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Major prion protein

Summary

UniProt ID

Q4FJQ7

Gene Symbol

Prnp

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005097

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Repeat
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

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GO Term
calcium-mediated signaling using intracellular calcium source
protein homooligomerization
cellular response to copper ion
negative regulation of long-term synaptic potentiation
cellular response to amyloid-beta
learning or memory
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein localization to plasma membrane

Displaying **all 10** entries
GO Term
cell surface
postsynaptic density
side of membrane
Golgi apparatus
plasma membrane
nuclear membrane
dendrite
inclusion body
cytosol
membrane raft

Displaying entries **1 - 10** of 11 in total

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GO Term
molecular condensate scaffold activity
cuprous ion binding
microtubule binding
protein-containing complex binding
protein-folding chaperone binding
type 5 metabotropic glutamate receptor binding
identical protein binding
ATP-dependent protein binding
transmembrane transporter binding
amyloid-beta binding

Annotation information from UniProt.

Sequence

MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites