GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name ▲	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
1-acyl-sn-glycerol-3-phosphate acyltransferase,putative	B9PPK8	BN1205_090430	Toxoplasma gondii VEG	432359		1-acylglycerol-3-phosphate O-acyltransferase activity membrane	GO:0003841 GO:0016020
1-acylglycerol-3-phosphate O-acyltransferase ABHD5	Q8WTS1	ABHD5	Homo sapiens	9606		1-acylglycerol-3-phosphate O-acyltransferase activity carboxylic ester hydrolase activity cell differentiation cytosol fatty acid metabolic process intracellular membrane-bounded organelle lipase activator activity lipid droplet lipid homeostasis lysophosphatidic acid acyltransferase activity mitochondrion negative regulation of sequestering of triglyceride nucleoplasm phosphatidic acid biosynthetic process positive regulation of triglyceride catabolic process	GO:0003841 GO:0005654 GO:0005739 GO:0005811 GO:0005829 GO:0006631 GO:0006654 GO:0010891 GO:0010898 GO:0030154 GO:0042171 GO:0043231 GO:0052689 GO:0055088 GO:0060229
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3	Q9NST1	PNPLA3	Homo sapiens	9606	2	1-acylglycerol-3-phosphate O-acyltransferase activity acylglycerol O-acyltransferase activity acylglycerol acyl-chain remodeling cellular response to 3,3',5-triiodo-L-thyronine cellular response to insulin stimulus cytoplasm diolein transacylation activity endoplasmic reticulum membrane glycerophospholipid metabolic process lipid droplet lipid droplet organization lipid homeostasis lipoprotein lipase activity long-chain fatty acid metabolic process long-chain fatty acyl-CoA binding lysophosphatidic acid acyltransferase activity lysophosphatidic acid binding membrane mono-olein transacylation activity phosphatidic acid biosynthetic process phospholipase A2 activity response to sucrose triglyceride acyl-chain remodeling triglyceride biosynthetic process triglyceride catabolic process triglyceride lipase activity white fat cell differentiation	GO:0001676 GO:0003841 GO:0004465 GO:0004623 GO:0004806 GO:0005737 GO:0005789 GO:0005811 GO:0006650 GO:0006654 GO:0009744 GO:0016020 GO:0016411 GO:0019432 GO:0019433 GO:0032869 GO:0034389 GO:0035727 GO:0036042 GO:0036153 GO:0036155 GO:0042171 GO:0050872 GO:0051264 GO:0051265 GO:0055088 GO:1905243
1-acylglycerol-3-phosphate O-acyltransferase Pnpla3	Q91WW7	Pnpla3	Mus musculus	10090	2	1-acylglycerol-3-phosphate O-acyltransferase activity cytoplasm diolein transacylation activity glycerophospholipid metabolic process lipid droplet lipid droplet organization lipid homeostasis long-chain fatty acid metabolic process long-chain fatty acyl-CoA binding lysophosphatidic acid acyltransferase activity lysophosphatidic acid binding membrane mono-olein transacylation activity phosphatidic acid biosynthetic process phospholipase A2 activity response to dietary excess triglyceride acyl-chain remodeling triglyceride biosynthetic process triglyceride catabolic process triglyceride lipase activity	GO:0001676 GO:0002021 GO:0003841 GO:0004623 GO:0004806 GO:0005737 GO:0005811 GO:0006650 GO:0006654 GO:0016020 GO:0019432 GO:0019433 GO:0034389 GO:0035727 GO:0036042 GO:0036153 GO:0042171 GO:0051264 GO:0051265 GO:0055088
1-alkyl-2-acetylglycerophosphocholine esterase (Fragment)	Q3U1V7	Pla2g7	Mus musculus	10090	2	1-alkyl-2-acetylglycerophosphocholine esterase activity	GO:0003847
1-alkyl-2-acetylglycerophosphocholine esterase (Fragment)	E9Q330	Pla2g7	Mus musculus	10090	2	1-alkyl-2-acetylglycerophosphocholine esterase activity	GO:0003847
