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Phosphatidylcholine-sterol acyltransferase

Summary

UniProt ID

P04180

Gene Symbol

LCAT

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011357

GlyConnect

GlyGen

P04180

PubChem

P04180

SwissLipids

SLP:000000660

The Human Metabolome Database

HMDBP00069

Annotation

Keyword

3D-structure
Acyltransferase
Cholesterol metabolism
Corneal dystrophy
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
regulation of high-density lipoprotein particle assembly
reverse cholesterol transport
phospholipid metabolic process
cholesterol metabolic process
cholesterol homeostasis
phosphatidylcholine biosynthetic process
cholesterol transport
very-low-density lipoprotein particle remodeling
phosphatidylcholine metabolic process
high-density lipoprotein particle remodeling

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
extracellular exosome
high-density lipoprotein particle

Displaying **all 5** entries
GO Term
platelet-activating factor acetyltransferase activity
1-alkyl-2-acetylglycerophosphocholine esterase activity
phosphatidylcholine-sterol O-acyltransferase activity
sterol esterase activity
apolipoprotein A-I binding

Annotation information from UniProt.

Sequence

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
44		23586699
296		23586699

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HDL remodeling	Homo sapiens

Disease

Displaying entries **31 - 40** of **150** in total

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DO ID	Disease Name	Source
DOID:0110156	Charcot-Marie-Tooth disease type 2B1	DisGeNET DisGeNET
DOID:0110157	Charcot-Marie-Tooth disease type 2J	DisGeNET DisGeNET
DOID:0110158	Charcot-Marie-Tooth disease type 2I	DisGeNET DisGeNET
DOID:0110159	Charcot-Marie-Tooth disease type 2B	DisGeNET DisGeNET
DOID:0110160	Charcot-Marie-Tooth disease axonal type 2T	DisGeNET DisGeNET
DOID:0110161	Charcot-Marie-Tooth disease type 2R	DisGeNET DisGeNET
DOID:0110163	Charcot-Marie-Tooth disease axonal type 2F	DisGeNET DisGeNET
DOID:0110164	Charcot-Marie-Tooth disease type 2D	DisGeNET DisGeNET
DOID:0110165	Charcot-Marie-Tooth disease type 2E	DisGeNET DisGeNET
DOID:0110166	Charcot-Marie-Tooth disease axonal type 2H	DisGeNET DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements