GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites ▼	GO Labels	GO IDs
Neurogenic locus notch homolog protein 1	Q07008	Notch1	Rattus norvegicus	10116	48	MAML1-RBP-Jkappa- ICN1 complex Notch binding Notch signaling involved in heart development Notch signaling pathway Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation T-helper 17 type immune response acrosomal vesicle adherens junction animal organ regeneration aortic valve morphogenesis apical plasma membrane apoptotic process apoptotic process involved in embryonic digit morphogenesis arterial endothelial cell differentiation astrocyte differentiation atrioventricular node development atrioventricular valve morphogenesis auditory receptor cell fate commitment axonogenesis branching morphogenesis of an epithelial tube calcium ion binding calcium-ion regulated exocytosis cardiac atrium morphogenesis cardiac chamber formation cardiac epithelial to mesenchymal transition cardiac left ventricle morphogenesis cardiac muscle cell myoblast differentiation cardiac muscle cell proliferation cardiac muscle tissue morphogenesis cardiac right atrium morphogenesis cardiac right ventricle formation cardiac septum morphogenesis cardiac vascular smooth muscle cell development cardiac ventricle morphogenesis cell differentiation cell differentiation in spinal cord cell migration involved in endocardial cushion formation cell periphery cell population proliferation cell surface cellular response to follicle-stimulating hormone stimulus cellular response to hypoxia cellular response to tumor cell cellular response to vascular endothelial growth factor stimulus chromatin DNA binding chromatin binding cilium assembly collecting duct development compartment pattern specification coronary artery morphogenesis coronary sinus valve morphogenesis coronary vein morphogenesis cytoplasm cytoplasmic vesicle cytoskeleton determination of left/right symmetry distal tubule development embryonic hindlimb morphogenesis embryonic limb morphogenesis endocardial cell differentiation endocardial cushion development endocardial cushion morphogenesis endocardium development endocardium morphogenesis endoderm development endoplasmic reticulum enzyme binding enzyme inhibitor activity epidermal cell fate specification epidermis development epithelial cell fate commitment epithelial cell proliferation epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation forebrain development foregut morphogenesis gene expression glial cell differentiation glomerular mesangial cell development growth involved in heart morphogenesis hair follicle morphogenesis heart development heart looping heart trabecula morphogenesis homeostasis of number of cells within a tissue humoral immune response identical protein binding in utero embryonic development inflammatory response to antigenic stimulus inhibition of neuroepithelial cell differentiation interleukin-17-mediated signaling pathway keratinocyte differentiation lamellipodium left/right axis specification liver development lung development luteolysis mesenchymal cell development mitral valve formation negative regulation of BMP signaling pathway negative regulation of DNA-templated transcription negative regulation of anoikis negative regulation of biomineral tissue development negative regulation of calcium ion-dependent exocytosis negative regulation of canonical Wnt signaling pathway negative regulation of cardiac muscle hypertrophy negative regulation of catalytic activity negative regulation of cell adhesion molecule production negative regulation of cell migration involved in sprouting angiogenesis negative regulation of cell population proliferation negative regulation of cell proliferation involved in heart valve morphogenesis negative regulation of cell-cell adhesion mediated by cadherin negative regulation of cell-substrate