GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
TM2 domain-containing protein 1	Q9BX74	TM2D1	Homo sapiens	9606	5	G protein-coupled receptor activity amyloid-beta binding apoptotic signaling pathway plasma membrane	GO:0001540 GO:0004930 GO:0005886 GO:0097190
Protocadherin beta-10	Q9UN67	PCDHB10	Homo sapiens	9606	5	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules membrane plasma membrane synapse synapse assembly	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0007268 GO:0007416 GO:0016020 GO:0016339 GO:0045202
Glia-derived nexin	Q07235	Serpine2	Mus musculus	10090	2	blood coagulation cell differentiation cerebellar granular layer morphogenesis collagen-containing extracellular matrix cytosol dense core granule biogenesis detection of mechanical stimulus involved in sensory perception extracellular region extracellular space glycosaminoglycan binding heparin binding innervation long-term synaptic potentiation mating plug formation negative regulation of blood coagulation negative regulation of cell growth negative regulation of cell population proliferation negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of plasminogen activation negative regulation of platelet activation negative regulation of platelet aggregation negative regulation of protein catabolic process negative regulation of protein processing negative regulation of proteolysis negative regulation of smoothened signaling pathway negative regulation of sodium ion transport neuromuscular junction neuronal cell body platelet activation platelet alpha granule positive regulation of astrocyte differentiation positive regulation of neuron projection development protein catabolic process regulation of synaptic transmission, glutamatergic regulation of timing of cell differentiation response to wounding secretion by cell secretory granule organization seminal vesicle epithelium development serine-type endopeptidase inhibitor activity signaling receptor binding	GO:0004867 GO:0005102 GO:0005539 GO:0005576 GO:0005615 GO:0005829 GO:0007596 GO:0008201 GO:0008285 GO:0009611 GO:0010544 GO:0010757 GO:0010766 GO:0010955 GO:0010976 GO:0021683 GO:0030154 GO:0030163 GO:0030168 GO:0030195 GO:0030308 GO:0031091 GO:0031594 GO:0032940 GO:0033363 GO:0042177 GO:0042628 GO:0043025 GO:0045861 GO:0045879 GO:0048505 GO:0048711 GO:0050974 GO:0051898 GO:0051966 GO:0060291 GO:0060384 GO:0061108 GO:0061110 GO:0062023 GO:0090331
Rho-related BTB domain-containing protein 3	O94955	RHOBTB3	Homo sapiens	9606	1	ATP binding ATP hydrolysis activity GTPase activity cytoplasm cytosol extracellular exosome male gonad development proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis retrograde transport, endosome to Golgi small GTPase binding trans-Golgi network membrane ubiquitin protein ligase binding	GO:0003924 GO:0005524 GO:0005737 GO:0005829 GO:0008584 GO:0016887 GO:0030162 GO:0031267 GO:0031625 GO:0032588 GO:0042147 GO:0043161 GO:0070062
Lymphoid enhancer-binding factor 1	Q9UJU2	LEF1	Homo sapiens	9606	1	B cell proliferation BMP signaling pathway C2H2 zinc finger domain binding DNA binding DNA binding, bending DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding T cell receptor V(D)J recombination T-helper 1 cell differentiation anatomical structure regression apoptotic process involved in blood vessel morphogenesis armadillo repeat domain binding beta-catenin binding beta-catenin-TCF complex branching involved in blood vessel morphogenesis canonical Wnt signaling pathway cell chemotaxis cellular response to cytokine stimulus cellular response to interleukin-4 chorio-allantoic fusion chromatin binding cytoplasm dentate gyrus development embryonic limb morphogenesis epithelial cell apoptotic process epithelial to mesenchymal transition face morphogenesis forebrain neuroblast division forebrain radial glial cell differentiation formation of radial glial scaffolds gamma-catenin binding histone binding histone deacetylase binding mammary gland development negative regulation of DNA binding negative regulation of DNA-templated transcription negative regulation of apoptotic process negative regulation of apoptotic process in bone marrow cell negative regulation of interleukin-13 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production negative regulation of striated muscle tissue development negative regulation of transcription by RNA polymerase II neutrophil differentiation nuclear estrogen receptor binding nucleoplasm nucleus odontogenesis of dentin-containing tooth osteoblast differentiation paraxial mesoderm formation positive regulation by host of viral transcription positive regulation of DNA-templated transcription positive regulation of Wnt signaling pathway positive regulation of cell cycle process positive regulation of cell differentiation positive regulation of cell migration positive regulation of cell proliferation in bone marrow positive regulation of chondrocyte proliferation positive regulation of epithelial to mesenchymal transition positive regulation of gamma-delta T cell differentiation positive regulation of gene expression positive regulation of granulocyte differentiation positive regulation of transcription by RNA polymerase II protein localization to chromatin protein-DNA complex regulation of neurogenesis regulation of transcription