1-phosphatidylinositol 3-phosphate 5-kinase	Q9Y2I7	PIKFYVE	Homo sapiens	9606	4	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process 1-phosphatidylinositol-3-phosphate 5-kinase activity 1-phosphatidylinositol-4-phosphate 5-kinase activity 1-phosphatidylinositol-5-kinase activity ATP binding Golgi membrane antigen processing and presentation of exogenous peptide antigen via MHC class II cell-cell junction cytoplasmic vesicle cytosol early endosome membrane endosome membrane intracellular signal transduction late endosome membrane melanosome organization membrane raft myelin assembly neutrophil chemotaxis peptidyl-serine autophosphorylation perinuclear region of cytoplasm phagocytic vesicle membrane phagosome maturation phagosome-lysosome fusion phosphatidylinositol 5-phosphate metabolic process phosphatidylinositol biosynthetic process phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity protein localization to nucleus protein serine kinase activity protein serine/threonine kinase activity protein targeting to membrane receptor-mediated endocytosis of virus by host cell regulation of autophagosome assembly regulation of reactive oxygen species biosynthetic process retrograde transport, endosome to Golgi vesicle membrane zinc ion binding	GO:0000139 GO:0000285 GO:0004674 GO:0005524 GO:0005829 GO:0005911 GO:0006612 GO:0006661 GO:0008270 GO:0010008 GO:0012506 GO:0016308 GO:0019065 GO:0019886 GO:0030593 GO:0030670 GO:0031410 GO:0031901 GO:0031902 GO:0032288 GO:0032438 GO:0034504 GO:0035556 GO:0036289 GO:0042147 GO:0043813 GO:0045121 GO:0048471 GO:0052810 GO:0090382 GO:0090385 GO:0106310 GO:1903100 GO:1903426 GO:1904562 GO:2000785
1-phosphatidylinositol 3-phosphate 5-kinase FAB1	P34756	FAB1	Saccharomyces cerevisiae S288C	559292	17	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process 1-phosphatidylinositol-3-phosphate 5-kinase activity ATP binding PAS complex endosome membrane fungal-type vacuole membrane metal ion binding mitochondrion phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-3-phosphate binding phosphorylation regulation of phosphatidylinositol biosynthetic process	GO:0000285 GO:0000329 GO:0005524 GO:0005739 GO:0010008 GO:0010511 GO:0016310 GO:0032266 GO:0046854 GO:0046872 GO:0070772 GO:1903100
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	Q9Z1B3	Plcb1	Mus musculus	10090		G protein-coupled acetylcholine receptor signaling pathway G2/M transition of mitotic cell cycle GABA-ergic synapse GTPase activator activity activation of meiosis involved in egg activation brain development calcium ion binding calmodulin binding cell adhesion cellular response to fluoride cellular response to glyceraldehyde cellular response to ionomycin cellular response to vasopressin cerebral cortex development chromatin cytoplasm enzyme binding erythrocyte differentiation fat cell differentiation glutamate receptor signaling pathway glutamatergic synapse identical protein binding inositol trisphosphate metabolic process insulin receptor signaling pathway insulin-like growth factor receptor signaling pathway interleukin-1-mediated signaling pathway interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway ion channel modulating, G protein-coupled receptor signaling pathway lamin binding learning ligand-gated ion channel signaling pathway mRNA processing macrophage differentiation memory myelin sheath negative regulation of DNA-templated transcription negative regulation of monocyte extravasation nuclear membrane nuclear speck nucleus oocyte maturation phosphatidylinositol catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway plasma membrane positive regulation of CD24 production positive regulation of DNA-templated transcription positive regulation of G1/S transition of mitotic cell cycle positive regulation of JNK cascade positive regulation of acrosome reaction positive regulation of developmental growth positive regulation of embryonic development positive regulation of insulin secretion positive regulation of interleukin-12 production positive regulation of myoblast differentiation positive regulation of sodium:proton antiporter activity postsynaptic cytosol postsynaptic modulation of chemical synaptic transmission protein-containing complex regulation of G protein-coupled receptor signaling pathway regulation of establishment of endothelial barrier regulation of