adhesion negative regulation of cold-induced thermogenesis negative regulation of collagen biosynthetic process negative regulation of endothelial cell chemotaxis negative regulation of epithelial cell proliferation negative regulation of extracellular matrix constituent secretion negative regulation of gene expression negative regulation of glial cell proliferation negative regulation of inner ear auditory receptor cell differentiation negative regulation of myoblast differentiation negative regulation of myotube differentiation negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of oligodendrocyte differentiation negative regulation of ossification negative regulation of osteoblast differentiation negative regulation of photoreceptor cell differentiation negative regulation of pro-B cell differentiation negative regulation of programmed cell death negative regulation of stem cell differentiation negative regulation of transcription by RNA polymerase II neural tube development neuroendocrine cell differentiation neuron differentiation neuron fate commitment neuronal stem cell population maintenance nucleus oligodendrocyte differentiation outflow tract morphogenesis pericardium morphogenesis plasma membrane positive regulation of BMP signaling pathway positive regulation of DNA-templated transcription positive regulation of ERK1 and ERK2 cascade positive regulation of Notch signaling pathway positive regulation of Ras protein signal transduction positive regulation of aorta morphogenesis positive regulation of apoptotic process positive regulation of apoptotic process involved in morphogenesis positive regulation of astrocyte differentiation positive regulation of cardiac epithelial to mesenchymal transition positive regulation of cardiac muscle cell proliferation positive regulation of cell migration positive regulation of cell population proliferation positive regulation of endothelial cell differentiation positive regulation of epithelial cell proliferation positive regulation of epithelial to mesenchymal transition positive regulation of gene expression positive regulation of glial cell differentiation positive regulation of keratinocyte differentiation positive regulation of neuroblast proliferation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of viral genome replication positive regulation of viral transcription prostate gland epithelium morphogenesis protein catabolic process protein import into nucleus pulmonary valve morphogenesis receptor complex regulation of Notch signaling pathway regulation of cardioblast proliferation regulation of cell migration regulation of cell population proliferation regulation of epithelial cell proliferation regulation of epithelial cell proliferation involved in prostate gland development regulation of extracellular matrix assembly regulation of gene expression regulation of inner ear auditory receptor cell differentiation regulation of neurogenesis regulation of somitogenesis regulation of stem cell proliferation regulation of transcription by RNA polymerase II response to lipopolysaccharide response to muramyl dipeptide retinal cone cell differentiation ruffle secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development skeletal muscle cell differentiation somatic stem cell division spermatogenesis sprouting angiogenesis tissue regeneration transcription by RNA polymerase II transcription coactivator activity transcription regulator activator activity transmembrane signaling receptor activity tube formation vasculogenesis involved in coronary vascular morphogenesis venous blood vessel morphogenesis venous endothelial cell differentiation ventricular septum morphogenesis ventricular trabecula myocardium morphogenesis	GO:0000122 GO:0001554 GO:0001669 GO:0001701 GO:0001726 GO:0001837 GO:0001889 GO:0001947 GO:0002040 GO:0002052 GO:0002085 