GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Low-density lipoprotein receptor-related protein 1	P98157	LRP1	Gallus gallus	9031	50	Wnt receptor activity Wnt-protein binding alpha-2 macroglobulin receptor activity calcium ion binding canonical Wnt signaling pathway clathrin-coated pit	GO:0005509 GO:0005905 GO:0016964 GO:0017147 GO:0042813 GO:0060070
Protein eyes shut homolog	A0A2K5V015	EYS	Macaca fascicularis	9541	50	calcium ion binding cytoplasm extracellular region interphotoreceptor matrix microtubule organizing center photoreceptor outer segment response to stimulus visual perception	GO:0001750 GO:0005509 GO:0005576 GO:0005737 GO:0005815 GO:0007601 GO:0033165 GO:0050896
Syndecan-1	P18827	SDC1	Homo sapiens	9606	49	Golgi lumen Sertoli cell development canonical Wnt signaling pathway cargo receptor activity cell migration cell surface external side of plasma membrane extracellular exosome identical protein binding lysosomal lumen myoblast development plasma membrane positive regulation of exosomal secretion positive regulation of extracellular exosome assembly protein-containing complex receptor-mediated endocytosis response to cAMP response to calcium ion response to glucocorticoid response to hydrogen peroxide response to toxic substance striated muscle cell development ureteric bud development	GO:0001657 GO:0005796 GO:0005886 GO:0006898 GO:0009636 GO:0009897 GO:0009986 GO:0016477 GO:0032991 GO:0038024 GO:0042542 GO:0042802 GO:0043202 GO:0048627 GO:0051384 GO:0051591 GO:0051592 GO:0055002 GO:0060009 GO:0060070 GO:0070062 GO:1903543 GO:1903553
Ankyrin-3	Q12955	ANK3	Homo sapiens	9606	49	Golgi apparatus Golgi to plasma membrane protein transport T-tubule Z disc axon initial segment axonogenesis basal plasma membrane basolateral plasma membrane cadherin binding cell surface cellular response to magnesium ion costamere cytoskeletal anchor activity cytoskeletal protein binding cytosol dendrite endoplasmic reticulum establishment of protein localization intercalated disc lateral plasma membrane lysosome magnesium ion homeostasis maintenance of protein location in plasma membrane membrane assembly mitotic cytokinesis negative regulation of delayed rectifier potassium channel activity neuromuscular junction neuromuscular junction development neuron projection neuronal action potential node of Ranvier plasma membrane plasma membrane organization positive regulation of cation channel activity positive regulation of cell communication by electrical coupling positive regulation of gene expression positive regulation of homotypic cell-cell adhesion positive regulation of membrane depolarization during cardiac muscle cell action potential positive regulation of membrane potential positive regulation of protein targeting to membrane positive regulation of sodium ion transmembrane transporter activity positive regulation of sodium ion transport postsynaptic membrane protein localization to axon protein localization to plasma membrane protein-macromolecule adaptor activity regulation of potassium ion transport sarcolemma sarcoplasmic reticulum signal transduction spectrin binding spectrin-associated cytoskeleton structural constituent of cytoskeleton transmembrane transporter binding	GO:0000281 GO:0005200 GO:0005764 GO:0005783 GO:0005794 GO:0005829 GO:0005886 GO:0007009 GO:0007165 GO:0007409 GO:0007528 GO:0008092 GO:0008093 GO:0009925 GO:0009986 GO:0010628 GO:0010650 GO:0010765 GO:0010960 GO:0014704 GO:0014731 GO:0016323 GO:0016328 GO:0016529 GO:0019228 GO:0030018 GO:0030315 GO:0030425 GO:0030507 GO:0030674 GO:0031594 GO:0033268 GO:0034112 GO:0042383 GO:0043001 GO:0043005 GO:0043034 GO:0043194 GO:0043266 GO:0044325 GO:0045184 GO:0045211 GO:0045296 GO:0045838 GO:0071286 GO:0071709 GO:0072659 GO:0072660 GO:0090314 GO:0099612 GO:1900827 GO:1902260 GO:2000651 GO:2001259
Cubilin homolog	Q20911	cubn-1	Caenorhabditis elegans	6239	49	calcium ion binding extracellular region lipid metabolic process protein transport	GO:0005509 GO:0005576 GO:0006629 GO:0015031