fertilization regulation of retrograde trans-synaptic signaling by endocanabinoid release of sequestered calcium ion into cytosol response to monosaccharide response to peptide hormone signal transduction	GO:0000086 GO:0000785 GO:0001556 GO:0004435 GO:0005096 GO:0005509 GO:0005516 GO:0005521 GO:0005546 GO:0005634 GO:0005737 GO:0005886 GO:0006397 GO:0007155 GO:0007165 GO:0007200 GO:0007207 GO:0007213 GO:0007215 GO:0007420 GO:0007612 GO:0007613 GO:0008277 GO:0008286 GO:0016607 GO:0019899 GO:0021987 GO:0030218 GO:0030225 GO:0031161 GO:0031965 GO:0032024 GO:0032417 GO:0032735 GO:0032957 GO:0032991 GO:0034284 GO:0035722 GO:0035723 GO:0040019 GO:0042802 GO:0043209 GO:0043434 GO:0045444 GO:0045663 GO:0045892 GO:0045893 GO:0046330 GO:0046488 GO:0048009 GO:0048015 GO:0048639 GO:0051209 GO:0060466 GO:0070498 GO:0080154 GO:0098978 GO:0098982 GO:0099105 GO:0099170 GO:0099178 GO:0099524 GO:1900087 GO:1902618 GO:1903140 GO:1904117 GO:1904637 GO:1905631 GO:1990806 GO:2000344 GO:2000438 GO:2000560
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1	P10687	Plcb1	Rattus norvegicus	10116		G protein-coupled acetylcholine receptor signaling pathway G2/M transition of mitotic cell cycle GABA-ergic synapse GTPase activator activity activation of meiosis involved in egg activation calcium ion binding calmodulin binding cellular response to fluoride cellular response to glyceraldehyde cellular response to ionomycin cellular response to vasopressin cerebral cortex development chromatin cytoplasm enzyme binding fat cell differentiation glutamate receptor signaling pathway glutamatergic synapse identical protein binding inositol trisphosphate metabolic process insulin-like growth factor receptor signaling pathway interleukin-1-mediated signaling pathway interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway ion channel modulating, G protein-coupled receptor signaling pathway lamin binding learning ligand-gated ion channel signaling pathway memory negative regulation of DNA-templated transcription negative regulation of monocyte extravasation nuclear membrane nuclear speck nucleus phosphatidylinositol catabolic process phosphatidylinositol metabolic process phosphatidylinositol phospholipase C activity phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-mediated signaling phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of CD24 production positive regulation of DNA-templated transcription positive regulation of G1/S transition of mitotic cell cycle positive regulation of JNK cascade positive regulation of acrosome reaction positive regulation of developmental growth positive regulation of embryonic development positive regulation of insulin secretion positive regulation of interleukin-12 production positive regulation of myoblast differentiation postsynapse postsynaptic cytosol postsynaptic modulation of chemical synaptic transmission protein-containing complex regulation of G protein-coupled receptor signaling pathway regulation of establishment of endothelial barrier regulation of fertilization regulation of retrograde trans-synaptic signaling by endocanabinoid release of sequestered calcium ion into cytosol response to monosaccharide response to organonitrogen compound response to peptide hormone	GO:0000086 GO:0000785 GO:0004435 GO:0005096 GO:0005509 GO:0005516 GO:0005521 GO:0005546 GO:0005634 GO:0005737 GO:0007200 GO:0007207 GO:0007213 GO:0007215 GO:0007612 GO:0007613 GO:0008277 GO:0010243 GO:0016607 GO:0019899 GO:0021987 GO:0031161 GO:0031965 GO:0032024 GO:0032735 GO:0032957 GO:0032991 GO:0034284 GO:0035722 GO:0035723 GO:0040019 GO:0042802 GO:0043434 GO:0045444 GO:0045663 GO:0045892 GO:0045893 GO:0046330 GO:0046488 GO:0048009 GO:0048015 GO:0048639 GO:0051209 GO:0060466 GO:0070498 GO:0080154 GO:0098794 GO:0098978 GO:0098982 GO:0099105 GO:0099170 GO:0099178 GO:0099524 GO:1900087 GO:1902618 GO:1903140 GO:1904117 GO:1904637 GO:1905631 GO:1990806 GO:2000344 GO:2000438 GO:2000560