GO:0002193 GO:0002437 GO:0003151 GO:0003157 GO:0003160 GO:0003162 GO:0003169 GO:0003180 GO:0003181 GO:0003182 GO:0003184 GO:0003192 GO:0003197 GO:0003198 GO:0003203 GO:0003207 GO:0003208 GO:0003209 GO:0003213 GO:0003214 GO:0003219 GO:0003222 GO:0003241 GO:0003252 GO:0003264 GO:0003270 GO:0003273 GO:0003332 GO:0003344 GO:0003682 GO:0003713 GO:0004857 GO:0004888 GO:0005112 GO:0005509 GO:0005634 GO:0005737 GO:0005783 GO:0005856 GO:0005886 GO:0005912 GO:0006357 GO:0006366 GO:0006606 GO:0006915 GO:0006959 GO:0007219 GO:0007221 GO:0007283 GO:0007368 GO:0007386 GO:0007409 GO:0007440 GO:0007492 GO:0007507 GO:0008283 GO:0008284 GO:0008285 GO:0008544 GO:0008593 GO:0009912 GO:0009957 GO:0009986 GO:0010001 GO:0010467 GO:0010468 GO:0010614 GO:0010628 GO:0010629 GO:0010718 GO:0010812 GO:0010832 GO:0014031 GO:0014807 GO:0016324 GO:0017156 GO:0019899 GO:0021515 GO:0021915 GO:0030027 GO:0030154 GO:0030163 GO:0030182 GO:0030216 GO:0030279 GO:0030324 GO:0030326 GO:0030334 GO:0030335 GO:0030513 GO:0030514 GO:0030900 GO:0031069 GO:0031100 GO:0031410 GO:0031490 GO:0032495 GO:0032496 GO:0032966 GO:0035116 GO:0035148 GO:0035914 GO:0035924 GO:0042127 GO:0042246 GO:0042670 GO:0042802 GO:0043065 GO:0043069 GO:0043086 GO:0043235 GO:0045070 GO:0045603 GO:0045607 GO:0045608 GO:0045618 GO:0045662 GO:0045665 GO:0045668 GO:0045687 GO:0045747 GO:0045892 GO:0045893 GO:0045944 GO:0045955 GO:0046427 GO:0046533 GO:0046579 GO:0048103 GO:0048663 GO:0048708 GO:0048709 GO:0048711 GO:0048715 GO:0048754 GO:0048845 GO:0048873 GO:0050434 GO:0050673 GO:0050678 GO:0050679 GO:0050680 GO:0050767 GO:0050768 GO:0055008 GO:0060038 GO:0060045 GO:0060253 GO:0060271 GO:0060317 GO:0060354 GO:0060379 GO:0060411 GO:0060412 GO:0060528 GO:0060740 GO:0060768 GO:0060842 GO:0060843 GO:0060948 GO:0060956 GO:0060979 GO:0060982 GO:0061101 GO:0061314 GO:0061384 GO:0062043 GO:0070168 GO:0070374 GO:0070986 GO:0071228 GO:0071372 GO:0071456 GO:0071944 GO:0072017 GO:0072044 GO:0072091 GO:0072144 GO:0072148 GO:0072538 GO:0090051 GO:0090090 GO:0097150 GO:0097400 GO:0120163 GO:0140537 GO:1901201 GO:1902263 GO:1902339 GO:1903849 GO:2000048 GO:2000737 GO:2000811 GO:2000974 GO:2001027
Fibrillin-1	P35555	FBN1	Homo sapiens	9606	48	anatomical structure morphogenesis basement membrane calcium ion binding camera-type eye development cell adhesion mediated by integrin cellular response to insulin-like growth factor stimulus cellular response to transforming growth factor beta stimulus collagen-containing extracellular matrix embryonic eye morphogenesis endoplasmic reticulum lumen extracellular matrix extracellular matrix constituent conferring elasticity extracellular matrix structural constituent extracellular region extracellular space heart development heparin binding hormone activity identical protein binding integrin binding metanephros development microfibril negative regulation of osteoclast development negative regulation of osteoclast differentiation post-embryonic eye morphogenesis protein-containing complex binding sequestering of BMP in extracellular matrix sequestering of TGFbeta in extracellular matrix skeletal system development	GO:0001501 GO:0001527 GO:0001656 GO:0005178 GO:0005179 GO:0005201 GO:0005509 GO:0005576 GO:0005604 GO:0005615 GO:0005788 GO:0007507 GO:0008201 GO:0009653 GO:0030023 GO:0031012 GO:0033627 GO:0035582 GO:0035583 GO:0042802 GO:0043010 GO:0044877 GO:0045671 GO:0048048 GO:0048050 GO:0062023 GO:0071560 GO:1990314 GO:2001205
Mucin-2	Q02817	MUC2	Homo sapiens	9606	48	Golgi lumen collagen-containing extracellular matrix cupric ion binding cuprous ion binding detoxification of copper ion extracellular matrix extracellular space host-mediated regulation of intestinal microbiota composition inner mucus layer maintenance of gastrointestinal epithelium mucus secretion outer mucus layer plasma membrane	GO:0005615 GO:0005796 GO:0005886 GO:0010273 GO:0030277 GO:0031012 GO:0048874 GO:0062023 GO:0070254 GO:0070702 GO:0070703 GO:1903135 GO:1903136
