GlyCosmos Portal

GlyCosmos Glycoproteins

Integrated list of glycoproteins extracted from UniProt and annotated with glycosylation data from GlyGen and GlyConnect. For each entry, information such as glycosylation site, glycans, diseases, 3D structures, and pathway information are available.

Database	Last Updated
GlyConnect	April 19, 2023
GlycoProtDB	October 1, 2021
GlyGen	October 2, 2023
Human Protein Atlas	June 19, 2023 (Protein Atlas version 23)
MCAW-DB	July 10, 2019
The O-GlcNAc Database	April 10, 2023 (v1.3)
Reactome	February 28, 2024 (Version 87)
UniProt	December 27, 2023

Protein Name	UniProt ID	Gene Symbol	Species	Taxonomy ID	No. of Glycosylation Sites	GO Labels	GO IDs
Deoxyribonuclease-1	P24855	DNASE1	Homo sapiens	9606	2	DNA binding DNA catabolic process actin binding apoptotic process deoxyribonuclease I activity extracellular exosome extracellular region neutrophil activation involved in immune response nuclear envelope nucleus regulation of acute inflammatory response regulation of neutrophil mediated cytotoxicity zymogen granule	GO:0002283 GO:0002673 GO:0003677 GO:0003779 GO:0004530 GO:0005576 GO:0005634 GO:0005635 GO:0006308 GO:0006915 GO:0042588 GO:0070062 GO:0070948
Disks large homolog 1	Q12959	DLG1	Homo sapiens	9606	1	Golgi apparatus L27 domain binding MPP7-DLG1-LIN7 complex T cell proliferation actin filament organization actin filament polymerization adherens junction amyloid precursor protein metabolic process apical plasma membrane astral microtubule organization basement membrane basolateral plasma membrane bicellular tight junction bicellular tight junction assembly branching involved in ureteric bud morphogenesis cadherin binding cell junction cell projection membrane cell-cell adhesion cell-cell junction chemical synaptic transmission cortical actin cytoskeleton organization cortical microtubule organization cytoplasm cytoplasmic side of plasma membrane cytoskeletal protein binding cytosol embryonic skeletal system morphogenesis endoplasmic reticulum endoplasmic reticulum membrane endothelial cell proliferation establishment of centrosome localization establishment or maintenance of cell polarity establishment or maintenance of epithelial cell apical/basal polarity extracellular exosome glutamatergic synapse guanylate kinase activity hard palate development immunological synapse immunological synapse formation intercalated disc kinase binding lateral loop lateral plasma membrane lens development in camera-type eye membrane raft membrane raft organization microtubule molecular adaptor activity myelin sheath abaxonal region negative regulation of ERK1 and ERK2 cascade negative regulation of G1/S transition of mitotic cell cycle negative regulation of T cell proliferation negative regulation of epithelial cell proliferation negative regulation of p38MAPK cascade negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of transcription by RNA polymerase II neuromuscular junction neuron projection neurotransmitter receptor localization to postsynaptic specialization membrane node of Ranvier nucleus perinuclear region of cytoplasm peristalsis phosphatase binding phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphoprotein phosphatase activity plasma membrane positive regulation of actin filament polymerization positive regulation of cell population proliferation positive regulation of potassium ion transport positive regulation of protein localization to plasma membrane postsynaptic density membrane potassium channel regulator activity protein localization to plasma membrane protein-containing complex localization receptor clustering regulation of cell shape regulation of membrane potential regulation of myelination regulation of potassium ion export across plasma membrane regulation of potassium ion import regulation of protein localization to synapse regulation of sodium ion transmembrane transport regulation of ventricular cardiac muscle cell action potential regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization reproductive structure development sarcolemma smooth muscle tissue development structural constituent of postsynaptic density synaptic membrane transmembrane transporter binding	GO:0000122 GO:0001658 GO:0001771 GO:0001772 GO:0001935 GO:0002088 GO:0004385 GO:0004721 GO:0005604 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005874 GO:0005886 GO:0005911 GO:0005912 GO:0005923 GO:0007015 GO:0007163 GO:0007268 GO:0008092 GO:0008284 GO:0008360 GO:0009898 GO:0014704 GO:0015459 GO:0016323 GO:0016324 GO:0016328 GO:0019900 GO:0019902 GO:0030041 GO:0030054 GO:0030432 GO:0030838 GO:0030866 GO:0030953 GO:0031253 GO:0031503 GO:0031579 GO:0031594 GO:0031641 GO:0033268 GO:0035748 GO:0042098 GO:0042130 GO:0042383 GO:0042391 GO:0042982 GO:0043005 GO:0043113 GO:0043219 GO:0043268 GO:0043491 GO:0043622 GO:0044325 GO:0045121 GO:0045197 GO:0045296 GO:0048471 GO:0048608 GO:0048704 GO:0048745 GO:0050680 GO:0051660 GO:0051898 GO:0060022 GO:0060090 GO:0070062 GO:0070373 GO:0070830 GO:0072659 GO:0097016 GO:0097025 GO:0097060 GO:0098609 GO:0098839 GO:0098911 GO:0098919 GO:0098978 GO:0099645 GO:1902305 GO:1902473 GO:1903078 GO:1903286 GO:1903753 GO:1903760 GO:1903764 GO:2000134
Netrin-3	O00634	NTN3	Homo sapiens	9606	2	DNA-binding transcription factor activity, RNA polymerase II-specific Golgi apparatus RNA polymerase II cis-regulatory region sequence-specific DNA binding axon guidance extracellular region regulation of transcription by RNA polymerase II signaling receptor binding	GO:0000978 GO:0000981 GO:0005102 GO:0005576 GO:0005794 GO:0006357 GO:0007411
