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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal alpha-mannosidase
Summary
- UniProt ID
- O00754
- Gene Symbol
-
- MAN2B1
- LAMAN
- MANB
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011174
- GlyConnect
- GlyGen
- O00754
- PubChem
- O00754
- The Human Metabolome Database
- HMDBP11810
- The O-GlcNAc Database
- O00754
- RaftProt
- O00754
- O-GlcNAcAtlas
- O00754
Annotation
- Keyword
-
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lysosome
- Metal-binding
- Reference proteome
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| learning or memory |
| protein modification process |
| protein deglycosylation |
| mannose metabolic process |
| N-glycan processing |
| oligosaccharide catabolic process |
| GO Term |
|---|
| metal ion binding |
| carbohydrate binding |
| alpha-mannosidase activity |
Sequence
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQLREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Lysosomal oligosaccharide catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12798 | mucopolysaccharidosis | |
| DOID:12799 | mucopolysaccharidosis II | |
| DOID:12800 | mucopolysaccharidosis VI | |
| DOID:12801 | mucopolysaccharidosis III | |
| DOID:12802 | mucopolysaccharidosis I | |
| DOID:12804 | mucopolysaccharidosis IV | |
| DOID:13174 | dissociated nystagmus | |
| DOID:1443 | cerebral degeneration | |
| DOID:2007 | degeneration of macula and posterior pole | |
| DOID:2752 | glycogen storage disease II |