Nascent polypeptide-associated complex subunit alpha, muscle-specific form	P70670	Naca	Mus musculus	10090	47	DNA binding TBP-class protein binding cytoplasm myoblast migration nascent polypeptide-associated complex negative regulation of protein localization to endoplasmic reticulum nucleus protein targeting to membrane transcription coactivator activity unfolded protein binding	GO:0003677 GO:0003713 GO:0005634 GO:0005737 GO:0005854 GO:0006612 GO:0017025 GO:0051082 GO:0051451 GO:1905551
Cubilin	O60494	CUBN	Homo sapiens	9606	47	Golgi apparatus apical plasma membrane brush border membrane calcium ion binding cargo receptor activity cholesterol metabolic process clathrin-coated pit cobalamin binding cobalamin metabolic process cobalamin transport cytosol endocytic vesicle endoplasmic reticulum endosome establishment of localization in cell extracellular exosome extrinsic component of external side of plasma membrane lipoprotein transport lysosomal lumen lysosomal membrane membrane microvillus membrane plasma membrane protein homodimerization activity receptor complex receptor-mediated endocytosis response to bacterium signaling receptor activity tissue homeostasis	GO:0001894 GO:0005509 GO:0005765 GO:0005768 GO:0005783 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006898 GO:0008203 GO:0009235 GO:0009617 GO:0015889 GO:0016020 GO:0016324 GO:0030139 GO:0031232 GO:0031419 GO:0031526 GO:0031528 GO:0038023 GO:0038024 GO:0042803 GO:0042953 GO:0043202 GO:0043235 GO:0051649 GO:0070062
Protein transport protein Sec24B	O95487	SEC24B	Homo sapiens	9606	47	COPII vesicle coat COPII-coated vesicle cargo loading ER to Golgi transport vesicle membrane SNARE binding aorta morphogenesis auditory receptor cell stereocilium organization cochlear nucleus development coronary artery morphogenesis cytosol endoplasmic reticulum exit site endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport intracellular protein transport lung lobe morphogenesis neural tube closure outflow tract morphogenesis pulmonary artery morphogenesis regulation of cargo loading into COPII-coated vesicle regulation of establishment of planar polarity involved in neural tube closure zinc ion binding	GO:0000149 GO:0001843 GO:0003151 GO:0005789 GO:0005829 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0021747 GO:0030127 GO:0035909 GO:0060088 GO:0060463 GO:0060982 GO:0061156 GO:0070971 GO:0090110 GO:0090178 GO:1901301
Neurogenic locus notch homolog protein 1	G3I6Z6	NOTCH1	Cricetulus griseus	10029	47	Golgi lumen Golgi membrane Notch signaling involved in heart development adherens junction angiogenesis apical plasma membrane calcium ion binding cell differentiation cilium assembly nucleus regulation of DNA-templated transcription regulation of developmental process signaling receptor activity	GO:0000139 GO:0001525 GO:0005509 GO:0005634 GO:0005796 GO:0005912 GO:0006355 GO:0016324 GO:0030154 GO:0038023 GO:0050793 GO:0060271 GO:0061314
Receptor-type tyrosine-protein phosphatase eta	Q12913	PTPRJ	Homo sapiens	9606	47	B cell differentiation T cell receptor signaling pathway beta-catenin binding cadherin binding calcium-mediated signaling using intracellular calcium source cell surface cell-cell junction contact inhibition cytokine-mediated signaling pathway delta-catenin binding extracellular exosome gamma-catenin binding immunological synapse mitogen-activated protein kinase binding negative regulation of MAP kinase activity negative regulation of T cell receptor signaling pathway negative regulation of cell growth negative regulation of cell migration negative regulation of cell population proliferation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of vascular permeability peptidyl-tyrosine dephosphorylation phosphatase activity plasma