Sphingomyelin phosphodiesterase	P17405	SMPD1	Homo sapiens	9606	6	acid sphingomyelin phosphodiesterase activity cellular response to UV cellular response to calcium ion ceramide biosynthetic process cholesterol metabolic process endolysosome endosome extracellular exosome extracellular space glycosphingolipid metabolic process hydrolase activity, acting on glycosyl bonds lamellar body lipid droplet lysosomal lumen lysosome negative regulation of MAP kinase activity nervous system development phosphatidylcholine phospholipase C activity plasma membrane plasma membrane repair positive regulation of apoptotic process positive regulation of endocytosis positive regulation of protein dephosphorylation positive regulation of viral entry into host cell response to cocaine response to interleukin-1 response to ionizing radiation response to tumor necrosis factor response to type I interferon response to virus response to xenobiotic stimulus signal transduction sphingomyelin catabolic process sphingomyelin metabolic process sphingomyelin phosphodiesterase activity termination of signal transduction viral entry into host cell wound healing zinc ion binding	GO:0001778 GO:0004767 GO:0005615 GO:0005764 GO:0005768 GO:0005811 GO:0005886 GO:0006684 GO:0006685 GO:0006687 GO:0007165 GO:0007399 GO:0008203 GO:0008270 GO:0009410 GO:0009615 GO:0010212 GO:0016798 GO:0023021 GO:0034340 GO:0034480 GO:0034612 GO:0034644 GO:0035307 GO:0036019 GO:0042060 GO:0042220 GO:0042599 GO:0043065 GO:0043202 GO:0043407 GO:0045807 GO:0046513 GO:0046598 GO:0046718 GO:0061750 GO:0070062 GO:0070555 GO:0071277
Immunoglobulin heavy variable 3/OR16-8 (non-functional) (Fragment)	A0A075B7F1	IGHV3OR16-8	Homo sapiens	9606	1	antigen binding immunoglobulin mediated immune response	GO:0003823 GO:0016064
Kallikrein-11	Q9UBX7	KLK11	Homo sapiens	9606	4	Golgi apparatus extracellular exosome extracellular space proteolysis secretory granule serine-type endopeptidase activity serine-type peptidase activity	GO:0004252 GO:0005615 GO:0005794 GO:0006508 GO:0008236 GO:0030141 GO:0070062
TLR4 interactor with leucine rich repeats	Q9DBY4	Tril	Mus musculus	10090	4	extracellular matrix extracellular space inflammatory response innate immune response lipopolysaccharide binding lipopolysaccharide receptor complex regulation of cytokine production involved in immune response toll-like receptor 4 signaling pathway	GO:0001530 GO:0002718 GO:0005615 GO:0006954 GO:0031012 GO:0034142 GO:0045087 GO:0046696
H-2 class I histocompatibility antigen, D-K alpha chain	P14426	H2-D1	Mus musculus	10090	3	14-3-3 protein binding CD8 receptor binding CD8-positive, alpha-beta T cell activation Golgi apparatus Golgi medial cisterna Golgi membrane MHC class I peptide loading complex MHC class I protein binding MHC class I protein complex MHC class Ib protein complex T cell mediated cytotoxicity T cell receptor binding TAP binding TAP complex binding TAP1 binding TAP2 binding adaptive immune response antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib beta-2-microglobulin binding cell surface cis-Golgi network membrane defense response to Gram-positive bacterium early endosome early endosome membrane endoplasmic reticulum endoplasmic reticulum exit site external side of plasma membrane extracellular space identical protein binding immune response lumenal side of endoplasmic reticulum membrane lysosomal membrane natural killer cell lectin-like receptor binding natural killer cell tolerance induction negative regulation of natural killer cell mediated cytotoxicity negative regulation of neuron projection development peptide antigen binding peptide binding phagocytic vesicle membrane plasma membrane positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of T cell mediated cytotoxicity positive regulation of TRAIL production positive regulation of antibody-dependent cellular cytotoxicity positive regulation of immunoglobulin production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell proliferation positive regulation of tumor necrosis factor production protection from natural killer cell mediated cytotoxicity protein homodimerization activity protein-containing complex binding protein-folding chaperone binding regulation of natural killer cell mediated immunity signaling receptor binding	GO:0000139 GO:0001815 GO:0001913 GO:0001916 GO:0002250 GO:0002476 GO:0002477 GO:0002485 GO:0002486 GO:0002519 GO:0002639 GO:0002715 GO:0002717 GO:0002729 GO:0005102 GO:0005615 GO:0005765 GO:0005769 GO:0005783 GO:0005794 GO:0005797 GO:0005886 GO:0006955 GO:0009897 GO:0009986 GO:0010977 GO:0019731 GO:0030670 GO:0030881 GO:0031901 GO:0032398 GO:0032736 GO:0032753 GO:0032759 GO:0032760 GO:0032819 GO:0033106 GO:0036037 GO:0042270 GO:0042277 GO:0042288 GO:0042605 GO:0042608 GO:0042610 GO:0042612 GO:0042802 GO:0042803 GO:0042824 GO:0044877 GO:0045953 GO:0045954 GO:0046703 GO:0046977 GO:0046978 GO:0046979 GO:0050830 GO:0051087 GO:0062061 GO:0070971 GO:0071889 GO:0098553 GO:2000566 GO:2001187
Glycophorin-A	P14221	GYPA	Macaca fuscata fuscata	9543	18	ankyrin-1 complex	GO:0170014
Somatomedin-B and thrombospondin type-1 domain-containing protein	Q8IVN8	SBSPON	Homo sapiens	9606	1	collagen-containing extracellular matrix extracellular region	GO:0005576 GO:0062023