscle cell migration protease binding protein kinase C-activating G protein-coupled receptor signaling pathway protein-containing complex binding receptor complex receptor internalization receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of phospholipase A2 activity regulation of pulmonary blood vessel remodeling signaling receptor binding transport across blood-brain barrier	GO:0002020 GO:0002265 GO:0003279 GO:0005102 GO:0005509 GO:0005634 GO:0005768 GO:0005769 GO:0005794 GO:0005856 GO:0005886 GO:0005905 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0007204 GO:0007205 GO:0008203 GO:0009897 GO:0010629 GO:0010812 GO:0010875 GO:0010976 GO:0010977 GO:0014912 GO:0015026 GO:0016020 GO:0016323 GO:0016964 GO:0030136 GO:0030178 GO:0030425 GO:0030512 GO:0031623 GO:0032050 GO:0032370 GO:0032374 GO:0032429 GO:0032593 GO:0032956 GO:0034185 GO:0035774 GO:0035909 GO:0038024 GO:0043025 GO:0043066 GO:0043235 GO:0043277 GO:0043524 GO:0044242 GO:0044295 GO:0044877 GO:0045177 GO:0045773 GO:0045807 GO:0048691 GO:0048694 GO:0050766 GO:0051222 GO:0051481 GO:0051895 GO:0060392 GO:0060976 GO:0061642 GO:0070374 GO:0097242 GO:0150093 GO:0150094 GO:0150104 GO:1900149 GO:1900223 GO:1903078 GO:1904109 GO:1904300 GO:1904646 GO:1904754 GO:1905109 GO:1905167 GO:2000343 GO:2000587
Zinc finger protein 40	P15822	HIVEP1	Homo sapiens	9606	51	BMP signaling pathway DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding cytosol metal ion binding mitochondrion negative regulation of transcription by RNA polymerase II nuclear body nucleoplasm nucleus positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II sequence-specific double-stranded DNA binding	GO:0000122 GO:0000978 GO:0000981 GO:0001227 GO:0005634 GO:0005654 GO:0005739 GO:0005829 GO:0006357 GO:0016604 GO:0030509 GO:0045944 GO:0046872 GO:1990837
Ankyrin repeat domain-containing protein 17	Q99NH0	Ankrd17	Mus musculus	10090	51	RNA binding blood vessel maturation chromatin chromatin binding cytoplasm defense response to bacterium endoderm development innate immune response male germ cell nucleus negative regulation of smooth muscle cell differentiation nuclear membrane nucleoplasm nucleus positive regulation of G1/S transition of mitotic cell cycle positive regulation of MDA-5 signaling pathway positive regulation of RIG-I signaling pathway positive regulation of canonical NF-kappaB signal transduction positive regulation of cell cycle regulation of DNA replication	GO:0000785 GO:0001673 GO:0001955 GO:0003682 GO:0003723 GO:0005634 GO:0005654 GO:0005737 GO:0006275 GO:0007492 GO:0031965 GO:0042742 GO:0043123 GO:0045087 GO:0045787 GO:0051151 GO:1900087 GO:1900245 GO:1900246
Fibrillin-2	P35556	FBN2	Homo sapiens	9606	50	anatomical structure morphogenesis bone trabecula formation calcium ion binding camera-type eye development collagen-containing extracellular matrix embryonic eye morphogenesis embryonic limb morphogenesis extracellular matrix extracellular matrix constituent conferring elasticity extracellular matrix structural constituent extracellular region hormone activity microfibril positive regulation of bone mineralization positive regulation of osteoblast differentiation sequestering of TGFbeta in extracellular matrix	GO:0001527 GO:0005179 GO:0005201 GO:0005509 GO:0005576 GO:0009653 GO:0030023 GO:0030326 GO:0030501 GO:0031012 GO:0035583 GO:0043010 GO:0045669 GO:0048048 GO:0060346 GO:0062023
Lipolysis-stimulated lipoprotein receptor	Q86X29	LSR	Homo sapiens	9606	50	bicellular tight junction cell junction chylomicron epithelial structure maintenance establishment of blood-brain barrier establishment of skin barrier extracellular exosome liver development low-density lipoprotein particle maintenance of blood-brain barrier plasma membrane protein localization to tricellular tight junction tight junction tricellular tight junction tricellular tight junction assembly very-low-density lipoprotein particle	GO:0001889 GO:0005886 GO:0005923 GO:0010669 GO:0030054 GO:0034361 GO:0034362 GO:0035633 GO:0042627 GO:0060856 GO:0061436 GO:0061689 GO:0061833 GO:0070062 GO:0070160 GO:1904274
Trans-Golgi network integral membrane protein 2	O43493	TGOLN2	Homo sapiens	9606	50	Golgi apparatus clathrin-coated endocytic vesicle membrane endoplasmic reticulum lumen endosome nucleoplasm plasma membrane trans-Golgi network trans-Golgi network transport vesicle transport vesicle	GO:0005654 GO:0005768 GO:0005788 GO:0005794 GO:0005802 GO:0005886 GO:0030133 GO:0030140 GO:0030669
RNA-binding protein EWS	Q01844	EWSR1	Homo sapiens	9606	50	Cajal body RNA binding calmodulin binding cytoplasm identical protein binding metal ion binding nucleolus nucleoplasm nucleus plasma membrane transcription coregulator activity	GO:0003712 GO:0003723 GO:0005516 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005886 GO:0015030 GO:0042802 GO:0046872