membrane platelet-derived growth factor receptor binding platelet-derived growth factor receptor signaling pathway positive chemotaxis positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of MAPK cascade positive regulation of cell adhesion positive regulation of focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of tumor necrosis factor production protein kinase binding protein tyrosine phosphatase activity regulation of cell adhesion ruffle membrane specific granule membrane	GO:0001772 GO:0004725 GO:0005161 GO:0005886 GO:0005911 GO:0008013 GO:0008285 GO:0009986 GO:0010642 GO:0016791 GO:0019221 GO:0019901 GO:0030155 GO:0030183 GO:0030308 GO:0030336 GO:0032587 GO:0032760 GO:0035335 GO:0035579 GO:0035584 GO:0042059 GO:0043116 GO:0043407 GO:0043410 GO:0045295 GO:0045296 GO:0045785 GO:0048008 GO:0050731 GO:0050852 GO:0050860 GO:0050918 GO:0051019 GO:0051894 GO:0051897 GO:0051898 GO:0060242 GO:0070062 GO:0070097 GO:1905451
Low-density lipoprotein receptor-related protein 2	A2ARV4	Lrp2	Mus musculus	10090	47	Golgi apparatus PDZ domain binding SH3 domain binding amyloid-beta clearance aorta development apical part of cell apical plasma membrane axon axonal growth cone brush border brush border membrane calcium ion binding cargo receptor activity cell population proliferation cell surface cellular response to growth factor stimulus chemoattraction of axon clathrin-coated pit coronary artery morphogenesis coronary vasculature development dendrite diol metabolic process endocytic hemoglobin import into cell endocytic vesicle endocytosis endoplasmic reticulum endosomal transport endosome endosome lumen external side of plasma membrane extracellular space folate import across plasma membrane forebrain development heart development hemoglobin binding hormone binding insulin-like growth factor I binding kidney development low-density lipoprotein particle receptor binding male gonad development membrane metal ion transport negative regulation of BMP signaling pathway negative regulation of apoptotic process neural tube closure neuron projection arborization nuclear receptor binding outflow tract septum morphogenesis plasma membrane positive regulation of endocytosis positive regulation of lipoprotein transport positive regulation of neurogenesis positive regulation of oligodendrocyte progenitor proliferation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction protein import protein transport protein transporter activity protein-containing complex protein-containing complex binding protein-folding chaperone binding pulmonary artery morphogenesis receptor complex receptor-mediated endocytosis response to X-ray response to leptin secondary heart field specification sensory perception of sound transcytosis vagina development ventricular compact myocardium morphogenesis ventricular septum development vitamin D metabolic process	GO:0001822 GO:0001843 GO:0003139 GO:0003148 GO:0003223 GO:0003281 GO:0005509 GO:0005615 GO:0005768 GO:0005783 GO:0005794 GO:0005886 GO:0005903 GO:0005905 GO:0006897 GO:0006898 GO:0007507 GO:0007605 GO:0008283 GO:0008584 GO:0009897 GO:0009986 GO:0010165 GO:0015031 GO:0016020 GO:0016197 GO:0016324 GO:0016922 GO:0017038 GO:0017124 GO:0020028 GO:0030001 GO:0030139 GO:0030165 GO:0030424 GO:0030425 GO:0030492 GO:0030514 GO:0030900 GO:0031526 GO:0031904 GO:0031994 GO:0032991 GO:0034311 GO:0035904 GO:0038024 GO:0042359 GO:0042562 GO:0043066 GO:0043235 GO:0044295 GO:0044321 GO:0044877 GO:0045056 GO:0045177 GO:0045807 GO:0050750 GO:0050769 GO:0051087 GO:0051897 GO:0060068 GO:0060976 GO:0060982 GO:0061156 GO:0061642 GO:0070447 GO:0071363 GO:0097242 GO:0140058 GO:0140077 GO:0140318 GO:1904447
Protein PRRC2C	Q3TLH4	Prrc2c	Mus musculus	10090	46	cytoplasmic stress granule cytosol hematopoietic progenitor cell differentiation stress granule assembly	GO:0002244 GO:0005829 GO:0010494 GO:0034063