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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Glypican-3
Summary
- UniProt ID
- P51654
- Gene Symbol
-
- GPC3
- OCI5
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011721
- GlyGen
- P51654
- PubChem
- P51654
- The O-GlcNAc Database
- P51654
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disease variant
- Disulfide bond
- GPI-anchor
- Heparan sulfate
- Phosphoprotein
- Protease inhibitor
- Pyrrolidone carboxylic acid
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| collagen-containing extracellular matrix |
| side of membrane |
| lysosomal lumen |
| endoplasmic reticulum lumen |
| Golgi lumen |
| cell surface |
| GO Term |
|---|
| peptidyl-dipeptidase inhibitor activity |
Sequence
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:5299 | endometrial clear cell adenocarcinoma | |
| DOID:5348 | adult endodermal sinus tumor | |
| DOID:5403 | microcystic adenoma | |
| DOID:5517 | stomach carcinoma | |
| DOID:5557 | testicular germ cell cancer | |
| DOID:5572 | Beckwith-Wiedemann syndrome | |
| DOID:5672 | large intestine cancer | |
| DOID:5675 | cribriform carcinoma | |
| DOID:5681 | ovarian embryonal carcinoma | |
| DOID:6053 | childhood germ cell cancer |