by RNA polymerase II secondary palate development sensory perception of taste sequence-specific DNA binding sequence-specific double-stranded DNA binding somitogenesis sprouting angiogenesis tongue development trachea gland development transcription by RNA polymerase II transcription corepressor binding transcription regulator complex transcription regulator inhibitor activity	GO:0000122 GO:0000977 GO:0000978 GO:0000981 GO:0001222 GO:0001227 GO:0001228 GO:0001569 GO:0001649 GO:0001756 GO:0001837 GO:0002040 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005654 GO:0005667 GO:0005737 GO:0006357 GO:0006366 GO:0008013 GO:0008301 GO:0010628 GO:0010718 GO:0021542 GO:0021861 GO:0021873 GO:0021943 GO:0030177 GO:0030223 GO:0030326 GO:0030331 GO:0030335 GO:0030509 GO:0030854 GO:0030879 GO:0032696 GO:0032713 GO:0032714 GO:0032993 GO:0033153 GO:0042100 GO:0042393 GO:0042475 GO:0042826 GO:0043066 GO:0043392 GO:0043565 GO:0043586 GO:0043923 GO:0045063 GO:0045295 GO:0045588 GO:0045597 GO:0045843 GO:0045892 GO:0045893 GO:0045944 GO:0048341 GO:0050767 GO:0050909 GO:0060033 GO:0060070 GO:0060325 GO:0060326 GO:0060710 GO:0061153 GO:0062009 GO:0070016 GO:0070742 GO:0071168 GO:0071345 GO:0071353 GO:0071864 GO:0071866 GO:0090068 GO:0140416 GO:1902262 GO:1902732 GO:1904019 GO:1990837 GO:1990907
P2X purinoceptor 4	Q9JJX6	P2rx4	Mus musculus	10090	7	ATP binding ATP-gated ion channel activity apical part of cell apoptotic signaling pathway axon behavioral response to pain cadherin binding calcium ion transmembrane transport calcium ion transport cell body cell junction cellular response to ATP cellular response to zinc ion copper ion binding dendrite dendritic spine excitatory postsynaptic potential extracellularly ATP-gated monoatomic cation channel activity identical protein binding inorganic cation transmembrane transport ligand-gated calcium channel activity ligand-gated monoatomic cation channel activity lysosomal membrane membrane membrane depolarization monoatomic ion transmembrane transport negative regulation of cardiac muscle hypertrophy neuronal action potential neuronal cell body nitric oxide biosynthetic process perinuclear region of cytoplasm plasma membrane positive regulation of blood vessel endothelial cell migration positive regulation of calcium ion transport into cytosol positive regulation of calcium-mediated signaling positive regulation of endothelial cell chemotaxis positive regulation of microglial cell migration positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction purinergic nucleotide receptor activity purinergic nucleotide receptor signaling pathway regulation of blood pressure regulation of cardiac muscle contraction regulation of chemotaxis regulation of sodium ion transport relaxation of cardiac muscle response to ATP response to axon injury response to fluid shear stress response to ischemia sensory perception of pain sensory perception of touch signal transduction signaling receptor binding terminal bouton vasodilation zinc ion binding	GO:0001614 GO:0002028 GO:0002931 GO:0004931 GO:0005102 GO:0005507 GO:0005524 GO:0005765 GO:0005886 GO:0006809 GO:0006816 GO:0007165 GO:0008217 GO:0008270 GO:0010524 GO:0010614 GO:0016020 GO:0019228 GO:0019233 GO:0030054 GO:0030424 GO:0030425 GO:0033198 GO:0034220 GO:0034405 GO:0035381 GO:0035590 GO:0042311 GO:0042802 GO:0043025 GO:0043195 GO:0043197 GO:0043536 GO:0044297 GO:0045177 GO:0045296 GO:0048266 GO:0048471 GO:0048678 GO:0050850 GO:0050920 GO:0050975 GO:0051897 GO:0051899 GO:0055117 GO:0055119 GO:0060079 GO:0070588 GO:0071294 GO:0071318 GO:0097190 GO:0098662 GO:0099094 GO:0099604 GO:1904141 GO:2001028
Deoxyribonuclease-2-alpha	O00115	DNASE2	Homo sapiens	9606	4	DNA binding DNA metabolic process apoptotic DNA fragmentation deoxyribonuclease II activity enucleate erythrocyte differentiation extracellular exosome lysosome regulation of immune response	GO:0003677 GO:0004531 GO:0005764 GO:0006259 GO:0006309 GO:0043353 GO:0050776 GO:0070062
Solute carrier organic anion transporter family member 1B3	Q9NPD5	SLCO1B3	Homo sapiens	9606	8	basal plasma membrane basolateral plasma membrane bile acid and bile salt transport bile acid transmembrane transporter activity heme catabolic process monoatomic ion transport organic anion transmembrane transporter activity organic anion transport plasma membrane serine-type endopeptidase inhibitor activity sodium-independent organic anion transmembrane transporter activity sodium-independent organic anion transport xenobiotic metabolic process	GO:0004867 GO:0005886 GO:0006805 GO:0006811 GO:0008514 GO:0009925 GO:0015125 GO:0015347 GO:0015711 GO:0015721 GO:0016323 GO:0042167 GO:0043252
Rho GTPase-activating protein 28	Q9P2N2	ARHGAP28	Homo sapiens	9606	1	GTPase activator activity cell junction cytoplasm cytosol negative regulation of stress fiber assembly nucleoplasm regulation of actin filament polymerization regulation of small GTPase mediated signal transduction signal transduction	GO:0005096 GO:0005654 GO:0005737 GO:0005829 GO:0007165 GO:0030054 GO:0030833 GO:0051056 GO:0051497
Cysteine proteinase 1	P04988	cprA	Dictyostelium discoideum	44689		cysteine-type endopeptidase activity extracellular space hyperosmotic response lysosome proteolysis involved in protein catabolic process	GO:0004197 GO:0005615 GO:0005764 GO:0006972 GO:0051603