Mucin-2	Q80Z19	Muc2	Mus musculus	10090	49	apoptotic process collagen-containing extracellular matrix cupric ion binding cuprous ion binding detoxification of copper ion extracellular matrix extracellular matrix structural constituent extracellular space glandular epithelial cell development host-mediated regulation of intestinal microbiota composition identical protein binding inner mucus layer maintenance of gastrointestinal epithelium mucus layer mucus secretion negative regulation of cell migration negative regulation of cell population proliferation outer mucus layer positive regulation of apoptotic process	GO:0002068 GO:0005201 GO:0005615 GO:0006915 GO:0008285 GO:0010273 GO:0030277 GO:0030336 GO:0031012 GO:0042802 GO:0043065 GO:0048874 GO:0062023 GO:0070254 GO:0070701 GO:0070702 GO:0070703 GO:1903135 GO:1903136
Low-density lipoprotein receptor-related protein 1B	Q9JI18	Lrp1b	Mus musculus	10090	49	calcium ion binding in utero embryonic development low-density lipoprotein particle receptor activity low-density lipoprotein particle receptor binding membrane plasma membrane receptor complex	GO:0001701 GO:0005041 GO:0005509 GO:0005886 GO:0016020 GO:0043235 GO:0050750
Prolow-density lipoprotein receptor-related protein 1	G3V928	Lrp1	Rattus norvegicus	10116	49	Golgi apparatus alpha-2 macroglobulin receptor activity amyloid-beta clearance amyloid-beta clearance by cellular catabolic process amyloid-beta clearance by transcytosis aorta morphogenesis apical part of cell apolipoprotein binding apoptotic cell clearance astrocyte activation involved in immune response axonal growth cone basolateral plasma membrane calcium ion binding cardiac septum development cargo receptor activity cellular lipid catabolic process cellular response to amyloid-beta cerebral cortex development chemoattraction of axon cholesterol metabolic process clathrin heavy chain binding clathrin-coated pit clathrin-coated vesicle coreceptor activity coronary vasculature development cytoskeleton dendrite early endosome endosome enzyme-linked receptor protein signaling pathway external side of plasma membrane insulin-responsive compartment low-density lipoprotein receptor complex lysosomal transport membrane negative regulation of SMAD protein signal transduction negative regulation of Wnt signaling pathway negative regulation of apoptotic process negative regulation of cell-substrate adhesion negative regulation of cytosolic calcium ion concentration negative regulation of endopeptidase activity negative regulation of focal adhesion assembly negative regulation of gene expression negative regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of platelet-derived growth factor receptor-beta signaling pathway negative regulation of smooth muscle cell migration negative regulation of transforming growth factor beta receptor signaling pathway neuronal cell body nucleus phagocytosis plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of Schwann cell migration positive regulation of amyloid-beta clearance positive regulation of axon extension positive regulation of axon extension involved in regeneration positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of cholesterol efflux positive regulation of cholesterol import positive regulation of cholesterol transport positive regulation of collateral sprouting of injured axon positive regulation of cytosolic calcium ion concentration positive regulation of endocytosis positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of lipid transport positive regulation of lysosomal protein catabolic process positive regulation of neuron projection development positive regulation of phagocytosis positive regulation of protein localization to plasma membrane positive regulation of protein transport positive regulation of transcytosis positive regulation of vascular associated smooth muscle cell migration protease binding protein kinase C-activating G protein-coupled receptor signaling pathway protein-containing complex binding receptor complex receptor internalization receptor-mediated endocytosis regulation of actin cytoskeleton organization regulation of cholesterol transport regulation of pulmonary blood vessel remodeling signaling receptor binding transport across blood-brain barrier	GO:0002020 GO:0002265 GO:0003279 GO:0005102 GO:0005509 GO:0005634 GO:0005768 GO:0005769 GO:0005794 GO:0005856 GO:0005886 GO:0005905 GO:0006898 GO:0006909 GO:0007041 GO:0007167 GO:0007204 GO:0007205 GO:0008203 GO:0009897 GO:0010629 GO:0010812 GO:0010875 GO:0010951 GO:0010976 GO:0010977 GO:0014912 GO:0015026 GO:0016020 GO:0016323 GO:0016964 GO:0021987 GO:0030136 GO:0030178 GO:0030425 GO:0030512 GO:0031623 GO:0032050 GO:0032370 GO:0032374 GO:0032376 GO:0032593 GO:0032956 GO:0034185 GO:0035774 GO:0035909 GO:0038024 GO:0043025 GO:0043066 GO:0043235 GO:0043277 GO:0043524 GO:0044242 GO:0044295 GO:0044877 GO:0045177 GO:0045773 GO:0045807 GO:0048691 GO:0048694 GO:0050766 GO:0051222 GO:0051481 GO:0051895 GO:0060392 GO:0060976 GO:0061642 GO:0062136 GO:0070374 GO:0097242 GO:0150093 GO:0150094 GO:0150104 GO:1900149 GO:1900223 GO:1903078 GO:1904109 GO:1904300 GO:1904646 GO:1904754 GO:1905109 GO:1905167 GO:2000343 GO:2000587
Hyphally regulated cell wall protein 3	Q59XA7	HYR3	Candida albicans SC5314	237561	48	cell surface extracellular region fungal-type cell wall side of membrane	GO:0005576 GO:0009277 GO:0009986 GO:0098552
Sortilin-related receptor	Q92673	SORL1	Homo sapiens	9606	48	Golgi apparatus Golgi cisterna Golgi membrane adaptive thermogenesis amyloid-beta binding cell migration cell surface diet induced thermogenesis early endosome early endosome membrane endoplasmic reticulum endoplasmic reticulum membrane endosome endosome membrane endosome to plasma membrane protein transport extracellular exosome extracellular space insulin receptor recycling low-density lipoprotein particle binding low-density lipoprotein particle receptor activity membrane multivesicular body multivesicular body membrane negative regulation of BMP signaling pathway negative regulation of MAP kinase activity negative regulation of amyloid-beta formation negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of neurofibrillary tangle assembly negative regulation of neurogenesis negative regulation of protein binding negative regulation of protein-containing complex assembly negative regulation of tau-protein kinase activity negative regulation of triglyceride catabolic process neuronal cell body neuropeptide binding neuropeptide signaling pathway nuclear envelope lumen perinucleolar compartment plasma membrane positive regulation of ER to Golgi vesicle-mediated transport positive regulation of adipose tissue development positive regulation of choline O-acetyltransferase activity positive regulation of early endosome to recycling endosome transport positive regulation of endocytic recycling positive regulation of glial cell-derived neurotrophic factor production positive regulation of insulin receptor signaling pathway positive regulation of protein catabolic process positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization to early endosome post-Golgi vesicle-mediated transport protein localization to Golgi apparatus protein maturation protein retention in Golgi apparatus protein targeting protein targeting to lysosome receptor-mediated endocytosis recycling endosome recycling endosome membrane regulation of smooth muscle cell migration small GTPase binding trans-Golgi network transmembrane signaling receptor activity transport vesicle membrane	GO:0000139 GO:0001540 GO:0002024 GO:0004888 GO:0005041 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005771 GO:0005783 GO:0005789 GO:0005794 GO:0005802 GO:0005886 GO:0006605 GO:0006622 GO:0006892 GO:0006898 GO:0007218 GO:0009986 GO:0010008 GO:0010897 GO:0014910 GO:0016020 GO:0016477 GO:0030169 GO:0030514 GO:0030658 GO:0031267 GO:0031333 GO:0031901 GO:0031985 GO:0032091 GO:0032585 GO:0034067 GO:0038020 GO:0042923 GO:0043025 GO:0043407 GO:0045053 GO:0045732 GO:0046628 GO:0050768 GO:0051604 GO:0055037 GO:0055038 GO:0070062 GO:0070863 GO:0097356 GO:0099638 GO:1900168 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:1904179 GO:1990845 GO:2001137